Julien Sage

Publications

• IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors. Jameson KL, Mazur PK, Zehnder AM, Zhang J, Zarnegar B, Sage J, Khavari PA. Nat Med. 2013; 19 (5): 626-30
• Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. Garfin PM, Min D, Bryson JL, Serwold T, Edris B, Blackburn CC, Richie ER, Weinberg KI, Manley NR, Sage J, Viatour P. J Exp Med. 2013
• The RB family is required for the self-renewal and survival of human embryonic stem cells. Conklin JF, Baker J, Sage J. Nat Commun. 2012: 3 1244
• The retinoblastoma tumor suppressor and stem cell biology. Sage J, Genes Dev. 2012; 26 (13): 1409-20
• A crucial requirement for Hedgehog signaling in small cell lung cancer. Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. Nat Med. 2011; 17 (11): 1504-8
• Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ. Sci Transl Med. 2011; 3 (96): 96ra77
• Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. Viatour P, Ehmer U, Saddic LA, Dorrell C, Andersen JB, Lin C, Zmoos AF, Mazur PK, Schaffer BE, Ostermeier A, Vogel H, Sylvester KG, Thorgeirsson SS, Grompe M, Sage J. J Exp Med. 2011; 208 (10): 1963-76
• PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK. Nature. 2011; 478 (7369): 349-55
• G1 arrest and differentiation can occur independently of Rb family function. Wirt SE, Adler AS, Gebala V, Weimann JM, Schaffer BE, Saddic LA, Viatour P, Vogel H, Chang HY, Meissner A, Sage J. J Cell Biol. 2010; 191 (4): 809-25
• Methylation of the retinoblastoma tumor suppressor by SMYD2. Saddic LA, West LE, Aslanian A, Yates JR, Rubin SM, Gozani O, Sage J. J Biol Chem. 2010; 285 (48): 37733-40
• Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. Burkhart DL, Wirt SE, Zmoos AF, Kareta MS, Sage J. PLoS Genet. 2010; 6 (6): e1001003
• Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM. Cell Stem Cell. 2010; 7 (2): 198-213
• Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J. Cell Stem Cell. 2008; 3 (4): 416-28
• RB goes mitochondrial. Attardi LD, Sage J. Genes Dev. 2013; 27 (9): 975-9
• Characterization of the cell of origin for small cell lung cancer. Park KS, Liang MC, Raiser DM, Zamponi R, Roach RR, Curtis SJ, Walton Z, Schaffer BE, Roake CM, Zmoos AF, Kriegel C, Wong KK, Sage J, Kim CF. Cell Cycle. 2011; 10 (16): 2806-15
• Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma. Saddic LA, Wirt S, Vogel H, Felsher DW, Sage J. PLoS One. 2011; 6 (5): e19758
• MicroRNA programs in normal and aberrant stem and progenitor cells. Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C, Chen CZ. Genome Res. 2011; 21 (5): 798-810
• miR than meets the eye. Sage J, Ventura A. Genes Dev. 2011; 25 (16): 1663-7
• Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Schaffer BE, Park KS, Yiu G, Conklin JF, Lin C, Burkhart DL, Karnezis AN, Sweet-Cordero EA, Sage J. Cancer Res. 2010; 70 (10): 3877-83
• RB's original CIN? Sage J, Straight AF. Genes Dev. 2010; 24 (13): 1329-33
• Regulation of RB transcription in vivo by RB family members. Burkhart DL, Ngai LK, Roake CM, Viatour P, Thangavel C, Ho VM, Knudsen ES, Sage J. Mol Cell Biol. 2010; 30 (7): 1729-45
• p107 in the public eye: an Rb understudy and more. Wirt SE, Sage J. Cell Div. 2010: 5 9
• Keeping an eye on retinoblastoma control of human embryonic stem cells. Conklin JF, Sage J. J Cell Biochem. 2009; 108 (5): 1023-30
• The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras. Ho VM, Schaffer BE, Karnezis AN, Park KS, Sage J. Oncogene. 2009; 28 (10): 1393-9
• Cellular mechanisms of tumour suppression by the retinoblastoma gene. Burkhart DL, Sage J. Nat Rev Cancer. 2008; 8 (9): 671-82
• Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Sage J, Miller AL, Pérez-Mancera PA, Wysocki JM, Jacks T. Nature. 2003; 424 (6945): 223-8
• Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B, Theodorou E, Jacks T. Genes Dev. 2000; 14 (23): 3037-50