Publications
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Modulation of Hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms.
Norman KL,
Sarnow P.
J Virol.
2009
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Temperature protects insect cells from infection by cricket paralysis virus.
Cevallos RC,
Sarnow P.
J Virol.
2009
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The Imd pathway is involved in antiviral immune responses in Drosophila.
Costa A,
Jan E, Sarnow P, Schneider D.
PLoS One.
2009;
4
(10):
e7436
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Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs.
Gu S,
Jin L, Zhang F, Sarnow P, Kay MA.
Nat Struct Mol Biol.
2009;
16
(2):
144-50
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Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome.
Jopling CL,
Schütz S, Sarnow P.
Cell Host Microbe.
2008;
4
(1):
77-85
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How viruses avoid stress.
Schütz S,
Sarnow P.
Cell Host Microbe.
2007;
2
(5):
284-5
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Inhibition of U snRNP assembly by a virus-encoded proteinase.
Almstead LL,
Sarnow P.
Genes Dev.
2007;
21
(9):
1086-97
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Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122.
Jopling CL,
Norman KL, Sarnow P.
Cold Spring Harb Symp Quant Biol.
2006:
71
369-76
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Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis.
Bushell M,
Stoneley M, Kong YW, Hamilton TL, Spriggs KA, Dobbyn HC, Qin X, Sarnow P, Willis AE.
Mol Cell.
2006;
23
(3):
401-12
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Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site.
Lancaster AM,
Jan E, Sarnow P.
RNA.
2006;
12
(5):
894-902
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Interaction of viruses with the mammalian RNA interference pathway.
Schütz S,
Sarnow P.
Virology.
2006;
344
(1):
151-7
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MicroRNAs: expression, avoidance and subversion by vertebrate viruses.
Sarnow P,
Jopling CL, Norman KL, Schütz S, Wehner KA.
Nat Rev Microbiol.
2006;
4
(9):
651-9
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Takeover of host ribosomes by divergent IRES elements.
Sarnow P,
Cevallos RC, Jan E.
Biochem Soc Trans.
2005;
33
(Pt 6):
1479-82
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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.
Jopling CL,
Yi M, Lancaster AM, Lemon SM, Sarnow P.
Science.
2005;
309
(5740):
1577-81
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Factor-independent assembly of elongation-competent ribosomes by an internal ribosome entry site located in an RNA virus that infects penaeid shrimp.
Cevallos RC,
Sarnow P.
J Virol.
2005;
79
(2):
677-83
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Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition.
Cherry S,
Doukas T, Armknecht S, Whelan S, Wang H, Sarnow P, Perrimon N.
Genes Dev.
2005;
19
(4):
445-52
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Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection.
Graham KL,
Gustin KE, Rivera C, Kuyumcu-Martinez NM, Choe SS, Lloyd RE, Sarnow P, Utz PJ.
J Virol.
2004;
78
(12):
6313-21
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Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cells.
Qin X,
Sarnow P.
J Biol Chem.
2004;
279
(14):
13721-8
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Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor.
Spahn CM,
Jan E, Mulder A, Grassucci RA, Sarnow P, Frank J.
Cell.
2004;
118
(4):
465-75
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Translation inhibition during the induction of apoptosis: RNA or protein degradation?
Bushell M,
Stoneley M, Sarnow P, Willis AE.
Biochem Soc Trans.
2004;
32
(Pt 4):
606-10
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Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis.
Sarnow P,
J Virol.
2003;
77
(5):
2801-6
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Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis.
Jan E,
Kinzy TG, Sarnow P.
Proc Natl Acad Sci U S A.
2003;
100
(26):
15410-5
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Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved.
Thompson SR,
Sarnow P.
Virology.
2003;
315
(1):
259-66
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Cytoplasmic expression of mRNAs containing the internal ribosome entry site and 3' noncoding region of hepatitis C virus: effects of the 3' leader on mRNA translation and mRNA stability.
Kong LK,
Sarnow P.
J Virol.
2002;
76
(24):
12457-62
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Ribosomal proteins mediate the hepatitis C virus IRES-HeLa 40S interaction.
Otto GA,
Lukavsky PJ, Lancaster AM, Sarnow P, Puglisi JD.
RNA.
2002;
8
(7):
913-23
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Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus.
Gustin KE,
Sarnow P.
J Virol.
2002;
76
(17):
8787-96
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Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice.
McCaffrey AP,
Ohashi K, Meuse L, Shen S, Lancaster AM, Lukavsky PJ, Sarnow P, Kay MA.
Mol Ther.
2002;
5
(6):
676-84
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Hijacking the translation apparatus by RNA viruses.
Bushell M,
Sarnow P.
J Cell Biol.
2002;
158
(3):
395-9
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Factorless ribosome assembly on the internal ribosome entry site of cricket paralysis virus.
Jan E,
Sarnow P.
J Mol Biol.
2002;
324
(5):
889-902
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Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Fernandez J,
Yaman I, Sarnow P, Snider MD, Hatzoglou M.
J Biol Chem.
2002;
277
(21):
19198-205
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Internal ribosome entry sites in eukaryotic mRNA molecules.
Hellen CU,
Sarnow P.
Genes Dev.
2001;
15
(13):
1593-612
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Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source.
Kuhn KM,
DeRisi JL, Brown PO, Sarnow P.
Mol Cell Biol.
2001;
21
(3):
916-27
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Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition.
Gustin KE,
Sarnow P.
EMBO J.
2001;
20
(1-2):
240-9
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Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element.
Thompson SR,
Gulyas KD, Sarnow P.
Proc Natl Acad Sci U S A.
2001;
98
(23):
12972-7
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Structural and functional investigation of the hepatitis C virus IRES.
Puglisi JD,
Kim I, Lukavsky P, Otto G, Lancaster A, Sarnow P.
Nucleic Acids Res Suppl.
2001;
(1):
263
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Initiator Met-tRNA-independent translation mediated by an internal ribosome entry site element in cricket paralysis virus-like insect viruses.
Jan E,
Thompson SR, Wilson JE, Pestova TV, Hellen CU, Sarnow P.
Cold Spring Harb Symp Quant Biol.
2001:
66
285-92
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New ways of initiating translation in eukaryotes.
Schneider R,
Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M.
Mol Cell Biol.
2001;
21
(23):
8238-46
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Naturally occurring dicistronic cricket paralysis virus RNA is regulated by two internal ribosome entry sites.
Wilson JE,
Powell MJ, Hoover SE, Sarnow P.
Mol Cell Biol.
2000;
20
(14):
4990-9
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Distinct mRNAs that encode La autoantigen are differentially expressed and contain internal ribosome entry sites.
Carter MS,
Sarnow P.
J Biol Chem.
2000;
275
(36):
28301-7
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Initiation of protein synthesis from the A site of the ribosome.
Wilson JE,
Pestova TV, Hellen CU, Sarnow P.
Cell.
2000;
102
(4):
511-20
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function.
Lukavsky PJ,
Otto GA, Lancaster AM, Sarnow P, Puglisi JD.
Nat Struct Biol.
2000;
7
(12):
1105-10
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Regulation of host cell translation by viruses and effects on cell function.
Thompson SR,
Sarnow P.
Curr Opin Microbiol.
2000;
3
(4):
366-70
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Functional coupling between replication and packaging of poliovirus replicon RNA.
Nugent CI,
Johnson KL, Sarnow P, Kirkegaard K.
J Virol.
1999;
73
(1):
427-35
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Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray.
Johannes G,
Carter MS, Eisen MB, Brown PO, Sarnow P.
Proc Natl Acad Sci U S A.
1999;
96
(23):
13118-23
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Viral ribonucleoprotein complex formation and nucleolar-cytoplasmic relocalization of nucleolin in poliovirus-infected cells.
Waggoner S,
Sarnow P.
J Virol.
1998;
72
(8):
6699-709
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Internal ribosome entry sites tests with circular mRNAs.
Chen CY,
Sarnow P.
Methods Mol Biol.
1998:
77
355-63
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Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites.
Johannes G,
Sarnow P.
RNA.
1998;
4
(12):
1500-13
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Starting at the beginning, middle, and end: translation initiation in eukaryotes.
Sachs AB,
Sarnow P, Hentze MW.
Cell.
1997;
89
(6):
831-8
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Translation-competent extracts from Saccharomyces cerevisiae: effects of L-A RNA, 5' cap, and 3' poly(A) tail on translational efficiency of mRNAs.
Iizuka N,
Sarnow P.
Methods.
1997;
11
(4):
353-60
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Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions.
Yang Q,
Sarnow P.
Nucleic Acids Res.
1997;
25
(14):
2800-7
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In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules.
Haller AA,
Sarnow P.
Proc Natl Acad Sci U S A.
1997;
94
(16):
8521-6
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Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation.
McBratney S,
Sarnow P.
Mol Cell Biol.
1996;
16
(7):
3523-34
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Cap-independent translation and internal initiation of translation in eukaryotic cellular mRNA molecules.
Iizuka N,
Chen C, Yang Q, Johannes G, Sarnow P.
Curr Top Microbiol Immunol.
1995:
203
155-77
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Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs.
Chen CY,
Sarnow P.
Science.
1995;
268
(5209):
415-7
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Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.
Iizuka N,
Najita L, Franzusoff A, Sarnow P.
Mol Cell Biol.
1994;
14
(11):
7322-30
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A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA.
Wang C,
Sarnow P, Siddiqui A.
J Virol.
1994;
68
(11):
7301-7
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Biochemical and genetic evidence for a pseudoknot structure at the 3' terminus of the poliovirus RNA genome and its role in viral RNA amplification.
Jacobson SJ,
Konings DA, Sarnow P.
J Virol.
1993;
67
(6):
2961-71
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Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism.
Wang C,
Sarnow P, Siddiqui A.
J Virol.
1993;
67
(6):
3338-44
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Internal initiation of translation.
McBratney S,
Chen CY, Sarnow P.
Curr Opin Cell Biol.
1993;
5
(6):
961-5
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Gene regulation: translational initiation by internal ribosome binding.
Oh SK,
Sarnow P.
Curr Opin Genet Dev.
1993;
3
(2):
295-300
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Translational enhancement of the poliovirus 5' noncoding region mediated by virus-encoded polypeptide 2A.
Hambidge SJ,
Sarnow P.
Proc Natl Acad Sci U S A.
1992;
89
(21):
10272-6
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Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding.
Oh SK,
Scott MP, Sarnow P.
Genes Dev.
1992;
6
(9):
1643-53
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Association of heat shock protein 70 with enterovirus capsid precursor P1 in infected human cells.
Macejak DG,
Sarnow P.
J Virol.
1992;
66
(3):
1520-7
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Terminal 7-methyl-guanosine cap structure on the normally uncapped 5' noncoding region of poliovirus mRNA inhibits its translation in mammalian cells.
Hambidge SJ,
Sarnow P.
J Virol.
1991;
65
(11):
6312-5
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Internal initiation of translation mediated by the 5' leader of a cellular mRNA.
Macejak DG,
Sarnow P.
Nature.
1991;
353
(6339):
90-4
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Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirus.
Johnson KL,
Sarnow P.
J Virol.
1991;
65
(8):
4341-9
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An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells.
Simoes EA,
Sarnow P.
J Virol.
1991;
65
(2):
913-21
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Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome.
Najita L,
Sarnow P.
Proc Natl Acad Sci U S A.
1990;
87
(15):
5846-50
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Translational regulation of the immunoglobulin heavy-chain binding protein mRNA.
Macejak DG,
Sarnow P.
Enzyme.
1990;
44
(1-4):
310-9
-
Poliovirus genetics.
Sarnow P,
Jacobson SJ, Najita L.
Curr Top Microbiol Immunol.
1990:
161
155-88
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Role of 3'-end sequences in infectivity of poliovirus transcripts made in vitro.
Sarnow P,
J Virol.
1989;
63
(1):
467-70
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Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.
Sarnow P,
Proc Natl Acad Sci U S A.
1989;
86
(15):
5795-9
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Genetic complementation among poliovirus mutants derived from an infectious cDNA clone.
Bernstein HD,
Sarnow P, Baltimore D.
J Virol.
1986;
60
(3):
1040-9
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A poliovirus temperature-sensitive RNA synthesis mutant located in a noncoding region of the genome.
Sarnow P,
Bernstein HD, Baltimore D.
Proc Natl Acad Sci U S A.
1986;
83
(3):
571-5
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Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells.
Sarnow P,
Hearing P, Anderson CW, Halbert DN, Shenk T, Levine AJ.
J Virol.
1984;
49
(3):
692-700
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Physical mapping of human cytomegalovirus genes: identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide.
Nowak B,
Gmeiner A, Sarnow P, Levine AJ, Fleckenstein B.
Virology.
1984;
134
(1):
91-102
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Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins.
Nowak B,
Sullivan C, Sarnow P, Thomas R, Bricout F, Nicolas JC, Fleckenstein B, Levine AJ.
Virology.
1984;
132
(2):
325-38
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Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein.
Reich NC,
Sarnow P, Duprey E, Levine AJ.
Virology.
1983;
128
(2):
480-4
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Host range temperature-conditional mutants in the adenovirus DNA binding protein are defective in the assembly of infectious virus.
Nicolas JC,
Sarnow P, Girard M, Levine AJ.
Virology.
1983;
126
(1):
228-39
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Identification and characterization of an immunologically conserved adenovirus early region 11,000 Mr protein and its association with the nuclear matrix.
Sarnow P,
Hearing P, Anderson CW, Reich N, Levine AJ.
J Mol Biol.
1982;
162
(3):
565-83
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A mutation in the adenovirus type 5 DNA binding protein that fails to autoregulate the production of the DNA binding protein.
Nicolas JC,
Ingrand D, Sarnow P, Levine AJ.
Virology.
1982;
122
(2):
481-5
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Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.
Sarnow P,
Ho YS, Williams J, Levine AJ.
Cell.
1982;
28
(2):
387-94
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A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cells.
Sarnow P,
Sullivan CA, Levine AJ.
Virology.
1982;
120
(2):
510-7
-
A histone H4-specific methyltransferase. Properties, specificity and effects on nucleosomal histones.
Sarnow P,
Rasched I, Knippers R.
Biochim Biophys Acta.
1981;
655
(3):
349-58
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