Publications
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Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development.
ten Berge D,
Brugmann SA, Helms JA, Nusse R.
Development.
2008;
135
(19):
3247-57
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Wnt signaling mediates self-organization and axis formation in embryoid bodies.
ten Berge D,
Koole W, Fuerer C, Fish M, Eroglu E, Nusse R.
Cell Stem Cell.
2008;
3
(5):
508-18
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Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
Mikels AJ,
Nusse R.
PLoS Biol.
2006;
4
(4):
e115
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WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity.
Gordon MD,
Dionne MS, Schneider DS, Nusse R.
Nature.
2005;
437
(7059):
746-9
-
Wnt proteins are lipid-modified and can act as stem cell growth factors.
Willert K,
Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R.
Nature.
2003;
423
(6938):
448-52
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Telomerase modulates Wnt signalling by association with target gene chromatin.
Park JI,
Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.
Nature.
2009;
460
(7251):
66-72
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Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling.
Mikels A,
Minami Y, Nusse R.
J Biol Chem.
2009;
284
(44):
30167-76
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Towards an integrated view of Wnt signaling in development.
van Amerongen R,
Nusse R.
Development.
2009;
136
(19):
3205-14
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A study on the interactions between heparan sulfate proteoglycans and Wnt proteins.
Fuerer C,
Habib SJ, Nusse R.
Dev Dyn.
2009
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A dermal HOX transcriptional program regulates site-specific epidermal fate.
Rinn JL,
Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, Ridky TW, Stadler HS, Nusse R, Helms JA, Chang HY.
Genes Dev.
2008;
22
(3):
303-7
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Wnt signaling and stem cell control.
Nusse R,
Fuerer C, Ching W, Harnish K, Logan C, Zeng A, ten Berge D, Kalani Y.
Cold Spring Harb Symp Quant Biol.
2008:
73
59-66
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Translating insights from development into regenerative medicine: the function of Wnts in bone biology.
Leucht P,
Minear S, Ten Berge D, Nusse R, Helms JA.
Semin Cell Dev Biol.
2008;
19
(5):
434-43
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Alternative wnt signaling is initiated by distinct receptors.
van Amerongen R,
Mikels A, Nusse R.
Sci Signal.
2008;
1
(35):
re9
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Liposomal packaging generates Wnt protein with in vivo biological activity.
Morrell NT,
Leucht P, Zhao L, Kim JB, ten Berge D, Ponnusamy K, Carre AL, Dudek H, Zachlederova M, McElhaney M, Brunton S, Gunzner J, Callow M, Polakis P, Costa M, Zhang XM, Helms JA, Nusse R.
PLoS One.
2008;
3
(8):
e2930
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Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin.
Gordon MD,
Ayres JS, Schneider DS, Nusse R.
PLoS Pathog.
2008;
4
(7):
e1000111
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Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.
Chen WS,
Antic D, Matis M, Logan CY, Povelones M, Anderson GA, Nusse R, Axelrod JD.
Cell.
2008;
133
(6):
1093-105
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Lipid-independent secretion of a Drosophila Wnt protein.
Ching W,
Hang HC, Nusse R.
J Biol Chem.
2008;
283
(25):
17092-8
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Wnt signaling regulates pancreatic beta cell proliferation.
Rulifson IC,
Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK.
Proc Natl Acad Sci U S A.
2007;
104
(15):
6247-52
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Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments.
Klapholz-Brown Z,
Walmsley GG, Nusse YM, Nusse R, Brown PO.
PLoS One.
2007;
2
(9):
e945
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Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.
Hu M,
Kurobe M, Jeong YJ, Fuerer C, Ghole S, Nusse R, Sylvester KG.
Gastroenterology.
2007;
133
(5):
1579-91
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Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid.
Fish MP,
Groth AC, Calos MP, Nusse R.
Nat Protoc.
2007;
2
(10):
2325-31
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Cancer. Converging on beta-catenin in Wilms tumor.
Nusse R,
Science.
2007;
316
(5827):
988-9
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Wnt signaling mediates regional specification in the vertebrate face.
Brugmann SA,
Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA.
Development.
2007;
134
(18):
3283-95
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Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.
Marino S,
Nusse R.
PLoS One.
2007;
2
(6):
e519
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Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells.
Wodarz A,
Stewart DB, Nelson WJ, Nusse R.
J Cell Sci.
2006;
119
(Pt 12):
2425-34
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The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling.
Povelones M,
Nusse R.
EMBO J.
2005;
24
(19):
3493-503
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Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.
Kon C,
Cadigan KM, da Silva SL, Nusse R.
Genetics.
2005;
169
(4):
2087-100
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Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.
Povelones M,
Howes R, Fish M, Nusse R.
Genetics.
2005;
171
(4):
1643-54
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Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31.
Groth AC,
Fish M, Nusse R, Calos MP.
Genetics.
2004;
166
(4):
1775-82
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Convergence of Wnt, beta-catenin, and cadherin pathways.
Nelson WJ,
Nusse R.
Science.
2004;
303
(5663):
1483-7
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A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Penton A,
Wodarz A, Nusse R.
Genetics.
2002;
161
(2):
747-62
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Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless.
Cadigan KM,
Jou AD, Nusse R.
Development.
2002;
129
(14):
3393-402
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A transcriptional response to Wnt protein in human embryonic carcinoma cells.
Willert J,
Epping M, Pollack JR, Brown PO, Nusse R.
BMC Dev Biol.
2002:
2
8
-
Ligand receptor interactions in the Wnt signaling pathway in Drosophila.
Wu CH,
Nusse R.
J Biol Chem.
2002;
277
(44):
41762-9
-
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.
Rulifson EJ,
Kim SK, Nusse R.
Science.
2002;
296
(5570):
1118-20
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Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
Rousset R,
Mack JA, Wharton KA, Axelrod JD, Cadigan KM, Fish MP, Nusse R, Scott MP.
Genes Dev.
2001;
15
(6):
658-71
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Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless.
Rulifson EJ,
Wu CH, Nusse R.
Mol Cell.
2000;
6
(1):
117-26
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Interactions between wingless and frizzled molecules in Drosophila.
Nusse R,
Rulifson E, Fish M, Harryman-Samos C, Brink M, Wu CH, Cadigan K.
Ernst Schering Res Found Workshop.
2000;
(29):
1-11
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A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
Willert K,
Logan CY, Arora A, Fish M, Nusse R.
Development.
1999;
126
(18):
4165-73
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Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.
Willert K,
Shibamoto S, Nusse R.
Genes Dev.
1999;
13
(14):
1768-73
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WNT targets. Repression and activation.
Nusse R,
Trends Genet.
1999;
15
(1):
1-3
-
WNT signaling in the control of hair growth and structure.
Millar SE,
Willert K, Salinas PC, Roelink H, Nusse R, Sussman DJ, Barsh GS.
Dev Biol.
1999;
207
(1):
133-49
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Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression.
Lessing D,
Nusse R.
Development.
1998;
125
(8):
1469-76
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Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing.
Cadigan KM,
Fish MP, Rulifson EJ, Nusse R.
Cell.
1998;
93
(5):
767-77
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DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate.
Kozopas KM,
Samos CH, Nusse R.
Genes Dev.
1998;
12
(8):
1155-65
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Beta-catenin: a key mediator of Wnt signaling.
Willert K,
Nusse R.
Curr Opin Genet Dev.
1998;
8
(1):
95-102
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A versatile transcriptional effector of Wingless signaling.
Nusse R,
Cell.
1997;
89
(3):
321-3
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Casein kinase 2 associates with and phosphorylates dishevelled.
Willert K,
Brink M, Wodarz A, Varmus H, Nusse R.
EMBO J.
1997;
16
(11):
3089-96
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Wnt signaling: a common theme in animal development.
Cadigan KM,
Nusse R.
Genes Dev.
1997;
11
(24):
3286-305
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Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila.
Nusse R,
Samos CH, Brink M, Willert K, Cadigan KM, Wodarz A, Fish M, Rulifson E.
Cold Spring Harb Symp Quant Biol.
1997:
62
185-90
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A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.
Wang YK,
Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U.
Hum Mol Genet.
1997;
6
(3):
465-72
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Wnt meeting 1996.
Cadigan KM,
Nusse R.
Biochim Biophys Acta.
1997;
1332
(1):
R1-5
-
wingless signaling in the Drosophila eye and embryonic epidermis.
Cadigan KM,
Nusse R.
Development.
1996;
122
(9):
2801-12
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A new member of the frizzled family from Drosophila functions as a Wingless receptor
Nusse, R.,
Bhanot, P., Brink, M., Harryman Samos, C., Hsieh, J. C., Wang, Y. S., Macke, J. P., Andrew, D., Nathans, J..
Nature.
1996
382
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The dishevelled protein is modified by wingless signaling in Drosophila.
Yanagawa S,
van Leeuwen F, Wodarz A, Klingensmith J, Nusse R.
Genes Dev.
1995;
9
(9):
1087-97
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Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer.
van Leeuwen F,
Nusse R.
Semin Cancer Biol.
1995;
6
(3):
127-33
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Differential requirements for segment polarity genes in wingless signaling.
Noordermeer J,
Klingensmith J, Nusse R.
Mech Dev.
1995;
51
(2-3):
145-55
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The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS.
Fradkin LG,
Noordermeer JN, Nusse R.
Dev Biol.
1995;
168
(1):
202-13
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Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells.
Salinas PC,
Fletcher C, Copeland NG, Jenkins NA, Nusse R.
Development.
1994;
120
(5):
1277-86
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Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells.
van Leeuwen F,
Samos CH, Nusse R.
Nature.
1994;
368
(6469):
342-4
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Signaling by wingless in Drosophila.
Klingensmith J,
Nusse R.
Dev Biol.
1994;
166
(2):
396-414
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Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.
van den Heuvel M,
Klingensmith J, Perrimon N, Nusse R.
Dev Suppl.
1993:
105-14
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Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
van den Heuvel M,
Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R.
EMBO J.
1993;
12
(13):
5293-302
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Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene.
Roelink H,
Wang J, Black DM, Solomon E, Nusse R.
Genomics.
1993;
17
(3):
790-2
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The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo.
Noordermeer J,
Johnston P, Rijsewijk F, Nusse R, Lawrence PA.
Development.
1992;
116
(3):
711-9
-
The Wnt gene family in tumorigenesis and in normal development.
Nusse R,
J Steroid Biochem Mol Biol.
1992;
43
(1-3):
9-12
-
Wnt genes.
Nusse R,
Varmus HE.
Cell.
1992;
69
(7):
1073-87
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Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila.
Russell J,
Gennissen A, Nusse R.
Development.
1992;
115
(2):
475-85
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Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors.
Roelink H,
Wagenaar E, Nusse R.
Oncogene.
1992;
7
(3):
487-92
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Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres.
Salinas PC,
Nusse R.
Mech Dev.
1992;
39
(3):
151-60
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Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.
Roelink H,
Nusse R.
Genes Dev.
1991;
5
(3):
381-8
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