Publications
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Potential subversion of autophagosomal pathway by picornaviruses.
Taylor MP,
Kirkegaard K.
Autophagy.
2008;
4
(3):
286-9
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Modification of cellular autophagy protein LC3 by poliovirus.
Taylor MP,
Kirkegaard K.
J Virol.
2007;
81
(22):
12543-53
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Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase.
Richards OC,
Spagnolo JF, Lyle JM, Vleck SE, Kuchta RD, Kirkegaard K.
J Virol.
2006;
80
(15):
7405-15
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Nucleotide channel of RNA-dependent RNA polymerase used for intermolecular uridylylation of protein primer.
Tellez AB,
Crowder S, Spagnolo JF, Thompson AA, Peersen OB, Brutlag DL, Kirkegaard K.
J Mol Biol.
2006;
357
(2):
665-75
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Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain.
Pfeiffer JK,
Kirkegaard K.
Proc Natl Acad Sci U S A.
2006;
103
(14):
5520-5
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Topology of double-membraned vesicles and the opportunity for non-lytic release of cytoplasm.
Kirkegaard K,
Jackson WT.
Autophagy.
2005 Oct-Dec;
1
(3):
182-4
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Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA.
Pfeiffer JK,
Kirkegaard K.
J Virol.
2005;
79
(4):
2346-55
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Inhibition of cellular protein secretion by picornaviral 3A proteins.
Choe SS,
Dodd DA, Kirkegaard K.
Virology.
2005;
337
(1):
18-29
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Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase.
Boerner JE,
Lyle JM, Daijogo S, Semler BL, Schultz SC, Kirkegaard K, Richards OC.
J Virol.
2005;
79
(12):
7803-11
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Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses.
Crowder S,
Kirkegaard K.
Nat Genet.
2005;
37
(7):
701-9
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Subversion of cellular autophagosomal machinery by RNA viruses.
Jackson WT,
Giddings TH, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, Kirkegaard K.
PLoS Biol.
2005;
3
(5):
e156
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Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice.
Pfeiffer JK,
Kirkegaard K.
PLoS Pathog.
2005;
1
(2):
e11
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Intracellular topology and epitope shielding of poliovirus 3A protein.
Choe SS,
Kirkegaard K.
J Virol.
2004;
78
(11):
5973-82
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Cellular autophagy: surrender, avoidance and subversion by microorganisms.
Kirkegaard K,
Taylor MP, Jackson WT.
Nat Rev Microbiol.
2004;
2
(4):
301-14
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A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.
Pfeiffer JK,
Kirkegaard K.
Proc Natl Acad Sci U S A.
2003;
100
(12):
7289-94
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Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus.
Konan KV,
Giddings TH, Ikeda M, Li K, Lemon SM, Kirkegaard K.
J Virol.
2003;
77
(14):
7843-55
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Visualization and functional analysis of RNA-dependent RNA polymerase lattices.
Lyle JM,
Bullitt E, Bienz K, Kirkegaard K.
Science.
2002;
296
(5576):
2218-22
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Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.
Wang QM,
Hockman MA, Staschke K, Johnson RB, Case KA, Lu J, Parsons S, Zhang F, Rathnachalam R, Kirkegaard K, Colacino JM.
J Virol.
2002;
76
(8):
3865-72
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Similar structural basis for membrane localization and protein priming by an RNA-dependent RNA polymerase.
Lyle JM,
Clewell A, Richmond K, Richards OC, Hope DA, Schultz SC, Kirkegaard K.
J Biol Chem.
2002;
277
(18):
16324-31
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Poliovirus 3A protein limits interleukin-6 (IL-6), IL-8, and beta interferon secretion during viral infection.
Dodd DA,
Giddings TH, Kirkegaard K.
J Virol.
2001;
75
(17):
8158-65
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Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles.
Suhy DA,
Giddings TH, Kirkegaard K.
J Virol.
2000;
74
(19):
8953-65
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MHC I-dependent antigen presentation is inhibited by poliovirus protein 3A.
Deitz SB,
Dodd DA, Cooper S, Parham P, Kirkegaard K.
Proc Natl Acad Sci U S A.
2000;
97
(25):
13790-5
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Functional coupling between replication and packaging of poliovirus replicon RNA.
Nugent CI,
Johnson KL, Sarnow P, Kirkegaard K.
J Virol.
1999;
73
(1):
427-35
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KH domain integrity is required for wild-type localization of Sam68.
McBride AE,
Taylor SJ, Shalloway D, Kirkegaard K.
Exp Cell Res.
1998;
241
(1):
84-95
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Site size of cooperative single-stranded RNA binding by poliovirus RNA-dependent RNA polymerase.
Beckman MT,
Kirkegaard K.
J Biol Chem.
1998;
273
(12):
6724-30
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Poliovirus RNA recombination in cell-free extracts.
Tang RS,
Barton DJ, Flanegan JB, Kirkegaard K.
RNA.
1997;
3
(6):
624-33
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Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis.
Doedens JR,
Giddings TH, Kirkegaard K.
J Virol.
1997;
71
(12):
9054-64
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Cellular origin and ultrastructure of membranes induced during poliovirus infection.
Schlegel A,
Giddings TH, Ladinsky MS, Kirkegaard K.
J Virol.
1996;
70
(10):
6576-88
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