Publications
-
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.
Park CY,
Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.
Cell.
2009;
136
(5):
876-90
-
STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.
Mullins FM,
Park CY, Dolmetsch RE, Lewis RS.
Proc Natl Acad Sci U S A.
2009;
106
(36):
15495-500
-
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.
Luik RM,
Wang B, Prakriya M, Wu MM, Lewis RS.
Nature.
2008;
454
(7203):
538-42
-
The molecular choreography of a store-operated calcium channel.
Lewis RS,
Nature.
2007;
446
(7133):
284-7
-
Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode.
Prakriya M,
Lewis RS.
J Gen Physiol.
2006;
128
(3):
373-86
-
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.
Luik RM,
Wu MM, Buchanan J, Lewis RS.
J Cell Biol.
2006;
174
(6):
815-25
-
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane.
Wu MM,
Buchanan J, Luik RM, Lewis RS.
J Cell Biol.
2006;
174
(6):
803-13
-
Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment.
Bhakta NR,
Oh DY, Lewis RS.
Nat Immunol.
2005;
6
(2):
143-51
-
Calcium oscillations increase the efficiency and specificity of gene expression.
Dolmetsch RE,
Xu K, Lewis RS.
Nature.
1998;
392
(6679):
933-6
-
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
Zweifach A,
Lewis RS.
Proc Natl Acad Sci U S A.
1993;
90
(13):
6295-9
-
Some assembly required: constructing the elementary units of store-operated Ca2+ entry.
Wu MM,
Luik RM, Lewis RS.
Cell Calcium.
2007;
42
(2):
163-72
-
New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells.
Luik RM,
Lewis RS.
Trends Mol Med.
2007;
13
(3):
103-7
-
Real-time measurement of signaling and motility during T cell development in the thymus.
Bhakta NR,
Lewis RS.
Semin Immunol.
2005;
17
(6):
411-20
-
Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells.
Bautista DM,
Lewis RS.
J Physiol.
2004;
556
(Pt 3):
805-17
-
CRAC channels: activation, permeation, and the search for a molecular identity.
Prakriya M,
Lewis RS.
Cell Calcium.
2003 May-Jun;
33
(5-6):
311-21
-
Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells.
Bautista DM,
Hoth M, Lewis RS.
J Physiol.
2002;
541
(Pt 3):
877-94
-
Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels.
Prakriya M,
Lewis RS.
J Gen Physiol.
2002;
119
(5):
487-507
-
Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors.
Prakriya M,
Lewis RS.
J Physiol.
2001;
536
(Pt 1):
3-19
-
Calcium signaling mechanisms in T lymphocytes.
Lewis RS,
Annu Rev Immunol.
2001:
19
497-521
-
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.
Hoth M,
Button DC, Lewis RS.
Proc Natl Acad Sci U S A.
2000;
97
(19):
10607-12
-
Store-operated calcium channels.
Lewis RS,
Adv Second Messenger Phosphoprotein Res.
1999:
33
279-307
-
Differential activation of transcription factors induced by Ca2+ response amplitude and duration.
Dolmetsch RE,
Lewis RS, Goodnow CC, Healy JI.
Nature.
1997;
386
(6627):
855-8
-
Mitochondrial regulation of store-operated calcium signaling in T lymphocytes.
Hoth M,
Fanger CM, Lewis RS.
J Cell Biol.
1997;
137
(3):
633-48
-
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
Zweifach A,
Lewis RS.
J Gen Physiol.
1996;
107
(5):
597-610
-
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.
Zweifach A,
Lewis RS.
J Gen Physiol.
1995;
105
(2):
209-26
-
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
Fanger CM,
Hoth M, Crabtree GR, Lewis RS.
J Cell Biol.
1995;
131
(3):
655-67
-
Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.
Zweifach A,
Lewis RS.
J Biol Chem.
1995;
270
(24):
14445-51
-
Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.
Dolmetsch RE,
Lewis RS.
J Gen Physiol.
1994;
103
(3):
365-88
Help