Publications
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Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth.
Edris B,
Willingham SB, Weiskopf K, Volkmer AK, Volkmer JP, Mühlenberg T, Montgomery KD, Contreras-Trujillo H, Czechowicz A, Fletcher JA, West RB, Weissman IL, van de Rijn M.
Proc Natl Acad Sci U S A.
2013;
110
(9):
3501-6
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Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.
Pang WW,
Pluvinage JV, Price EA, Sridhar K, Arber DA, Greenberg PL, Schrier SL, Park CY, Weissman IL.
Proc Natl Acad Sci U S A.
2013;
110
(8):
3011-6
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Repeated, long-term cycling of putative stem cells between niches in a basal chordate.
Rinkevich Y,
Voskoboynik A, Rosner A, Rabinowitz C, Paz G, Oren M, Douek J, Alfassi G, Moiseeva E, Ishizuka KJ, Palmeri KJ, Weissman IL, Rinkevich B.
Dev Cell.
2013;
24
(1):
76-88
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Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.
Inlay MA,
Choe V, Bharathi S, Fernhoff NB, Baker JR, Weissman IL, Choi SK.
Chem Commun (Camb).
2013;
49
(43):
4971-3
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Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells.
Kim D,
Wang J, Willingham SB, Martin R, Wernig G, Weissman IL.
Leukemia.
2012;
26
(12):
2538-45
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Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma.
Edris B,
Weiskopf K, Volkmer AK, Volkmer JP, Willingham SB, Contreras-Trujillo H, Liu J, Majeti R, West RB, Fletcher JA, Beck AH, Weissman IL, van de Rijn M.
Proc Natl Acad Sci U S A.
2012;
109
(17):
6656-61
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CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells.
Kim D,
Park CY, Medeiros BC, Weissman IL.
Leukemia.
2012;
26
(12):
2530-7
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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.
Jan M,
Snyder TM, Corces-Zimmerman MR, Vyas P, Weissman IL, Quake SR, Majeti R.
Sci Transl Med.
2012;
4
(149):
149ra118
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E. Donnall Thomas (1920-2012).
Blume KG,
Weissman IL.
Proc Natl Acad Sci U S A.
2012;
109
(51):
20777-8
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Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells.
Raval A,
Kusler B, Pang WW, Weissman IL, Mitchell BS, Park CY.
Leukemia.
2012;
26
(4):
853-5
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Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.
Blauwkamp TA,
Nigam S, Ardehali R, Weissman IL, Nusse R.
Nat Commun.
2012:
3
1070
-
Flipping the script on macrophages in leiomyosarcoma.
Edris B,
Weiskopf K, Weissman IL, van de Rijn M.
Oncoimmunology.
2012;
1
(7):
1202-1204
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Frequency of cells expressing CD44, a head and neck cancer stem cell marker: correlation with tumor aggressiveness.
Joshua B,
Kaplan MJ, Doweck I, Pai R, Weissman IL, Prince ME, Ailles LE.
Head Neck.
2012;
34
(1):
42-9
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Gene Expression Commons: an open platform for absolute gene expression profiling.
Seita J,
Sahoo D, Rossi DJ, Bhattacharya D, Serwold T, Inlay MA, Ehrlich LI, Fathman JW, Dill DL, Weissman IL.
PLoS One.
2012;
7
(7):
e40321
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Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature.
Rinkevich Y,
Mori T, Sahoo D, Xu PX, Bermingham JR, Weissman IL.
Nat Cell Biol.
2012;
14
(12):
1251-60
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In vivo directed differentiation of pluripotent stem cells for skeletal regeneration.
Levi B,
Hyun JS, Montoro DT, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT.
Proc Natl Acad Sci U S A.
2012;
109
(50):
20379-84
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Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
Drukker M,
Tang C, Ardehali R, Rinkevich Y, Seita J, Lee AS, Mosley AR, Weissman IL, Soen Y.
Nat Biotechnol.
2012;
30
(6):
531-42
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Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH,
Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L.
J Exp Med.
2012;
209
(7):
1325-34
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Long-term outcome of patients with metastatic breast cancer treated with high-dose chemotherapy and transplantation of purified autologous hematopoietic stem cells.
Müller AM,
Kohrt HE, Cha S, Laport G, Klein J, Guardino AE, Johnston LJ, Stockerl-Goldstein KE, Hanania E, Juttner C, Blume KG, Negrin RS, Weissman IL, Shizuru JA.
Biol Blood Marrow Transplant.
2012;
18
(1):
125-33
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Programmed cell removal: a new obstacle in the road to developing cancer.
Chao MP,
Majeti R, Weissman IL.
Nat Rev Cancer.
2012;
12
(1):
58-67
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Remodeling of endogenous mammary epithelium by breast cancer stem cells.
Parashurama N,
Lobo NA, Ito K, Mosley AR, Habte FG, Zabala M, Smith BR, Lam J, Weissman IL, Clarke MF, Gambhir SS.
Stem Cells.
2012;
30
(10):
2114-27
-
Stem cell therapies could change medicine... if they get the chance.
Weissman I,
Cell Stem Cell.
2012;
10
(6):
663-5
-
The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications.
Chao MP,
Weissman IL, Majeti R.
Curr Opin Immunol.
2012;
24
(2):
225-32
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The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Willingham SB,
Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL.
Proc Natl Acad Sci U S A.
2012;
109
(17):
6662-7
-
The road to purified hematopoietic stem cell transplants is paved with antibodies.
Logan AC,
Weissman IL, Shizuru JA.
Curr Opin Immunol.
2012;
24
(5):
640-8
-
The safety of embryonic stem cell therapy relies on teratoma removal.
Tang C,
Weissman IL, Drukker M.
Oncotarget.
2012;
3
(1):
7-8
-
Three differentiation states risk-stratify bladder cancer into distinct subtypes.
Volkmer JP,
Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, Lerner SP, van de Rijn M, Shortliffe LD, Weissman IL, Chan KS.
Proc Natl Acad Sci U S A.
2012;
109
(6):
2078-83
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50 years later: remembering the paper.
Weissman IL,
Radiat Res.
2011;
175
(2):
143-4
-
An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells.
Tang C,
Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, Inlay MA, Ardehali R, Chavez SL, Pera RR, Behr B, Wu JC, Weissman IL, Drukker M.
Nat Biotechnol.
2011;
29
(9):
829-34
-
Enhanced survival of pluripotent stem cells under stressful conditions.
Ardehali R,
Ali SR, Inlay MA, Mosley AR, Weissman IL.
Cell Cycle.
2011;
10
(16):
2610-1
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Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy.
Chao MP,
Tang C, Pachynski RK, Chin R, Majeti R, Weissman IL.
Blood.
2011;
118
(18):
4890-901
-
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip.
Rinkevich Y,
Lindau P, Ueno H, Longaker MT, Weissman IL.
Nature.
2011;
476
(7361):
409-13
-
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.
Monje M,
Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy PA.
Proc Natl Acad Sci U S A.
2011;
108
(11):
4453-8
-
Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye.
Majeti R,
Weissman IL.
Cancer Cell.
2011;
19
(1):
9-10
-
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.
Pang WW,
Price EA, Sahoo D, Beerman I, Maloney WJ, Rossi DJ, Schrier SL, Weissman IL.
Proc Natl Acad Sci U S A.
2011;
108
(50):
20012-7
-
Identification of the earliest natural killer cell-committed progenitor in murine bone marrow.
Fathman JW,
Bhattacharya D, Inlay MA, Seita J, Karsunky H, Weissman IL.
Blood.
2011;
118
(20):
5439-47
-
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Richie Ehrlich LI,
Serwold T, Weissman IL.
Blood.
2011;
117
(9):
2618-24
-
In vivo molecular MRI of cell survival and teratoma formation following embryonic stem cell transplantation into the injured murine myocardium.
Chung J,
Kee K, Barral JK, Dash R, Kosuge H, Wang X, Weissman I, Robbins RC, Nishimura D, Quertermous T, Reijo-Pera RA, Yang PC.
Magn Reson Med.
2011;
66
(5):
1374-81
-
Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.
Heffner GC,
Clutter MR, Nolan GP, Weissman IL.
Stem Cells.
2011;
29
(11):
1774-82
-
Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors.
Ardehali R,
Inlay MA, Ali SR, Tang C, Drukker M, Weissman IL.
Proc Natl Acad Sci U S A.
2011;
108
(8):
3282-7
-
Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker.
Jan M,
Chao MP, Cha AC, Alizadeh AA, Gentles AJ, Weissman IL, Majeti R.
Proc Natl Acad Sci U S A.
2011;
108
(12):
5009-14
-
Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement.
Czechowicz A,
Weissman IL.
Hematol Oncol Clin North Am.
2011;
25
(1):
75-87
-
Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.
McGowan KA,
Pang WW, Bhardwaj R, Perez MG, Pluvinage JV, Glader BE, Malek R, Mendrysa SM, Weissman IL, Park CY, Barsh GS.
Blood.
2011;
118
(13):
3622-33
-
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.
Gibbs KD,
Gilbert PM, Sachs K, Zhao F, Blau HM, Weissman IL, Nolan GP, Majeti R.
Blood.
2011;
117
(16):
4226-33
-
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia.
Chao MP,
Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, Park CY, Weissman IL, Majeti R.
Cancer Res.
2011;
71
(4):
1374-84
-
Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding.
Lu R,
Neff NF, Quake SR, Weissman IL.
Nat Biotechnol.
2011;
29
(10):
928-33
-
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
Razorenova OV,
Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ.
Proc Natl Acad Sci U S A.
2011;
108
(5):
1931-6
-
Hematopoietic stem cell: self-renewal versus differentiation.
Seita J,
Weissman IL.
Wiley Interdiscip Rev Syst Biol Med.
2010 Nov-Dec;
2
(6):
640-53
-
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.
Chao MP,
Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, Jan M, Cha AC, Chan CK, Tan BT, Park CY, Zhao F, Kohrt HE, Malumbres R, Briones J, Gascoyne RD, Lossos IS, Levy R, Weissman IL, Majeti R.
Cell.
2010;
142
(5):
699-713
-
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.
Chao MP,
Jaiswal S, Weissman-Tsukamoto R, Alizadeh AA, Gentles AJ, Volkmer J, Weiskopf K, Willingham SB, Raveh T, Park CY, Majeti R, Weissman IL.
Sci Transl Med.
2010;
2
(63):
63ra94
-
Cancer stem cells in bladder cancer: a revisited and evolving concept.
Chan KS,
Volkmer JP, Weissman I.
Curr Opin Urol.
2010;
20
(5):
393-7
-
Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?
Chang E,
Forsberg EC, Wu J, Bingyin Wang, Prohaska SS, Allsopp R, Weissman IL, Cooke JP.
Vasc Med.
2010;
15
(5):
375-85
-
Coronary arteries form by developmental reprogramming of venous cells.
Red-Horse K,
Ueno H, Weissman IL, Krasnow MA.
Nature.
2010;
464
(7288):
549-53
-
Differential DNA damage response in stem and progenitor cells.
Seita J,
Rossi DJ, Weissman IL.
Cell Stem Cell.
2010;
7
(2):
145-7
-
Distinguishing mast cell and granulocyte differentiation at the single-cell level.
Franco CB,
Chen CC, Drukker M, Weissman IL, Galli SJ.
Cell Stem Cell.
2010;
6
(4):
361-8
-
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271.
Boiko AD,
Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, Ly DP, Butler PD, Yang GP, Joshua B, Kaplan MJ, Longaker MT, Weissman IL.
Nature.
2010;
466
(7302):
133-7
-
Lymphocytes, Jim Gowans and in vivo veritas.
Weissman I,
Nat Immunol.
2010;
11
(12):
1073-5
-
Macrophages as mediators of tumor immunosurveillance.
Jaiswal S,
Chao MP, Majeti R, Weissman IL.
Trends Immunol.
2010;
31
(6):
212-9
-
MiDReG: a method of mining developmentally regulated genes using Boolean implications.
Sahoo D,
Seita J, Bhattacharya D, Inlay MA, Weissman IL, Plevritis SK, Dill DL.
Proc Natl Acad Sci U S A.
2010;
107
(13):
5732-7
-
MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets.
Ooi AG,
Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY.
Proc Natl Acad Sci U S A.
2010;
107
(50):
21505-10
-
Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement.
Czechowicz A,
Weissman IL.
Immunol Allergy Clin North Am.
2010;
30
(2):
159-71
-
The origin and fate of yolk sac hematopoiesis: application of chimera analyses to developmental studies.
Ueno H,
Weissman IL.
Int J Dev Biol.
2010;
54
(6-7):
1019-31
-
A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells.
Cheshier SH,
Kalani MY, Lim M, Ailles L, Huhn SL, Weissman IL.
Neurosurgery.
2009;
65
(2):
237-49; discussion 249-50; quiz N6
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells.
Diehn M,
Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF.
Nature.
2009;
458
(7239):
780-3
-
Automated microfluidic chromatin immunoprecipitation from 2,000 cells.
Wu AR,
Hiatt JB, Lu R, Attema JL, Lobo NA, Weissman IL, Clarke MF, Quake SR.
Lab Chip.
2009;
9
(10):
1365-70
-
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.
Majeti R,
Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD, van Rooijen N, Weissman IL.
Cell.
2009;
138
(2):
286-99
-
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.
Jaiswal S,
Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL.
Cell.
2009;
138
(2):
271-85
-
Cancer stem cell-directed therapies: recent data from the laboratory and clinic.
Park CY,
Tseng D, Weissman IL.
Mol Ther.
2009;
17
(2):
219-30
-
Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes.
Ehrlich LI,
Oh DY, Weissman IL, Lewis RS.
Immunity.
2009;
31
(6):
986-98
-
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells.
Majeti R,
Becker MW, Tian Q, Lee TL, Yan X, Liu R, Chiang JH, Hood L, Clarke MF, Weissman IL.
Proc Natl Acad Sci U S A.
2009;
106
(9):
3396-401
-
Endochondral ossification is required for haematopoietic stem-cell niche formation.
Chan CK,
Chen CC, Luppen CA, Kim JB, DeBoer AT, Wei K, Helms JA, Kuo CJ, Kraft DL, Weissman IL.
Nature.
2009;
457
(7228):
490-4
-
Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150.
Papathanasiou P,
Attema JL, Karsunky H, Xu J, Smale ST, Weissman IL.
Stem Cells.
2009;
27
(10):
2498-508
-
Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development.
Yamane T,
Hosen N, Yamazaki H, Weissman IL.
Proc Natl Acad Sci U S A.
2009;
106
(22):
8953-8
-
Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction.
Li Z,
Wilson KD, Smith B, Kraft DL, Jia F, Huang M, Xie X, Robbins RC, Gambhir SS, Weissman IL, Wu JC.
PLoS One.
2009;
4
(12):
e8443
-
Hematopoietic stem and progenitor cells and the inflammatory response.
Jaiswal S,
Weissman IL.
Ann N Y Acad Sci.
2009:
1174
118-21
-
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.
Chan KS,
Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL.
Proc Natl Acad Sci U S A.
2009;
106
(33):
14016-21
-
Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation.
Xie X,
Chan KS, Cao F, Huang M, Li Z, Lee A, Weissman IL, Wu JC.
Stem Cells Dev.
2009;
18
(2):
205-14
-
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.
Inlay MA,
Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL.
Genes Dev.
2009;
23
(20):
2376-81
-
Manganese-guided cellular MRI of human embryonic stem cell and human bone marrow stromal cell viability.
Yamada M,
Gurney PT, Chung J, Kundu P, Drukker M, Smith AK, Weissman IL, Nishimura D, Robbins RC, Yang PC.
Magn Reson Med.
2009;
62
(4):
1047-54
-
Niche recycling through division-independent egress of hematopoietic stem cells.
Bhattacharya D,
Czechowicz A, Ooi AG, Rossi DJ, Bryder D, Weissman IL.
J Exp Med.
2009;
206
(12):
2837-50
-
Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Serwold T,
Ehrlich LI, Weissman IL.
Blood.
2009;
113
(4):
807-15
-
Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.
Papathanasiou P,
Attema JL, Karsunky H, Hosen N, Sontani Y, Hoyne GF, Tunningley R, Smale ST, Weissman IL.
Stem Cells.
2009;
27
(12):
3082-92
-
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.
Ootani A,
Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, Kuo CJ.
Nat Med.
2009;
15
(6):
701-6
-
The ISSCR: who are we and where are we going?
Weissman I,
Cell Stem Cell.
2009;
5
(2):
151-3
-
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Ooi AG,
Karsunky H, Majeti R, Butz S, Vestweber D, Ishida T, Quertermous T, Weissman IL, Forsberg EC.
Stem Cells.
2009;
27
(3):
653-61
-
Two-step oligoclonal development of male germ cells.
Ueno H,
Turnbull BB, Weissman IL.
Proc Natl Acad Sci U S A.
2009;
106
(1):
175-80
-
Establishment of a normal hematopoietic and leukemia stem cell hierarchy.
Chao MP,
Seita J, Weissman IL.
Cold Spring Harb Symp Quant Biol.
2008:
73
439-49
-
Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages.
Karsunky H,
Inlay MA, Serwold T, Bhattacharya D, Weissman IL.
Blood.
2008;
111
(12):
5562-70
-
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.
Viatour P,
Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J.
Cell Stem Cell.
2008;
3
(4):
416-28
-
Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture.
Bababeygy SR,
Cheshier SH, Hou LC, Higgins DM, Weissman IL, Tse VC.
Stem Cells Dev.
2008;
17
(1):
11-8
-
Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.
Cao YA,
Wagers AJ, Karsunky H, Zhao H, Reeves R, Wong RJ, Stevenson DK, Weissman IL, Contag CH.
Blood.
2008;
112
(12):
4494-502
-
Identification of the endostyle as a stem cell niche in a colonial chordate.
Voskoboynik A,
Soen Y, Rinkevich Y, Rosner A, Ueno H, Reshef R, Ishizuka KJ, Palmeri KJ, Moiseeva E, Rinkevich B, Weissman IL.
Cell Stem Cell.
2008;
3
(4):
456-64
-
In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood.
Park CY,
Majeti R, Weissman IL.
Nat Protoc.
2008;
3
(12):
1932-40
-
Isolation of Human Fetal Liver Progenitors and Their Enhanced Proliferation by Three-Dimensional Coculture with Endothelial Cells.
Xiong A,
Austin TW, Lagasse E, Uchida N, Tamaki S, Bordier BB, Weissman IL, Glenn JS, Millan MT.
Tissue Eng Part A.
2008
-
Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells.
Xiong A,
Austin TW, Lagasse E, Uchida N, Tamaki S, Bordier BB, Weissman IL, Glenn JS, Millan MT.
Tissue Eng Part A.
2008;
14
(6):
995-1006
-
Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells.
Hendry SL,
van der Bogt KE, Sheikh AY, Arai T, Dylla SJ, Drukker M, McConnell MV, Kutschka I, Hoyt G, Cao F, Weissman IL, Connolly AJ, Pelletier MP, Wu JC, Robbins RC, Yang PC.
J Thorac Cardiovasc Surg.
2008;
136
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Multimodality evaluation of the viability of stem cells delivered into different zones of myocardial infarction.
Hung TC,
Suzuki Y, Urashima T, Caffarelli A, Hoyt G, Sheikh AY, Yeung AC, Weissman I, Robbins RC, Bulte JW, Bulte JM, Yang PC.
Circ Cardiovasc Imaging.
2008;
1
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6-13
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SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity.
Narala SR,
Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H.
Mol Biol Cell.
2008;
19
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1210-9
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Space-time considerations for hematopoietic stem cell transplantation.
Bhattacharya D,
Ehrlich LI, Weissman IL.
Eur J Immunol.
2008;
38
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The E. Donnall Thomas lecture: normal and neoplastic stem cells.
Weissman IL,
Biol Blood Marrow Transplant.
2008;
14
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849-58
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The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
Beliakoff J,
Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z.
Mol Cell Biol.
2008;
28
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282-92
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The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.
Weissman IL,
Shizuru JA.
Blood.
2008;
112
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3543-53
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Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.
Cao F,
Wagner RA, Wilson KD, Xie X, Fu JD, Drukker M, Lee A, Li RA, Gambhir SS, Weissman IL, Robbins RC, Wu JC.
PLoS One.
2008;
3
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Wnt-mediated self-renewal of neural stem/progenitor cells.
Kalani MY,
Cheshier SH, Cord BJ, Bababeygy SR, Vogel H, Weissman IL, Palmer TD, Nusse R.
Proc Natl Acad Sci U S A.
2008;
105
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16970-5
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B-cell development fails in the absence of the Pbx1 proto-oncogene.
Sanyal M,
Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML.
Blood.
2007;
109
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4191-9
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Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells.
Hosen N,
Yamane T, Muijtjens M, Pham K, Clarke MF, Weissman IL.
Stem Cells.
2007;
25
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1635-44
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CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.
Hosen N,
Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL.
Proc Natl Acad Sci U S A.
2007;
104
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Cancer stem cells in solid tumors.
Ailles LE,
Weissman IL.
Curr Opin Biotechnol.
2007;
18
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460-6
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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.
Rossi DJ,
Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL.
Nature.
2007;
447
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Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.
Serwold T,
Hochedlinger K, Inlay MA, Jaenisch R, Weissman IL.
J Immunol.
2007;
179
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Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches.
Czechowicz A,
Kraft D, Weissman IL, Bhattacharya D.
Science.
2007;
318
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Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis.
Attema JL,
Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL.
Proc Natl Acad Sci U S A.
2007;
104
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Generation of a monoclonal antibody library against human embryonic stem cells.
Drukker M,
Muscat C, Weissman IL.
Methods Mol Biol.
2007:
407
63-81
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Hematopoietic stem cell aging: mechanism and consequence.
Rossi DJ,
Bryder D, Weissman IL.
Exp Gerontol.
2007;
42
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385-90
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Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.
Rossi DJ,
Seita J, Czechowicz A, Bhattacharya D, Bryder D, Weissman IL.
Cell Cycle.
2007;
6
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2371-6
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Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood.
Majeti R,
Park CY, Weissman IL.
Cell Stem Cell.
2007;
1
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635-45
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Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.
Cao F,
Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC.
Cloning Stem Cells.
2007;
9
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107-17
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Striving for normality: whole body regeneration through a series of abnormal generations.
Voskoboynik A,
Simon-Blecher N, Soen Y, Rinkevich B, De Tomaso AW, Ishizuka KJ, Weissman IL.
FASEB J.
2007;
21
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The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis.
Hosen N,
Shirakata T, Nishida S, Yanagihara M, Tsuboi A, Kawakami M, Oji Y, Oka Y, Okabe M, Tan B, Sugiyama H, Weissman IL.
Leukemia.
2007;
21
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The effect of bleeding on hematopoietic stem cell cycling and self-renewal.
Cheshier SH,
Prohaska SS, Weissman IL.
Stem Cells Dev.
2007;
16
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707-17
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Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation.
Bhattacharya D,
Cheah MT, Franco CB, Hosen N, Pin CL, Sha WC, Weissman IL.
J Immunol.
2007;
179
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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
Clarke MF,
Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM.
Cancer Res.
2006;
66
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9339-44
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Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands.
Ueno H,
Weissman IL.
Dev Cell.
2006;
11
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519-33
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Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells.
Wagers AJ,
Weissman IL.
Stem Cells.
2006;
24
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Flk2+ myeloid progenitors are the main source of Langerhans cells.
Mende I,
Karsunky H, Weissman IL, Engleman EG, Merad M.
Blood.
2006;
107
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1383-90
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Hematopoietic stem cells: expression profiling and beyond.
Forsberg EC,
Bhattacharya D, Weissman IL.
Stem Cell Rev.
2006;
2
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23-30
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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.
Bryder D,
Rossi DJ, Weissman IL.
Am J Pathol.
2006;
169
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338-46
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In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.
Cao F,
Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC.
Circulation.
2006;
113
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1005-14
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Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain.
Santarelli JG,
Udani V, Yung YC, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V.
Neurosurgery.
2006;
59
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374-82; discussion 374-82
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New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.
Forsberg EC,
Serwold T, Kogan S, Weissman IL, Passegué E.
Cell.
2006;
126
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415-26
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Pten, tumorigenesis, and stem cell self-renewal.
Rossi DJ,
Weissman IL.
Cell.
2006;
125
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229-31
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Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning.
Bhattacharya D,
Rossi DJ, Bryder D, Weissman IL.
J Exp Med.
2006;
203
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73-85
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Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors.
Bhattacharya D,
Bryder D, Rossi DJ, Weissman IL.
Cell Cycle.
2006;
5
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1135-9
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The cancer stem cell hypothesis: a work in progress.
Tan BT,
Park CY, Ailles LE, Weissman IL.
Lab Invest.
2006;
86
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fester, A candidate allorecognition receptor from a primitive chordate.
Nyholm SV,
Passegue E, Ludington WB, Voskoboynik A, Mitchel K, Weissman IL, De Tomaso AW.
Immunity.
2006;
25
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163-73
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Cell intrinsic alterations underlie hematopoietic stem cell aging.
Rossi DJ,
Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, Weissman IL.
Proc Natl Acad Sci U S A.
2005;
102
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Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors.
Karsunky H,
Merad M, Mende I, Manz MG, Engleman EG, Weissman IL.
Exp Hematol.
2005;
33
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173-81
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Differential expression of novel potential regulators in hematopoietic stem cells.
Forsberg EC,
Prohaska SS, Katzman S, Heffner GC, Stuart JM, Weissman IL.
PLoS Genet.
2005;
1
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Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal.
Yamane T,
Dylla SJ, Muijtjens M, Weissman IL.
Proc Natl Acad Sci U S A.
2005;
102
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Frizzled 9 knock-out mice have abnormal B-cell development.
Ranheim EA,
Kwan HC, Reya T, Wang YK, Weissman IL, Francke U.
Blood.
2005;
105
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2487-94
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Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates.
Passegué E,
Wagers AJ, Giuriato S, Anderson WC, Weissman IL.
J Exp Med.
2005;
202
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1599-611
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Hematopoietic cells maintain hematopoietic fates upon entering the brain.
Massengale M,
Wagers AJ, Vogel H, Weissman IL.
J Exp Med.
2005;
201
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1579-89
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Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system.
Shizuru JA,
Negrin RS, Weissman IL.
Annu Rev Med.
2005:
56
509-38
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Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis.
Udani VM,
Santarelli JG, Yung YC, Wagers AJ, Cheshier SH, Weissman IL, Tse V.
Stem Cells Dev.
2005;
14
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478-86
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Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri.
Laird DJ,
Chang WT, Weissman IL, Lauzon RJ.
Dev Dyn.
2005;
234
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997-1005
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Identification of mast cell progenitors in adult mice.
Chen CC,
Grimbaldeston MA, Tsai M, Weissman IL, Galli SJ.
Proc Natl Acad Sci U S A.
2005;
102
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11408-13
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Identification of phenotypic neural stem cells in a pediatric astroblastoma.
Huhn SL,
Yung Y, Cheshier S, Harsh G, Ailles L, Weissman I, Vogel H, Tse V.
J Neurosurg.
2005;
103
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446-50
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Isolation and characterization of a protochordate histocompatibility locus.
De Tomaso AW,
Nyholm SV, Palmeri KJ, Ishizuka KJ, Ludington WB, Mitchel K, Weissman IL.
Nature.
2005;
438
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Normal and neoplastic stem cells.
Weissman IL,
Novartis Found Symp.
2005:
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35-50; discussion 50-4, 92-7
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Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain.
Santarelli JG,
Udani V, Yung CY, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V.
Clin Neurosurg.
2005:
52
384-8
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Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
Conboy IM,
Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA.
Nature.
2005;
433
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760-4
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Stem cell research: paths to cancer therapies and regenerative medicine.
Weissman I,
JAMA.
2005;
294
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Stem cells are units of natural selection in a colonial ascidian.
Laird DJ,
De Tomaso AW, Weissman IL.
Cell.
2005;
123
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1351-60
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Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus.
García-Ojeda ME,
Dejbakhsh-Jones S, Chatterjea-Matthes D, Mukhopadhyay A, BitMansour A, Weissman IL, Brown JM, Strober S.
J Immunol.
2005;
175
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4363-73
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Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury.
Kofidis T,
de Bruin JL, Yamane T, Tanaka M, Lebl DR, Swijnenburg RJ, Weissman IL, Robbins RC.
Circulation.
2005;
111
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2486-93
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They are not stealthy in the heart: embryonic stem cells trigger cell infiltration, humoral and T-lymphocyte-based host immune response.
Kofidis T,
deBruin JL, Tanaka M, Zwierzchoniewska M, Weissman I, Fedoseyeva E, Haverich A, Robbins RC.
Eur J Cardiothorac Surg.
2005;
28
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461-6
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Chronic versus acute myelogenous leukemia: a question of self-renewal.
Jamieson CH,
Weissman IL, Passegué E.
Cancer Cell.
2004;
6
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531-3
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Circulation and chemotaxis of fetal hematopoietic stem cells.
Christensen JL,
Wright DE, Wagers AJ, Weissman IL.
PLoS Biol.
2004;
2
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E75
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Continuous development precludes radioprotection in a colonial ascidian.
Laird DJ,
Weissman IL.
Dev Comp Immunol.
2004;
28
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201-9
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Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease.
Merad M,
Hoffmann P, Ranheim E, Slaymaker S, Manz MG, Lira SA, Charo I, Cook DN, Weissman IL, Strober S, Engleman EG.
Nat Med.
2004;
10
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510-7
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Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells.
Sherwood RI,
Christensen JL, Weissman IL, Wagers AJ.
Stem Cells.
2004;
22
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1292-304
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Evolution of a protochordate allorecognition locus.
De Tomaso AW,
Weissman IL.
Science.
2004;
303
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977
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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.
Jamieson CH,
Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL.
N Engl J Med.
2004;
351
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657-67
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Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.
Balsam LB,
Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC.
Nature.
2004;
428
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668-73
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Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor.
Yung YC,
Cheshier S, Santarelli JG, Huang Z, Wagers A, Weissman I, Tse V.
Microcirculation.
2004;
11
(8):
699-708
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Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration.
Kofidis T,
de Bruin JL, Yamane T, Balsam LB, Lebl DR, Swijnenburg RJ, Tanaka M, Weissman IL, Robbins RC.
Stem Cells.
2004;
22
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1239-45
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Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.
Sherwood RI,
Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ.
Cell.
2004;
119
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543-54
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JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.
Passegué E,
Wagner EF, Weissman IL.
Cell.
2004;
119
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431-43
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Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
So CW,
Karsunky H, Wong P, Weissman IL, Cleary ML.
Blood.
2004;
103
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3192-9
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Plasticity of adult stem cells.
Wagers AJ,
Weissman IL.
Cell.
2004;
116
(5):
639-48
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Shifting foci of hematopoiesis during reconstitution from single stem cells.
Cao YA,
Wagers AJ, Beilhack A, Dusich J, Bachmann MH, Negrin RS, Weissman IL, Contag CH.
Proc Natl Acad Sci U S A.
2004;
101
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221-6
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Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri.
Laird DJ,
Weissman IL.
Dev Biol.
2004;
273
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185-94
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Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.
Kelly S,
Bliss TM, Shah AK, Sun GH, Ma M, Foo WC, Masel J, Yenari MA, Weissman IL, Uchida N, Palmer T, Steinberg GK.
Proc Natl Acad Sci U S A.
2004;
101
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11839-44
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Varicella-zoster virus infection of human neural cells in vivo.
Baiker A,
Fabel K, Cozzio A, Zerboni L, Fabel K, Sommer M, Uchida N, He D, Weissman I, Arvin AM.
Proc Natl Acad Sci U S A.
2004;
101
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10792-7
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Construction and characterization of large-insert genomic libraries (BAC and fosmid) from the Ascidian Botryllus schlosseri and initial physical mapping of a histocompatibility locus.
de Tomaso AW,
Weissman IL.
Mar Biotechnol (NY).
2003 Mar-Apr;
5
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103-15
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Characterization of mouse clonogenic megakaryocyte progenitors.
Nakorn TN,
Miyamoto T, Weissman IL.
Proc Natl Acad Sci U S A.
2003;
100
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205-10
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Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation.
Arber C,
BitMansour A, Sparer TE, Higgins JP, Mocarski ES, Weissman IL, Shizuru JA, Brown JM.
Blood.
2003;
102
(2):
421-8
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Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice.
Chatterjea-Matthes D,
García-Ojeda ME, Dejbakhsh-Jones S, Jerabek L, Manz MG, Weissman IL, Strober S.
J Immunol.
2003;
171
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1207-15
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Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.
Jaiswal S,
Traver D, Miyamoto T, Akashi K, Lagasse E, Weissman IL.
Proc Natl Acad Sci U S A.
2003;
100
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10002-7
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Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo.
Karsunky H,
Merad M, Cozzio A, Weissman IL, Manz MG.
J Exp Med.
2003;
198
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305-13
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Gene expression analysis of purified hematopoietic stem cells and committed progenitors.
Terskikh AV,
Miyamoto T, Chang C, Diatchenko L, Weissman IL.
Blood.
2003;
102
(1):
94-101
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Initial characterization of a protochordate histocompatibility locus.
De Tomaso AW,
Weissman IL.
Immunogenetics.
2003;
55
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480-90
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MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice.
So CW,
Karsunky H, Passegué E, Cozzio A, Weissman IL, Cleary ML.
Cancer Cell.
2003;
3
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161-71
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Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
Passegué E,
Jamieson CH, Ailles LE, Weissman IL.
Proc Natl Acad Sci U S A.
2003:
100 Suppl 1
11842-9
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Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice.
Beilhack GF,
Scheffold YC, Weissman IL, Taylor C, Jerabek L, Burge MJ, Masek MA, Shizuru JA.
Diabetes.
2003;
52
(1):
59-68
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Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors.
Cozzio A,
Passegué E, Ayton PM, Karsunky H, Cleary ML, Weissman IL.
Genes Dev.
2003;
17
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3029-35
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Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.
Allsopp RC,
Morin GB, DePinho R, Harley CB, Weissman IL.
Blood.
2003;
102
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517-20
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Wnt proteins are lipid-modified and can act as stem cell growth factors.
Willert K,
Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R.
Nature.
2003;
423
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448-52
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Cell fate determination from stem cells.
Wagers AJ,
Christensen JL, Weissman IL.
Gene Ther.
2002;
9
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606-12
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Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor.
Wagers AJ,
Allsopp RC, Weissman IL.
Exp Hematol.
2002;
30
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176-85
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Developmental plasticity of lymphoid progenitors.
Prohaska SS,
Scherer DC, Weissman IL, Kondo M.
Semin Immunol.
2002;
14
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377-84
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Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.
Wright DE,
Bowman EP, Wagers AJ, Butcher EC, Weissman IL.
J Exp Med.
2002;
195
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1145-54
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Intrathymic injection for analysis of T-cell progenitor activity.
Jerabek L,
Weissman IL.
Methods Mol Med.
2002:
63
161-5
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Langerhans cells renew in the skin throughout life under steady-state conditions.
Merad M,
Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG.
Nat Immunol.
2002;
3
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1135-41
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Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling.
King AG,
Kondo M, Scherer DC, Weissman IL.
Proc Natl Acad Sci U S A.
2002;
99
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Little evidence for developmental plasticity of adult hematopoietic stem cells.
Wagers AJ,
Sherwood RI, Christensen JL, Weissman IL.
Science.
2002;
297
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Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S.
Na Nakorn T,
Traver D, Weissman IL, Akashi K.
J Clin Invest.
2002;
109
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1579-85
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Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.
Miyamoto T,
Iwasaki H, Reizis B, Ye M, Graf T, Weissman IL, Akashi K.
Dev Cell.
2002;
3
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137-47
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Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation.
BitMansour A,
Burns SM, Traver D, Akashi K, Contag CH, Weissman IL, Brown JM.
Blood.
2002;
100
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4660-7
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Prospective isolation of human clonogenic common myeloid progenitors.
Manz MG,
Miyamoto T, Akashi K, Weissman IL.
Proc Natl Acad Sci U S A.
2002;
99
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Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?
Allsopp RC,
Weissman IL.
Oncogene.
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21
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Stem cells--scientific, medical, and political issues.
Weissman IL,
N Engl J Med.
2002;
346
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Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells.
Allsopp RC,
Cheshier S, Weissman IL.
J Exp Med.
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196
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The road ended up at stem cells.
Weissman IL,
Immunol Rev.
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185
159-74
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Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle.
Wright DE,
Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL.
Blood.
2001;
97
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2278-85
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Dendritic cell development from common myeloid progenitors.
Manz MG,
Traver D, Akashi K, Merad M, Miyamoto T, Engleman EG, Weissman IL.
Ann N Y Acad Sci.
2001:
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167-73; discussion 173-4
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Dendritic cell potentials of early lymphoid and myeloid progenitors.
Manz MG,
Traver D, Miyamoto T, Weissman IL, Akashi K.
Blood.
2001;
97
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Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets.
Traver D,
Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL.
Blood.
2001;
98
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627-35
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Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells.
Christensen JL,
Weissman IL.
Proc Natl Acad Sci U S A.
2001;
98
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From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Terskikh AV,
Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL.
Proc Natl Acad Sci U S A.
2001;
98
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Immunity to infections following hematopoietic cell transplantation.
Brown JM,
Weissman IL, Shizuru JA.
Curr Opin Immunol.
2001;
13
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451-7
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L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis.
Qian F,
Hanahan D, Weissman IL.
Proc Natl Acad Sci U S A.
2001;
98
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3976-81
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Lymphocyte development from hematopoietic stem cells.
Kondo M,
Scherer DC, King AG, Manz MG, Weissman IL.
Curr Opin Genet Dev.
2001;
11
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Physiological migration of hematopoietic stem and progenitor cells.
Wright DE,
Wagers AJ, Gulati AP, Johnson FL, Weissman IL.
Science.
2001;
294
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Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations.
Weissman IL,
Anderson DJ, Gage F.
Annu Rev Cell Dev Biol.
2001:
17
387-403
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Stem cells, cancer, and cancer stem cells.
Reya T,
Morrison SJ, Clarke MF, Weissman IL.
Nature.
2001;
414
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Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells.
Allsopp RC,
Cheshier S, Weissman IL.
J Exp Med.
2001;
193
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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.
DiMartino JF,
Selleri L, Traver D, Firpo MT, Rhee J, Warnke R, O'Gorman S, Weissman IL, Cleary ML.
Blood.
2001;
98
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618-26
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"Fluorescent timer": protein that changes color with time.
Terskikh A,
Fradkov A, Ermakova G, Zaraisky A, Tan P, Kajava AV, Zhao X, Lukyanov S, Matz M, Kim S, Weissman I, Siebert P.
Science.
2000;
290
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1585-8
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50 million years of chordate evolution: seeking the origins of adaptive immunity.
Laird DJ,
De Tomaso AW, Cooper MD, Weissman IL.
Proc Natl Acad Sci U S A.
2000;
97
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6924-6
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.
Akashi K,
Traver D, Miyamoto T, Weissman IL.
Nature.
2000;
404
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193-7
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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation.
Miyamoto T,
Weissman IL, Akashi K.
Proc Natl Acad Sci U S A.
2000;
97
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7521-6
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B lymphopoiesis in the thymus.
Akashi K,
Richie LI, Miyamoto T, Carr WH, Weissman IL.
J Immunol.
2000;
164
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5221-6
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Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines.
Kondo M,
Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K, Weissman IL.
Nature.
2000;
407
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383-6
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Development of CD8alpha-positive dendritic cells from a common myeloid progenitor.
Traver D,
Akashi K, Manz M, Merad M, Miyamoto T, Engleman EG, Weissman IL.
Science.
2000;
290
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Function of cytokines in lymphocyte development.
Kondo M,
Weissman IL.
Curr Top Microbiol Immunol.
2000:
251
59-65
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Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other.
Domen J,
Weissman IL.
J Exp Med.
2000;
192
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Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny.
Klug CA,
Cheshier S, Weissman IL.
Blood.
2000;
96
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894-901
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Lymphoid precursors.
Akashi K,
Reya T, Dalma-Weiszhausz D, Weissman IL.
Curr Opin Immunol.
2000;
12
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144-50
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Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection.
Shizuru JA,
Weissman IL, Kernoff R, Masek M, Scheffold YC.
Proc Natl Acad Sci U S A.
2000;
97
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9555-60
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Stem cells: units of development, units of regeneration, and units in evolution.
Weissman IL,
Cell.
2000;
100
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157-68
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The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential.
Domen J,
Cheshier SH, Weissman IL.
J Exp Med.
2000;
191
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Translating stem and progenitor cell biology to the clinic: barriers and opportunities.
Weissman IL,
Science.
2000;
287
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Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer.
Negrin RS,
Atkinson K, Leemhuis T, Hanania E, Juttner C, Tierney K, Hu WW, Johnston LJ, Shizurn JA, Stockerl-Goldstein KE, Blume KG, Weissman IL, Bower S, Baynes R, Dansey R, Karanes C, Peters W, Klein J.
Biol Blood Marrow Transplant.
2000;
6
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262-71
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Allorecognition in colonial tunicates: protection against predatory cell lineages?
Magor BG,
De Tomaso A, Rinkevich B, Weissman IL.
Immunol Rev.
1999:
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CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers.
Gandy KL,
Domen J, Aguila H, Weissman IL.
Immunity.
1999;
11
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Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo.
Trahey M,
Weissman IL.
Proc Natl Acad Sci U S A.
1999;
96
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Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates.
Stoner DS,
Rinkevich B, Weissman IL.
Proc Natl Acad Sci U S A.
1999;
96
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In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells.
Cheshier SH,
Morrison SJ, Liao X, Weissman IL.
Proc Natl Acad Sci U S A.
1999;
96
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Lymphoid development from hematopoietic stem cells.
Akashi K,
Traver D, Kondo M, Weissman IL.
Int J Hematol.
1999;
69
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217-26
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Lymphoid development from stem cells and the common lymphocyte progenitors.
Akashi K,
Kondo M, Cheshier S, Shizuru J, Gandy K, Domen J, Mebius R, Traver D, Weissman IL.
Cold Spring Harb Symp Quant Biol.
1999:
64
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Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate.
Domen J,
Weissman IL.
Mol Med Today.
1999;
5
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201-8
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An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation.
García-Ojeda ME,
Dejbakhsh-Jones S, Weissman IL, Strober S.
J Exp Med.
1998;
187
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Characterization of a polymorphic protein localized to vascular epithelium in Botryllus schlosseri: role in tunic synthesis?
Fagan MB,
Weissman IL.
Mol Mar Biol Biotechnol.
1998;
7
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204-13
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Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population?
Randall TD,
Weissman IL.
Stem Cells.
1998;
16
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38-48
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Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.
Klug CA,
Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL.
Proc Natl Acad Sci U S A.
1998;
95
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657-62
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Linkage analysis of HSP70 genes and historecognition locus in botryllus schlosseri.
Fagan MB,
Weissman IL.
Immunogenetics.
1998;
47
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468-76
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Mapping the genome of a model protochordate. I. A low resolution genetic map encompassing the fusion/histocompatibility (Fu/HC) locus of Botryllus schlosseri.
De Tomaso AW,
Saito Y, Ishizuka KJ, Palmeri KJ, Weissman IL.
Genetics.
1998;
149
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277-87
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Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia.
Traver D,
Akashi K, Weissman IL, Lagasse E.
Immunity.
1998;
9
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47-57
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Role of interleukin-7 in T-cell development from hematopoietic stem cells.
Akashi K,
Kondo M, Weissman IL.
Immunol Rev.
1998:
165
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Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation.
Domen J,
Gandy KL, Weissman IL.
Blood.
1998;
91
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2272-82
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Tolerance of allogeneic heart grafts in mice simultaneously reconstituted with purified allogeneic hematopoietic stem cells.
Gandy KL,
Weissman IL.
Transplantation.
1998;
65
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295-304
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Two distinct pathways of positive selection for thymocytes.
Akashi K,
Kondo M, Weissman IL.
Proc Natl Acad Sci U S A.
1998;
95
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Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice.
Akashi K,
Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL.
Cell.
1997;
89
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1033-41
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Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice.
Kondo M,
Akashi K, Domen J, Sugamura K, Weissman IL.
Immunity.
1997;
7
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155-62
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Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization.
Morrison SJ,
Wright DE, Weissman IL.
Proc Natl Acad Sci U S A.
1997;
94
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Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice.
Lagasse E,
Weissman IL.
Cell.
1997;
89
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1021-31
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From stem cells to lymphocytes: biology and transplantation.
Aguila HL,
Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE, Morrison SJ, Shizuru J, Strober S, Uchida N, Wright DE, Weissman IL.
Immunol Rev.
1997:
157
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HSP70 genes and historecognition in Botryllus schlosseri: implications for MHC evolution.
Fagan MB,
Weissman IL.
Hereditas.
1997;
127
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25-35
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Highly polymorphic microsatellite loci in the colonial ascidian Botryllus schlosseri.
Stoner DS,
Quattro JM, Weissman IL.
Mol Mar Biol Biotechnol.
1997;
6
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163-71
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Identification of a lineage of multipotent hematopoietic progenitors.
Morrison SJ,
Wandycz AM, Hemmati HD, Wright DE, Weissman IL.
Development.
1997;
124
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Identification of clonogenic common lymphoid progenitors in mouse bone marrow.
Kondo M,
Weissman IL, Akashi K.
Cell.
1997;
91
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661-72
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Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment.
Randall TD,
Weissman IL.
Blood.
1997;
89
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3596-606
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A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes.
Mebius RE,
Streeter PR, Michie S, Butcher EC, Weissman IL.
Proc Natl Acad Sci U S A.
1996;
93
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Activation of physiological cell death mechanisms by a necrosis-causing agent.
Vaux DL,
Whitney D, Weissman IL.
Microsc Res Tech.
1996;
34
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259-66
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Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells.
Randall TD,
Lund FE, Howard MC, Weissman IL.
Blood.
1996;
87
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Flow cytometric identification of murine neutrophils and monocytes.
Lagasse E,
Weissman IL.
J Immunol Methods.
1996;
197
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From thymic lineages back to hematopoietic stem cells, sometimes using homing receptors.
Weissman IL,
J Immunol.
1996;
156
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Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells.
Aguila HL,
Weissman IL.
Blood.
1996;
87
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1225-31
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Searching for hematopoietic stem cells. II. The heterogeneity of Thy-1.1(lo)Lin(-/lo)Sca-1+ mouse hematopoietic stem cells separated by counterflow centrifugal elutriation.
Uchida N,
Jerabek L, Weissman IL.
Exp Hematol.
1996;
24
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649-59
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Sequence and characterization of two HSP70 genes in the colonial protochordate Botryllus schlosseri.
Fagan MB,
Weissman IL.
Immunogenetics.
1996;
44
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134-42
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Somatic and germ cell parasitism in a colonial ascidian: possible role for a highly polymorphic allorecognition system.
Stoner DS,
Weissman IL.
Proc Natl Acad Sci U S A.
1996;
93
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Telomerase activity in hematopoietic cells is associated with self-renewal potential.
Morrison SJ,
Prowse KR, Ho P, Weissman IL.
Immunity.
1996;
5
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207-16
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The aging of hematopoietic stem cells.
Morrison SJ,
Wandycz AM, Akashi K, Globerson A, Weissman IL.
Nat Med.
1996;
2
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1011-6
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The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection.
Akashi K,
Weissman IL.
Immunity.
1996;
5
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147-61
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Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment.
Shizuru JA,
Jerabek L, Edwards CT, Weissman IL.
Biol Blood Marrow Transplant.
1996;
2
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3-14
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Extrathymic maturation of alpha beta T cells from hemopoietic stem cells.
Dejbakhsh-Jones S,
Jerabek L, Weissman IL, Strober S.
J Immunol.
1995;
155
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3338-44
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Heterogeneity of hematopoietic stem cells: implications for clinical applications.
Morrison SJ,
Weissman IL.
Proc Assoc Am Physicians.
1995;
107
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187-94
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Life histories and senescence of Botryllus schlosseri (Chordata, Ascidiacea) in Monterey Bay.
Chadwick-Furman NE,
Weissman IL.
Biol Bull.
1995;
189
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36-41
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The biology of hematopoietic stem cells.
Morrison SJ,
Uchida N, Weissman IL.
Annu Rev Cell Dev Biol.
1995:
11
35-71
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The purification and characterization of fetal liver hematopoietic stem cells.
Morrison SJ,
Hemmati HD, Wandycz AM, Weissman IL.
Proc Natl Acad Sci U S A.
1995;
92
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10302-6
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Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells.
Aguila HL,
Hershberger RJ, Weissman IL.
Proc Natl Acad Sci U S A.
1995;
92
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10192-6
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Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells.
Mehta BA,
Schmidt-Wolf IG, Weissman IL, Negrin RS.
Blood.
1995;
86
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3493-9
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An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney.
Friedman J,
Weissman I, Friedman J, Alpert S.
Am J Pathol.
1994;
144
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1247-56
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Characterization of preneoplastic thymocytes and of their neoplastic progression in irradiated C57BL/Ka mice.
Sen-Majumdar A,
Guidos C, Kina T, Lieberman M, Weissman IL.
J Immunol.
1994;
153
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1581-92
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Demonstration that Thy(lo) subsets of mouse bone marrow that express high levels of lineage markers are not significant hematopoietic progenitors.
Morrison SJ,
Lagasse E, Weissman IL.
Blood.
1994;
83
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3480-90
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Developmental switches in the immune system.
Weissman IL,
Cell.
1994;
76
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207-18
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Expression of granzyme A in salivary gland biopsies from patients with primary Sjögren's syndrome.
Alpert S,
Kang HI, Weissman I, Fox RI.
Arthritis Rheum.
1994;
37
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1046-54
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Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation.
Qian F,
Vaux DL, Weissman IL.
Cell.
1994;
77
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335-47
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In vitro development of B cells and macrophages from early mouse fetal thymocytes.
Péault B,
Khazaal I, Weissman IL.
Eur J Immunol.
1994;
24
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781-4
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Infection and multiple sclerosis: a possible role for superantigens?
Brocke S,
Veromaa T, Weissman IL, Gijbels K, Steinman L.
Trends Microbiol.
1994;
2
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250-4
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Isolation and characterization of major histocompatibility complex class IIB genes from the nurse shark.
Bartl S,
Weissman IL.
Proc Natl Acad Sci U S A.
1994;
91
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262-6
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PCR primers containing an inosine triplet to complement a variable codon within a conserved protein-coding region.
Bartl S,
Weissman IL.
Biotechniques.
1994;
16
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246-8, 250
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Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor V beta gene products.
Sen-Majumdar A,
Weissman IL, Hansteen G, Marian J, Waller EK, Lieberman M.
J Virol.
1994;
68
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1165-72
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Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells.
Uchida N,
Aguila HL, Fleming WH, Jerabek L, Weissman IL.
Blood.
1994;
83
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3758-79
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Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain.
Crowe DT,
Chiu H, Fong S, Weissman IL.
J Biol Chem.
1994;
269
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Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells.
Weissman IL,
Immunity.
1994;
1
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529-31
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The common gamma (gamma c) chain for multiple cytokine receptors.
Weissman IL,
Jpn J Cancer Res.
1994;
85
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The isolation of putative major histocompatibility complex gene fragments from dogfish and nurse shark.
Bartl S,
Weissman IL.
Ann N Y Acad Sci.
1994:
712
346-9
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The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype.
Morrison SJ,
Weissman IL.
Immunity.
1994;
1
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661-73
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bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.
Lagasse E,
Weissman IL.
J Exp Med.
1994;
179
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A colonial invertebrate species that displays a hierarchy of allorecognition responses
I.L. Weissman,
Rinkevich, G., Y. Saito,.
Biological Bulletin.
1993
184
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Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.
Berlin C,
Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC.
Cell.
1993;
74
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185-95
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Characterization of posttransplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice.
Waller EK,
Ziemianska M, Bangs CD, Cleary M, Weissman I, Kamel OW.
Blood.
1993;
82
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247-61
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Cloning and characterization of cyclophilin C-associated protein: a candidate natural cellular ligand for cyclophilin C.
Friedman J,
Trahey M, Weissman I.
Proc Natl Acad Sci U S A.
1993;
90
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Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate.
Kraft DL,
Weissman IL, Waller EK.
J Exp Med.
1993;
178
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265-77
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Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells.
Fleming WH,
Alpern EJ, Uchida N, Ikuta K, Spangrude GJ, Weissman IL.
J Cell Biol.
1993;
122
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897-902
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Heterogeneity of hematopoietic stem cells.
Uchida N,
Fleming WH, Alpern EJ, Weissman IL.
Curr Opin Immunol.
1993;
5
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177-84
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How the immune system develops.
Weissman IL,
Cooper MD.
Sci Am.
1993;
269
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64-71
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LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation.
Su L,
Hershberger RJ, Weissman IL.
Genes Dev.
1993;
7
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735-48
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Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.
Vaux DL,
Weissman IL.
Mol Cell Biol.
1993;
13
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Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells.
Schmidt-Wolf IG,
Lefterova P, Mehta BA, Fernandez LP, Huhn D, Blume KG, Weissman IL, Negrin RS.
Exp Hematol.
1993;
21
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Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo.
Fleming WH,
Alpern EJ, Uchida N, Ikuta K, Weissman IL.
Proc Natl Acad Sci U S A.
1993;
90
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The Peyer's patch homing receptor.
Hu MC,
Holzmann B, Crowe DT, Neuhaus H, Weissman IL.
Curr Top Microbiol Immunol.
1993:
184
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The use of granzyme A as a marker of heart transplant rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats.
Chen RH,
Ivens KW, Alpert S, Billingham ME, Fathman CG, Flavin TF, Shizuru JA, Starnes VA, Weissman IL, Griffiths GM.
Transplantation.
1993;
55
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The whole body view.
Weissman IL,
Curr Biol.
1993;
3
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766-9
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Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.
Vaux DL,
Aguila HL, Weissman IL.
Int Immunol.
1992;
4
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821-4
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Characterization of several classes of mouse hematopoietic progenitor cells.
Heimfeld S,
Weissman IL.
Curr Top Microbiol Immunol.
1992:
177
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Development of gamma delta T-cell subsets from fetal hematopoietic stem cells.
Ikuta K,
Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL.
Ann N Y Acad Sci.
1992:
651
21-32
-
Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.
Ikuta K,
Weissman IL.
Proc Natl Acad Sci U S A.
1992;
89
(4):
1502-6
-
Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides.
Hershberger RJ,
Gershenfeld HK, Weissman IL, Su L.
J Biol Chem.
1992;
267
(35):
25488-93
-
Human T-cell development in SCID-hu mice: staphylococcal enterotoxins induce specific clonal deletions, proliferation, and anergy.
Waller EK,
Sen-Majumdar A, Kamel OW, Hansteen GA, Schick MR, Weissman IL.
Blood.
1992;
80
(12):
3144-56
-
Lymphocyte homing receptors.
Hu MC,
Siegelman MH, Holzmann B, Crowe DT, Weissman IL.
Cold Spring Harb Symp Quant Biol.
1992:
57
291-308
-
Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage.
Lagasse E,
Weissman IL.
Blood.
1992;
79
(8):
1907-15
-
Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis.
Griffiths GM,
Alpert S, Lambert E, McGuire J, Weissman IL.
Proc Natl Acad Sci U S A.
1992;
89
(2):
549-53
-
Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2.
Vaux DL,
Weissman IL, Kim SK.
Science.
1992;
258
(5090):
1955-7
-
Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.
Uchida N,
Weissman IL.
J Exp Med.
1992;
175
(1):
175-84
-
Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis.
Lieberman M,
Hansteen GA, Waller EK, Weissman IL, Sen-Majumdar A.
J Exp Med.
1992;
176
(2):
399-405
-
Clonal analysis of hematopoietic stem-cell differentiation in vivo.
Smith LG,
Weissman IL, Heimfeld S.
Proc Natl Acad Sci U S A.
1991;
88
(7):
2788-92
-
Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule.
Neuhaus H,
Hu MC, Hemler ME, Takada Y, Holzmann B, Weissman IL.
J Cell Biol.
1991;
115
(4):
1149-58
-
Development of mouse hematopoietic lineages.
Heimfeld S,
Weissman IL.
Curr Top Dev Biol.
1991:
25
155-75
-
Granzyme A and perforin as markers for rejection in cardiac transplantation.
Griffiths GM,
Namikawa R, Mueller C, Liu CC, Young JD, Billingham M, Weissman I.
Eur J Immunol.
1991;
21
(3):
687-93
-
Growth of primary T-cell non-Hodgkin's lymphomata in SCID-hu mice: requirement for a human lymphoid microenvironment.
Waller EK,
Kamel OW, Cleary ML, Majumdar AS, Schick MR, Lieberman M, Weissman IL.
Blood.
1991;
78
(10):
2650-65
-
Identification of a 107-kD glycoprotein that mediates adhesion between stromal cells and hematolymphoid cells.
Kina T,
Majumdar AS, Heimfeld S, Kaneshima H, Holzmann B, Katsura Y, Weissman IL.
J Exp Med.
1991;
173
(2):
373-81
-
Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor.
Ikuta K,
Ingolia DE, Friedman J, Heimfeld S, Weissman IL.
Int J Cell Cloning.
1991;
9
(5):
451-60
-
The junctional modifications of a T cell receptor gamma chain are determined at the level of thymic precursors.
Ikuta K,
Weissman IL.
J Exp Med.
1991;
174
(5):
1279-82
-
Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA.
Friedman J,
Weissman I.
Cell.
1991;
66
(4):
799-806
-
Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity.
Schmidt-Wolf IG,
Negrin RS, Kiem HP, Blume KG, Weissman IL.
J Exp Med.
1991;
174
(1):
139-49
-
A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells.
Ikuta K,
Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL.
Cell.
1990;
62
(5):
863-74
-
Allorecognition histocompatibility in a protochordate species: is the relationship to MHC somatic or structural?
Weissman IL,
Saito Y, Rinkevich B.
Immunol Rev.
1990:
113
227-41
-
An immunodominant murine lymphoma cell surface heterodimer marks thymic progenitor subsets.
Majumdar AS,
Guidos C, Kaneshima H, White JH, Marian J, Lieberman M, Weissman IL.
J Immunol.
1990;
144
(1):
111-21
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B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation.
Fariñas MC,
Adkins B, Stall AM, Weissman I, Strober S.
Arthritis Rheum.
1990;
33
(5):
702-10
-
Biosynthesis pathway of gp90MEL-14, the mouse lymph node-specific homing receptor.
van de Rijn M,
Weissman IL, Siegelman M.
J Immunol.
1990;
145
(5):
1477-82
-
Characterization of a rat monoclonal antibody specific for a determinant encoded by the V beta 7 gene segment. Depletion of V beta 7+ T cells in mice with Mls-1a haplotype.
Okada CY,
Holzmann B, Guidos C, Palmer E, Weissman IL.
J Immunol.
1990;
144
(9):
3473-7
-
Structural similarity between a primitive chordate membrane heterodimer and lymphocyte antigen receptors.
Danska JS,
McIntyre BW, McDevitt HO, Weissman IL.
Int Immunol.
1990;
2
(9):
795-802
-
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.
Guidos CJ,
Danska JS, Fathman CG, Weissman IL.
J Exp Med.
1990;
172
(3):
835-45
-
The growth factor IL-7 induces expression of a transformation-associated antigen in normal pre-B cells.
Sherwood PJ,
Weissman IL.
Int Immunol.
1990;
2
(5):
399-406
-
The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding.
Siegelman MH,
Cheng IC, Weissman IL, Wakeland EK.
Cell.
1990;
61
(4):
611-22
-
Some observation on the life history of lymphocytes.
Weissman IL,
Harvey Lect.
1989-1990:
85
43-69
-
Developmental analysis of the mouse hematolymphoid system.
Heimfeld S,
Guidos CJ, Holzmann B, Siegelman MH, Weissman IL.
Cold Spring Harb Symp Quant Biol.
1989:
54 Pt 1
75-85
-
Developmental potential of CD4-8- thymocytes. Peripheral progeny include mature CD4-8- T cells bearing alpha beta T cell receptor.
Guidos CJ,
Weissman IL, Adkins B.
J Immunol.
1989;
142
(11):
3773-80
-
Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains.
Siegelman MH,
Weissman IL.
Proc Natl Acad Sci U S A.
1989;
86
(14):
5562-6
-
Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha.
Holzmann B,
McIntyre BW, Weissman IL.
Cell.
1989;
56
(1):
37-46
-
Identification of a novel bone marrow-derived B-cell progenitor population that coexpresses B220 and Thy-1 and is highly enriched for Abelson leukemia virus targets.
Tidmarsh GF,
Heimfeld S, Whitlock CA, Weissman IL, Müller-Sieburg CE.
Mol Cell Biol.
1989;
9
(6):
2665-71
-
Integrin molecules involved in lymphocyte homing to Peyer's patches.
Holzmann B,
Weissman IL.
Immunol Rev.
1989:
108
45-61
-
Intrathymic maturation of murine T lymphocytes from CD8+ precursors.
Guidos CJ,
Weissman IL, Adkins B.
Proc Natl Acad Sci U S A.
1989;
86
(19):
7542-6
-
Measurement of binding specificity between T cell lymphomas and murine leukemia viruses.
O'Neill HC,
Weissman IL.
J Immunol Methods.
1989;
122
(1):
79-90
-
Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.
van de Rijn M,
Heimfeld S, Spangrude GJ, Weissman IL.
Proc Natl Acad Sci U S A.
1989;
86
(12):
4634-8
-
Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains.
Siegelman MH,
van de Rijn M, Weissman IL.
Science.
1989;
243
(4895):
1165-72
-
Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.
Holzmann B,
Weissman IL.
EMBO J.
1989;
8
(6):
1735-41
-
Relative V beta transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. Inverse correlation of I-E and Mls expression with relative abundance of several V beta transcripts in peripheral lymphoid tissues.
Okada CY,
Weissman IL.
J Exp Med.
1989;
169
(5):
1703-19
-
Role of interleukin-4 in T-cell ontogeny: changes in cell surface phenotype and lymphokine production of immature thymocytes after culture with interleukin-4 and phorbol ester.
Guidos C,
Ransom J, Fischer M, Weissman I, Zlotnik A.
J Autoimmun.
1989:
2 Suppl
141-53
-
Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow.
Spangrude GJ,
Klein J, Heimfeld S, Aihara Y, Weissman IL.
J Immunol.
1989;
142
(2):
425-30
-
Approaches to an understanding of pathogenetic mechanisms in AIDS.
Weissman I,
Rev Infect Dis.
1988 Mar-Apr;
10
(2):
385-98
-
A T cell- and natural killer cell-specific, trypsin-like serine protease. Implications of a cytolytic cascade.
Gershenfeld HK,
Hershberger RJ, Mueller C, Weissman IL.
Ann N Y Acad Sci.
1988:
532
367-79
-
A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.
Mueller C,
Gershenfeld HK, Lobe CG, Okada CY, Bleackley RC, Weissman IL.
J Exp Med.
1988;
167
(3):
1124-36
-
Autoreactive blood cells and programmed cell death in growth and development of protochordates.
Harp JA,
Tsuchida CB, Weissman IL, Scofield VL.
J Exp Zool.
1988;
247
(3):
257-62
-
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
Gershenfeld HK,
Hershberger RJ, Shows TB, Weissman IL.
Proc Natl Acad Sci U S A.
1988;
85
(4):
1184-8
-
Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus.
McCune JM,
Rabin LB, Feinberg MB, Lieberman M, Kosek JC, Reyes GR, Weissman IL.
Cell.
1988;
53
(1):
55-67
-
Expression of two serine esterase genes during an allograft rejection in the mouse.
Mueller C,
Gershenfeld HK, Lobe CG, Okada CY, Bleackley RC, Weissman IL.
Transplant Proc.
1988;
20
(2):
251-3
-
Homing receptors and metastasis.
Sher BT,
Bargatze R, Holzmann B, Gallatin WM, Matthews D, Wu N, Picker L, Butcher EC, Weissman IL.
Adv Cancer Res.
1988:
51
361-90
-
In situ localization of HuHF serine protease mRNA and cytotoxic cell-associated antigens in human dermatoses. A novel method for the detection of cytotoxic cells in human tissues.
Wood GS,
Mueller C, Warnke RA, Weissman IL.
Am J Pathol.
1988;
133
(2):
218-25
-
Infection of the SCID-hu mouse by HIV-1.
Namikawa R,
Kaneshima H, Lieberman M, Weissman IL, McCune JM.
Science.
1988;
242
(4886):
1684-6
-
Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous.
Spangrude GJ,
Weissman IL.
J Immunol.
1988;
141
(6):
1877-90
-
Molecular tools for inactivating a yeast enzyme in vivo.
Carlson JR,
Weissman IL.
Mol Cell Biol.
1988;
8
(6):
2647-50
-
Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen.
Adkins B,
Tidmarsh GF, Weissman IL.
Immunogenetics.
1988;
27
(3):
180-6
-
Purification and characterization of mouse hematopoietic stem cells.
Spangrude GJ,
Heimfeld S, Weissman IL.
Science.
1988;
241
(4861):
58-62
-
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
McCune JM,
Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL.
Science.
1988;
241
(4873):
1632-9
-
The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets.
Spangrude GJ,
Aihara Y, Weissman IL, Klein J.
J Immunol.
1988;
141
(11):
3697-707
-
Total lymphoid irradiation leads to transient depletion of the mouse thymic medulla and persistent abnormalities among medullary stromal cells.
Adkins B,
Gandour D, Strober S, Weissman I.
J Immunol.
1988;
140
(10):
3373-9
-
Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus.
Spangrude GJ,
Muller-Sieburg CE, Heimfeld S, Weissman IL.
J Exp Med.
1988;
167
(5):
1671-83
-
Was the MHC made for the immune system, or did immunity take advantage of an ancient polymorphic gene family encoding cell surface interaction molecules? A speculative essay.
Weissman IL,
Int Rev Immunol.
1988;
3
(4):
397-416
-
High endothelial venule binding as a predictor of the dissemination of passaged murine lymphomas.
Bargatze RF,
Wu NW, Weissman IL, Butcher EC.
J Exp Med.
1987;
166
(4):
1125-31
-
Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen.
Lieberman M,
Hansteen GA, McCune JM, Scott ML, White JH, Weissman IL.
J Exp Med.
1987;
166
(6):
1883-93
-
Molecules recognized by anti-idiotypic monoclonal antibodies to the B cell lymphoma, BCL1.
Tamura GS,
McGrath MS, Weissman IL.
J Mol Cell Immunol.
1987;
3
(4):
243-53
-
The phenotype of thymocytes derived from a single clonogenic precursor.
Ezine S,
Jerabek L, Weissman I.
J Immunol.
1987;
139
(7):
2195-9
-
The in vivo behavior of T cell clones: altered migration due to loss of the lymphocyte surface homing receptor.
Dailey MO,
Gallatin WM, Weissman IL.
J Mol Cell Immunol.
1985;
2
(1):
27-36
-
Immunoglobulin gene rearrangement during pre-B cell differentiation.
Coffman RL,
Weissman IL.
J Mol Cell Immunol.
1983;
1
(1):
31-41
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