Greer Murphy M.D., Ph.D.

Publications

• FKBP5 Polymorphisms and Antidepressant Response in Geriatric Depression Sarginson J, Lazzeroni L, Ryan H, Schatzberg A, Murphy GM. American Journal of Medical Genetics, Part B Neuropsychiatric Genetics. 2009 In press
• Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells. Parvathy S, Rajadas J, Ryan H, Vaziri S, Anderson L, Murphy GM. Neurobiol Aging. 2009; 30 (11): 1792-804
• Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E. Selwood SP, Parvathy S, Cordell B, Ryan HS, Oshidari F, Vincent V, Yesavage J, Lazzeroni LC, Murphy GM. Neurobiol Aging. 2009; 30 (4): 574-90
• Cerebral Inflammation and Alzheimer's Dementia Saravanapavan, P, Murphy, GM.. In: Research Progress in Alzheimer's Disease and Dementia, vol. 2, edited by Miao-Kun Sun. 2007: 57-96
• Extended cognitive behavior therapy for cigarette smoking cessation. Killen JD, Fortmann SP, Schatzberg AF, Arredondo C, Murphy G, Hayward C, Celio M, Cromp D, Fong D, Pandurangi M. Addiction. 2008; 103 (8): 1381-90
• Apolipoprotein E varepsilon4 influences on episodic recall and brain structures in aging pilots. Adamson MM, Landy KM, Duong S, Fox-Bosetti S, Ashford JW, Murphy GM, Weiner M, Taylor JL. Neurobiol Aging. 2008
• Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele. O'Hara R, Sommer B, Way N, Kraemer HC, Taylor J, Murphy G. J Psychiatr Res. 2008; 42 (3): 199-204
• A Novel Quantitative Trait Locus on Mouse Chromosome 18, “era1,” Modifies the Entrainment of Circadian Rhythm Wisor JP, Striz M, DeVoss J, Murphy GM, Edgar DM, O'Hara B. Sleep. 2007; 30 (10): 1255-1263
• Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future. Faison WE, Schultz SK, Aerssens J, Alvidrez J, Anand R, Farrer LA, Jarvik L, Manly J, McRae T, Murphy GM, Olin JT, Regier D, Sano M, Mintzer JE. Int Psychogeriatr. 2007; 19 (3): 539-58
• Extended treatment with bupropion SR for cigarette smoking cessation. Killen JD, Fortmann SP, Murphy GM, Hayward C, Arredondo C, Cromp D, Celio M, Abe L, Wang Y, Schatzberg AF. J Consult Clin Psychol. 2006; 74 (2): 286-94
• The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease. Chuu JY, Taylor JL, Tinklenberg J, Noda A, Yesavage J, Murphy GM. J Alzheimers Dis. 2006; 9 (1): 43-9
• Spatial test for agricultural pesticide "blow-in" effect on prevalence of Parkinson's disease. Yesavage JA, Sheikh J, Noda A, Murphy G, O'Hara R, Hierholzer R, Battista M, Ashford JW, Schneider B, Hoblyn J, Kraemer HC, Tinklenberg J. J Geriatr Psychiatry Neurol. 2006; 19 (1): 32-5
• Application of microarray technology in psychotropic drug trials. Murphy GM, J Psychopharmacol. 2006; 20 (4 Suppl): 72-8
• Cytokines and Neurodegeneration Murphy, G, Saravanapavan, P. Cytokines and the CNS. 2005: 163-191
• Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers. O'Hara R, Schröder CM, Kraemer HC, Kryla N, Cao C, Miller E, Schatzberg AF, Yesavage JA, Murphy GM. Neurology. 2005; 65 (4): 642-4
• Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system. Mitrasinovic OM, Grattan A, Robinson CC, Lapustea NB, Poon C, Ryan H, Phong C, Murphy GM. J Neurosci. 2005; 25 (17): 4442-51
• Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission. Wisor JP, Edgar DM, Yesavage J, Ryan HS, McCormick CM, Lapustea N, Murphy GM. Neuroscience. 2005; 131 (2): 375-85
• Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response. Mitrasinovic OM, Robinson CC, Tenen DG, Lee YL, Poon C, Murphy GM. J Neurosci Res. 2004; 77 (3): 420-9
• Use of a VA pharmacy database to screen for areas at high risk for disease: Parkinson's disease and exposure to pesticides. Yesavage JA, Sheikh J, Noda A, Murphy G, O'Hara R, Hierholzer R, Battista M, Ashford JW, Kraemer HC, Tinklenberg J. J Geriatr Psychiatry Neurol. 2004; 17 (1): 36-8
• Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course. Yesavage JA, Friedman L, Kraemer H, Tinklenberg JR, Salehi A, Noda A, Taylor JL, O'Hara R, Murphy G. J Geriatr Psychiatry Neurol. 2004; 17 (1): 20-4
• Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Murphy GM, Hollander SB, Rodrigues HE, Kremer C, Schatzberg AF. Arch Gen Psychiatry. 2004; 61 (11): 1163-9
• Pharmacogenetics of antidepressant medication intolerance. Murphy GM, Kremer C, Rodrigues HE, Schatzberg AF. Am J Psychiatry. 2003; 160 (10): 1830-5
• Macrophage colony stimulating factor promotes phagocytosis by murine microglia. Mitrasinovic OM, Vincent VA, Simsek D, Murphy GM. Neurosci Lett. 2003; 344 (3): 185-8
• Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta. Mitrasinovic OM, Murphy GM. Neurobiol Aging. 2003; 24 (6): 807-15
• The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients. Murphy GM, Kremer C, Rodrigues H, Schatzberg AF. Biol Psychiatry. 2003; 54 (7): 665-73
• Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients. Schatzberg AF, Kremer C, Rodrigues HE, Murphy GM. Am J Geriatr Psychiatry. 2002 Sep-Oct; 10 (5): 541-50
• Proinflammatory effects of M-CSF and A beta in hippocampal organotypic cultures. Vincent VA, Selwood SP, Murphy GM. Neurobiol Aging. 2002 May-Jun; 23 (3): 349-62
• Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. Mitrasinovic OM, Murphy GM. J Biol Chem. 2002; 277 (33): 29889-96
• Analysis of neuronal gene expression with laser capture microdissection. Vincent VA, DeVoss JJ, Ryan HS, Murphy GM. J Neurosci Res. 2002; 69 (5): 578-86
• Macrophage colony stimulating factor prevents NMDA-induced neuronal death in hippocampal organotypic cultures. Vincent VA, Robinson CC, Simsek D, Murphy GM. J Neurochem. 2002; 82 (6): 1388-97
• Single base pair polymorphisms and their characterization with oligonucleotide microarrays. Murphy, GM., Dalma, D. Psychiatric Genetics. 2002; (12): 97-107
• Accelerated Phagocytosis of Amyloid-beta by Mouse and Human Microglia Overexpressing the M-CSF Receptor. Murphy, GM., Mitrasinovic, O.. Journal of Biological Chemistry. 2002; (277): 29889-29896
• Apolipoprotein E epsilon4 allele affects the relationship between stress and depression in caregivers of patients with Alzheimer's disease. Gallagher-Thompson D, O'Hara R, Simmons A, Kraemer HC, Murphy GM. J Geriatr Psychiatry Neurol. 2001; 14 (3): 115-9
• CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression. Murphy GM, Pollock BG, Kirshner MA, Pascoe N, Cheuk W, Mulsant BH, Reynolds CF. Neuropsychopharmacology. 2001; 25 (5): 737-43
• Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele. Murphy GM, Claassen JD, DeVoss JJ, Pascoe N, Taylor J, Tinklenberg JR, Yesavage JA. Neurology. 2001; 56 (11): 1595-7
• Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. Kadotani H, Kadotani T, Young T, Peppard PE, Finn L, Colrain IM, Murphy GM, Mignot E. JAMA. 2001; 285 (22): 2888-90
• Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. Mitrasinovic OM, Perez GV, Zhao F, Lee YL, Poon C, Murphy GM. J Biol Chem. 2001; 276 (32): 30142-9
• Absence of cardiac lipid accumulation in transgenic mice with heart-specific HSL overexpression. Suzuki J, Shen WJ, Nelson BD, Patel S, Veerkamp JH, Selwood SP, Murphy GM, Reaven E, Kraemer FB. Am J Physiol Endocrinol Metab. 2001; 281 (4): E857-66
• Rapid detection of the C-1496G polymorphism in the CYP2D6 *2 allele. Claassen JD, Pascoe N, Schatzberg AF, Murphy GM. Clin Chem. 2001; 47 (12): 2153-5
• Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF. Kahle PJ, Jakowec M, Teipel SJ, Hampel H, Petzinger GM, Di Monte DA, Silverberg GD, Möller HJ, Yesavage JA, Tinklenberg JR, Shooter EM, Murphy GM. Neurology. 2000; 54 (7): 1498-504
• A longitudinal study of apolipoprotein-E genotype and depressive symptoms in community-dwelling older adults. Mauricio M, O'Hara R, Yesavage JA, Friedman L, Kraemer HC, Van De Water M, Murphy GM. Am J Geriatr Psychiatry. 2000; 8 (3): 196-200
• Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease. Murphy GM, Zhao F, Yang L, Cordell B. Am J Pathol. 2000; 157 (3): 895-904
• The APOE epsilon4 allele is associated with decline on delayed recall performance in community-dwelling older adults. O'Hara R, Yesavage JA, Kraemer HC, Mauricio M, Friedman LF, Murphy GM. J Am Geriatr Soc. 1998; 46 (12): 1493-8
• Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. Murphy GM, Yang L, Cordell B. J Biol Chem. 1998; 273 (33): 20967-71
• No neuropathologic evidence for an increased frequency of Alzheimer's disease among elderly schizophrenics. Murphy GM, Lim KO, Wieneke M, Ellis WG, Forno LS, Hoff AL, Nordahl T. Biol Psychiatry. 1998; 43 (3): 205-9
• No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease. Murphy GM, Sullivan EV, Gallagher-Thompson D, Thompson LW, van Duijn CM, Forno LS, Ellis WG, Jagust WJ, Yesavage J, Tinklenberg JR. Neurology. 1997; 48 (5): 1313-6
• No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease. Murphy GM, Taylor J, Kraemer HC, Yesavage J, Tinklenberg JR. Am J Psychiatry. 1997; 154 (5): 603-8
• Beta-amyloid peptide secretion by a microglial cell line is induced by beta-amyloid-(25-35) and lipopolysaccharide. Bitting L, Naidu A, Cordell B, Murphy GM. J Biol Chem. 1996; 271 (27): 16084-9
• Rate of cognitive decline in Alzheimer's disease is not affected by the alpha-1-antichymotrypsin A allele or the CYP2D6 B mutant. Murphy GM, Yang L, Yesavage J, Tinklenberg JR. Neurosci Lett. 1996; 217 (2-3): 200-2
• Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease. Murphy GM, Forno LS, Ellis WG, Nochlin D, Levy-Lahad E, Poorkaj P, Bird TD, Jiang Z, Cordell B. Am J Pathol. 1996; 149 (6): 1839-46
• Macrophage inflammatory protein 1-alpha mRNA expression in an immortalized microglial cell line and cortical astrocyte cultures. Murphy GM, Jia XC, Song Y, Ong E, Shrivastava R, Bocchini V, Lee YL, Eng LF. J Neurosci Res. 1995; 40 (6): 755-63
• Leukemia inhibitory factor mRNA is expressed in cortical astrocyte cultures but not in an immortalized microglial cell line. Murphy GM, Song Y, Ong E, Lee YL, Schmidt KG, Bocchini V, Eng LF. Neurosci Lett. 1995; 184 (1): 48-51
• A RT-PCR study of gene expression in a mechanical injury model. Eng LF, Lee YL, Murphy GM, Yu AC. Prog Brain Res. 1995: 105 219-29
• Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. Murphy GM, Lee YL, Jia XC, Yu AC, Majewska A, Song Y, Schmidt K, Eng LF. J Neurochem. 1995; 65 (6): 2716-24
• Expression of interleukin-11 and its encoding mRNA by glioblastoma cells. Murphy GM, Bitting L, Majewska A, Schmidt K, Song Y, Wood CR. Neurosci Lett. 1995; 196 (3): 153-6
• TGF-beta 1 causes increased endothelial ICAM-1 expression and lung injury. Suzuki Y, Tanigaki T, Heimer D, Wang W, Ross WG, Murphy GA, Sakai A, Sussman HH, Vu TH, Raffin TA. J Appl Physiol. 1994; 77 (3): 1281-7
• Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders. Murphy GM, Forno LS, Higgins L, Scardina JM, Eng LF, Cordell B. Am J Pathol. 1994; 144 (5): 1082-8
• Reverse transcription and polymerase chain reaction technique for quantification of mRNA in primary astrocyte cultures. Murphy GM, Jia XC, Yu AC, Lee YL, Tinklenberg JR, Eng LF. J Neurosci Res. 1993; 35 (6): 643-51
• Astrocytic gliosis in the amygdala in Down's syndrome and Alzheimer's disease. Murphy GM, Ellis WG, Lee YL, Stultz KE, Shrivastava R, Tinklenberg JR, Eng LF. Prog Brain Res. 1992: 94 475-83
• Alzheimer's disease. Beta-amyloid precursor protein expression in the nucleus basalis of Meynert. Murphy GM, Greenberg BD, Ellis WG, Forno LS, Salamat SM, Gonzalez-DeWhitt PA, Lowery DE, Tinklenberg JR, Eng LF. Am J Pathol. 1992; 141 (2): 357-61
• The amygdala in Down's syndrome and familial Alzheimer's disease: four clinicopathological case reports. Murphy GM, Ellis WG. Biol Psychiatry. 1991; 30 (1): 92-106
• Alzheimer's disease: beta-amyloid precursor protein mRNA expression in mononuclear blood cells. Allen JS, Murphy GM, Eng LF, Stultz KE, Davies HD, Pickford LB, Tinklenberg JR. Neurosci Lett. 1991; 132 (1): 109-12
• Alzheimer's disease: beta-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe. Murphy GM, Murphy E, Greenberg BD, Cordell B, Eng LF, Ellis WG, Forno LS, Salamat SM, Gonzalez-DeWhitt PA, Lowery DE. Neurosci Lett. 1991; 131 (1): 100-4
• Antigenic profile of plaques and neurofibrillary tangles in the amygdala in Down's syndrome: a comparison with Alzheimer's disease. Murphy GM, Eng LF, Ellis WG, Perry G, Meissner LC, Tinklenberg JR. Brain Res. 1990; 537 (1-2): 102-8
• Beta-amyloid precursor detected in human cerebral cortex. Murphy GM, Eng LF, Cordell B, Wang Y, Ellis WG, Meissner L, Tinklenberg JR. Prog Neuropsychopharmacol Biol Psychiatry. 1990; 14 (3): 309-17
• Langur monkey mother loss: profile analysis with multivariate analysis of variance for separation subjects and controls. Dolhinow P, Murphy G. Folia Primatol (Basel). 1983; 40 (3): 181-96
• A morphological study of male rat cerebral cortical asymmetry. Dowling GA, Diamond MC, Murphy GM, Johnson RE. Exp Neurol. 1982; 75 (1): 51-67
• Langur monkey (Presbytis entellus) development. The first 3 months of life. Dolhinow P, Murphy G. Folia Primatol (Basel). 1982; 39 (3-4): 305-31
• Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa. Tinklenberg JR, Gillin JC, Murphy GM, Staub R, Wyatt RJ. Am J Psychiatry. 1979; 136 (3): 311-3
• The effects of phenylethylamine in rhesus monkeys. Tinklenberg JR, Gillin JC, Murphy GM, Staub R, Wyatt RJ. Am J Psychiatry. 1978; 135 (5): 576-8