Publications
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase C delta (δPKC) inhibits mitochondrial elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury.
Yogalingam G,
Hwang S, Ferreira JC, Mochly-Rosen D.
J Biol Chem.
2013
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In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate.
Josan S,
Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D.
NMR Biomed.
2013;
26
(6):
607-12
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Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.
Sun X,
Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG.
J Neurosci Res.
2013;
91
(6):
799-807
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Identification of εPKC targets during cardiac ischemic injury.
Budas G,
Costa HM, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D.
Circ J.
2012;
76
(6):
1476-85
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Nitroglycerin use in myocardial infarction patients.
Ferreira JC,
Mochly-Rosen D.
Circ J.
2012;
76
(1):
15-21
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Protein kinase C, an elusive therapeutic target?
Mochly-Rosen D,
Das K, Grimes KV.
Nat Rev Drug Discov.
2012;
11
(12):
937-57
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Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.
Ferreira JC,
Boer BN, Grinberg M, Brum PC, Mochly-Rosen D.
PLoS One.
2012;
7
(3):
e33175
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Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes.
Caino MC,
Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG.
Oncogene.
2012;
31
(20):
2593-600
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Regulation of cardiac excitability by protein kinase C isozymes.
Ferreira JC,
Mochly-Rosen D, Boutjdir M.
Front Biosci (Schol Ed).
2012:
4
532-46
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A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo.
Banh A,
Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT.
Clin Cancer Res.
2011;
17
(23):
7265-72
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ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance.
Sun L,
Ferreira JC, Mochly-Rosen D.
Sci Transl Med.
2011;
3
(107):
107ra111
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Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.
Qi X,
Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D.
Mol Biol Cell.
2011;
22
(2):
256-65
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Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
Khanna M,
Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD.
J Biol Chem.
2011;
286
(50):
43486-94
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Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells.
Ding Q,
Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W.
J Vasc Surg.
2011;
53
(4):
1044-51
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Myocardial salvage in acute myocardial infarction--challenges in clinical translation.
Mochly-Rosen D,
Grimes KV.
J Mol Cell Cardiol.
2011;
51
(4):
451-3
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PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses.
Palaniyandi SS,
Ferreira JC, Brum PC, Mochly-Rosen D.
J Cell Mol Med.
2011;
15
(8):
1769-77
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PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.
Kim J,
Koyanagi T, Mochly-Rosen D.
Prostate.
2011;
71
(9):
946-54
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Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.
Ferreira JC,
Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D.
J Mol Cell Cardiol.
2011;
51
(6):
980-7
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Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.
Kim J,
Thorne SH, Sun L, Huang B, Mochly-Rosen D.
Oncogene.
2011;
30
(3):
323-33
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Therapeutic potential for protein kinase C inhibitor in vascular restenosis.
Ding RQ,
Tsao J, Chai H, Mochly-Rosen D, Zhou W.
J Cardiovasc Pharmacol Ther.
2011;
16
(2):
160-7
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β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.
Fajardo G,
Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D.
J Mol Cell Cardiol.
2011;
51
(5):
781-9
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βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure.
Ferreira JC,
Brum PC, Mochly-Rosen D.
J Mol Cell Cardiol.
2011;
51
(4):
479-84
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Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.
Budas GR,
Disatnik MH, Chen CH, Mochly-Rosen D.
J Mol Cell Cardiol.
2010;
48
(4):
757-64
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Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
Perez-Miller S,
Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD.
Nat Struct Mol Biol.
2010;
17
(2):
159-64
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Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells.
Koda K,
Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R.
Circulation.
2010;
122
(8):
771-81
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Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.
Qvit N,
Mochly-Rosen D.
Drug Discov Today Dis Mech.
2010;
7
(2):
e87-e93
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Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion.
Churchill EN,
Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D.
Cardiovasc Res.
2010;
85
(2):
385-94
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Mitochondrial aldehyde dehydrogenase and cardiac diseases.
Chen CH,
Sun L, Mochly-Rosen D.
Cardiovasc Res.
2010;
88
(1):
51-7
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Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.
Budas GR,
Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D.
Cardiovasc Res.
2010;
88
(1):
83-92
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Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
Tang-Quan KR,
Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S.
Transpl Immunol.
2010;
23
(1-2):
65-70
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Regulation of mitochondrial processes: a target for heart failure.
Palaniyandi SS,
Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D.
Drug Discov Today Dis Mech.
2010;
7
(2):
e95-e102
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Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.
Deuse T,
Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S.
Circulation.
2010;
122
(11 Suppl):
S170-8
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deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.
Monti M,
Donnini S, Giachetti A, Mochly-Rosen D, Ziche M.
J Mol Cell Cardiol.
2010;
48
(4):
746-56
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Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.
Castañeda D,
Zhao H, Mochly-Rosen D, Steinberg GK.
Brain Res.
2009:
1251
256-61
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Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?
Budas GR,
Disatnik MH, Mochly-Rosen D.
Trends Cardiovasc Med.
2009;
19
(5):
158-64
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Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model.
Kaneda H,
Ikeno F, Inagaki K, Mochly-Rosen D.
Int J Cardiol.
2009;
133
(2):
256-9
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Protein kinase C in heart failure: a therapeutic target?
Palaniyandi SS,
Sun L, Ferreira JC, Mochly-Rosen D.
Cardiovasc Res.
2009;
82
(2):
229-39
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Rationally designed peptide regulators of protein kinase C.
Churchill EN,
Qvit N, Mochly-Rosen D.
Trends Endocrinol Metab.
2009;
20
(1):
25-33
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Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.
Churchill EN,
Disatnik MH, Mochly-Rosen D.
J Mol Cell Cardiol.
2009;
46
(2):
278-84
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Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
Chen CH,
Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D.
Science.
2008;
321
(5895):
1493-5
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Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats.
Koyanagi T,
Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D.
Am J Physiol Heart Circ Physiol.
2008;
295
(1):
H220-6
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Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
Kim J,
Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D.
Cancer Res.
2008;
68
(16):
6831-9
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Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways.
Yao L,
Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I.
Mol Pharmacol.
2008;
73
(4):
1105-12
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Ethanol for cardiac ischemia: the role of protein kinase c.
Churchill EN,
Disatnik MH, Budas GR, Mochly-Rosen D.
Ther Adv Cardiovasc Dis.
2008;
2
(6):
469-83
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Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.
Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, Widimsky P.
Circulation.
2008;
117
(7):
886-96
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Islet cell survival during isolation improved through protein kinase C epsilon activation.
Kvezereli M,
Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ.
Transplant Proc.
2008;
40
(2):
375-8
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Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure.
Palaniyandi SS,
Inagaki K, Mochly-Rosen D.
J Mol Cell Cardiol.
2008;
45
(6):
779-86
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PKC isozymes in chronic cardiac disease: possible therapeutic targets?
Churchill E,
Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D.
Annu Rev Pharmacol Toxicol.
2008:
48
569-99
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Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure.
Inagaki K,
Koyanagi T, Berry NC, Sun L, Mochly-Rosen D.
Hypertension.
2008;
51
(6):
1565-9
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Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.
Qi X,
Inagaki K, Sobel RA, Mochly-Rosen D.
J Clin Invest.
2008;
118
(1):
173-82
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The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis.
Qi X,
Mochly-Rosen D.
J Cell Sci.
2008;
121
(Pt 6):
804-13
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epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury.
Bright R,
Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D.
Neurosci Lett.
2008;
441
(1):
120-4
-
Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.
Budas GR,
Churchill EN, Mochly-Rosen D.
Pharmacol Res.
2007;
55
(6):
523-36
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Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic.
Budas GR,
Koyanagi T, Churchill EN, Mochly-Rosen D.
Biochem Soc Trans.
2007;
35
(Pt 5):
1021-6
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DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo.
Bright R,
Steinberg GK, Mochly-Rosen D.
Brain Res.
2007:
1144
146-55
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Happy birthday protein kinase C: past, present and future of a superfamily.
Battaini F,
Mochly-Rosen D.
Pharmacol Res.
2007;
55
(6):
461-6
-
Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage.
Ikeno F,
Inagaki K, Rezaee M, Mochly-Rosen D.
Cardiovasc Res.
2007;
73
(4):
699-709
-
Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007).
Newton AC,
Mochly-Rosen D.
IUBMB Life.
2007;
59
(12):
741-3
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Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.
Kheifets V,
Mochly-Rosen D.
Pharmacol Res.
2007;
55
(6):
467-76
-
Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage.
Budas GR,
Mochly-Rosen D.
Biochem Soc Trans.
2007;
35
(Pt 5):
1052-4
-
Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells.
Mamidipudi V,
Miller LD, Mochly-Rosen D, Cartwright CA.
Biochem Biophys Res Commun.
2007;
352
(2):
423-30
-
Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces.
Brandman R,
Disatnik MH, Churchill E, Mochly-Rosen D.
J Biol Chem.
2007;
282
(6):
4113-23
-
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model.
Koyanagi T,
Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D.
J Mol Cell Cardiol.
2007;
43
(4):
517-22
-
RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function.
Vallentin A,
Mochly-Rosen D.
J Biol Chem.
2007;
282
(3):
1650-7
-
Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide.
Liron T,
Chen LE, Khaner H, Vallentin A, Mochly-Rosen D.
J Mol Cell Cardiol.
2007;
42
(4):
835-41
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Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia.
Shimohata T,
Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK.
J Cereb Blood Flow Metab.
2007;
27
(8):
1463-75
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The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury.
Churchill EN,
Mochly-Rosen D.
Biochem Soc Trans.
2007;
35
(Pt 5):
1040-2
-
Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase.
Siwko S,
Mochly-Rosen D.
Int J Biochem Cell Biol.
2007;
39
(5):
978-87
-
deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart.
Qi X,
Vallentin A, Churchill E, Mochly-Rosen D.
J Mol Cell Cardiol.
2007;
43
(4):
420-8
-
Epsilon protein kinase C as a potential therapeutic target for the ischemic heart.
Inagaki K,
Churchill E, Mochly-Rosen D.
Cardiovasc Res.
2006;
70
(2):
222-30
-
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.
Kheifets V,
Bright R, Inagaki K, Schechtman D, Mochly-Rosen D.
J Biol Chem.
2006;
281
(32):
23218-26
-
Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.
Inagaki K,
Begley R, Ikeno F, Mochly-Rosen D.
Circulation.
2005;
111
(1):
44-50
-
DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia.
Inagaki K,
Mochly-Rosen D.
J Mol Cell Cardiol.
2005;
39
(2):
203-11
-
Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes.
Shumilla JA,
Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM.
J Pain.
2005;
6
(8):
535-49
-
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Tanaka M,
Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC.
J Thorac Cardiovasc Surg.
2005;
129
(5):
1160-7
-
PKC-{epsilon}-dependent survival signals in diabetic hearts.
Malhotra A,
Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG.
Am J Physiol Heart Circ Physiol.
2005;
289
(4):
H1343-50
-
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.
Raval AP,
Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA.
J Cereb Blood Flow Metab.
2005;
25
(6):
730-41
-
Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons.
Li HF,
Mochly-Rosen D, Kendig JJ.
Br J Pharmacol.
2005;
144
(3):
301-7
-
RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.
Szabo G,
Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S.
Alcohol Clin Exp Res.
2005;
29
(9):
1749-52
-
Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation.
Churchill EN,
Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI.
Circ Res.
2005;
97
(1):
78-85
-
The role of protein kinase C in cerebral ischemic and reperfusion injury.
Bright R,
Mochly-Rosen D.
Stroke.
2005;
36
(12):
2781-90
-
A critical intramolecular interaction for protein kinase Cepsilon translocation.
Schechtman D,
Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D.
J Biol Chem.
2004;
279
(16):
15831-40
-
Biodistribution of intracellularly acting peptides conjugated reversibly to Tat.
Begley R,
Liron T, Baryza J, Mochly-Rosen D.
Biochem Biophys Res Commun.
2004;
318
(4):
949-54
-
Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury.
Wang J,
Bright R, Mochly-Rosen D, Giffard RG.
Neuropharmacology.
2004;
47
(1):
136-45
-
Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice.
Lange-Asschenfeldt C,
Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA.
J Cereb Blood Flow Metab.
2004;
24
(6):
636-45
-
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma.
Sweitzer SM,
Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ.
Pain.
2004;
110
(1-2):
281-9
-
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon.
Gray MO,
Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO.
J Biol Chem.
2004;
279
(5):
3596-604
-
Protein kinase C delta mediates cerebral reperfusion injury in vivo.
Bright R,
Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D.
J Neurosci.
2004;
24
(31):
6880-8
-
Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats.
Sweitzer SM,
Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ.
J Pharmacol Exp Ther.
2004;
309
(2):
616-25
-
Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria.
Murriel CL,
Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D.
J Biol Chem.
2004;
279
(46):
47985-91
-
RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling.
Miller LD,
Lee KC, Mochly-Rosen D, Cartwright CA.
Oncogene.
2004;
23
(33):
5682-6
-
State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation.
Souroujon MC,
Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D.
J Biol Chem.
2004;
279
(17):
17617-24
-
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Tanaka M,
Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC.
Circulation.
2004;
110
(11 Suppl 1):
II194-9
-
Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator.
Inagaki K,
Hahn HS, Dorn GW, Mochly-Rosen D.
Circulation.
2003;
108
(7):
869-75
-
Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site.
Endemann G,
Schechtman D, Mochly-Rosen D.
Anal Biochem.
2003;
313
(2):
345-7
-
Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice.
Raval AP,
Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA.
J Neurosci.
2003;
23
(2):
384-91
-
Glutathione S-transferase pull-down assay.
Schechtman D,
Mochly-Rosen D, Ron D.
Methods Mol Biol.
2003:
233
345-50
-
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.
Inagaki K,
Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D.
Circulation.
2003;
108
(19):
2304-7
-
Methods for detecting binding proteins: an introduction.
Endemann G,
Mochly-Rosen D.
Methods Mol Biol.
2003:
233
307-25
-
Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors.
Braun MU,
Mochly-Rosen D.
J Mol Cell Cardiol.
2003;
35
(8):
895-903
-
Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery.
Murriel CL,
Mochly-Rosen D.
Arch Biochem Biophys.
2003;
420
(2):
246-54
-
Overlay method for detecting protein-protein interactions.
Schechtman D,
Murriel C, Bright R, Mochly-Rosen D.
Methods Mol Biol.
2003:
233
351-7
-
PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current.
Xiao GQ,
Mochly-Rosen D, Boutjdir M.
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Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.
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J Neurochem.
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Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.
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Am J Physiol Heart Circ Physiol.
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Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.
Ridge KM,
Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI.
Mol Biol Cell.
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Intracellular transport mechanisms of signal transducers.
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Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Knauf JA,
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J Clin Endocrinol Metab.
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Isozyme-specific inhibitors and activators of protein kinase C.
Schechtman D,
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Molecular dynamics characterization of the C2 domain of protein kinase Cbeta.
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J Biol Chem.
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Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.
Disatnik MH,
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J Cell Sci.
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The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
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J Biol Chem.
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Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.
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Adaptor proteins in protein kinase C-mediated signal transduction.
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Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C.
Mackay K,
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Cardiovasc Res.
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Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.
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Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels.
Xiao GQ,
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Am J Physiol Cell Physiol.
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Localization, anchoring, and functions of protein kinase C isozymes in the heart.
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Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).
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Chem Biol.
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Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.
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Proc Natl Acad Sci U S A.
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Opposing effects of delta and xi PKC in ethanol-induced cardioprotection.
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Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.
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Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation.
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Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
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J Neurosci.
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Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels.
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Am J Physiol Heart Circ Physiol.
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Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia.
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Pharmacological regulation of network kinetics by protein kinase C localization.
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Semin Immunol.
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Protein kinase C isozymes and the regulation of diverse cell responses.
Dempsey EC,
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Am J Physiol Lung Cell Mol Physiol.
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An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.
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J Biol Chem.
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Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C.
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Proc Natl Acad Sci U S A.
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Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C.
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FEBS Lett.
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Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
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Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA.
J Biol Chem.
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Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation.
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Pharmacol Res.
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Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes.
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J Mol Cell Cardiol.
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RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.
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Biochemistry.
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Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.
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Proc Natl Acad Sci U S A.
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Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.
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Proc Natl Acad Sci U S A.
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Anchoring proteins for protein kinase C: a means for isozyme selectivity.
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FASEB J.
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Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.
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J Biol Chem.
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Modulating protein kinase C signal transduction.
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A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death.
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J Biol Chem.
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An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.
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J Biol Chem.
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C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels.
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Circ Res.
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The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon.
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J Biol Chem.
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Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells.
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J Biol Chem.
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A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.
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An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research.
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Circ Res.
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Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells.
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Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.
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J Cell Biol.
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The HIV nef protein associates with protein kinase C theta.
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An autoregulatory region in protein kinase C: the pseudoanchoring site.
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Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme.
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Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction.
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Localization of protein kinases by anchoring proteins: a theme in signal transduction.
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Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes.
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Life Sci.
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Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes.
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The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
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Proc Natl Acad Sci U S A.
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Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.
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Proc Natl Acad Sci U S A.
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Developmental expression of protein kinase C subspecies in rat brain-pituitary axis.
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Mol Cell Endocrinol.
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Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.
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Cell Growth Differ.
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Localization of protein kinase C isozymes in cardiac myocytes.
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Exp Cell Res.
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Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells.
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J Cell Biol.
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Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.
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Proc Natl Acad Sci U S A.
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Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme.
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Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation.
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J Neurosci.
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p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.
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Biochemistry.
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Identification of intracellular receptor proteins for activated protein kinase C.
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Proc Natl Acad Sci U S A.
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Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme.
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J Biol Chem.
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The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism.
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A protein kinase C isozyme is translocated to cytoskeletal elements on activation.
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Cell Regul.
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Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport.
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Biochem Soc Symp.
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GTP-binding proteins are restricted to signal transduction sites.
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Biochem Biophys Res Commun.
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A general procedure for screening inhibitory antibodies: application for identifying anti-protein kinase C antibodies.
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Anal Biochem.
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Chronic ethanol causes heterologous desensitization of receptors by reducing alpha s messenger RNA.
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Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C.
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Biochemistry.
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Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.
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Domain structure and phosphorylation of protein kinase C.
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Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties.
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J Biol Chem.
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Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.
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Proc Natl Acad Sci U S A.
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Antigenic specificity of acetylcholine receptor in developing muscle. Studies with monoclonal antibodies.
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J Neuroimmunol.
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An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin.
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FEBS Lett.
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Muscle Nerve.
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Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs.
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Acetylcholine receptor: molecular dissection and monoclonal antibodies in the study of experimental myasthenia.
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Molecular aspects of experimental autoimmune myasthenia gravis.
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Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site.
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Immune regulation of experimental myasthenia.
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J Neurol Neurosurg Psychiatry.
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Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor.
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