Publications
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Syk-induced phosphatidylinositol-3-kinase activation in Epstein-Barr virus posttransplant lymphoproliferative disorder.
Hatton O,
Lambert SL, Phillips LK, Vaysberg M, Natkunam Y, Esquivel CO, Krams SM, Martinez OM.
Am J Transplant.
2013;
13
(4):
883-90
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Changes in natural killer cell subsets in pediatric liver transplant recipients.
Pham B,
Piard-Ruster K, Silva R, Gallo A, Esquivel CO, Martinez OM, Krams SM.
Pediatr Transplant.
2012;
16
(2):
176-82
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Differential expression of microRNAs during allograft rejection.
Wei L,
Wang M, Qu X, Mah A, Xiong X, Harris AG, Phillips LK, Martinez OM, Krams SM.
Am J Transplant.
2012;
12
(5):
1113-23
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Emerging therapeutic strategies for Epstein-Barr virus+ post-transplant lymphoproliferative disorder.
Hatton O,
Martinez OM, Esquivel CO.
Pediatr Transplant.
2012;
16
(3):
220-9
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Src kinase and Syk activation initiate PI3K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas.
Hatton O,
Lambert SL, Krams SM, Martinez OM.
PLoS One.
2012;
7
(8):
e42610
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Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
Wai LE,
Garcia JA, Martinez OM, Krams SM.
J Immunol.
2011;
186
(1):
222-9
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MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.
Chen Z,
Phillips LK, Gould E, Campisi J, Lee SW, Ormerod BK, Zwierzchoniewska M, Martinez OM, Palmer TD.
PLoS One.
2011;
6
(3):
e14787
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Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas.
Hatton O,
Phillips LK, Vaysberg M, Hurwich J, Krams SM, Martinez OM.
J Biol Chem.
2011;
286
(43):
37368-78
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Acute rejection of small intestine allografts is associated with increased expression of toll-like receptors.
Castillo RO,
Wang M, Ito T, Higgins J, Esquivel CO, Krams SM, Martinez OM.
Transplant Proc.
2010;
42
(7):
2676-8
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Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.
Zhuo M,
Fujiki M, Wang M, Piard-Ruster K, Wai LE, Wei L, Martinez OM, Krams SM.
Eur J Immunol.
2010;
40
(6):
1748-57
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Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4(+)CD25(+)FoxP3(+) T regulatory cells.
Fujiki M,
Esquivel CO, Martinez OM, Strober S, Uemoto S, Krams SM.
Liver Transpl.
2010;
16
(2):
147-54
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MicroRNAs as immune regulators: implications for transplantation.
Harris A,
Krams SM, Martinez OM.
Am J Transplant.
2010;
10
(4):
713-9
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Toll-like receptor 4 contributes to small intestine allograft rejection.
Krams SM,
Wang M, Castillo RO, Ito T, Phillips L, Higgins J, Kambham N, Esquivel CO, Martinez OM.
Transplantation.
2010;
90
(12):
1272-7
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Activation of the JAK/STAT pathway in Epstein Barr virus+-associated posttransplant lymphoproliferative disease: role of interferon-gamma.
Vaysberg M,
Lambert SL, Krams SM, Martinez OM.
Am J Transplant.
2009;
9
(10):
2292-302
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Decreases in circulating CD4+CD25hiFOXP3+ cells and increases in intragraft FOXP3+ cells accompany allograft rejection in pediatric liver allograft recipients.
Stenard F,
Nguyen C, Cox K, Kambham N, Umetsu DT, Krams SM, Esquivel CO, Martinez OM.
Pediatr Transplant.
2009;
13
(1):
70-80
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Epstein-Barr virus, rapamycin, and host immune responses.
Krams SM,
Martinez OM.
Curr Opin Organ Transplant.
2008;
13
(6):
563-8
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Molecular and immunologic mechanisms of cancer pathogenesis in solid organ transplant recipients.
Martinez OM,
de Gruijl FR.
Am J Transplant.
2008;
8
(11):
2205-11
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Rapamycin, but not cyclosporine or FK506, alters natural killer cell function.
Wai LE,
Fujiki M, Takeda S, Martinez OM, Krams SM.
Transplantation.
2008;
85
(1):
145-9
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Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos.
Vaysberg M,
Hatton O, Lambert SL, Snow AL, Wong B, Krams SM, Martinez OM.
J Biol Chem.
2008;
283
(52):
36573-85
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Epstein-Barr virus: evasive maneuvers in the development of PTLD.
Snow AL,
Martinez OM.
Am J Transplant.
2007;
7
(2):
271-7
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Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10.
Lambert SL,
Martinez OM.
J Immunol.
2007;
179
(12):
8225-34
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Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Riddle-Taylor E,
Nagasaki K, Lopez J, Esquivel CO, Martinez OM, Krams SM.
Transplantation.
2007;
84
(6):
778-85
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Rapamycin inhibits proliferation of Epstein-Barr virus-positive B-cell lymphomas through modulation of cell-cycle protein expression.
Vaysberg M,
Balatoni CE, Nepomuceno RR, Krams SM, Martinez OM.
Transplantation.
2007;
83
(8):
1114-21
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CD72 down-modulates BCR-induced signal transduction and diminishes survival in primary mature B lymphocytes.
Li DH,
Tung JW, Tarner IH, Snow AL, Yukinari T, Ngernmaneepothong R, Martinez OM, Parnes JR.
J Immunol.
2006;
176
(9):
5321-8
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EBV B lymphoma cell lines from patients with post-transplant lymphoproliferative disease are resistant to TRAIL-induced apoptosis.
Snow AL,
Vaysberg M, Krams SM, Martinez OM.
Am J Transplant.
2006;
6
(5 Pt 1):
976-85
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EBV can protect latently infected B cell lymphomas from death receptor-induced apoptosis.
Snow AL,
Lambert SL, Natkunam Y, Esquivel CO, Krams SM, Martinez OM.
J Immunol.
2006;
177
(5):
3283-93
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NKp30 is a functional activation receptor on a subset of rat natural killer cells.
Hsieh CL,
Nagasaki K, Martinez OM, Krams SM.
Eur J Immunol.
2006;
36
(8):
2170-80
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Reproduction and pregnancy in transplant recipients: current practices.
McKay DB,
Adams PL, Bumgardner GL, Davis CL, Fine RN, Krams SM, Martinez OM, Murphy B, Pavlakis M, Tolkoff-Rubin N, Sherman MS, Josephson MA.
Prog Transplant.
2006;
16
(2):
127-32
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Basic concepts in transplant immunology.
Martinez OM,
Rosen HR.
Liver Transpl.
2005;
11
(4):
370-81
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IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses.
Obara H,
Nagasaki K, Hsieh CL, Ogura Y, Esquivel CO, Martinez OM, Krams SM.
Am J Transplant.
2005;
5
(9):
2094-103
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Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation.
McKay DB,
Josephson MA, Armenti VT, August P, Coscia LA, Davis CL, Davison JM, Easterling T, Friedman JE, Hou S, Karlix J, Lake KD, Lindheimer M, Matas AJ, Moritz MJ, Riely CA, Ross LF, Scott JR, Wagoner LE, Wrenshall L, Adams PL, Bumgardner GL, Fine RN, Goral S, Krams SM, Martinez OM, Tolkoff-Rubin N, Pavlakis M, Scantlebury V.
Am J Transplant.
2005;
5
(7):
1592-9
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Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts.
Hsieh CL,
Ogura Y, Obara H, Ali UA, Rodriguez GM, Nepomuceno RR, Martinez OM, Krams SM.
Transplantation.
2004;
77
(1):
121-8
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Rapamycin Inhibits the Interleukin 10 Signal Transduction Pathway and the Growth of Epstein Barr Virus B-cell Lymphomas
Nepomuceno RR,
Balatoni CE, Natkunam Y, Snow AL, Krams SM, Martinez OM.
Cancer Research.
2003;
63
(15):
4472
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Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas.
Nepomuceno RR,
Balatoni CE, Natkunam Y, Snow AL, Krams SM, Martinez OM.
Cancer Res.
2003;
63
(15):
4472-80
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CD30 expression identifies the predominant proliferating T lymphocyte population in human alloimmune responses.
Chan KW,
Hopke CD, Krams SM, Martinez OM.
J Immunol.
2002;
169
(4):
1784-91
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Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder.
Nepomuceno RR,
Snow AL, Robert Beatty P, Krams SM, Martinez OM.
Transplantation.
2002;
74
(3):
396-402
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Epstein-Barr virus infection is associated with endothelial Bcl-2 expression in transplant liver allografts.
Millan MT,
Natkunam Y, Clarke-Katzenberg R, Desai D, Prapong W, So SK, Esquivel CO, Sibley R, Ferran C, Martinez OM.
Transplantation.
2002;
73
(3):
465-9
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Identification of Epstein-Barr virus-specific CD8+ T lymphocytes in the circulation of pediatric transplant recipients.
Falco DA,
Nepomuceno RR, Krams SM, Lee PP, Davis MM, Salvatierra O, Alexander SR, Esquivel CO, Cox KL, Frankel LR, Martinez OM.
Transplantation.
2002;
74
(4):
501-10
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NK cells and transplantation.
Hsieh CL,
Obara H, Ogura Y, Martinez OM, Krams SM.
Transpl Immunol.
2002;
9
(2-4):
111-4
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Apoptosis and allograft rejection in the absence of CD8+ T cells.
Ogura Y,
Martinez OM, Villanueva JC, Tait JF, Strauss HW, Higgins JP, Tanaka K, Esquivel CO, Blankenberg FG, Krams SM.
Transplantation.
2001;
71
(12):
1827-34
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Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis.
Fox CK,
Furtwaengler A, Nepomuceno RR, Martinez OM, Krams SM.
Liver.
2001;
21
(4):
272-9
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Resistance to Fas-mediated apoptosis in EBV-infected B cell lymphomas is due to defects in the proximal Fas signaling pathway.
Snow AL,
Chen LJ, Nepomuceno RR, Krams SM, Esquivel CO, Martinez OM.
J Immunol.
2001;
167
(9):
5404-11
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Radiolabeled annexin V imaging: diagnosis of allograft rejection in an experimental rodent model of liver transplantation.
Ogura Y,
Krams SM, Martinez OM, Kopiwoda S, Higgins JP, Esquivel CO, Strauss HW, Tait JF, Blankenberg FG.
Radiology.
2000;
214
(3):
795-800
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Significance of detecting Epstein-Barr-specific sequences in the peripheral blood of asymptomatic pediatric liver transplant recipients.
Krieger NR,
Martinez OM, Krams SM, Cox K, So S, Esquivel CO.
Liver Transpl.
2000;
6
(1):
62-6
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Involvement of Fas-Fas ligand interactions in graft rejection.
Martinez OM,
Krams SM.
Int Rev Immunol.
1999;
18
(5-6):
527-46
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Characterization of allograft rejection in an experimental model of small intestinal transplantation.
Hayashi M,
Martinez OM, Krams SM, Burns W, Esquivel CO.
J Gastrointest Surg.
1998 Jul-Aug;
2
(4):
325-32
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Allograft rejection after liver transplantation for autoimmune liver diseases.
Hayashi M,
Keeffe EB, Krams SM, Martinez OM, Ojogho ON, So SK, Garcia G, Imperial JC, Esquivel CO.
Liver Transpl Surg.
1998;
4
(3):
208-14
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Apoptosis as a mechanism of tissue injury in liver allograft rejection.
Krams SM,
Martinez OM.
Semin Liver Dis.
1998;
18
(2):
153-67
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Application of in situ hybridization technique for quantitative assessment of ongoing symptomatic Epstein-Barr virus infection after living related liver transplantation.
Egawa H,
Ohishi T, Arai T, Inomata Y, Uemoto S, Asonuma K, Kinchi T, Okajima H, Matsui A, Kawashima N, Martinez OM, Tanaka K.
Clin Transplant.
1998;
12
(2):
116-22
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CD30 expression identifies a functional alloreactive human T-lymphocyte subset.
Martinez OM,
Villanueva J, Abtahi S, Beatty PR, Esquivel CO, Krams SM.
Transplantation.
1998;
65
(9):
1240-7
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CD8+ cells are not necessary for allograft rejection or the induction of apoptosis in an experimental model of small intestinal transplantation.
Krams SM,
Hayashi M, Fox CK, Villanueva JC, Whitmer KJ, Burns W, Esquivel CO, Martinez OM.
J Immunol.
1998;
160
(8):
3673-80
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Effect of cyclosporine and tacrolimus on the growth of Epstein-Barr virus-transformed B-cell lines.
Beatty PR,
Krams SM, Esquivel CO, Martinez OM.
Transplantation.
1998;
65
(9):
1248-55
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Human hepatocytes produce an isoform of FAS that inhibits apoptosis.
Krams SM,
Fox CK, Beatty PR, Cao S, Villanueva JC, Esquivel CO, Martinez OM.
Transplantation.
1998;
65
(5):
713-21
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Cytokines are involved in the rejection of small intestine allografts.
Hayashi M,
Martinez OM, Krams SM, Burns W, Esquivel CO.
Transplant Proc.
1997;
29
(3):
1802
-
Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines.
Beatty PR,
Krams SM, Martinez OM.
J Immunol.
1997;
158
(9):
4045-51
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T cell receptor usage by cytotoxic T lymphocytes against autologous human melanoma.
Leong SP,
Liliental J, Krams SM, Zhou YM, Granberry ME, Martinez OM.
Anticancer Res.
1996 Nov-Dec;
16
(6B):
3355-61
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Elevations in IFN-gamma, IL-5, and IL-10 in patients with the autoimmune disease primary biliary cirrhosis: association with autoantibodies and soluble CD30.
Krams SM,
Cao S, Hayashi M, Villanueva JC, Martinez OM.
Clin Immunol Immunopathol.
1996;
80
(3 Pt 1):
311-20
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Immunoregulatory cytokines in chronic hepatitis C virus infection: pre- and posttreatment with interferon alfa.
Cacciarelli TV,
Martinez OM, Gish RG, Villanueva JC, Krams SM.
Hepatology.
1996;
24
(1):
6-9
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Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts.
Lang T,
Krams SM, Martinez OM.
Transplantation.
1996;
62
(6):
776-80
-
Acute liver allograft rejection in the rat. An analysis of the immune response.
Egawa H,
Martinez OM, Quinn MB, Villanueva JC, So S, Esquivel CO, Krams SM.
Transplantation.
1995;
59
(1):
97-102
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An increased incidence of Epstein-Barr virus infection and lymphoproliferative disorder in young children on FK506 after liver transplantation.
Cox KL,
Lawrence-Miyasaki LS, Garcia-Kennedy R, Lennette ET, Martinez OM, Krams SM, Berquist WE, So SK, Esquivel CO.
Transplantation.
1995;
59
(4):
524-9
-
Apoptosis as a mechanism of cell death in a rat model of liver allograft rejection.
Krams SM,
Egawa H, Quinn MB, Martinez OM.
Transplant Proc.
1995;
27
(1):
466-7
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Apoptosis as a mechanism of cell death in liver allograft rejection.
Krams SM,
Egawa H, Quinn MB, Villanueva JC, Garcia-Kennedy R, Martinez OM.
Transplantation.
1995;
59
(4):
621-5
-
Characterization of cytokine expression in an animal model of acute liver allograft rejection.
Egawa H,
Martinez OM, Quinn MB, So S, Esquivel CO, Krams SM.
Transplant Proc.
1995;
27
(1):
505-6
-
Circulating intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in pediatric liver recipients.
Lang T,
Krams SM, Villanueva JC, So SK, Berquist WE, Cox KL, Esquivel CO, Martinez OM.
Transplant Proc.
1995;
27
(1):
1148-9
-
Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis.
Martinez OM,
Villanueva JC, Gershwin ME, Krams SM.
Hepatology.
1995;
21
(1):
113-9
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Differential patterns of circulating intercellular adhesion molecule-1 (cICAM-1) and vascular cell adhesion molecule-1 (cVCAM-1) during liver allograft rejection.
Lang T,
Krams SM, Villanueva JC, Cox K, So S, Martinez OM.
Transplantation.
1995;
59
(4):
584-9
-
Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients.
Lang T,
Krams SM, Villanueva JC, Cox K, So S, Esquivel C, Martinez OM.
Transplant Proc.
1995;
27
(1):
1146-7
-
Elevated biliary interleukin 5 as an indicator of liver allograft rejection.
Lang T,
Krams SM, Berquist W, Cox KL, Esquivel CO, Martinez OM.
Transpl Immunol.
1995;
3
(4):
291-8
-
Expression of cytokines and immune mediators during chronic liver allograft rejection.
Hayashi M,
Martinez OM, Garcia-Kennedy R, So S, Esquivel CO, Krams SM.
Transplantation.
1995;
60
(12):
1533-8
-
Expression of the cytotoxic T cell mediator granzyme B during liver allograft rejection.
Krams SM,
Villanueva JC, Quinn MB, Martinez OM.
Transpl Immunol.
1995;
3
(2):
162-6
-
Interleukin-12: a possible cytotoxic T-lymphocyte differentiation factor in allograft recipients.
Gish RG,
Krams SM, Martinez OM.
Transplant Proc.
1995;
27
(1):
459-60
-
Long-term nonresponsiveness to a liver allograft may be cytokine mediated.
Egawa H,
Martinez OM, Quinn MB, Villanueva JC, So S, Esquivel CO, Krams SM.
Transplant Proc.
1995;
27
(1):
241-2
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Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients.
Martinez OM,
Villanueva JC, Lawrence-Miyasaki L, Quinn MB, Gish R, Cox K, So S, Esquivel CO, Krams SM.
Transplant Proc.
1995;
27
(1):
1211-2
-
Viral and immunologic aspects of Epstein-Barr virus infection in pediatric liver transplant recipients.
Martinez OM,
Villanueva JC, Lawrence-Miyasaki L, Quinn MB, Cox K, Krams SM.
Transplantation.
1995;
59
(4):
519-24
-
Evidence for a nonclassical pathway of graft rejection involving interleukin 5 and eosinophils.
Martinez OM,
Ascher NL, Ferrell L, Villanueva J, Lake J, Roberts JP, Krams SM.
Transplantation.
1993;
55
(4):
909-18
-
IL-2 and IL-5 gene expression in response to alloantigen in liver allograft recipients and in vitro.
Martinez OM,
Villanueva JC, Lake J, Roberts JP, Ascher NL, Krams SM.
Transplantation.
1993;
55
(5):
1159-66
-
Intragraft eosinophilia and interleukin-5 mRNA accompany liver allograft rejection.
Martinez OM,
Krams SM, Villanueva JC, Ferrell L, Lake J, Roberts JP, Ascher NL.
Transplant Proc.
1993;
25
(1 Pt 1):
126-7
-
New immunologic insights into mechanisms of allograft rejection.
Krams SM,
Ascher NL, Martinez OM.
Gastroenterol Clin North Am.
1993;
22
(2):
381-400
-
T-cell receptor-V alpha gene use in sequential liver allograft biopsies.
Krams SM,
Martinez OM, Villanueva JC, Lake J, Roberts JP, Ascher NL.
Transplant Proc.
1993;
25
(1 Pt 1):
84-5
-
Intragraft cytokine profile during human liver allograft rejection.
Martinez OM,
Krams SM, Sterneck M, Villanueva JC, Falco DA, Ferrell LD, Lake J, Roberts JP, Ascher NL.
Transplantation.
1992;
53
(2):
449-56
-
Allogeneic hepatocytes stimulate the production of immunoregulatory molecules in mixed lymphocyte hepatocyte cultures.
Martinez OM,
Burke EC, Alan TJ, Ascher NL.
Transplant Proc.
1991;
23
(1 Pt 1):
805-6
-
MHC expression on human hepatocytes before and after isolation.
Burke EC,
Martinez OM, Freise CE, McVicar J, Roberts JP, Ascher NL.
Transplant Proc.
1991;
23
(1 Pt 2):
1428-9
-
Altered monocyte function in uremia.
Gibbons RA,
Martinez OM, Garovoy MR.
Clin Immunol Immunopathol.
1990;
56
(1):
66-80
-
IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells.
Martinez OM,
Gibbons RS, Garovoy MR, Aronson FR.
J Immunol.
1990;
144
(6):
2211-5
-
Reduction in HLA-DR, HLA-DQ and HLA-DP expression by Leu-M3+ cells from the peripheral blood of patients with thermal injury.
Gibbons RA,
Martinez OM, Lim RC, Horn JK, Garovoy MR.
Clin Exp Immunol.
1989;
75
(3):
371-5
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