Publications
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Molecular and evolutionary history of melanism in North American gray wolves.
Anderson TM,
vonHoldt BM, Candille SI, Musiani M, Greco C, Stahler DR, Smith DW, Padhukasahasram B, Randi E, Leonard JA, Bustamante CD, Ostrander EA, Tang H, Wayne RK, Barsh GS.
Science.
2009;
323
(5919):
1339-43
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Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
McGowan KA,
Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, de Angelis MH, Myers RM, Attardi LD, Barsh GS.
Nat Genet.
2008;
40
(8):
963-70
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A -defensin mutation causes black coat color in domestic dogs.
Candille SI,
Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS.
Science.
2007;
318
(5855):
1418-23
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Linkage and segregation analysis of black and brindle coat color in domestic dogs.
Kerns JA,
Cargill EJ, Clark LA, Candille SI, Berryere TG, Olivier M, Lust G, Todhunter RJ, Schmutz SM, Murphy KE, Barsh GS.
Genetics.
2007;
176
(3):
1679-89
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A healthy tan?
Barsh G,
Attardi LD.
N Engl J Med.
2007;
356
(21):
2208-10
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PI3K integrates the action of insulin and leptin on hypothalamic neurons.
Xu AW,
Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS.
J Clin Invest.
2005;
115
(4):
951-8
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Effects of hypothalamic neurodegeneration on energy balance.
Xu AW,
Kaelin CB, Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW, Barsh GS.
PLoS Biol.
2005;
3
(12):
e415
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Effects of G-protein mutations on skin color.
Van Raamsdonk CD,
Fitch KR, Fuchs H, de Angelis MH, Barsh GS.
Nat Genet.
2004;
36
(9):
961-8
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Dorsoventral patterning of the mouse coat by Tbx15.
Candille SI,
Van Raamsdonk CD, Chen C, Kuijper S, Chen-Tsai Y, Russ A, Meijlink F, Barsh GS.
PLoS Biol.
2004;
2
(1):
E3
-
Spongiform degeneration in mahoganoid mutant mice.
He L,
Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS, Gunn TM.
Science.
2003;
299
(5607):
710-2
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What controls variation in human skin color?
Barsh GS,
PLoS Biol.
2003;
1
(1):
E27
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Genetics of dark skin in mice.
Fitch KR,
McGowan KA, van Raamsdonk CD, Fuchs H, Lee D, Puech A, Hérault Y, Threadgill DW, Hrabé de Angelis M, Barsh GS.
Genes Dev.
2003;
17
(2):
214-28
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Genetic approaches to studying energy balance: perception and integration.
Barsh GS,
Schwartz MW.
Nat Rev Genet.
2002;
3
(8):
589-600
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A biochemical function for attractin in agouti-induced pigmentation and obesity.
He L,
Gunn TM, Bouley DM, Lu XY, Watson SJ, Schlossman SF, Duke-Cohan JS, Barsh GS.
Nat Genet.
2001;
27
(1):
40-7
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Melanocortin 1 receptor variation in the domestic dog.
Newton JM,
Wilkie AL, He L, Jordan SA, Metallinos DL, Holmes NG, Jackson IJ, Barsh GS.
Mamm Genome.
2000;
11
(1):
24-30
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Genetics of body-weight regulation.
Barsh GS,
Farooqi IS, O'Rahilly S.
Nature.
2000;
404
(6778):
644-51
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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
Ollmann MM,
Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS.
Science.
1997;
278
(5335):
135-8
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Response--How the Gray Wolf Got Its Color.
Barsh GS,
Anderson TM, Vonholdt BM, Candille SI, Musiani M, Stahler DR, Leonard JA, Padhukasahasram B, Randi E, Bustamante CD, Ostrander EA, Tang H, Wayne RK.
Science.
2009;
325
(5936):
34
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Genetics of Sex-linked yellow in the Syrian hamster.
Alizadeh A,
Hong LZ, Kaelin CB, Raudsepp T, Manuel H, Barsh GS.
Genetics.
2009;
181
(4):
1427-36
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The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
Beliakoff J,
Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z.
Mol Cell Biol.
2008;
28
(1):
282-92
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New ligands for melanocortin receptors.
Kaelin CB,
Candille SI, Yu B, Jackson P, Thompson DA, Nix MA, Binkley J, Millhauser GL, Barsh GS.
Int J Obes (Lond).
2008:
32 Suppl 7
S19-27
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Worldwide human relationships inferred from genome-wide patterns of variation.
Li JZ,
Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM.
Science.
2008;
319
(5866):
1100-4
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Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements.
Alizadeh A,
Fitch KR, Niswender CM, McKnight GS, Barsh GS.
Pigment Cell Melanoma Res.
2008;
21
(1):
63-9
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Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.
van de Wall E,
Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC.
Endocrinology.
2008;
149
(4):
1773-85
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Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation.
April CS,
Barsh GS.
PLoS Genet.
2007;
3
(1):
e9
-
How hair gets its pigment.
Barsh G,
Cotsarelis G.
Cell.
2007;
130
(5):
779-81
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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
Claret M,
Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.
J Clin Invest.
2007;
117
(8):
2325-36
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Mammalian comparative sequence analysis of the Agrp locus.
Kaelin CB,
Cooper GM, Sidow A, Barsh GS.
PLoS One.
2007;
2
(1):
e702
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Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.
Kim BY,
Olzmann JA, Barsh GS, Chin LS, Li L.
Mol Biol Cell.
2007;
18
(4):
1129-42
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Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding.
Xu AW,
Ste-Marie L, Kaelin CB, Barsh GS.
Endocrinology.
2007;
148
(1):
72-80
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Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevus.
McGowan KA,
Fuchs H, Hrabé de Angelis M, Barsh GS.
J Invest Dermatol.
2007;
127
(1):
60-4
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How the dog got its spots.
Barsh GS,
Nat Genet.
2007;
39
(11):
1304-6
-
Skin layer-specific transcriptional profiles in normal and recessive yellow (Mc1re/Mc1re) mice.
April CS,
Barsh GS.
Pigment Cell Res.
2006;
19
(3):
194-205
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Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid.
Kaelin CB,
Gong L, Xu AW, Yao F, Hockman K, Morton GJ, Schwartz MW, Barsh GS, MacKenzie RG.
Mol Endocrinol.
2006;
20
(10):
2591-602
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A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis.
McGowan KA,
Aradhya S, Fuchs H, de Angelis MH, Barsh GS.
J Invest Dermatol.
2006;
126
(5):
1013-6
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Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice.
Kaelin CB,
Xu AW, Lu XY, Barsh GS.
Endocrinology.
2004;
145
(12):
5798-806
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Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs.
Kerns JA,
Newton J, Berryere TG, Rubin EM, Cheng JF, Schmutz SM, Barsh GS.
Mamm Genome.
2004;
15
(10):
798-808
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Exclusion of melanocortin-1 receptor (mc1r) and agouti as candidates for dominant black in dogs.
Kerns JA,
Olivier M, Lust G, Barsh GS.
J Hered.
2003 Jan-Feb;
94
(1):
75-9
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Accessory proteins for melanocortin signaling: attractin and mahogunin.
He L,
Eldridge AG, Jackson PK, Gunn TM, Barsh GS.
Ann N Y Acad Sci.
2003:
994
288-98
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Immunology: hepatitis A virus link to atopic disease.
McIntire JJ,
Umetsu SE, Macaubas C, Hoyte EG, Cinnioglu C, Cavalli-Sforza LL, Barsh GS, Hallmayer JF, Underhill PA, Risch NJ, Freeman GJ, DeKruyff RH, Umetsu DT.
Nature.
2003;
425
(6958):
576
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Genetic and biochemical studies of the Agouti-attractin system.
Barsh GS,
He L, Gunn TM.
J Recept Signal Transduct Res.
2002 Feb-Nov;
22
(1-4):
63-77
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Identification and preliminary characterization of mouse Adam33.
Gunn TM,
Azarani A, Kim PH, Hyman RW, Davis RW, Barsh GS.
BMC Genet.
2002:
3
2
-
In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
Clément K,
Viguerie N, Diehn M, Alizadeh A, Barbe P, Thalamas C, Storey JD, Brown PO, Barsh GS, Langin D.
Genome Res.
2002;
12
(2):
281-91
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Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
McIntire JJ,
Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH.
Nat Immunol.
2001;
2
(12):
1109-16
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Molecular and phenotypic analysis of Attractin mutant mice.
Gunn TM,
Inui T, Kitada K, Ito S, Wakamatsu K, He L, Bouley DM, Serikawa T, Barsh GS.
Genetics.
2001;
158
(4):
1683-95
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Neuroendocrine regulation by the Agouti/Agrp-melanocortin system.
Barsh G,
Gunn T, He L, Wilson B, Lu X, Gantz I, Watson S.
Endocr Res.
2000;
26
(4):
571
-
Mahogany/attractin: en route from phenotype to function.
Gunn TM,
Barsh GS.
Trends Cardiovasc Med.
2000;
10
(2):
76-81
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Regulation of mouse lens fiber cell development and differentiation by the Maf gene.
Ring BZ,
Cordes SP, Overbeek PA, Barsh GS.
Development.
2000;
127
(2):
307-17
-
Biochemical and genetic studies of pigment-type switching.
Barsh G,
Gunn T, He L, Schlossman S, Duke-Cohan J.
Pigment Cell Res.
2000:
13 Suppl 8
48-53
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Gene trap insertional mutagenesis in mice: new vectors and germ line mutations in two novel genes.
Neilan EG,
Barsh GS.
Transgenic Res.
1999;
8
(6):
451-8
-
WNT signaling in the control of hair growth and structure.
Millar SE,
Willert K, Salinas PC, Roelink H, Nusse R, Sussman DJ, Barsh GS.
Dev Biol.
1999;
207
(1):
133-49
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The role of agouti-related protein in regulating body weight.
Wilson BD,
Ollmann MM, Barsh GS.
Mol Med Today.
1999;
5
(6):
250-6
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Down-regulation of melanocortin receptor signaling mediated by the amino terminus of Agouti protein in Xenopus melanophores.
Ollmann MM,
Barsh GS.
J Biol Chem.
1999;
274
(22):
15837-46
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Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.
Wilson BD,
Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ, Barsh GS.
Endocrinology.
1999;
140
(5):
2387-97
-
Molecular pharmacology of Agouti protein in vitro and in vivo.
Barsh GS,
Ollmann MM, Wilson BD, Miller KA, Gunn TM.
Ann N Y Acad Sci.
1999:
885
143-52
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The mouse mahogany locus encodes a transmembrane form of human attractin.
Gunn TM,
Miller KA, He L, Hyman RW, Davis RW, Azarani A, Schlossman SF, Duke-Cohan JS, Barsh GS.
Nature.
1999;
398
(6723):
152-6
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Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.
Ollmann MM,
Lamoreux ML, Wilson BD, Barsh GS.
Genes Dev.
1998;
12
(3):
316-30
-
Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans.
Larsson NG,
Oldfors A, Garman JD, Barsh GS, Clayton DA.
Hum Mol Genet.
1997;
6
(2):
185-91
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Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease.
Desai KH,
Sato R, Schauble E, Barsh GS, Kobilka BK, Bernstein D.
Am J Physiol.
1997;
272
(2 Pt 2):
H1053-61
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Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
Hein L,
Stevens ME, Barsh GS, Pratt RE, Kobilka BK, Dzau VJ.
Proc Natl Acad Sci U S A.
1997;
94
(12):
6391-6
-
Genetic studies of the mouse mutations mahogany and mahoganoid.
Miller KA,
Gunn TM, Carrasquillo MM, Lamoreux ML, Galbraith DB, Barsh GS.
Genetics.
1997;
146
(4):
1407-15
-
Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam).
Larsson NG,
Barsh GS, Clayton DA.
Mamm Genome.
1997;
8
(2):
139-40
-
Isolation and characterization of a mouse homolog of the X-linked ocular albinism (OA1) gene.
Newton JM,
Orlow SJ, Barsh GS.
Genomics.
1996;
37
(2):
219-25
-
Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus.
Chen Y,
Duhl DM, Barsh GS.
Genetics.
1996;
144
(1):
265-77
-
Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.
Link RE,
Desai K, Hein L, Stevens ME, Chruscinski A, Bernstein D, Barsh GS, Kobilka BK.
Science.
1996;
273
(5276):
803-5
-
The genetics of pigmentation: from fancy genes to complex traits.
Barsh GS,
Trends Genet.
1996;
12
(8):
299-305
-
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
Rohrer DK,
Desai KH, Jasper JR, Stevens ME, Regula DP, Barsh GS, Bernstein D, Kobilka BK.
Proc Natl Acad Sci U S A.
1996;
93
(14):
7375-80
-
A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein.
Larsson NG,
Garman JD, Oldfors A, Barsh GS, Clayton DA.
Nat Genet.
1996;
13
(3):
296-302
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Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
Hein L,
Dzau VJ, Barsh GS.
Genomics.
1995;
30
(2):
369-71
-
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.
Hein L,
Barsh GS, Pratt RE, Dzau VJ, Kobilka BK.
Nature.
1995;
377
(6551):
744-7
-
Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated.
Millar SE,
Miller MW, Stevens ME, Barsh GS.
Development.
1995;
121
(10):
3223-32
-
Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.
Link RE,
Stevens MS, Kulatunga M, Scheinin M, Barsh GS, Kobilka BK.
Mol Pharmacol.
1995;
48
(1):
48-55
-
Structure and function of ASP, the human homolog of the mouse agouti gene.
Wilson BD,
Ollmann MM, Kang L, Stoffel M, Bell GI, Barsh GS.
Hum Mol Genet.
1995;
4
(2):
223-30
-
The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.
Cordes SP,
Barsh GS.
Cell.
1994;
79
(6):
1025-34
-
Neomorphic agouti mutations in obese yellow mice.
Duhl DM,
Vrieling H, Miller KA, Wolff GL, Barsh GS.
Nat Genet.
1994;
8
(1):
59-65
-
Association of Xmv-10 and the non-agouti (a) mutation explained by close linkage instead of causality.
Winkes BM,
Ollmann MM, Barsh GS.
Mamm Genome.
1994;
5
(1):
3-10
-
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
Miller MW,
Duhl DM, Winkes BM, Arredondo-Vega F, Saxon PJ, Wolff GL, Epstein CJ, Hershfield MS, Barsh GS.
EMBO J.
1994;
13
(8):
1806-16
-
Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs.
Duhl DM,
Stevens ME, Vrieling H, Saxon PJ, Miller MW, Epstein CJ, Barsh GS.
Development.
1994;
120
(6):
1695-708
-
Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.
Vrieling H,
Duhl DM, Millar SE, Miller KA, Barsh GS.
Proc Natl Acad Sci U S A.
1994;
91
(12):
5667-71
-
Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5.
Link RE,
Kobilka BK, Barsh GS.
Mamm Genome.
1993;
4
(11):
650-5
-
Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice.
Dedera DA,
Waller EK, LeBrun DP, Sen-Majumdar A, Stevens ME, Barsh GS, Cleary ML.
Cell.
1993;
74
(5):
833-43
-
Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.
Miller MW,
Duhl DM, Vrieling H, Cordes SP, Ollmann MM, Winkes BM, Barsh GS.
Genes Dev.
1993;
7
(3):
454-67
-
Subtype-specific differences in the intracellular sorting of G protein-coupled receptors.
von Zastrow M,
Link R, Daunt D, Barsh G, Kobilka B.
J Biol Chem.
1993;
268
(2):
763-6
-
Construction, analysis, and application of a radiation hybrid mapping panel surrounding the mouse agouti locus.
Ollmann MM,
Winkes BM, Barsh GS.
Genomics.
1992;
13
(3):
731-40
-
Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor.
Chruscinski AJ,
Link RE, Daunt DA, Barsh GS, Kobilka BK.
Biochem Biophys Res Commun.
1992;
186
(3):
1280-7
-
Expression of TAPA-1 in preimplantation mouse embryos.
Andria ML,
Barsh GS, Levy S.
Biochem Biophys Res Commun.
1992;
186
(3):
1201-6
-
Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.
Link R,
Daunt D, Barsh G, Chruscinski A, Kobilka B.
Mol Pharmacol.
1992;
42
(1):
16-27
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