Publications
-
Armodafinil, the R-enantiomer of modafinil: wake-promoting effects and pharmacokinetic profile in the rat.
Wisor JP,
Dement WC, Aimone L, Williams M, Bozyczko-Coyne D.
Pharmacol Biochem Behav.
2006;
85
(3):
492-9
-
Sleep extension: getting as much extra sleep as possible.
Dement WC,
Clin Sports Med.
2005;
24
(2):
251-68, viii
-
History of sleep medicine.
Dement WC,
Neurol Clin.
2005;
23
(4):
945-65, v
-
The paradox of sleep: the early years.
Dement WC,
Arch Ital Biol.
2004;
142
(4):
333-45
-
The impact of extended sleep on daytime alertness, vigilance, and mood.
Kamdar BB,
Kaplan KA, Kezirian EJ, Dement WC.
Sleep Med.
2004;
5
(5):
441-8
-
Restless legs syndrome symptoms in primary care: a prevalence study.
Nichols DA,
Allen RP, Grauke JH, Brown JB, Rice ML, Hyde PR, Dement WC, Kushida CA.
Arch Intern Med.
2003;
163
(19):
2323-9
-
Tiredness versus sleepiness: semantics or a target for public education?
Dement WC,
Hall J, Walsh JK.
Sleep.
2003;
26
(4):
485-6
-
Teaching family medicine medical students about sleep disorders.
Schillinger E,
Kushida C, Fahrenbach R, Dement W, LeBaron S.
Fam Med.
2003;
35
(8):
547-9
-
Technical protocol for the use of esophageal manometry in the diagnosis of sleep-related breathing disorders.
Kushida CA,
Giacomini A, Lee MK, Guilleminault C, Dement WC.
Sleep Med.
2002;
3
(2):
163-73
-
Cervical positioning for reduction of sleep-disordered breathing in mild-to-moderate OSAS.
Kushida CA,
Sherrill CM, Hong SC, Palombini L, Hyde P, Dement WC.
Sleep Breath.
2001;
5
(2):
71-8
-
Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients.
Kushida CA,
Chang A, Gadkary C, Guilleminault C, Carrillo O, Dement WC.
Sleep Med.
2001;
2
(5):
389-96
-
Symptom-Based Prevalence of Sleep Disorders in an Adult Primary Care Population.
Kushida CA,
Nichols DA, Simon RD, Young T, Grauke JH, Britzmann JB, Hyde PR, Dement WC.
Sleep Breath.
2000;
4
(1):
9-14
-
Primary Care: Is It the Setting to Address Sleep Disorders?
Dement WC,
Netzer NC.
Sleep Breath.
2000;
4
(1):
1-XX
-
Cervical positional effects on snoring and apneas.
Kushida CA,
Rao S, Guilleminault C, Giraudo S, Hsieh J, Hyde P, Dement WC.
Sleep Res Online.
1999;
2
(1):
7-10
-
Breeding history of the Stanford colony of narcoleptic dogs.
Cederberg R,
Nishino S, Dement WC, Mignot E.
Vet Rec.
1998;
142
(2):
31-6
-
The study of human sleep: a historical perspective.
Dement WC,
Thorax.
1998:
53 Suppl 3
S2-7
-
Development of cataplexy in genetically narcoleptic Dobermans.
Riehl J,
Nishino S, Cederberg R, Dement WC, Mignot E.
Exp Neurol.
1998;
152
(2):
292-302
-
Effects of adrenalectomy and subsequent corticosterone replacement on rat sleep state and EEG power spectra.
Bradbury MJ,
Dement WC, Edgar DM.
Am J Physiol.
1998;
275
(2 Pt 2):
R555-65
-
Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.
Reid MS,
Nishino S, Tafti M, Siegel JM, Dement WC, Mignot E.
Exp Neurol.
1998;
151
(1):
89-104
-
Nasal obstruction and obstructive sleep apnea: a review.
Kushida CA,
Guilleminault C, Clerk AA, Dement WC.
Allergy Asthma Proc.
1997 Mar-Apr;
18
(2):
69-71
-
Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock.
Edgar DM,
Reid MS, Dement WC.
Am J Physiol.
1997;
273
(1 Pt 2):
R265-9
-
Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog.
Tafti M,
Nishino S, Liao W, Dement WC, Mignot E.
J Comp Neurol.
1997;
379
(2):
185-97
-
Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy.
Mignot E,
Kimura A, Lattermann A, Lin X, Yasunaga S, Mueller-Eckhardt G, Rattazzi C, Lin L, Guilleminault C, Grumet FC, Mayer G, Dement WC, Underhill P.
Tissue Antigens.
1997;
49
(4):
329-41
-
Circadian distribution of rest/activity in narcoleptic and control dogs: assessment with ambulatory activity monitoring.
Nishino S,
Tafti M, Sampathkumaran R, Dement WC, Mignot E.
J Sleep Res.
1997;
6
(2):
120-7
-
Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy.
Nishino S,
Arrigoni J, Shelton J, Kanbayashi T, Dement WC, Mignot E.
J Neurosci.
1997;
17
(16):
6401-8
-
Serotonin-containing fibers in the suprachiasmatic hypothalamus attenuate light-induced phase delays in mice.
Bradbury MJ,
Dement WC, Edgar DM.
Brain Res.
1997;
768
(1-2):
125-34
-
Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine model.
Tafti M,
Nishino S, Aldrich MS, Liao W, Dement WC, Mignot E.
J Neurosci.
1996;
16
(15):
4588-95
-
Thalidomide, immune modulation and narcolepsy.
Kanbayashi T,
Nishino S, Tafti M, Hishikawa Y, Dement WC, Mignot E.
Sleep.
1996;
19
(2):
116
-
Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
Kanbayashi T,
Nishino S, Tafti M, Hishikawa Y, Dement WC, Mignot E.
Neuroreport.
1996;
7
(12):
1881-6
-
Effect of 5-HT1A receptor agonists and antagonists on canine cataplexy.
Nishino S,
Shelton J, Renaud A, Dement WC, Mignot E.
J Pharmacol Exp Ther.
1995;
272
(3):
1170-5
-
Sleep and sleep-disordered breathing in commercial long-haul truck drivers.
Stoohs RA,
Bingham LA, Itoi A, Guilleminault C, Dement WC.
Chest.
1995;
107
(5):
1275-82
-
Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat.
Seidel WF,
Maze M, Dement WC, Edgar DM.
J Pharmacol Exp Ther.
1995;
275
(1):
263-73
-
Narcolepsy and immunity.
Mignot E,
Tafti M, Dement WC, Grumet FC.
Adv Neuroimmunol.
1995;
5
(1):
23-37
-
Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy.
Nishino S,
Tafti M, Reid MS, Shelton J, Siegel JM, Dement WC, Mignot E.
J Neurosci.
1995;
15
(7 Pt 1):
4806-14
-
Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs.
Shelton J,
Nishino S, Vaught J, Dement WC, Mignot E.
Sleep.
1995;
18
(10):
817-26
-
Cholinergic mechanisms in canine narcolepsy--I. Modulation of cataplexy via local drug administration into the pontine reticular formation.
Reid MS,
Tafti M, Geary JN, Nishino S, Siegel JM, Dement WC, Mignot E.
Neuroscience.
1994;
59
(3):
511-22
-
Circadian rhythms in narcolepsy: studies on a 90 minute day.
Dantz B,
Edgar DM, Dement WC.
Electroencephalogr Clin Neurophysiol.
1994;
90
(1):
24-35
-
Cholinergic mechanisms in canine narcolepsy--II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy.
Reid MS,
Siegel JM, Dement WC, Mignot E.
Neuroscience.
1994;
59
(3):
523-30
-
Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors.
Reid MS,
Tafti M, Nishino S, Siegel JM, Dement WC, Mignot E.
Sleep.
1994;
17
(5):
424-35
-
Modafinil binds to the dopamine uptake carrier site with low affinity.
Mignot E,
Nishino S, Guilleminault C, Dement WC.
Sleep.
1994;
17
(5):
436-7
-
Traffic accidents in commercial long-haul truck drivers: the influence of sleep-disordered breathing and obesity.
Stoohs RA,
Guilleminault C, Itoi A, Dement WC.
Sleep.
1994;
17
(7):
619-23
-
DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.
Mignot E,
Lin X, Arrigoni J, Macaubas C, Olive F, Hallmayer J, Underhill P, Guilleminault C, Dement WC, Grumet FC.
Sleep.
1994;
17
(8 Suppl):
S60-7
-
An immunoglobulin switchlike sequence is linked with canine narcolepsy.
Mignot E,
Bell RA, Rattazzi C, Lovett M, Grumet FC, Dement WC.
Sleep.
1994;
17
(8 Suppl):
S68-76
-
Neuropharmacology and neurochemistry of canine narcolepsy.
Nishino S,
Reid MS, Dement WC, Mignot E.
Sleep.
1994;
17
(8 Suppl):
S84-92
-
Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats.
Sutin EL,
Dement WC, Heller HC, Kilduff TS.
Neurobiol Aging.
1993 Sep-Oct;
14
(5):
441-6
-
It's time to wake up to the importance of sleep disorders.
Dement WC,
Mitler MM.
JAMA.
1993 Mar 24-31;
269
(12):
1548-50
-
Sleep apnea and hypertension in commercial truck drivers.
Stoohs RA,
Guilleminault C, Dement WC.
Sleep.
1993;
16
(8 Suppl):
S11-3; discussion 13-4
-
Desmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compounds.
Nishino S,
Arrigoni J, Shelton J, Dement WC, Mignot E.
Sleep.
1993;
16
(8):
706-12
-
Sleep and "sundowning" in nursing home patients with dementia.
Bliwise DL,
Carroll JS, Lee KA, Nekich JC, Dement WC.
Psychiatry Res.
1993;
48
(3):
277-92
-
The history of narcolepsy and other sleep disorders.
Dement WC,
J Hist Neurosci.
1993;
2
(2):
121-34
-
Further characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsy.
Nishino S,
Fruhstorfer B, Arrigoni J, Guilleminault C, Dement WC, Mignot E.
J Pharmacol Exp Ther.
1993;
264
(3):
1079-84
-
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.
Mignot E,
Nishino S, Sharp LH, Arrigoni J, Siegel JM, Reid MS, Edgar DM, Ciaranello RD, Dement WC.
J Neurosci.
1993;
13
(3):
1057-64
-
Serotonin and the mammalian circadian system: II. Phase-shifting rat behavioral rhythms with serotonergic agonists.
Edgar DM,
Miller JD, Prosser RA, Dean RR, Dement WC.
J Biol Rhythms.
1993;
8
(1):
17-31
-
Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers.
Mignot E,
Renaud A, Nishino S, Arrigoni J, Guilleminault C, Dement WC.
Psychopharmacology (Berl).
1993;
113
(1):
76-82
-
"Somnolence: its importance in society".
Dement WC,
Gelb M.
Neurophysiol Clin.
1993;
23
(1):
5-14
-
Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration.
Trachsel L,
Edgar DM, Seidel WF, Heller HC, Dement WC.
Brain Res.
1992;
589
(2):
253-61
-
Monoaminergic uptake in synaptosomes prepared from frozen brain tissue samples of normal and narcoleptic canines.
Valtier D,
Dement WC, Mignot E.
Brain Res.
1992;
588
(1):
115-9
-
Monoaminc and metabolite levels in the cerebrospinal fluid of hibernating and euthermic marmots.
Reid MS,
Kilduff TS, Romero LM, Florant GL, Dement WC, Heller HC.
J Sleep Res.
1992;
1
(1):
45-50
-
DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcoleptics.
Mignot E,
Lin X, Kalil J, George C, Singh S, Billiard M, Montplaisir J, Arrigoni J, Guilleminault C, Dement WC.
Sleep.
1992;
15
(5):
415-22
-
Melatonin influences Fos expression in the rat suprachiasmatic.
Kilduff TS,
Landel HB, Nagy GS, Sutin EL, Dement WC, Heller HC.
Brain Res Mol Brain Res.
1992;
16
(1-2):
47-56
-
The proper use of sleeping pills in the primary care setting.
Dement WC,
J Clin Psychiatry.
1992:
53 Suppl
50-6; discussion 57-60
-
MSLT-defined sleepiness and neuropsychological test performance do not correlate in the elderly.
Bliwise DL,
Carskadon MA, Seidel WF, Nekich JC, Dement WC.
Neurobiol Aging.
1991 Sep-Oct;
12
(5):
463-8
-
Triazolam-induced sleep in the rat: influence of prior sleep, circadian time, and light/dark cycles.
Edgar DM,
Seidel WF, Dement WC.
Psychopharmacology (Berl).
1991;
105
(3):
374-80
-
Regularly scheduled voluntary exercise synchronizes the mouse circadian clock.
Edgar DM,
Dement WC.
Am J Physiol.
1991;
261
(4 Pt 2):
R928-33
-
Dopamine D2 mechanisms in canine narcolepsy.
Nishino S,
Arrigoni J, Valtier D, Miller JD, Guilleminault C, Dement WC, Mignot E.
J Neurosci.
1991;
11
(9):
2666-71
-
Objective measurements of daytime sleepiness and performance comparing quazepam with flurazepam in two adult populations using the Multiple Sleep Latency Test.
Dement WC,
J Clin Psychiatry.
1991:
52 Suppl
31-7
-
Real-time automated sleep scoring: validation of a microcomputer-based system for mice.
Van Gelder RN,
Edgar DM, Dement WC.
Sleep.
1991;
14
(1):
48-55
-
Platelet alpha 2 adrenoceptors in human and canine narcolepsy.
Valtier D,
Nishino S, Guilleminault C, Dement WC, Mignot E.
Biol Psychiatry.
1991;
29
(4):
376-82
-
Relative validity of self-reported snoring as a symptom of sleep apnea in a sleep clinic population.
Bliwise DL,
Nekich JC, Dement WC.
Chest.
1991;
99
(3):
600-8
-
Activity feedback to the mammalian circadian pacemaker: influence on observed measures of rhythm period length.
Edgar DM,
Martin CE, Dement WC.
J Biol Rhythms.
1991;
6
(3):
185-99
-
Introduction. Clinical considerations. Overview of the efficacy and safety of benzodiazepine hypnotics using objective methods.
Dement WC,
J Clin Psychiatry.
1991:
52 Suppl
27-30
-
Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice.
Edgar DM,
Kilduff TS, Martin CE, Dement WC.
Physiol Behav.
1991;
50
(2):
373-8
-
Triazolam fails to induce sleep in suprachiasmatic nucleus-lesioned rats.
Edgar DM,
Seidel WF, Martin CE, Sayeski PP, Dement WC.
Neurosci Lett.
1991;
125
(2):
125-8
-
Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment.
Mignot E,
Wang C, Rattazzi C, Gaiser C, Lovett M, Guilleminault C, Dement WC, Grumet FC.
Proc Natl Acad Sci U S A.
1991;
88
(8):
3475-8
-
Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep.
Renaud A,
Nishino S, Dement WC, Guilleminault C, Mignot E.
Eur J Pharmacol.
1991;
205
(1):
11-6
-
Regional changes in central monoamine and metabolite levels during the hibernation cycle in the golden-mantled ground squirrel.
Haak LL,
Mignot E, Kilduff TS, Dement WC, Heller HC.
Brain Res.
1991;
563
(1-2):
215-20
-
Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs.
Nishino S,
Mignot E, Kilduff TS, Sakai T, Hayaishi O, Dement WC.
Biol Psychiatry.
1990;
28
(10):
904-10
-
Predictors of observed sleep/wakefulness in residents in long-term care.
Bliwise DL,
Carroll JS, Dement WC.
J Gerontol.
1990;
45
(4):
M126-30
-
Effects of central alpha-2 adrenergic compounds on canine narcolepsy, a disorder of rapid eye movement sleep.
Nishino S,
Haak L, Shepherd H, Guilleminault C, Sakai T, Dement WC, Mignot E.
J Pharmacol Exp Ther.
1990;
253
(3):
1145-52
-
Systematic 24-hr behavioral observations of sleep and wakefulness in a skilled-care nursing facility.
Bliwise DL,
Bevier WC, Bliwise NG, Edgar DM, Dement WC.
Psychol Aging.
1990;
5
(1):
16-24
-
Amplified RNA synthesized from limited quantities of heterogeneous cDNA.
Van Gelder RN,
von Zastrow ME, Yool A, Dement WC, Barchas JD, Eberwine JH.
Proc Natl Acad Sci U S A.
1990;
87
(5):
1663-7
-
CNS monoamines and their metabolites in canine narcolepsy: a replication study.
Miller JD,
Faull KF, Bowersox SS, Dement WC.
Brain Res.
1990;
509
(1):
169-71
-
A personal history of sleep disorders medicine.
Dement WC,
J Clin Neurophysiol.
1990;
7
(1):
17-47
-
Direct measurement of daytime sleepiness after administration of cetirizine and hydroxyzine with a standardized electroencephalographic assessment.
Seidel WF,
Cohen S, Bliwise NG, Dement WC.
J Allergy Clin Immunol.
1990;
86
(6 Pt 2):
1029-33
-
Sleep apnea in Alzheimer's disease.
Bliwise DL,
Yesavage JA, Tinklenberg JR, Dement WC.
Neurobiol Aging.
1989 Jul-Aug;
10
(4):
343-6
-
Nerve conduction and creatinine clearance in aged subjects with periodic movements in sleep.
Bliwise DL,
Ingham RH, Date ES, Dement WC.
J Gerontol.
1989;
44
(5):
M164-7
-
A method for checking interobserver reliability in observational sleep studies.
Carroll JS,
Bliwise DL, Dement WC.
Sleep.
1989;
12
(4):
363-7
-
Restriction fragment length polymorphism in canine narcolepsy.
Motoyama M,
Kilduff TS, Lee BS, Dement WC, McDevitt HO.
Immunogenetics.
1989;
29
(2):
124-6
-
Evidence for multiple [3H]prazosin binding sites in canine brain membranes.
Mignot E,
Bowersox SS, Maddaluno J, Dement W, Ciaranello R.
Brain Res.
1989;
486
(1):
56-66
-
Narcolepsy without unique MHC class II antigen association: studies in the canine model.
Dean RR,
Kilduff TS, Dement WC, Grumet FC.
Hum Immunol.
1989;
25
(1):
27-35
-
Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.
Nishino S,
Mignot E, Fruhstorfer B, Dement WC, Hayaishi O.
Proc Natl Acad Sci U S A.
1989;
86
(7):
2483-7
-
REM latency in Alzheimer's disease.
Bliwise DL,
Tinklenberg J, Yesavage JA, Davies H, Pursley AM, Petta DE, Widrow L, Guilleminault C, Zarcone VP, Dement WC.
Biol Psychiatry.
1989;
25
(3):
320-8
-
Canine narcolepsy is associated with an elevated number of alpha 2-receptors in the locus coeruleus.
Fruhstorfer B,
Mignot E, Bowersox S, Nishino S, Dement WC, Guilleminault C.
Brain Res.
1989;
500
(1-2):
209-14
-
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
Mignot E,
Guilleminault C, Bowersox S, Frusthofer B, Nishino S, Maddaluno J, Ciaranello R, Dement WC.
Brain Res.
1989;
490
(1):
186-91
-
Nightly variation of periodic leg movements in sleep in middle aged and elderly individuals.
Bliwise DL,
Carskadon MA, Dement WC.
Arch Gerontol Geriatr.
1988;
7
(4):
273-9
-
Effect of running wheel availability on circadian patterns of sleep and wakefulness in mice.
Welsh D,
Richardson GS, Dement WC.
Physiol Behav.
1988;
43
(6):
771-77
-
Effect of alpha 1-adrenoceptors blockade with prazosin in canine narcolepsy.
Mignot E,
Guilleminault C, Bowersox S, Rappaport A, Dement WC.
Brain Res.
1988;
444
(1):
184-8
-
Profile of mood states changes during and after 5 weeks of nightly triazolam administration.
Bliwise DL,
Seidel WF, Cohen SA, Bliwise NG, Dement WC.
J Clin Psychiatry.
1988;
49
(9):
349-55
-
Role of central alpha-1 adrenoceptors in canine narcolepsy.
Mignot E,
Guilleminault C, Bowersox S, Rappaport A, Dement WC.
J Clin Invest.
1988;
82
(3):
885-94
-
The influence of ambient temperature on sleep characteristics in the aged cat.
Bowersox SS,
Dement WC, Glotzbach SF.
Brain Res.
1988;
457
(1):
200-3
-
Determinants of daytime sleepiness in obstructive sleep apnea.
Guilleminault C,
Partinen M, Quera-Salva MA, Hayes B, Dement WC, Nino-Murcia G.
Chest.
1988;
94
(1):
32-7
-
Influence of freezer storage time on cerebral biogenic amine and metabolite concentrations and receptor ligand binding characteristics.
Faull KF,
Bowersox SS, Zeller-DeAmicis L, Maddaluno JF, Ciaranello RD, Dement WC.
Brain Res.
1988;
450
(1-2):
225-30
-
Sleep apnea and mortality in an aged cohort.
Bliwise DL,
Bliwise NG, Partinen M, Pursley AM, Dement WC.
Am J Public Health.
1988;
78
(5):
544-7
-
Periodic leg movement, L-dopa, 5-hydroxytryptophan, and L-tryptophan.
Guilleminault C,
Mondini S, Montplaisir J, Mancuso J, Cobasko D, Dement WC.
Sleep.
1987;
10
(4):
393-7
-
Cetirizine effects on objective measures of daytime sleepiness and performance.
Seidel WF,
Cohen S, Bliwise NG, Dement WC.
Ann Allergy.
1987;
59
(6 Pt 2):
58-62
-
HLA-DR restriction-fragment-length polymorphisms in narcolepsy.
Holloman JD,
Bell JI, Kilduff TS, Dement WC, Guilleminault C, McDevitt HO.
J Neurosci Res.
1987;
18
(1):
239-44
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