Publications
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Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
Borghese CM,
Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.
J Pharmacol Exp Ther.
2012;
340
(2):
304-16
-
Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.
Perkins DI,
Trudell JR, Asatryan L, Davies DL, Alkana RL.
J Pharmacol Exp Ther.
2012;
341
(2):
543-51
-
Induced changes in protein receptors conferring resistance to anesthetics.
Bertaccini EJ,
Trudell JR.
Curr Opin Anaesthesiol.
2012;
25
(4):
405-10
-
Teaching an old GABA receptor new tricks.
Trudell JR,
Bertaccini E, Maciver MB.
Anesth Analg.
2012;
115
(2):
270-3
-
The TM2 6' position of GABA(A) receptors mediates alcohol inhibition.
Johnson WD,
Howard RJ, Trudell JR, Harris RA.
J Pharmacol Exp Ther.
2012;
340
(2):
445-56
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Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.
Howard RJ,
Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA.
Alcohol Clin Exp Res.
2011;
35
(9):
1561-73
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Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.
Murail S,
Wallner B, Trudell JR, Bertaccini E, Lindahl E.
Biophys J.
2011;
100
(7):
1642-50
-
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.
Howard RJ,
Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA.
Proc Natl Acad Sci U S A.
2011;
108
(29):
12149-54
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A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.
McCracken ML,
Borghese CM, Trudell JR, Harris RA.
J Pharmacol Exp Ther.
2010;
335
(3):
600-6
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Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.
Todorovic J,
Welsh BT, Bertaccini EJ, Trudell JR, Mihic SJ.
Proc Natl Acad Sci U S A.
2010;
107
(17):
7987-92
-
Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors.
Asatryan L,
Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL.
J Pharmacol Exp Ther.
2010;
334
(3):
720-8
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Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.
McCracken LM,
McCracken ML, Gong DH, Trudell JR, Harris RA.
ACS Chem Neurosci.
2010;
1
(7):
482
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Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4.
Bertaccini EJ,
Wallner B, Trudell JR, Lindahl E.
J Chem Inf Model.
2010;
50
(12):
2248-55
-
Molecular targets and mechanisms for ethanol action in glycine receptors.
Perkins DI,
Trudell JR, Crawford DK, Alkana RL, Davies DL.
Pharmacol Ther.
2010;
127
(1):
53-65
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Zinc enhances ethanol modulation of the alpha1 glycine receptor.
McCracken LM,
Trudell JR, Goldstein BE, Harris RA, Mihic SJ.
Neuropharmacology.
2010;
58
(3):
676-81
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Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.
Perkins DI,
Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL.
J Biol Chem.
2009;
284
(40):
27304-14
-
Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation.
Lobo IA,
Harris RA, Trudell JR.
J Neurochem.
2008;
104
(6):
1649-62
-
Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein.
Bertaccini EJ,
Lindahl E, Sixma T, Trudell JR.
J Chem Inf Model.
2008;
48
(4):
855-60
-
Ethanol's molecular targets.
Harris RA,
Trudell JR, Mihic SJ.
Sci Signal.
2008;
1
(28):
re7
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General anesthetics have additive actions on three ligand gated ion channels.
Jenkins A,
Lobo IA, Gong D, Trudell JR, Solt K, Harris RA, Eger EI.
Anesth Analg.
2008;
107
(2):
486-93
-
Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies.
Sanghvi M,
Hamouda AK, Jozwiak K, Blanton MP, Trudell JR, Arias HR.
Biochim Biophys Acta.
2008;
1778
(12):
2690-9
-
Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit.
Trudell JR,
Yue ME, Bertaccini EJ, Jenkins A, Harrison NL.
J Chem Inf Model.
2008;
48
(2):
344-9
-
Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.
Crawford DK,
Perkins DI, Trudell JR, Bertaccini EJ, Davies DL, Alkana RL.
J Biol Chem.
2008;
283
(41):
27698-706
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Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.
Perkins DI,
Trudell JR, Crawford DK, Alkana RL, Davies DL.
J Neurochem.
2008;
106
(3):
1337-49
-
Normal-mode analysis of the glycine alpha1 receptor by three separate methods.
Bertaccini EJ,
Trudell JR, Lindahl E.
J Chem Inf Model.
2007 Jul-Aug;
47
(4):
1572-9
-
Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.
Crawford DK,
Trudell JR, Bertaccini EJ, Li K, Davies DL, Alkana RL.
J Neurochem.
2007;
102
(6):
2097-109
-
The common chemical motifs within anesthetic binding sites.
Bertaccini EJ,
Trudell JR, Franks NP.
Anesth Analg.
2007;
104
(2):
318-24
-
Accessibility to residues in transmembrane segment four of the glycine receptor.
Lobo IA,
Trudell JR, Harris RA.
Neuropharmacology.
2006;
50
(2):
174-81
-
Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors.
Arias HR,
Bhumireddy P, Spitzmaul G, Trudell JR, Bouzat C.
Biochemistry.
2006;
45
(7):
2014-26
-
The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.
Won A,
Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI.
Anesth Analg.
2006;
102
(5):
1419-26
-
Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site.
Bertaccini EJ,
Shapiro J, Brutlag DL, Trudell JR.
J Chem Inf Model.
2005 Jan-Feb;
45
(1):
128-35
-
Emerging molecular mechanisms of general anesthetic action.
Hemmings HC,
Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL.
Trends Pharmacol Sci.
2005;
26
(10):
503-10
-
Homology Modeling of a Human Glycine Alpha 1 Receptor Reveals a Plausible Anesthetic Binding Site
Bertaccini EJ,
Shapiro J, Brutlag DL, Trudell JR.
J Chem Inf Model.
2005;
Jan-Feb 45
(1):
128-35
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A Novel Hyperkplexia-causing Mutation in the Pre-TM1 Segment of the Human Glycine Receptor Alpha1 Subunit Inhibits Gating By Agonist and Impairs Membrane Expression
Castaldo, P.,
Stefanoni, P., Miceli, F.Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL,.
Journal of Biological Chemistry.
2004;
279
(24):
25598-604
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A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.
Castaldo P,
Stefanoni P, Miceli F, Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL, Annunziato L, Taglialatela M.
J Biol Chem.
2004;
279
(24):
25598-604
-
Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.
Schofield CM,
Trudell JR, Harrison NL.
Biochemistry.
2004;
43
(31):
10058-63
-
Are sobriety and consciousness determined by water in protein cavities?
Trudell JR,
Harris RA.
Alcohol Clin Exp Res.
2004;
28
(1):
1-3
-
Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics.
Lobo IA,
Mascia MP, Trudell JR, Harris RA.
J Biol Chem.
2004;
279
(32):
33919-27
-
Charged residues in the beta2 subunit involved in GABAA receptor activation.
Kash TL,
Dizon MJ, Trudell JR, Harrison NL.
J Biol Chem.
2004;
279
(6):
4887-93
-
Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates.
Trudell JR,
Bertaccini E.
J Mol Graph Model.
2004;
23
(1):
39-49
-
Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening.
Lobo IA,
Trudell JR, Harris RA.
J Neurochem.
2004;
90
(4):
962-9
-
Evaluation of a Proposed Mechanism of Ligand-gated Ion Channel Activation in the GABAA and Glycine Receptors
Kash TL,
Kim T, Trudell JR, Harrison NL.
Neuroscience Letters.
2004;
371
(2-3):
230-4
-
Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors.
Kash TL,
Kim T, Trudell JR, Harrison NL.
Neurosci Lett.
2004;
371
(2-3):
230-4
-
Multiple Sites of Ethanol Action in Alpha1 and Alpha2 Glycine Receptors Suggested By Sensitivity to Pressure Antagonism
Davies, D.L.,
Crawford, D.K., Trudell, J.
Journal of Neurochemistry.
2004;
89
(5):
1175-85
-
Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism.
Davies DL,
Crawford DK, Trudell JR, Mihic SJ, Alkana RL.
J Neurochem.
2004;
89
(5):
1175-85
-
Structural Elements Involved in Activation of the GABA-A Receptor
Kash, T.L.,
Trudell, J.R., Harrison, N.L.
Biochemical Society Transactions.
2004:
32
540-6
-
Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor.
Kash TL,
Trudell JR, Harrison NL.
Biochem Soc Trans.
2004;
32
(Pt3):
540-6
-
Coupling of agonist binding to channel gating in the GABA(A) receptor.
Kash TL,
Jenkins A, Kelley JC, Trudell JR, Harrison NL.
Nature.
2003;
421
(6920):
272-5
-
Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure.
Davies DL,
Trudell JR, Mihic SJ, Crawford DK, Alkana RL.
Alcohol Clin Exp Res.
2003;
27
(5):
743-55
-
Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
Sonner JM,
Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI.
Anesth Analg.
2003;
97
(3):
718-40
-
Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives.
Arias HR,
Trudell JR, Bayer EZ, Hester B, McCardy EA, Blanton MP.
Biochemistry.
2003;
42
(24):
7358-70
-
Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.
Borghese CM,
Henderson LA, Bleck V, Trudell JR, Harris RA.
J Pharmacol Exp Ther.
2003;
307
(1):
42-52
-
Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor.
Arias HR,
Kem WR, Trudell JR, Blanton MP.
Int Rev Neurobiol.
2003:
54
1-50
-
Anesthetic and ethanol effects on spontaneously opening glycine receptor channels.
Beckstead MJ,
Phelan R, Trudell JR, Bianchini MJ, Mihic SJ.
J Neurochem.
2002;
82
(6):
1343-51
-
Molecular modelling of specific and non-specific anaesthetic interactions.
Trudell JR,
Bertaccini E.
Br J Anaesth.
2002;
89
(1):
32-40
-
Predicting the transmembrane secondary structure of ligand-gated ion channels.
Bertaccini E,
Trudell JR.
Protein Eng.
2002;
15
(6):
443-54
-
Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure.
Jenkins A,
Andreasen A, Trudell JR, Harrison NL.
Neuropharmacology.
2002;
43
(4):
669-78
-
Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling.
Trudell J,
Biochim Biophys Acta.
2002;
1565
(1):
91-6
-
Anesthetics and ion channels: molecular models and sites of action.
Yamakura T,
Bertaccini E, Trudell JR, Harris RA.
Annu Rev Pharmacol Toxicol.
2001:
41
23-51
-
Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.
Jenkins A,
Greenblatt EP, Faulkner HJ, Bertaccini E, Light A, Lin A, Andreasen A, Viner A, Trudell JR, Harrison NL.
J Neurosci.
2001;
21
(6):
RC136
-
Luciferase as a model for the site of inhaled anesthetic action.
Zhang Y,
Stabernack CR, Dutton R, Sonner J, Trudell JR, Mihic SJ, Yamakura T, Harris RA, Gong D, Eger EI.
Anesth Analg.
2001;
93
(5):
1246-52
-
Molecular modeling of ligand-gated ion channels: progress and challenges.
Bertaccini E,
Trudell JR.
Int Rev Neurobiol.
2001:
48
141-66
-
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.
Mascia MP,
Trudell JR, Harris RA.
Proc Natl Acad Sci U S A.
2000;
97
(16):
9305-10
-
The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis.
Zhang Y,
Trudell JR, Mascia MP, Laster MJ, Gong DH, Harris RA, Eger EI.
Anesth Analg.
2000;
91
(5):
1294-9
-
Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.
Ueno S,
Lin A, Nikolaeva N, Trudell JR, Mihic SJ, Harris RA, Harrison NL.
Br J Pharmacol.
2000;
131
(2):
296-302
-
Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.
Ueno S,
Trudell JR, Eger EI, Harris RA.
Anesth Analg.
1999;
88
(4):
877-83
-
An improved monobromobimane assay for glutathione utilizing tris- (2-carboxyethyl)phosphine as the reductant.
Anderson MT,
Trudell JR, Voehringer DW, Tjioe IM, Herzenberg LA, Herzenberg LA.
Anal Biochem.
1999;
272
(1):
107-9
-
Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart.
Eger EI,
Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR.
Anesth Analg.
1999;
88
(6):
1395-400
-
Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.
Eger EI,
Ionescu P, Laster MJ, Gong D, Hudlicky T, Kendig JJ, Harris RA, Trudell JR, Pohorille A.
Anesth Analg.
1999;
88
(4):
867-76
-
A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action.
Trudell JR,
Koblin DD, Eger EI.
Anesth Analg.
1998;
87
(2):
411-8
-
Concentration measures of volatile anesthetics in the aqueous phase using calcium sensitive electrodes.
Hagan CE,
Pearce RA, Trudell JR, MacIver MB.
J Neurosci Methods.
1998;
81
(1-2):
177-84
-
Contributions of dipole moments, quadrupole moments, and molecular polarizabilities to the anesthetic potency of fluorobenzenes.
Trudell JR,
Biophys Chem.
1998;
73
(1-2):
7-11
-
Evaluation of forcefields for molecular mechanics/dynamics calculations involving halogenated anesthetics.
Trudell JR,
Bertaccini E.
Toxicol Lett.
1998:
100-101
413-9
-
Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics)
Koblin DD,
Fang Z, Eger EI, Laster MJ, Gong D, Ionescu P, Halsey MJ, Trudell JR.
Anesth Analg.
1998;
87
(2):
419-24
-
Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
Wick MJ,
Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL, Harris RA.
Proc Natl Acad Sci U S A.
1998;
95
(11):
6504-9
-
Sites of volatile anesthetic action on kainate (Glutamate receptor 6) receptors.
Minami K,
Wick MJ, Stern-Bach Y, Dildy-Mayfield JE, Brozowski SJ, Gonzales EL, Trudell JR, Harris RA.
J Biol Chem.
1998;
273
(14):
8248-55
-
Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites.
Eger EI,
Koblin DD, Harris RA, Kendig JJ, Pohorille A, Halsey MJ, Trudell JR.
Anesth Analg.
1997;
84
(4):
915-8
-
Expression of bcl-2 inhibits cellular radical generation.
Wiedau-Pazos M,
Trudell JR, Altenbach C, Kane DJ, Hubbell WL, Bredesen DE.
Free Radic Res.
1996;
24
(3):
205-12
-
Induction of HSP72 in rat liver by chronic ethanol consumption combined with exercise: association with the prevention of ethanol-induced fatty liver by exercise.
Trudell JR,
Lin WQ, Chrystof DA, Kirshenbaum G, Ardies CM.
Alcohol Clin Exp Res.
1995;
19
(3):
753-8
-
Binding of anti-trifluoroacetyl antibodies to isolated hepatocytes observed by digital fluorescence microscopy.
Niederstadt M,
Stier A, Trudell JR.
Biochem Biophys Res Commun.
1994;
200
(1):
71-7
-
Effect of alcohol on expression of heat shock protein 73 in monolayers of hepatocytes from alcohol-exposed rats.
Lin WQ,
Trudell JR.
Biochem Biophys Res Commun.
1994;
205
(1):
186-94
-
Nuclear translocation of heat shock protein 72 in liver cells of halothane-exposed rats.
Lin WQ,
Van Dyke RA, Marsh HM, Trudell JR.
Biochem Biophys Res Commun.
1994;
199
(2):
647-52
-
Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane-exposed rats.
Lin WQ,
van Dyke RA, Marsh HM, Trudell JR.
Mol Pharmacol.
1994;
46
(4):
639-43
-
Antibodies raised against trifluoroacetyl-protein adducts bind to N-trifluoroacetyl-phosphatidylethanolamine in hexagonal phase phospholipid micelles.
Trudell JR,
Ardies CM, Anderson WR.
J Pharmacol Exp Ther.
1991;
257
(2):
657-62
-
Binding of anti-acetaldehyde IgG antibodies to hepatocytes with an acetaldehyde-phosphatidylethanolamine adduct on their surface.
Trudell JR,
Ardies CM, Green CE, Allen K.
Alcohol Clin Exp Res.
1991;
15
(2):
295-9
-
Inhibition of protein kinase C by local anesthetics.
Trudell JR,
Costa AK, Hubbell WL.
Ann N Y Acad Sci.
1991:
625
743-6
-
The effect of alcohol and anesthetic metabolites on cell membranes. A possible direct immune mechanism.
Trudell JR,
Ardies CM, Anderson WR.
Ann N Y Acad Sci.
1991:
625
806-17
-
Cross-reactivity of antibodies raised against acetaldehyde adducts of protein with acetaldehyde adducts of phosphatidyl-ethanolamine: possible role in alcoholic cirrhosis.
Trudell JR,
Ardies CM, Anderson WR.
Mol Pharmacol.
1990;
38
(5):
587-93
-
Toxicity of styrene vapor in hepatocyte monolayers at low oxygen tensions.
Costa AK,
Trudell JR.
Environ Health Perspect.
1990:
84
209-13
-
In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.
Costa AK,
Baker MA, Brown JM, Trudell JR.
Cancer Res.
1989;
49
(4):
925-9
-
Inhibition of protein kinase C phosphorylation by mono- and divalent cations.
Trudell JR,
Costa AK, Csernansky CA.
Biochem Biophys Res Commun.
1989;
162
(1):
45-50
-
Interaction of hypoxia and carbon tetrachloride toxicity in hepatocyte monolayers.
Costa AK,
Trudell JR.
Exp Mol Pathol.
1989;
50
(2):
183-92
-
Properties of enzymes in hepatocytes that convert 5-HPETE or LTA4 into LTB4.
Trudell JR,
Gut J.
Free Radic Biol Med.
1989;
7
(3):
275-84
-
Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes.
Schieble TM,
Costa AK, Heffel DF, Trudell JR.
Anesthesiology.
1988;
68
(4):
485-94
-
Conversion of 5-hydroperoxyeicosatetraenoic acid into leukotriene B4 by rat hepatocytes: a novel cellular source for leukotriene B4.
Gut J,
Goldman DW, Trudell JR.
Mol Pharmacol.
1988;
34
(3):
256-64
-
Direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites: application to leukotriene biosynthesis.
Gut J,
Jamieson GC, Trudell JR.
Basic Life Sci.
1988:
49
185-9
-
Leukotriene biosynthesis: direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites.
Gut J,
Trudell JR, Jamieson GC.
Biomed Environ Mass Spectrom.
1988;
15
(9):
509-16
-
Toxicity of 1,2-dibromoethane in primary hepatocyte monolayer cultures: lack of dependence on oxygen concentration.
Costa AK,
Trudell JR.
Toxicol Appl Pharmacol.
1988;
95
(2):
241-7
-
Conversion of leukotriene A4 to leukotriene B4: catalysis by human liver microsomes under anaerobic conditions.
Gut J,
Goldman DW, Jamieson GC, Trudell JR.
Arch Biochem Biophys.
1987;
259
(2):
497-509
-
Ethyl acetate extraction of spin-trapped free radicals: a reevaluation.
Trudell JR,
Free Radic Biol Med.
1987;
3
(2):
133-6
-
Leukotriene D4 increases extravascular lung water in the dog.
Shapiro JM,
Mihm FG, Trudell JR, Stevens JH, Feeley TW.
Circ Shock.
1987;
21
(2):
121-8
-
Quantification of 5- and 15-HPETE's by direct chemical ionization mass spectrometry.
Gut J,
Jamieson GC, Trudell JR.
Free Radic Biol Med.
1987;
3
(5):
323-8
-
Toxicity of calcium ionophore A23187 in monolayers of hypoxic hepatocytes.
Costa AK,
Schieble TM, Heffel DF, Trudell JR.
Toxicol Appl Pharmacol.
1987;
87
(1):
43-7
-
Toxicity of t-butylhydroperoxide in hepatocyte monolayers exposed to hypoxia and reoxygenation.
Costa AK,
Heffel DF, Schieble TM, Trudell JR.
In Vitro Cell Dev Biol.
1987;
23
(7):
501-6
-
Oxygen concentration-dependent metabolism of leukotriene B4 by hepatocyte monolayers.
Gut J,
Costa AK, Trudell JR.
Biochim Biophys Acta.
1986;
878
(2):
194-9
-
Equilibrium of 1% halothane with components of the central nervous system.
Trudell JR,
Anesth Analg.
1985;
64
(8):
847
-
Is there light at the end of the tunnel?
Trudell JR,
Anesth Analg.
1985;
64
(4):
385
-
Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium ionophore A23187.
Trudell JR,
Bendix M, Bosterling B.
Biochim Biophys Acta.
1984;
803
(4):
338-41
-
Production of 5- and 15-hydroperoxyeicosatetraenoic acid from arachidonic acid by halothane-free radicals generated by UV-irradiation.
Bösterling B,
Trudell JR.
Anesthesiology.
1984;
60
(3):
209-13
-
Evidence for leukotriene A4 as an intermediate in the conversion of 5-HPETE to leukotriene B4 catalyzed by cytochrome P-450.
Bösterling B,
Trudell JR.
Biochem Biophys Res Commun.
1983;
115
(3):
995-1001
-
Leukotriene B4 metabolism by hepatic cytochrome P-450.
Bösterling B,
Trudell JR.
Biochem Biophys Res Commun.
1983;
114
(2):
850-4
-
Association of cytochrome b5 and cytochrome P-450 reductase with cytochrome P-450 in the membrane of reconstituted vesicles.
Bösterling B,
Trudell JR.
J Biol Chem.
1982;
257
(9):
4783-7
-
Binding of halothane-free radicals to fatty acids following UV irradiation.
Bösterling B,
Trevor A, Trudell JR.
Anesthesiology.
1982;
56
(5):
380-4
-
Lipid-protein interactions as determinants of activation or inhibition by cytochrome b5 of cytochrome P-450-mediated oxidations.
Bösterling B,
Trudell JR, Trevor AJ, Bendix M.
J Biol Chem.
1982;
257
(8):
4375-80
-
Phospholipid transfer between vesicles. Dependence on presence of cytochrome P-450 and phosphatidylcholine-phosphatidylethanolamine ratio.
Bösterling B,
Trudell JR.
Biochim Biophys Acta.
1982;
689
(1):
155-60
-
Reductive metabolism of carbon tetrachloride by human cytochromes P-450 reconstituted in phospholipid vesicles: mass spectral identification of trichloromethyl radical bound to dioleoyl phosphatidylcholine.
Trudell JR,
Bösterling B, Trevor AJ.
Proc Natl Acad Sci U S A.
1982;
79
(8):
2678-82
-
Reductive metabolism of halothane by human and rabbit cytochrome P-450. Binding of 1-chloro-2,2,2-trifluoroethyl radical to phospholipids.
Trudell JR,
Bösterling B, Trevor AJ.
Mol Pharmacol.
1982;
21
(3):
710-7
-
1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids.
Trudell JR,
Bösterling, Trevor A.
Biochem Biophys Res Commun.
1981;
102
(1):
372-7
-
Low-level binding of halothane metabolites to rat liver histones in vivo.
Edmunds HN,
Trudell JR, Cohen EN.
Anesthesiology.
1981;
54
(4):
298-304
-
Perturbations of peptide-induced lateral phase separations in phosphatidic acid bilayers by the inhalation anesthetic methoxyflurane.
Galla HJ,
Trudell JR.
Mol Pharmacol.
1981;
19
(3):
432-7
-
Phospholipid interactions with cytochrome P-450 in reconstituted vesicles. Preference for negatively-charged phosphatidic acid.
Bösterling B,
Trudell JR, Galla HJ.
Biochim Biophys Acta.
1981;
643
(3):
547-56
-
Spin trap evidence for production of superoxide radical anions by purified NADPH-cytochrome P-450 reductase.
Bösterling B,
Trudell JR.
Biochem Biophys Res Commun.
1981;
98
(2):
569-75
-
Asymmetric antagonistic effects of an inhalation anesthetic and high pressure on the phase transition temperature of dipalmitoyl phosphatidic acid bilayers.
Galla HJ,
Trudell JR.
Biochim Biophys Acta.
1980;
599
(1):
336-40
-
Formation of free radical intermediates during nitrous oxide metabolism by human intestinal contents.
Bösterling B,
Trudell JR, Hong K, Cohen EN.
Biochem Pharmacol.
1980;
29
(21):
3037-8
-
Metabolism of nitrous oxide by human and rat intestinal contents.
Hong K,
Trudell JR, O'Neil JR, Cohen EN.
Anesthesiology.
1980;
52
(1):
16-9
-
Pressure-induced changes in the molecular organization of a lipid-peptide complex: polymyxin binding to phosphatidic acid membranes.
Galla HJ,
Trudell JR.
Biochim Biophys Acta.
1980;
602
(3):
522-30
-
Nerve membrane lipid fluidity: opposing effects of high pressure and ethanol.
Mastrangelo CJ,
Kendig JJ, Trudell JR, Cohen EN.
Undersea Biomed Res.
1979;
6
(1):
47-53
-
Reconstitution of cytochrome P-450 and cytochrome P-450 reductase into phosphatidylcholine-phosphatidylethanolamine bilayers: characterization of structure and metabolic activity.
Bösterling B,
Stier A, Hildebrandt AG, Dawson JH, Trudell JR.
Mol Pharmacol.
1979;
16
(1):
332-42
-
Volatile metabolites and decomposition products of halothane in man.
Sharp JH,
Trudell JR, Cohen EN.
Anesthesiology.
1979;
50
(1):
2-8
-
Antagonism of membrane compression effects by high pressure gas mixtures in a phospholipid bilayer system.
Mastrangelo CJ,
Trudell JR, Cohen EN.
Life Sci.
1978;
22
(3):
239-44
-
Effect of clinical concentrations of halothane on phospholipid-cholesterol membrane fluidity.
Mastrangelo CJ,
Trudell JR, Edmunds HN, Cohen EN.
Mol Pharmacol.
1978;
14
(3):
463-7
-
Magnetic circular dichroism of purified forms of rabbit liver cytochromes P-450 and P-420.
Dawson JH,
Trudell JR, Linder RE, Barth G, Bunnenberg E, Djerassi C.
Biochemistry.
1978;
17
(1):
33-42
-
A unitary theory of anesthesia based on lateral phase separations in nerve membranes [proceedings].
Trudell JR,
Biophys J.
1977;
18
(3):
358-9
-
A unitary theory of anesthesia based on lateral phase separations in nerve membranes.
Trudell JR,
Anesthesiology.
1977;
46
(1):
5-10
-
Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450.
Hjelmeland LM,
Aronow L, Trudell JR.
Mol Pharmacol.
1977;
13
(4):
634-9
-
Magnetic circular dichroism studies of non-iron "hyper" porphyrin complexes as models for reduced + CO cytochrome P-450.
Dawson JH,
Trudell JR, Barth G, Linder RE, Bunnenberg E, Djerassi C, Gouterman M, Connell CR, Sayer P.
J Am Chem Soc.
1977;
99
(2):
641-2
-
The membrane volume occupied by anesthetic molecules: a reinterpretation of the erythrocyte expansion data.
Trudell JR,
Biochim Biophys Acta.
1977;
470
(3):
509-10
-
Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450.
Hjelmeland LM,
Aronow L, Trudell JR.
Biochem Biophys Res Commun.
1976;
76
(2):
541-9
-
Letter: Chloroperoxidase. Evidence for P-450 type heme environment from magnetic circular dichroism spectroscopy.
Dawson JH,
Trudell JR, Barth G, Linder RE, Bunnenberg E, Djerassi C, Chiang R, Hager LP.
J Am Chem Soc.
1976;
98
(12):
3709-10
-
Letter: Oxidized cytochrome P-450. Magnetic circular dichroism evidence for thiolate ligation in the substrate-bound form. Implications for the catalytic mechanism.
Dawson JH,
Holm RH, Trudell JR, Barth G, Linder RE, Bunnenberg E, Djerassi C, Tang SC.
J Am Chem Soc.
1976;
98
(12):
3707-8
-
Localization of molecular halothane in phospholipid bilayer model nerve membranes.
Trudell JR,
Hubbell WL.
Anesthesiology.
1976;
44
(3):
202-5
-
Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes P-450 and P-420 and their synthetic models: further evidence for mercaptide as the fifth ligand to iron.
Collman JP,
Sorrell TN, Dawson JH, Trudell JR, Bunnenberg E, Djerassi C.
Proc Natl Acad Sci U S A.
1976;
73
(1):
6-10
-
The compression-ordering and solubility-disordering effects of high pressure gases on phospholipid bilayers.
Chin JH,
Trudell JR, Cohen EN.
Life Sci.
1976;
18
(5):
489-97
-
Biodegradation of inhalation anesthetics.
Cohen EN,
Trudell JR.
Clin Anesth.
1975;
11
(1):
103-9
-
Effects of pressure and anesthetics on conduction and synaptic transmission.
Kendig JJ,
Trudell JR, Cohen EN.
J Pharmacol Exp Ther.
1975;
195
(2):
216-24
-
The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers.
Trudell JR,
Payan DG, Chin JH, Cohen EN.
Proc Natl Acad Sci U S A.
1975;
72
(1):
210-3
-
Urinary metabolites of halothane in man.
Cohen EN,
Trudell JR, Edmunds HN, Watson E.
Anesthesiology.
1975;
43
(4):
392-401
-
Editorial: The applicability of membrane models to studies of the mechanism of anesthetic action.
Trudell JR,
Anesthesiology.
1974;
41
(3):
215-6
-
Magnetic circular dichroism studies XXXV. A comparison of cytochromes P-450 and P-448.
Dawson JH,
Dolinger PM, Trudell JR, Barth G, Linder RE, Bunnenberg E, Djerassi C.
Proc Natl Acad Sci U S A.
1974;
71
(11):
4594-7
-
Magnetic circular dichroism studies. XXV. A preliminary investigation of microsomal cytochromes.
Dolinger PM,
Kielczewski M, Trudell JR, Barth G, Linder RE, Bunnenberg E, Djerassi C.
Proc Natl Acad Sci U S A.
1974;
71
(2):
399-403
-
Metabolism of isoflurane in Fischer 344 rats and man.
Hitt BA,
Mazze RI, Cousins MJ, Edmunds HN, Barr GA, Trudell JR.
Anesthesiology.
1974;
40
(1):
62-7
-
Pressure-induced elevation of phase transition temperature in dipalmitoylphosphatidylcholine bilayers. An electron spin resonance measurement of the enthalpy of phase transition.
Trudell JR,
Payan DG, Chin JH, Cohen EN.
Biochim Biophys Acta.
1974;
373
(3):
436-43
-
The effect of pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers.
Trudell JR,
Payan DG, Chin JH, Cohen EN.
Biochim Biophys Acta.
1974;
373
(1):
141-4
-
Electron spin resonance studies with the volatile anesthetics on phospholipid model membranes.
Trudell JR,
Hubbell WL, Cohen EN.
Ann N Y Acad Sci.
1973:
222
530-8
-
Halothane stereoisomers: lack of stereospecificity in two model systems.
Kendig JJ,
Trudell JR, Cohen EN.
Anesthesiology.
1973;
39
(5):
518-24
-
Pressure reversal of anesthesia: the extent of small-molecule exclusion from spin-labeled phospholipid model membranes.
Trudell JR,
Hubbell WL, Cohen EN, Kendig JJ.
Anesthesiology.
1973;
38
(3):
207-11
-
Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles.
Trudell JR,
Hubbell WL, Cohen EN.
Biochim Biophys Acta.
1973;
291
(2):
328-34
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