Publications
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HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Guce AI,
Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ.
Nat Struct Mol Biol.
2013;
20
(1):
90-8
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Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.
Rajasekaran N,
Wang N, Truong P, Rinderknecht C, Macaubas C, Beilhack GF, Shizuru JA, Mellins ED.
Arthritis Rheum.
2013;
65
(3):
681-92
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Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading.
Hou T,
Rinderknecht CH, Hadjinicolaou AV, Busch R, Mellins E.
Methods Mol Biol.
2013:
960
411-32
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Susceptibility to childhood onset rheumatoid arthritis: Investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
Prahalad S,
Conneely KN, Jiang Y, Sudman M, Wallace CA, Brown MR, Ponder LA, Rohani-Pichavant M, Zwick ME, Cutler DJ, Angeles-Han ST, Vogler LB, Kennedy C, Rouster-Stevens K, Wise CA, Punaro M, Reed AM, Mellins ED, Bohnsack JF, Glass DN, Thompson SD.
Arthritis Rheum.
2013
-
A new era in the treatment of systemic juvenile idiopathic arthritis.
Sandborg C,
Mellins ED.
N Engl J Med.
2012;
367
(25):
2439-40
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Alternative activation in systemic juvenile idiopathic arthritis monocytes.
Macaubas C,
Nguyen KD, Peck A, Buckingham J, Deshpande C, Wong E, Alexander HC, Chang SY, Begovich A, Sun Y, Park JL, Pan KH, Lin R, Lih CJ, Augustine EM, Phillips C, Hadjinicolaou AV, Lee T, Mellins ED.
Clin Immunol.
2012;
142
(3):
362-72
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Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.
Prahalad S,
Thompson SD, Conneely KN, Jiang Y, Leong T, Prozonic J, Brown MR, Ponder LA, Angeles-Han ST, Vogler LB, Kennedy C, Wallace CA, Wise CA, Punaro M, Reed A, Park JL, Mellins ED, Zeft AS, Bohnsack JF, Glass DN.
Arthritis Rheum.
2012;
64
(3):
925-30
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Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis.
Yoon T,
Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern LJ, Mellins ED.
Proc Natl Acad Sci U S A.
2012;
109
(28):
11276-81
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An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.
Hou T,
Macmillan H, Chen Z, Keech CL, Jin X, Sidney J, Strohman M, Yoon T, Mellins ED.
J Immunol.
2011;
187
(5):
2442-52
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Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions.
Mellins ED,
Macaubas C, Grom AA.
Nat Rev Rheumatol.
2011;
7
(7):
416-26
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Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.
Nguyen KD,
Macaubas C, Nadeau KC, Truong P, Yoon T, Lee T, Park JL, Mellins ED.
Blood.
2011;
117
(14):
3793-8
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On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.
Busch R,
De Riva A, Hadjinicolaou AV, Jiang W, Hou T, Mellins ED.
Expert Rev Mol Med.
2012:
14
e15
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Self-antigen recognition by follicular lymphoma B-cell receptors.
Sachen KL,
Strohman MJ, Singletary J, Alizadeh AA, Kattah NH, Lossos C, Mellins ED, Levy S, Levy R.
Blood.
2012;
120
(20):
4182-90
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Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.
Rothbard JB,
Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, Robinson WH, Steinman L.
J Immunol.
2011;
186
(7):
4263-8
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Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels.
Lee AW,
Wang N, Hornell TM, Harding JJ, Deshpande C, Hertel L, Lacaille V, Pashine A, Macaubas C, Mocarski ES, Mellins ED.
Mol Immunol.
2011;
48
(9-10):
1160-7
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Cathepsin G: roles in antigen presentation and beyond.
Burster T,
Macmillan H, Hou T, Boehm BO, Mellins ED.
Mol Immunol.
2010;
47
(4):
658-65
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DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.
Rinderknecht CH,
Roh S, Pashine A, Belmares MP, Patil NS, Lu N, Truong P, Hou T, Macaubas C, Yoon T, Wang N, Busch R, Mellins ED.
Immunology.
2010;
131
(1):
18-32
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Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states.
Macaubas C,
Nguyen K, Deshpande C, Phillips C, Peck A, Lee T, Park JL, Sandborg C, Mellins ED.
Clin Immunol.
2010;
134
(2):
206-16
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I-Ag7 is subject to post-translational chaperoning by CLIP.
Rinderknecht CH,
Lu N, Crespo O, Truong P, Hou T, Wang N, Rajasekaran N, Mellins ED.
Int Immunol.
2010;
22
(8):
705-16
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Macrophage activation syndrome: advances towards understanding pathogenesis.
Grom AA,
Mellins ED.
Curr Opin Rheumatol.
2010;
22
(5):
561-6
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Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules.
Burster T,
Macmillan H, Hou T, Schilling J, Truong P, Boehm BO, Zou F, Lau K, Strohman M, Schaffert S, Busch R, Mellins ED.
Immunology.
2010;
130
(3):
436-46
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Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis.
Srivastava S,
Macaubas C, Deshpande C, Alexander HC, Chang SY, Sun Y, Park JL, Lee T, Begovich A, Mellins ED.
Clin Immunol.
2010;
136
(2):
257-68
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Plasma profiles in active systemic juvenile idiopathic arthritis: Biomarkers and biological implications.
Ling XB,
Park JL, Carroll T, Nguyen KD, Lau K, Macaubas C, Chen E, Lee T, Sandborg C, Milojevic D, Kanegaye JT, Gao S, Burns J, Schilling J, Mellins ED.
Proteomics.
2010;
10
(24):
4415-30
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Plasticity of T-cell phenotype and function: the T helper type 17 example.
Peck A,
Mellins ED.
Immunology.
2010;
129
(2):
147-53
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Precarious balance: Th17 cells in host defense.
Peck A,
Mellins ED.
Infect Immun.
2010;
78
(1):
32-8
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Urine Peptidomic and Targeted Plasma Protein Analyses in the Diagnosis and Monitoring of Systemic Juvenile Idiopathic Arthritis.
Ling XB,
Lau K, Deshpande C, Park JL, Milojevic D, Macaubas C, Xiao C, Lopez-Avila V, Kanegaye J, Burns JC, Cohen H, Schilling J, Mellins ED.
Clin Proteomics.
2010;
6
(4):
175-193
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Urine peptidomics for clinical biomarker discovery.
Ling XB,
Mellins ED, Sylvester KG, Cohen HJ.
Adv Clin Chem.
2010:
51
181-213
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Breaking old paradigms: Th17 cells in autoimmune arthritis.
Peck A,
Mellins ED.
Clin Immunol.
2009;
132
(3):
295-304
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Oligoarticular and polyarticular JIA: epidemiology and pathogenesis.
Macaubas C,
Nguyen K, Milojevic D, Park JL, Mellins ED.
Nat Rev Rheumatol.
2009;
5
(11):
616-26
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Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM.
Fallang LE,
Roh S, Holm A, Bergseng E, Yoon T, Fleckenstein B, Bandyopadhyay A, Mellins ED, Sollid LM.
J Immunol.
2008;
181
(8):
5451-61
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Modulation of peripheral B cell tolerance by CD72 in a murine model.
Li DH,
Winslow MM, Cao TM, Chen AH, Davis CR, Mellins ED, Utz PJ, Crabtree GR, Parnes JR.
Arthritis Rheum.
2008;
58
(10):
3192-204
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Clinical research networks: a step towards evidence-based practice in pediatric rheumatology.
Mellins ED,
Rider LG.
Nat Clin Pract Rheumatol.
2007;
3
(2):
59
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Influenza A virus elevates active cathepsin B in primary murine DC.
Burster T,
Giffon T, Dahl ME, Björck P, Bogyo M, Weber E, Mahmood K, Lewis DB, Mellins ED.
Int Immunol.
2007;
19
(5):
645-55
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Posttranslational regulation of I-Ed by affinity for CLIP.
Rinderknecht CH,
Belmares MP, Catanzarite TL, Bankovich AJ, Holmes TH, Garcia KC, Nanda NK, Busch R, Kovats S, Mellins ED.
J Immunol.
2007;
179
(9):
5907-15
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Candidate early predictors for progression to joint damage in systemic juvenile idiopathic arthritis.
Sandborg C,
Holmes TH, Lee T, Biederman K, Bloch DA, Emery H, McCurdy D, Mellins ED.
J Rheumatol.
2006;
33
(11):
2322-9
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Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells.
Lee AW,
Hertel L, Louie RK, Burster T, Lacaille V, Pashine A, Abate DA, Mocarski ES, Mellins ED.
J Immunol.
2006;
177
(6):
3960-71
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Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation.
Hornell TM,
Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED.
J Immunol.
2006;
176
(6):
3536-47
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Medicine on a need-to-know basis.
Busch R,
Byrne B, Gandrud L, Sears D, Meyer E, Kattah M, Kurihara C, Haertel E, Parnes JR, Mellins ED.
Nat Immunol.
2006;
7
(6):
543-7
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Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression.
Busch R,
Rinderknecht CH, Roh S, Lee AW, Harding JJ, Burster T, Hornell TM, Mellins ED.
Immunol Rev.
2005:
207
242-60
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Bordetella pertussis infection of primary human monocytes alters HLA-DR expression.
Shumilla JA,
Lacaille V, Hornell TM, Huang J, Narasimhan S, Relman DA, Mellins ED.
Infect Immun.
2004;
72
(3):
1450-62
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Selective developmental defects of cord blood antigen-presenting cell subsets.
Drohan L,
Harding JJ, Holm B, Cordoba-Tongson E, Dekker CL, Holmes T, Maecker H, Mellins ED.
Hum Immunol.
2004;
65
(11):
1356-69
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Cytokines elicited by T cell epitopes from a synovial autoantigen: altered peptide ligands can reduce interferon-gamma and interleukin-10 production.
Hall FC,
Visconti KC, Ahmad RC, Parry SL, Miltenburg AM, McConnell HM, Mellins ED, Sønderstrup G.
Arthritis Rheum.
2003;
48
(8):
2375-85
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Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM.
Belmares MP,
Busch R, Mellins ED, McConnell HM.
Biochemistry.
2003;
42
(3):
838-47
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Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides.
Pashine A,
Busch R, Belmares MP, Munning JN, Doebele RC, Buckingham M, Nolan GP, Mellins ED.
Immunity.
2003;
19
(2):
183-92
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Point mutations in or near the antigen-binding groove of HLA-DR3 implicate class II-associated invariant chain peptide affinity as a constraint on MHC class II polymorphism.
Doebele RC,
Pashine A, Liu W, Zaller DM, Belmares M, Busch R, Mellins ED.
J Immunol.
2003;
170
(9):
4683-92
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Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor.
Hornell TM,
Beresford GW, Bushey A, Boss JM, Mellins ED.
J Immunol.
2003;
171
(5):
2374-83
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Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus.
Hertel L,
Lacaille VG, Strobl H, Mellins ED, Mocarski ES.
J Virol.
2003;
77
(13):
7563-74
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Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes.
Hall FC,
Rabinowitz JD, Busch R, Visconti KC, Belmares M, Patil NS, Cope AP, Patel S, McConnell HM, Mellins ED, Sonderstrup G.
Eur J Immunol.
2002;
32
(3):
662-70
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Stabilization of soluble, low-affinity HLA-DM/HLA-DR1 complexes by leucine zippers.
Busch R,
Pashine A, Garcia KC, Mellins ED.
J Immunol Methods.
2002;
263
(1-2):
111-21
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Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
Belmares MP,
Busch R, Wucherpfennig KW, McConnell HM, Mellins ED.
J Immunol.
2002;
169
(9):
5109-17
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Autoantigenic HCgp39 epitopes are presented by the HLA-DM-dependent presentation pathway in human B cells.
Patil NS,
Hall FC, Drover S, Spurrell DR, Bos E, Cope AP, Sonderstrup G, Mellins ED.
J Immunol.
2001;
166
(1):
33-41
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Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles.
Patil NS,
Pashine A, Belmares MP, Liu W, Kaneshiro B, Rabinowitz J, McConnell H, Mellins ED.
J Immunol.
2001;
167
(12):
7157-68
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Accessory molecules for MHC class II peptide loading.
Busch R,
Doebele RC, Patil NS, Pashine A, Mellins ED.
Curr Opin Immunol.
2000;
12
(1):
99-106
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Determination of the HLA-DM interaction site on HLA-DR molecules.
Doebele RC,
Busch R, Scott HM, Pashine A, Mellins ED.
Immunity.
2000;
13
(4):
517-27
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pH stability of HLA-DR4 complexes with antigenic peptides.
Belmares MP,
Rabinowitz JD, Liu W, Mellins ED, McConnell HM.
Biochemistry.
2000;
39
(47):
14558-66
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Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function.
Busch R,
Doebele RC, von Scheven E, Fahrni J, Mellins ED.
J Immunol.
1998;
160
(2):
734-43
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Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM.
Busch R,
Reich Z, Zaller DM, Sloan V, Mellins ED.
J Biol Chem.
1998;
273
(42):
27557-64
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Mediation by HLA-DM of dissociation of peptides from HLA-DR.
Sloan VS,
Cameron P, Porter G, Gammon M, Amaya M, Mellins E, Zaller DM.
Nature.
1995;
375
(6534):
802-6
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An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.
Morris P,
Shaman J, Attaya M, Amaya M, Goodman S, Bergman C, Monaco JJ, Mellins E.
Nature.
1994;
368
(6471):
551-4
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