Publications
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A nucleotide sugar transporter involved in glycosylation of the toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites.
Caffaro CE,
Koshy AA, Liu L, Zeiner GM, Hirschberg CB, Boothroyd JC.
PLoS Pathog.
2013;
9
(5):
e1003331
-
Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.
Buchholz KR,
Bowyer PW, Boothroyd JC.
Eukaryot Cell.
2013;
12
(3):
399-410
-
Have it your way: how polymorphic, injected kinases and pseudokinases enable toxoplasma to subvert host defenses.
Boothroyd JC,
PLoS Pathog.
2013;
9
(4):
e1003296
-
A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.
Fleckenstein MC,
Reese ML, Könen-Waisman S, Boothroyd JC, Howard JC, Steinfeldt T.
PLoS Biol.
2012;
10
(7):
e1001358
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A forward genetic screen reveals that calcium-dependent protein kinase 3 regulates egress in Toxoplasma.
Garrison E,
Treeck M, Ehret E, Butz H, Garbuz T, Oswald BP, Settles M, Boothroyd J, Arrizabalaga G.
PLoS Pathog.
2012;
8
(11):
e1003049
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Infected dendritic cells facilitate systemic dissemination and transplacental passage of the obligate intracellular parasite Neospora caninum in mice.
Collantes-Fernandez E,
Arrighi RB, Alvarez-García G, Weidner JM, Regidor-Cerrillo J, Boothroyd JC, Ortega-Mora LM, Barragan A.
PLoS One.
2012;
7
(3):
e32123
-
Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance.
Fritz HM,
Bowyer PW, Bogyo M, Conrad PA, Boothroyd JC.
PLoS One.
2012;
7
(1):
e29955
-
Tissue barriers of the human placenta to infection with Toxoplasma gondii.
Robbins JR,
Zeldovich VB, Poukchanski A, Boothroyd JC, Bakardjiev AI.
Infect Immun.
2012;
80
(1):
418-28
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Toxoplasma co-opts host cells it does not invade.
Koshy AA,
Dietrich HK, Christian DA, Melehani JH, Shastri AJ, Hunter CA, Boothroyd JC.
PLoS Pathog.
2012;
8
(7):
e1002825
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Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
Fritz HM,
Buchholz KR, Chen X, Durbin-Johnson B, Rocke DM, Conrad PA, Boothroyd JC.
PLoS One.
2012;
7
(2):
e29998
-
A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on Toxoplasma virulence.
Reese ML,
Boothroyd JC.
J Biol Chem.
2011;
286
(33):
29366-75
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Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.
Srinivasan P,
Beatty WL, Diouf A, Herrera R, Ambroggio X, Moch JK, Tyler JS, Narum DL, Pierce SK, Boothroyd JC, Haynes JD, Miller LH.
Proc Natl Acad Sci U S A.
2011;
108
(32):
13275-80
-
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
Hall CI,
Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M.
Proc Natl Acad Sci U S A.
2011;
108
(26):
10568-73
-
Chemistry and biology of macrolide antiparasitic agents.
Lee Y,
Choi JY, Fu H, Harvey C, Ravindran S, Roush WR, Boothroyd JC, Khosla C.
J Med Chem.
2011;
54
(8):
2792-804
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Evidence for host cells as the major contributor of lipids in the intravacuolar network of Toxoplasma-infected cells.
Caffaro CE,
Boothroyd JC.
Eukaryot Cell.
2011;
10
(8):
1095-9
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Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.
Tyler JS,
Treeck M, Boothroyd JC.
Trends Parasitol.
2011;
27
(9):
410-20
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Identification of tissue cyst wall components by transcriptome analysis of in vivo and in vitro Toxoplasma gondii bradyzoites.
Buchholz KR,
Fritz HM, Chen X, Durbin-Johnson B, Rocke DM, Ferguson DJ, Conrad PA, Boothroyd JC.
Eukaryot Cell.
2011;
10
(12):
1637-47
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Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence.
Reese ML,
Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP.
Proc Natl Acad Sci U S A.
2011;
108
(23):
9625-30
-
Strain-dependent host transcriptional responses to Toxoplasma infection are largely conserved in mammalian and avian hosts.
Ong YC,
Boyle JP, Boothroyd JC.
PLoS One.
2011;
6
(10):
e26369
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The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex.
Tyler JS,
Boothroyd JC.
PLoS Pathog.
2011;
7
(2):
e1001282
-
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.
Treeck M,
Sanders JL, Elias JE, Boothroyd JC.
Cell Host Microbe.
2011;
10
(4):
410-9
-
Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction.
Morgado P,
Ong YC, Boothroyd JC, Lodoen MB.
Infect Immun.
2011;
79
(11):
4401-12
-
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.
Jensen KD,
Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP.
Cell Host Microbe.
2011;
9
(6):
472-83
-
A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection.
Lodoen MB,
Gerke C, Boothroyd JC.
Cell Microbiol.
2010;
12
(1):
55-66
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Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8.
Pernas L,
Boothroyd JC.
Int J Parasitol.
2010;
40
(12):
1367-71
-
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
Khaminets A,
Hunn JP, Könen-Waisman S, Zhao YO, Preukschat D, Coers J, Boyle JP, Ong YC, Boothroyd JC, Reichmann G, Howard JC.
Cell Microbiol.
2010;
12
(7):
939-61
-
Toxoplasma gondii infection specifically increases the levels of key host microRNAs.
Zeiner GM,
Norman KL, Thomson JM, Hammond SM, Boothroyd JC.
PLoS One.
2010;
5
(1):
e8742
-
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.
Ong YC,
Reese ML, Boothroyd JC.
J Biol Chem.
2010;
285
(37):
28731-40
-
Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions.
Koshy AA,
Fouts AE, Lodoen MB, Alkan O, Blau HM, Boothroyd JC.
Nat Methods.
2010;
7
(4):
307-9
-
Use of two novel approaches to discriminate between closely related host microRNAs that are manipulated by Toxoplasma gondii during infection.
Zeiner GM,
Boothroyd JC.
RNA.
2010;
16
(6):
1268-74
-
4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion.
Ravindran S,
Lodoen MB, Verhelst SH, Bogyo M, Boothroyd JC.
PLoS One.
2009;
4
(12):
e8143
-
A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuole.
Reese ML,
Boothroyd JC.
Traffic.
2009;
10
(10):
1458-70
-
A pseudouridine synthase homologue is critical to cellular differentiation in Toxoplasma gondii.
Anderson MZ,
Brewer J, Singh U, Boothroyd JC.
Eukaryot Cell.
2009;
8
(3):
398-409
-
Expansion of host range as a driving force in the evolution of Toxoplasma.
Boothroyd JC,
Mem Inst Oswaldo Cruz.
2009;
104
(2):
179-84
-
Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.
Kafsack BF,
Pena JD, Coppens I, Ravindran S, Boothroyd JC, Carruthers VB.
Science.
2009;
323
(5913):
530-3
-
Toxoplasma gondii: 25 years and 25 major advances for the field.
Boothroyd JC,
Int J Parasitol.
2009;
39
(8):
935-46
-
A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence.
Saeij JP,
Arrizabalaga G, Boothroyd JC.
Infect Immun.
2008;
76
(6):
2402-10
-
Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression.
Boyle JP,
Saeij JP, Harada SY, Ajioka JW, Boothroyd JC.
Eukaryot Cell.
2008;
7
(8):
1403-14
-
Kiss and spit: the dual roles of Toxoplasma rhoptries.
Boothroyd JC,
Dubremetz JF.
Nat Rev Microbiol.
2008;
6
(1):
79-88
-
RNA analysis by biosynthetic tagging using 4-thiouracil and uracil phosphoribosyltransferase.
Zeiner GM,
Cleary MD, Fouts AE, Meiring CD, Mocarski ES, Boothroyd JC.
Methods Mol Biol.
2008:
419
135-46
-
Secretion of proteins into host cells by Apicomplexan parasites.
Ravindran S,
Boothroyd JC.
Traffic.
2008;
9
(5):
647-56
-
The Toxoplasma gondii dense granule protein GRA7 is phosphorylated upon invasion and forms an unexpected association with the rhoptry proteins ROP2 and ROP4.
Dunn JD,
Ravindran S, Kim SK, Boothroyd JC.
Infect Immun.
2008;
76
(12):
5853-61
-
Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors.
Vyas A,
Kim SK, Giacomini N, Boothroyd JC, Sapolsky RM.
Proc Natl Acad Sci U S A.
2007;
104
(15):
6442-7
-
Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine.
Kim SK,
Karasov A, Boothroyd JC.
Infect Immun.
2007;
75
(4):
1626-34
-
Infection with Toxoplasma gondii bradyzoites has a diminished impact on host transcript levels relative to tachyzoite infection.
Fouts AE,
Boothroyd JC.
Infect Immun.
2007;
75
(2):
634-42
-
Pulling together: an integrated model of Toxoplasma cell invasion.
Carruthers V,
Boothroyd JC.
Curr Opin Microbiol.
2007;
10
(1):
83-9
-
The BSR4 protein is up-regulated in Toxoplasma gondii bradyzoites, however the dominant surface antigen recognised by the P36 monoclonal antibody is SRS9.
Van TT,
Kim SK, Camps M, Boothroyd JC, Knoll LJ.
Int J Parasitol.
2007;
37
(8-9):
877-85
-
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue.
Saeij JP,
Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC.
Nature.
2007;
445
(7125):
324-7
-
Toxoplasma gondii dysregulates IFN-gamma-inducible gene expression in human fibroblasts: insights from a genome-wide transcriptional profiling.
Kim SK,
Fouts AE, Boothroyd JC.
J Immunol.
2007;
178
(8):
5154-65
-
Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells.
Gilbert LA,
Ravindran S, Turetzky JM, Boothroyd JC, Bradley PJ.
Eukaryot Cell.
2007;
6
(1):
73-83
-
Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice.
Boyle JP,
Saeij JP, Boothroyd JC.
Exp Parasitol.
2007;
116
(3):
302-5
-
Analysis of gene expression during development: lessons from the Apicomplexa.
Boyle JP,
Saeij JP, Cleary MD, Boothroyd JC.
Microbes Infect.
2006;
8
(6):
1623-30
-
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii.
Boyle JP,
Rajasekar B, Saeij JP, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC.
Proc Natl Acad Sci U S A.
2006;
103
(27):
10514-9
-
Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii.
Alexander DL,
Arastu-Kapur S, Dubremetz JF, Boothroyd JC.
Eukaryot Cell.
2006;
5
(7):
1169-73
-
Polymorphic secreted kinases are key virulence factors in toxoplasmosis.
Saeij JP,
Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC.
Science.
2006;
314
(5806):
1780-3
-
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space.
Coppens I,
Dunn JD, Romano JD, Pypaert M, Zhang H, Boothroyd JC, Joiner KA.
Cell.
2006;
125
(2):
261-74
-
A novel rhoptry protein in Toxoplasma gondii bradyzoites and merozoites.
Schwarz JA,
Fouts AE, Cummings CA, Ferguson DJ, Boothroyd JC.
Mol Biochem Parasitol.
2005;
144
(2):
159-66
-
Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains.
Saeij JP,
Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC.
Infect Immun.
2005;
73
(2):
695-702
-
Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay.
Cleary MD,
Meiering CD, Jan E, Guymon R, Boothroyd JC.
Nat Biotechnol.
2005;
23
(2):
232-7
-
Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii.
Khan A,
Taylor S, Su C, Mackey AJ, Boyle J, Cole R, Glover D, Tang K, Paulsen IT, Berriman M, Boothroyd JC, Pfefferkorn ER, Dubey JP, Ajioka JW, Roos DS, Wootton JC, Sibley LD.
Nucleic Acids Res.
2005;
33
(9):
2980-92
-
Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host.
Saeij JP,
Boyle JP, Boothroyd JC.
Trends Parasitol.
2005;
21
(10):
476-81
-
Disruption of a locus encoding a nucleolar zinc finger protein decreases tachyzoite-to-bradyzoite differentiation in Toxoplasma gondii.
Vanchinathan P,
Brewer JL, Harb OS, Boothroyd JC, Singh U.
Infect Immun.
2005;
73
(10):
6680-8
-
Identification and disruption of a rhoptry-localized homologue of sodium hydrogen exchangers in Toxoplasma gondii.
Karasov AO,
Boothroyd JC, Arrizabalaga G.
Int J Parasitol.
2005;
35
(3):
285-91
-
Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles.
Alexander DL,
Mital J, Ward GE, Bradley P, Boothroyd JC.
PLoS Pathog.
2005;
1
(2):
e17
-
Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii.
Bradley PJ,
Ward C, Cheng SJ, Alexander DL, Coller S, Coombs GH, Dunn JD, Ferguson DJ, Sanderson SJ, Wastling JM, Boothroyd JC.
J Biol Chem.
2005;
280
(40):
34245-58
-
Stage-specific expression of surface antigens by Toxoplasma gondii as a mechanism to facilitate parasite persistence.
Kim SK,
Boothroyd JC.
J Immunol.
2005;
174
(12):
8038-48
-
A GFP-based motif-trap reveals a novel mechanism of targeting for the Toxoplasma ROP4 protein.
Bradley PJ,
Li N, Boothroyd JC.
Mol Biochem Parasitol.
2004;
137
(1):
111-20
-
An unusual genotype of Toxoplasma gondii is common in California sea otters (Enhydra lutris nereis) and is a cause of mortality.
Miller MA,
Grigg ME, Kreuder C, James ER, Melli AC, Crosbie PR, Jessup DA, Boothroyd JC, Brownstein D, Conrad PA.
Int J Parasitol.
2004;
34
(3):
275-84
-
Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation.
Arrizabalaga G,
Ruiz F, Moreno S, Boothroyd JC.
J Cell Biol.
2004;
165
(5):
653-62
-
Role of calcium during Toxoplasma gondii invasion and egress.
Arrizabalaga G,
Boothroyd JC.
Int J Parasitol.
2004;
34
(3):
361-8
-
The induction of acute ileitis by a single microbial antigen of Toxoplasma gondii.
Rachinel N,
Buzoni-Gatel D, Dutta C, Mennechet FJ, Luangsay S, Minns LA, Grigg ME, Tomavo S, Boothroyd JC, Kasper LH.
J Immunol.
2004;
173
(4):
2725-35
-
DNA microarrays in parasitology: strengths and limitations.
Boothroyd JC,
Blader I, Cleary M, Singh U.
Trends Parasitol.
2003;
19
(10):
470-6
-
Serotyping of Toxoplasma gondii infections in humans using synthetic peptides.
Kong JT,
Grigg ME, Uyetake L, Parmley S, Boothroyd JC.
J Infect Dis.
2003;
187
(9):
1484-95
-
Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole.
Bradley PJ,
Hsieh CL, Boothroyd JC.
Mol Biochem Parasitol.
2002 Nov-Dec;
125
(1-2):
189-93
-
An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii.
Camps M,
Arrizabalaga G, Boothroyd J.
Mol Microbiol.
2002;
43
(5):
1309-18
-
Genetic analysis of tachyzoite to bradyzoite differentiation mutants in Toxoplasma gondii reveals a hierarchy of gene induction.
Singh U,
Brewer JL, Boothroyd JC.
Mol Microbiol.
2002;
44
(3):
721-33
-
Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription.
Vaena de Avalos S,
Blader IJ, Fisher M, Boothroyd JC, Burleigh BA.
J Biol Chem.
2002;
277
(1):
639-44
-
Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease?
Boothroyd JC,
Grigg ME.
Curr Opin Microbiol.
2002;
5
(4):
438-42
-
Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily.
He XL,
Grigg ME, Boothroyd JC, Garcia KC.
Nat Struct Biol.
2002;
9
(8):
606-11
-
Toxoplasma gondii asexual development: identification of developmentally regulated genes and distinct patterns of gene expression.
Cleary MD,
Singh U, Blader IJ, Brewer JL, Boothroyd JC.
Eukaryot Cell.
2002;
1
(3):
329-40
-
Adaptation of signature-tagged mutagenesis for Toxoplasma gondii: a negative screening strategy to isolate genes that are essential in restrictive growth conditions.
Knoll LJ,
Furie GL, Boothroyd JC.
Mol Biochem Parasitol.
2001;
116
(1):
11-6
-
Isolation and characterization of a cold-sensitive attachment/invasion mutant of Toxoplasma gondii.
Uyetake L,
Ortega-Barria E, Boothroyd JC.
Exp Parasitol.
2001;
97
(1):
55-9
-
Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells.
Blader IJ,
Manger ID, Boothroyd JC.
J Biol Chem.
2001;
276
(26):
24223-31
-
Rapid identification of virulent type I strains of the protozoan pathogen Toxoplasma gondii by PCR-restriction fragment length polymorphism analysis at the B1 gene.
Grigg ME,
Boothroyd JC.
J Clin Microbiol.
2001;
39
(1):
398-400
-
Resistance as a tool in the study of old and new drug targets in Toxoplasma.
McFadden DC,
Camps M, Boothroyd JC.
Drug Resist Updat.
2001;
4
(2):
79-84
-
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries.
Grigg ME,
Bonnefoy S, Hehl AB, Suzuki Y, Boothroyd JC.
Science.
2001;
294
(5540):
161-5
-
Success and virulence in the AIDS pathogen Toxoplasma as the result of sexual recombination between two distinct ancestries
Grigg ME,
Suzuki Y, Boothroyd JC.
Science.
2001:
294
161-16
-
Surface antigens of Toxoplasma gondii: variations on a theme.
Lekutis C,
Ferguson DJ, Grigg ME, Camps M, Boothroyd JC.
Int J Parasitol.
2001;
31
(12):
1285-92
-
Targeted disruption of an essential RNA-binding protein perturbs cell division in Trypanosoma brucei.
Manger ID,
Boothroyd JC.
Mol Biochem Parasitol.
2001;
116
(2):
239-45
-
The pro region of Toxoplasma ROP1 is a rhoptry-targeting signal.
Bradley PJ,
Boothroyd JC.
Int J Parasitol.
2001;
31
(11):
1177-86
-
Toxoplasma gondii: selective killing of extracellular parasites by oxidation using pyrrolidine dithiocarbamate.
Camps M,
Boothroyd JC.
Exp Parasitol.
2001;
98
(4):
206-14
-
Unusual abundance of atypical strains associated with human ocular toxoplasmosis.
Grigg ME,
Ganatra J, Boothroyd JC, Margolis TP.
J Infect Dis.
2001;
184
(5):
633-9
-
Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance.
McFadden DC,
Tomavo S, Berry EA, Boothroyd JC.
Mol Biochem Parasitol.
2000;
108
(1):
1-12
-
Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress.
Black MW,
Arrizabalaga G, Boothroyd JC.
Mol Cell Biol.
2000;
20
(24):
9399-408
-
Lytic cycle of Toxoplasma gondii.
Black MW,
Boothroyd JC.
Microbiol Mol Biol Rev.
2000;
64
(3):
607-23
-
The trans-spliced L30 ribosomal protein mRNA of Trypanosoma brucei is not subject to autogenous feedback control at the messenger RNA level.
Wilson K,
Uyetake L, Boothroyd JC.
Mol Biochem Parasitol.
2000;
111
(1):
199-205
-
Toxoplasma gondii homologue of plasmodium apical membrane antigen 1 is involved in invasion of host cells.
Hehl AB,
Lekutis C, Grigg ME, Bradley PJ, Dubremetz JF, Ortega-Barria E, Boothroyd JC.
Infect Immun.
2000;
68
(12):
7078-86
-
Toxoplasma gondii: identification of a developmentally regulated family of genes related to SAG2.
Lekutis C,
Ferguson DJ, Boothroyd JC.
Exp Parasitol.
2000;
96
(2):
89-96
-
Cytochrome b mutation identified in a decoquinate-resistant mutant of Toxoplasma gondii.
McFadden DC,
Boothroyd JC.
J Eukaryot Microbiol.
1999 Sep-Oct;
46
(5):
81S-82S
-
A Toxoplasma lectin-like activity specific for sulfated polysaccharides is involved in host cell infection.
Ortega-Barria E,
Boothroyd JC.
J Biol Chem.
1999;
274
(3):
1267-76
-
Identification of the pro-mature processing site of Toxoplasma ROP1 by mass spectrometry.
Bradley PJ,
Boothroyd JC.
Mol Biochem Parasitol.
1999;
100
(1):
103-9
-
Trypanosoma brucei: cis-acting sequences involved in the developmental regulation of PARP expression.
Wilson K,
Uyetake L, Boothroyd J.
Exp Parasitol.
1999;
91
(3):
222-30
-
Analysis of Toxoplasma gondii stably transfected with a transmembrane variant of its major surface protein, SAG1.
Seeber F,
Dubremetz JF, Boothroyd JC.
J Cell Sci.
1998:
111 ( Pt 1)
23-9
-
Development of a stable episomal shuttle vector for Toxoplasma gondii.
Black MW,
Boothroyd JC.
J Biol Chem.
1998;
273
(7):
3972-9
-
Expressed sequence tag analysis of the bradyzoite stage of Toxoplasma gondii: identification of developmentally regulated genes.
Manger ID,
Hehl A, Parmley S, Sibley LD, Marra M, Hillier L, Waterston R, Boothroyd JC.
Infect Immun.
1998;
66
(4):
1632-7
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Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa.
Ajioka JW,
Boothroyd JC, Brunk BP, Hehl A, Hillier L, Manger ID, Marra M, Overton GC, Roos DS, Wan KL, Waterston R, Sibley LD.
Genome Res.
1998;
8
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18-28
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Identification of a nuclear protein in Trypanosoma brucei with homology to RNA-binding proteins from cis-splicing systems.
Manger ID,
Boothroyd JC.
Mol Biochem Parasitol.
1998;
97
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1-11
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Isolation of developmentally regulated genes from Toxoplasma gondii by a gene trap with the positive and negative selectable marker hypoxanthine-xanthine-guanine phosphoribosyltransferase.
Knoll LJ,
Boothroyd JC.
Mol Cell Biol.
1998;
18
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807-14
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Molecular Biology's Lessons about Toxoplasma Development: Stage-specific Homologs.
Knoll LJ,
Boothroyd JC.
Parasitol Today.
1998;
14
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490-3
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Processing of Toxoplasma ROP1 protein in nascent rhoptries.
Soldati D,
Lassen A, Dubremetz JF, Boothroyd JC.
Mol Biochem Parasitol.
1998;
96
(1-2):
37-48
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The surface of Toxoplasma tachyzoites is dominated by a family of glycosylphosphatidylinositol-anchored antigens related to SAG1.
Manger ID,
Hehl AB, Boothroyd JC.
Infect Immun.
1998;
66
(5):
2237-44
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The surface of Toxoplasma: more and less.
Boothroyd JC,
Hehl A, Knoll LJ, Manger ID.
Int J Parasitol.
1998;
28
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Genetic analysis in Toxoplasma: gene discovery with expressed sequence tags and rapid mapping of natural polymorphisms.
Hehl A,
Manger ID, Boothroyd JC.
Methods.
1997;
13
(2):
89-102
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Genetic and biochemical analysis of development in Toxoplasma gondii.
Boothroyd JC,
Black M, Bonnefoy S, Hehl A, Knoll LJ, Manger ID, Ortega-Barria E, Tomavo S.
Philos Trans R Soc Lond B Biol Sci.
1997;
352
(1359):
1347-54
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Identification and characterization of SRS1, a Toxoplasma gondii surface antigen upstream of and related to SAG1.
Hehl A,
Krieger T, Boothroyd JC.
Mol Biochem Parasitol.
1997;
89
(2):
271-82
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Use of Toxoplasma gondii expressing beta-galactosidase for colorimetric assessment of drug activity in vitro.
McFadden DC,
Seeber F, Boothroyd JC.
Antimicrob Agents Chemother.
1997;
41
(9):
1849-53
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Escherichia coli beta-galactosidase as an in vitro and in vivo reporter enzyme and stable transfection marker in the intracellular protozoan parasite Toxoplasma gondii.
Seeber F,
Boothroyd JC.
Gene.
1996;
169
(1):
39-45
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Implications of conserved structural motifs in disparate trypanosome surface proteins.
Carrington M,
Boothroyd J.
Mol Biochem Parasitol.
1996;
81
(2):
119-26
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Sequence divergence in a family of variant surface glycoprotein genes from trypanosomes: coding region hypervariability and downstream recombinogenic repeats.
Field MC,
Boothroyd JC.
J Mol Evol.
1996;
42
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500-11
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Use of chimeric recombinant polypeptides to analyse conformational, surface epitopes on trypanosome variant surface glycoproteins.
Hsia R,
Beals T, Boothroyd JC.
Mol Microbiol.
1996;
19
(1):
53-63
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A homologue of the nuclear GTPase ran/TC4 from Trypanosoma brucei.
Field MC,
Field H, Boothroyd JC.
Mol Biochem Parasitol.
1995;
69
(1):
131-4
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A selector of transcription initiation in the protozoan parasite Toxoplasma gondii.
Soldati D,
Boothroyd JC.
Mol Cell Biol.
1995;
15
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87-93
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Complementation of a Toxoplasma gondii ROP1 knock-out mutant using phleomycin selection.
Soldati D,
Kim K, Kampmeier J, Dubremetz JF, Boothroyd JC.
Mol Biochem Parasitol.
1995;
74
(1):
87-97
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Interconnection between organellar functions, development and drug resistance in the protozoan parasite, Toxoplasma gondii.
Tomavo S,
Boothroyd JC.
Int J Parasitol.
1995;
25
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1293-9
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Restriction enzyme-mediated integration elevates transformation frequency and enables co-transfection of Toxoplasma gondii.
Black M,
Seeber F, Soldati D, Kim K, Boothroyd JC.
Mol Biochem Parasitol.
1995;
74
(1):
55-63
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Toxoplasma gondii: stable complementation of sag1 (p30) mutants using SAG1 transfection and fluorescence-activated cell sorting.
Kim K,
Boothroyd JC.
Exp Parasitol.
1995;
80
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46-53
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Trypanosoma brucei: molecular cloning of homologues of small GTP-binding proteins involved in vesicle trafficking.
Field MC,
Boothroyd JC.
Exp Parasitol.
1995;
81
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313-20
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Toxoplasma workshop overview.
Schwartzman JD,
Boothroyd JC, Kasper LH.
J Eukaryot Microbiol.
1994 Sep-Oct;
41
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19S-21S
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Conformationally appropriate expression of the Toxoplasma antigen SAG1 (p30) in CHO cells.
Kim K,
Bülow R, Kampmeier J, Boothroyd JC.
Infect Immun.
1994;
62
(1):
203-9
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Development of genetic systems for Toxoplasma gondii.
Sibley LD,
Pfefferkorn ER, Boothroyd JC.
Parasitol Today.
1993;
9
(10):
392-5
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Expression of Toxoplasma gondii P30 as fusions with glutathione S-transferase in animal cells by Sindbis recombinant virus.
Xiong C,
Grieve RB, Kim K, Boothroyd JC.
Mol Biochem Parasitol.
1993;
61
(1):
143-8
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Gene replacement in Toxoplasma gondii with chloramphenicol acetyltransferase as selectable marker.
Kim K,
Soldati D, Boothroyd JC.
Science.
1993;
262
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911-4
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Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote.
Bangs JD,
Uyetake L, Brickman MJ, Balber AE, Boothroyd JC.
J Cell Sci.
1993:
105 ( Pt 4)
1101-13
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Population biology of Toxoplasma gondii.
Boothroyd JC,
Sibley LD.
Res Immunol.
1993;
144
(1):
14-6
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Population biology of Toxoplasma: clonality, virulence, and speciation (or not).
Boothroyd JC,
Infect Agents Dis.
1993;
2
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100-2
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Transient transfection and expression in the obligate intracellular parasite Toxoplasma gondii.
Soldati D,
Boothroyd JC.
Science.
1993;
260
(5106):
349-52
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A Toxoplasma gondii rhoptry protein associated with host cell penetration has unusual charge asymmetry.
Ossorio PN,
Schwartzman JD, Boothroyd JC.
Mol Biochem Parasitol.
1992;
50
(1):
1-15
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Antigen-specific (p30) mouse CD8+ T cells are cytotoxic against Toxoplasma gondii-infected peritoneal macrophages.
Kasper LH,
Khan IA, Ely KH, Buelow R, Boothroyd JC.
J Immunol.
1992;
148
(5):
1493-8
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Construction of a molecular karyotype for Toxoplasma gondii.
Sibley LD,
Boothroyd JC.
Mol Biochem Parasitol.
1992;
51
(2):
291-300
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Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii.
Sibley LD,
LeBlanc AJ, Pfefferkorn ER, Boothroyd JC.
Genetics.
1992;
132
(4):
1003-15
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Genes that allow yeast cells to grow in the absence of the HDEL receptor.
Hardwick KG,
Boothroyd JC, Rudner AD, Pelham HR.
EMBO J.
1992;
11
(11):
4187-95
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Genomic organization and context of a trypanosome variant surface glycoprotein gene family.
Beals TP,
Boothroyd JC.
J Mol Biol.
1992;
225
(4):
961-71
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Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides.
Bangs JD,
Crain PF, Hashizume T, McCloskey JA, Boothroyd JC.
J Biol Chem.
1992;
267
(14):
9805-15
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Sequence divergence among members of a trypanosome variant surface glycoprotein gene family.
Beals TP,
Boothroyd JC.
J Mol Biol.
1992;
225
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973-83
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Virulent strains of Toxoplasma gondii comprise a single clonal lineage.
Sibley LD,
Boothroyd JC.
Nature.
1992;
359
(6390):
82-5
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Inhibition of protein synthesis results in super-induction of procyclin (PARP) RNA levels.
Dorn PL,
Aman RA, Boothroyd JC.
Mol Biochem Parasitol.
1991;
44
(1):
133-9
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Mitochondrial-like DNA sequences flanked by direct and inverted repeats in the nuclear genome of Toxoplasma gondii.
Ossorio PN,
Sibley LD, Boothroyd JC.
J Mol Biol.
1991;
222
(3):
525-36
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Proposal for a uniform genetic nomenclature in Toxoplasma gondii.
Sibley LD,
Pfefferkorn ER, Boothroyd JC.
Parasitol Today.
1991;
7
(12):
327-8
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Protection of mice from fatal Toxoplasma gondii infection by immunization with p30 antigen in liposomes.
Bülow R,
Boothroyd JC.
J Immunol.
1991;
147
(10):
3496-500
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An expression-site-associated gene family of trypanosomes is expressed in vivo and shows homology to a variant surface glycoprotein gene.
Hobbs MR,
Boothroyd JC.
Mol Biochem Parasitol.
1990;
43
(1):
1-16
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Lack of introns in the ribosomal protein gene S14 of trypanosomes.
Perelman D,
Boothroyd JC.
Mol Cell Biol.
1990;
10
(6):
3284-8
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Rapid prenatal diagnosis of congenital Toxoplasma infection by using polymerase chain reaction and amniotic fluid.
Grover CM,
Thulliez P, Remington JS, Boothroyd JC.
J Clin Microbiol.
1990;
28
(10):
2297-301
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A developmentally regulated gene of trypanosomes encodes a homologue of rat protein-disulfide isomerase and phosphoinositol-phospholipase C.
Hsu MP,
Muhich ML, Boothroyd JC.
Biochemistry.
1989;
28
(15):
6440-6
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Cloning of cDNAs encoding a 28 kilodalton antigen of Toxoplasma gondii.
Prince JB,
Araujo FG, Remington JS, Burg JL, Boothroyd JC, Sharma SD.
Mol Biochem Parasitol.
1989;
34
(1):
3-13
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Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction.
Burg JL,
Grover CM, Pouletty P, Boothroyd JC.
J Clin Microbiol.
1989;
27
(8):
1787-92
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Heat-shock disruption of trans-splicing in trypanosomes: effect on Hsp70, Hsp85 and tubulin mRNA synthesis.
Muhich ML,
Hsu MP, Boothroyd JC.
Gene.
1989;
82
(1):
169-75
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Synthesis of trypanosome hsp70 mRNA is resistant to disruption of trans-splicing by heat shock.
Muhich ML,
Boothroyd JC.
J Biol Chem.
1989;
264
(13):
7107-10
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The major surface antigen, P30, of Toxoplasma gondii is anchored by a glycolipid.
Nagel SD,
Boothroyd JC.
J Biol Chem.
1989;
264
(10):
5569-74
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Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii.
Burg JL,
Perelman D, Kasper LH, Ware PL, Boothroyd JC.
J Immunol.
1988;
141
(10):
3584-91
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Polycistronic transcripts in trypanosomes and their accumulation during heat shock: evidence for a precursor role in mRNA synthesis.
Muhich ML,
Boothroyd JC.
Mol Cell Biol.
1988;
8
(9):
3837-46
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The alpha- and beta-tubulins of Toxoplasma gondii are encoded by single copy genes containing multiple introns.
Nagel SD,
Boothroyd JC.
Mol Biochem Parasitol.
1988;
29
(2-3):
261-73
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The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.
Sutton RE,
Boothroyd JC.
Mol Cell Biol.
1988;
8
(1):
494-6
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Trypanosome trans-splicing utilizes 2'-5' branches and a corresponding debranching activity.
Sutton RE,
Boothroyd JC.
EMBO J.
1988;
7
(5):
1431-7
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An unusually compact ribosomal DNA repeat in the protozoan Giardia lamblia.
Boothroyd JC,
Wang A, Campbell DA, Wang CC.
Nucleic Acids Res.
1987;
15
(10):
4065-84
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Precise identification of cleavage sites involved in the unusual processing of trypanosome ribosomal RNA.
Campbell DA,
Kubo K, Clark CG, Boothroyd JC.
J Mol Biol.
1987;
196
(1):
113-24
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Evidence for trans splicing in trypanosomes.
Sutton RE,
Boothroyd JC.
Cell.
1986;
47
(4):
527-35
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Antigenic variation in African trypanosomes.
Boothroyd JC,
Annu Rev Microbiol.
1985:
39
475-502
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Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes.
Campbell DA,
Thornton DA, Boothroyd JC.
Nature.
1984 Sep 27-Oct 3;
311
(5984):
350-5
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The 5'-limit of transposition and upstream barren region of a trypanosome VSG gene: tandem 76 base-pair repeats flanking (TAA)90.
Campbell DA,
van Bree MP, Boothroyd JC.
Nucleic Acids Res.
1984;
12
(6):
2759-74
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Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus.
Makoff AJ,
Paynter CA, Rowlands DJ, Boothroyd JC.
Nucleic Acids Res.
1982;
10
(24):
8285-95
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Complete nucleotide sequence of complementary DNA coding for a variant surface glycoprotein from Trypanosoma brucei.
Boothroyd JC,
Paynter CA, Coleman SL, Cross GA.
J Mol Biol.
1982;
157
(3):
547-56
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The nucleotide sequence of cDNA coding for the structural proteins of foot-and-mouth disease virus.
Boothroyd JC,
Harris TJ, Rowlands DJ, Lowe PA.
Gene.
1982;
17
(2):
153-61
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Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5' end.
Boothroyd JC,
Cross GA.
Gene.
1982;
20
(2):
281-9
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Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end.
Bernards A,
Van der Ploeg LH, Frasch AC, Borst P, Boothroyd JC, Coleman S, Cross GA.
Cell.
1981;
27
(3 Pt 2):
497-505
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Homologous 3'-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei.
Majumder HK,
Boothroyd JC, Weber H.
Nucleic Acids Res.
1981;
9
(18):
4745-53
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Molecular cloning of foot and mouth disease virus genome and nucleotide sequences in the structural protein genes.
Boothroyd JC,
Highfield PE, Cross GA, Rowlands DJ, Lowe PA, Brown F, Harris TJ.
Nature.
1981;
290
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800-2
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Variant surface glycoproteins of Trypanosoma brucei are synthesised with cleavable hydrophobic sequences at the carboxy and amino termini.
Boothroyd JC,
Paynter CA, Cross GA, Bernards A, Borst P.
Nucleic Acids Res.
1981;
9
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4735-43
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A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic 'tail' absent from purified glycoprotein.
Boothroyd JC,
Cross GA, Hoeijmakers JH, Borst P.
Nature.
1980;
288
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624-6
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An introduction to antigenic variation in trypanosomes.
Cross GA,
Holder AA, Allen G, Boothroyd JC.
Am J Trop Med Hyg.
1980;
29
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1027-32
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New genes and promoters suggested by the DNA sequence near the end of the coliphage T7 early operon.
Boothroyd JC,
Hayward RS.
Nucleic Acids Res.
1979;
7
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1931-43
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Synchronous Growth and Plastid Replication in the Naturally Wall-less Alga Olisthodiscus luteus.
Cattolico RA,
Boothroyd JC, Gibbs SP.
Plant Physiol.
1976;
57
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497-503
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