Publications
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Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.
Reuter JA,
Ortiz-Urda S, Kretz M, Garcia J, Scholl FA, Pasmooij AM, Cassarino D, Chang HY, Khavari PA.
Cancer Cell.
2009;
15
(6):
477-88
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Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.
Sen GL,
Webster DE, Barragan DI, Chang HY, Khavari PA.
Genes Dev.
2008;
22
(14):
1865-70
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Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.
Scholl FA,
Dumesic PA, Barragan DI, Harada K, Bissonauth V, Charron J, Khavari PA.
Dev Cell.
2007;
12
(4):
615-29
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Type VII collagen is required for Ras-driven human epidermal tumorigenesis.
Ortiz-Urda S,
Garcia J, Green CL, Chen L, Lin Q, Veitch DP, Sakai LY, Lee H, Marinkovich MP, Khavari PA.
Science.
2005;
307
(5716):
1773-6
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Use of human tissue to assess the oncogenic activity of melanoma-associated mutations.
Chudnovsky Y,
Adams AE, Robbins PB, Lin Q, Khavari PA.
Nat Genet.
2005;
37
(7):
745-9
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CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
Zhang JY,
Tao S, Kimmel R, Khavari PA.
J Cell Biol.
2005;
168
(4):
561-6
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Targets for molecular therapy of skin cancer.
Green CL,
Khavari PA.
Semin Cancer Biol.
2004;
14
(1):
63-9
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NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.
Zhang JY,
Green CL, Tao S, Khavari PA.
Genes Dev.
2004;
18
(1):
17-22
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Mek1 alters epidermal growth and differentiation.
Scholl FA,
Dumesic PA, Khavari PA.
Cancer Res.
2004;
64
(17):
6035-40
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Intracellular delivery of functional proteins via decoration with transporter peptides.
Siprashvili Z,
Reuter JA, Khavari PA.
Mol Ther.
2004;
9
(5):
721-8
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Profiling epithelial stem cells.
Khavari PA,
Nat Biotechnol.
2004;
22
(4):
393-4
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Pathways sufficient to induce epidermal carcinogenesis.
Ridky TW,
Khavari PA.
Cell Cycle.
2004;
3
(5):
621-4
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Lentivectors for regulated and reversible cutaneous gene delivery.
Siprashvili Z,
Khavari PA.
Mol Ther.
2004;
9
(1):
93-100
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Escaping G1 restraints on neoplasia--Cdk4 regulation by Ras and NF-kappa B.
Lazarov M,
Green CL, Zhang JY, Kubo Y, Dajee M, Khavari PA.
Cell Cycle.
2003 Mar-Apr;
2
(2):
79-80
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PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa.
Ortiz-Urda S,
Thyagarajan B, Keene DR, Lin Q, Calos MP, Khavari PA.
Hum Gene Ther.
2003;
14
(9):
923-8
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Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer.
Ortiz-Urda S,
Lin Q, Yant SR, Keene D, Kay MA, Khavari PA.
Gene Ther.
2003;
10
(13):
1099-104
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Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue.
Ortiz-Urda S,
Lin Q, Green CL, Keene DR, Marinkovich MP, Khavari PA.
J Clin Invest.
2003;
111
(2):
251-5
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Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides.
Siprashvili Z,
Scholl FA, Oliver SF, Adams A, Contag CH, Wender PA, Khavari PA.
Hum Gene Ther.
2003;
14
(13):
1225-33
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Inducible activation of Ras and Raf in adult epidermis.
Tarutani M,
Cai T, Dajee M, Khavari PA.
Cancer Res.
2003;
63
(2):
319-23
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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
Dajee M,
Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ, Marinkovich MP, Tao S, Lin Q, Kubo Y, Khavari PA.
Nature.
2003;
421
(6923):
639-43
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Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.
Hinata K,
Gervin AM, Jennifer Zhang Y, Khavari PA.
Oncogene.
2003;
22
(13):
1955-64
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Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation.
Cai T,
Nishida K, Hirano T, Khavari PA.
J Cell Biol.
2002;
159
(1):
103-12
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Cutaneous gene transfer for skin and systemic diseases.
Khavari PA,
Rollman O, Vahlquist A.
J Intern Med.
2002;
252
(1):
1-10
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Stable nonviral genetic correction of inherited human skin disease
Ortiz-Urda S,
Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA.
Nature Medicine.
2002:
8
1166-1170
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Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation.
Dajee M,
Tarutani M, Deng H, Cai T, Khavari PA.
Oncogene.
2002;
21
(10):
1527-38
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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis.
Lazarov M,
Kubo Y, Cai T, Dajee M, Tarutani M, Lin Q, Fang M, Tao S, Green CL, Khavari PA.
Nat Med.
2002;
8
(10):
1105-14
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Stable nonviral genetic correction of inherited human skin disease.
Ortiz-Urda S,
Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA.
Nat Med.
2002;
8
(10):
1166-70
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Peptide delivery to tissues via reversibly linked protein transduction sequences.
Robbins PB,
Oliver SF, Sheu SM, Goodnough JB, Wender P, Khavari PA.
Biotechniques.
2002;
33
(1):
190-2, 194
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Sustainable systemic delivery via a single injection of lentivirus into human skin tissue.
Baek SC,
Lin Q, Robbins PB, Fan H, Khavari PA.
Hum Gene Ther.
2001;
12
(12):
1551-8
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In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa.
Robbins PB,
Lin Q, Goodnough JB, Tian H, Chen X, Khavari PA.
Proc Natl Acad Sci U S A.
2001;
98
(9):
5193-8
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Impact of laminin 5 beta3 gene versus protein replacement on gene expression patterns in junctional epidermolysis bullosa.
Robbins PB,
Sheu SM, Goodnough JB, Khavari PA.
Hum Gene Ther.
2001;
12
(11):
1443-8
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Nuclear factor kappaB subunits induce epithelial cell growth arrest.
Seitz CS,
Deng H, Hinata K, Lin Q, Khavari PA.
Cancer Res.
2000;
60
(15):
4085-92
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Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation.
Rothbard JB,
Garlington S, Lin Q, Kirschberg T, Kreider E, McGrane PL, Wender PA, Khavari PA.
Nat Med.
2000;
6
(11):
1253-7
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Genetic correction of inherited epidermal disorders.
Khavari PA,
Hum Gene Ther.
2000;
11
(16):
2277-82
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NF-kappaB determines localization and features of cell death in epidermis.
Seitz CS,
Freiberg RA, Hinata K, Khavari PA.
J Clin Invest.
2000;
105
(3):
253-60
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Introductory remarks
Taichman LB,
Khavari PA, De Luca M.
Hum Gene Ther.
2000;
11
(16):
2245
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Gene therapy for a lethal genetic blistering disease: a status report.
Bauer EA,
Herron GS, Marinkovich MP, Khavari PA, Lane AT.
Trans Am Clin Climatol Assoc.
1999:
110
86-92
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Immunization via hair follicles by topical application of naked DNA to normal skin.
Fan H,
Lin Q, Morrissey GR, Khavari PA.
Nat Biotechnol.
1999;
17
(9):
870-2
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BP180 gene delivery in junctional epidermolysis bullosa.
Seitz CS,
Giudice GJ, Balding SD, Marinkovich MP, Khavari PA.
Gene Ther.
1999;
6
(1):
42-7
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Sonic hedgehog opposes epithelial cell cycle arrest.
Fan H,
Khavari PA.
J Cell Biol.
1999;
147
(1):
71-6
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Raindrop seborrheic keratoses: a distinctive pattern on the backs of elderly patients.
Heffernan MP,
Khavari PA.
Arch Dermatol.
1998;
134
(3):
382-3
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Gene therapy for genetic skin disease.
Khavari PA,
J Invest Dermatol.
1998;
110
(4):
462-7
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Abnormal transglutaminase 1 expression pattern in a subset of patients with erythrodermic autosomal recessive ichthyosis.
Choate KA,
Williams ML, Khavari PA.
J Invest Dermatol.
1998;
110
(1):
8-12
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Transglutaminase 1 expression in a patient with features of harlequin ichthyosis: case report.
Choate KA,
Williams ML, Elias PM, Khavari PA.
J Am Acad Dermatol.
1998;
38
(2 Pt 2):
325-9
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Multiple asymptomatic papules in the popliteal fossa.
Bazar KA,
Khavari P.
Arch Dermatol.
1998;
134
(6):
745, 747-8
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High-efficiency gene transfer and pharmacologic selection of genetically engineered human keratinocytes.
Deng H,
Choate KA, Lin Q, Khavari PA.
Biotechniques.
1998;
25
(2):
274-80
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Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.
Seitz CS,
Lin Q, Deng H, Khavari PA.
Proc Natl Acad Sci U S A.
1998;
95
(5):
2307-12
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Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog.
Fan H,
Oro AE, Scott MP, Khavari PA.
Nat Med.
1997;
3
(7):
788-92
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Direct cutaneous gene delivery in a human genetic skin disease.
Choate KA,
Khavari PA.
Hum Gene Ther.
1997;
8
(14):
1659-65
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Sustainable cutaneous gene delivery.
Deng H,
Lin Q, Khavari PA.
Nat Biotechnol.
1997;
15
(13):
1388-91
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Transcriptional control in keratinocytes and fibroblasts using synthetic ligands.
Freiberg RA,
Ho SN, Khavari PA.
J Clin Invest.
1997;
99
(11):
2610-5
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Sustainability of keratinocyte gene transfer and cell survival in vivo.
Choate KA,
Khavari PA.
Hum Gene Ther.
1997;
8
(8):
895-901
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Cutaneous gene therapy.
Khavari PA,
Krueger GG.
Dermatol Clin.
1997;
15
(1):
27-35
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Therapeutic gene delivery to the skin.
Khavari PA,
Mol Med Today.
1997;
3
(12):
533-8
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Gene therapy: progress, problems, prospects.
Blau H,
Khavari P.
Nat Med.
1997;
3
(6):
612-3
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A model of corrective gene transfer in X-linked ichthyosis.
Freiberg RA,
Choate KA, Deng H, Alperin ES, Shapiro LJ, Khavari PA.
Hum Mol Genet.
1997;
6
(6):
927-33
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Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts.
Freiberg RA,
Spencer DM, Choate KA, Duh HJ, Schreiber SL, Crabtree GR, Khavari PA.
J Invest Dermatol.
1997;
108
(2):
215-9
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Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.
Wang W,
Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR.
EMBO J.
1996;
15
(19):
5370-82
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Specific triggering of the Fas signal transduction pathway in normal human keratinocytes.
Freiberg RA,
Spencer DM, Choate KA, Peng PD, Schreiber SL, Crabtree GR, Khavari PA.
J Biol Chem.
1996;
271
(49):
31666-9
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Corrective gene transfer in the human skin disorder lamellar ichthyosis.
Choate KA,
Medalie DA, Morgan JR, Khavari PA.
Nat Med.
1996;
2
(11):
1263-7
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Transglutaminase 1 delivery to lamellar ichthyosis keratinocytes.
Choate KA,
Kinsella TM, Williams ML, Nolan GP, Khavari PA.
Hum Gene Ther.
1996;
7
(18):
2247-53
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Increased proportion of aggressive-growth basal cell carcinoma in the Veterans Affairs population of Palo Alto, California.
Wrone DA,
Swetter SM, Egbert BM, Smoller BR, Khavari PA.
J Am Acad Dermatol.
1996;
35
(6):
907-10
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brg1: a putative murine homologue of the Drosophila brahma gene, a homeotic gene regulator.
Randazzo FM,
Khavari P, Crabtree G, Tamkun J, Rossant J.
Dev Biol.
1994;
161
(1):
229-42
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The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest.
Dunaief JL,
Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR, Goff SP.
Cell.
1994;
79
(1):
119-30
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Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex.
Kwon H,
Imbalzano AN, Khavari PA, Kingston RE, Green MR.
Nature.
1994;
370
(6489):
477-81
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BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.
Khavari PA,
Peterson CL, Tamkun JW, Mendel DB, Crabtree GR.
Nature.
1993;
366
(6451):
170-4
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Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.
Mendel DB,
Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A, Crabtree GR.
Science.
1991;
254
(5039):
1762-7
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Periodic acid-Schiff-positive organisms in primary cutaneous Bacillus cereus infection. Case report and an investigation of the periodic acid-Schiff staining properties of bacteria.
Khavari PA,
Bolognia JL, Eisen R, Edberg SC, Grimshaw SC, Shapiro PE.
Arch Dermatol.
1991;
127
(4):
543-6
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Cytotoxic cellular mediators of the immune response to neoplasia: a review.
Khavari P,
Yale J Biol Med.
1987 Sep-Oct;
60
(5):
409-19
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Differential effects of antibodies to Lyt-2 and L3T4 on cytolysis by cloned, Ia-restricted T cells expressing both proteins.
Jones B,
Khavari PA, Conrad PJ, Janeway CA.
J Immunol.
1987;
139
(2):
380-4
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Quantitative bacteriological analysis of sputum as a test of antibiotic efficacy.
Lorian V,
Khavari P, Gray N.
Appl Microbiol.
1967;
15
(3):
564-5
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