Amato Giaccia

Publications

• ATM activation and signaling under hypoxic conditions. Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. Mol Cell Biol. 2009; 29 (2): 526-37
• Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ. Cancer Cell. 2009; 15 (1): 35-44
• The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A, Giaccia AJ. Cancer Res. 2009; 69 (3): 775-84
• Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Cancer Cell. 2009; 15 (6): 527-38
• Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B, Cao H, Trotti A, Erler JT, Chung CH, Dicker A, Pajak TF, Giaccia AJ, Ang KK. J Clin Oncol. 2009; 27 (26): 4281-6
• Bringing H2AX into the angiogenesis family. Rankin EB, Giaccia AJ, Hammond EM. Cancer Cell. 2009; 15 (6): 459-61
• Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Mol Imaging. 2008 May-Jun; 7 (3): 139-46
• The role of hypoxia-inducible factors in tumorigenesis. Rankin EB, Giaccia AJ. Cell Death Differ. 2008; 15 (4): 678-85
• The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, Attardi LD. Mol Cell. 2008; 30 (3): 303-14
• A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. Cancer Cell. 2008; 14 (1): 90-102
• Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. Turcotte S, Sutphin PD, Giaccia AJ. Autophagy. 2008; 4 (7): 944-6
• Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Chan DA, Giaccia AJ. Cell Cycle. 2008; 7 (19): 2987-90
• Notch1 is an effector of Akt and hypoxia in melanoma development. Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ, Powell MB. J Clin Invest. 2008; 118 (11): 3660-70
• Short hairpin RNA interference therapy for ischemic heart disease. Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Circulation. 2008; 118 (14 Suppl): S226-33
• Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Mol Biol Cell. 2008; 19 (1): 86-94
• Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Mol Imaging. 2007 Jul-Aug; 6 (4): 219-28
• Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC. Mol Cell Biol. 2007; 27 (3): 912-25
• HIF gene expression in cancer therapy. Chan DA, Krieg AJ, Turcotte S, Giaccia AJ. Methods Enzymol. 2007: 435 323-45
• Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Circulation. 2007; 116 (24): 2818-29
• In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis. Xu Y, Malladi P, Chiou M, Bekerman E, Giaccia AJ, Longaker MT. Tissue Eng. 2007; 13 (12): 2981-93
• Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC. Int J Radiat Oncol Biol Phys. 2007; 69 (1): 167-75
• Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ. Cancer Res. 2007; 67 (12): 5896-905
• Imaging tumoral hypoxia: oxygen concentrations and beyond. Graves EE, Giaccia AJ. Oncology (Williston Park). 2007; 21 (3): 368-76; discussion 377-8, 384
• Hypoxia, gene expression, and metastasis. Chan DA, Giaccia AJ. Cancer Metastasis Rev. 2007; 26 (2): 333-9
• Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells. Malladi P, Xu Y, Chiou M, Giaccia AJ, Longaker MT. Tissue Eng. 2007; 13 (6): 1159-71
• Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Sutphin PD, Giaccia AJ, Chan DA. Dev Cell. 2007; 12 (6): 845-6
• Comment on: osteopontin as toxic marker. Le QT, Cao H, Koong A, Giaccia A. Radiother Oncol. 2006; 78 (2): 230; author reply 230-1
• DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ. Mol Cell Biol. 2006; 26 (5): 1598-609
• HIF1alpha delays premature senescence through the activation of MIF. Welford SM, Bedogni B, Gradin K, Poellinger L, Broome Powell M, Giaccia AJ. Genes Dev. 2006; 20 (24): 3366-71
• An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Le QT, Chen E, Salim A, Cao H, Kong CS, Whyte R, Donington J, Cannon W, Wakelee H, Tibshirani R, Mitchell JD, Richardson D, O'Byrne KJ, Koong AC, Giaccia AJ. Clin Cancer Res. 2006; 12 (5): 1507-14
• Genome-wide analysis of p53 under hypoxic conditions. Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Mol Cell Biol. 2006; 26 (9): 3492-504
• Lysyl oxidase is essential for hypoxia-induced metastasis. Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ. Nature. 2006; 440 (7088): 1222-6
• Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R, Nacalumi R, Höckel M, Le Q, Longaker M, Yang G, Koong A, Giaccia A. Cancer Res. 2006; 66 (11): 5816-27
• Checking in on hypoxia/reoxygenation. Freiberg RA, Krieg AJ, Giaccia AJ, Hammond EM. Cell Cycle. 2006; 5 (12): 1304-7
• Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Hammond EM, Giaccia AJ. Clin Cancer Res. 2006; 12 (17): 5007-9
• Functional analysis of p53 binding under differential stresses. Krieg AJ, Hammond EM, Giaccia AJ. Mol Cell Biol. 2006; 26 (19): 7030-45
• Lysyl oxidase mediates hypoxic control of metastasis. Erler JT, Giaccia AJ. Cancer Res. 2006; 66 (21): 10238-41
• Plasma osteopontin is an independent prognostic marker for head and neck cancers. Petrik D, Lavori PW, Cao H, Zhu Y, Wong P, Christofferson E, Kaplan MJ, Pinto HA, Sutphin P, Koong AC, Giaccia AJ, Le QT. J Clin Oncol. 2006; 24 (33): 5291-7
• The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation. Hammond EM, Freiberg RA, Giaccia AJ. Cancer Lett. 2006; 238 (2): 161-7
• Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Malladi P, Xu Y, Chiou M, Giaccia AJ, Longaker MT. Am J Physiol Cell Physiol. 2006; 290 (4): C1139-46
• Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Kaper F, Dornhoefer N, Giaccia AJ. Cancer Res. 2006; 66 (3): 1561-9
• Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Børresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, Brown PO. PLoS Med. 2006; 3 (3): e47
• Galectin-1: a link between tumor hypoxia and tumor immune privilege. Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, Zhao S, Kong C, Richardson D, O'Byrne KJ, Giaccia AJ, Koong AC. J Clin Oncol. 2005; 23 (35): 8932-41
• Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le QT. Oncogene. 2005; 24 (43): 6555-63
• The role of p53 in hypoxia-induced apoptosis. Hammond EM, Giaccia AJ. Biochem Biophys Res Commun. 2005; 331 (3): 718-25
• Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Chan DA, Sutphin PD, Yen SE, Giaccia AJ. Mol Cell Biol. 2005; 25 (15): 6415-26
• The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Bedogni B, Welford SM, Cassarino DS, Nickoloff BJ, Giaccia AJ, Powell MB. Cancer Cell. 2005; 8 (6): 443-54
• A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. Nelson DW, Cao H, Zhu Y, Sunar-Reeder B, Choi CY, Faix JD, Brown JM, Koong AC, Giaccia AJ, Le QT. Cancer Res. 2005; 65 (14): 6151-8
• Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Cancer Res. 2005; 65 (8): 3171-8
• Adaptive myogenesis under hypoxia. Yun Z, Lin Q, Giaccia AJ. Mol Cell Biol. 2005; 25 (8): 3040-55
• The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Johnson TM, Hammond EM, Giaccia A, Attardi LD. Nat Genet. 2005; 37 (2): 145-52
• Angiogenesis is required for successful bone induction during distraction osteogenesis. Fang TD, Salim A, Xia W, Nacamuli RP, Guccione S, Song HM, Carano RA, Filvaroff EH, Bednarski MD, Giaccia AJ, Longaker MT. J Bone Miner Res. 2005; 20 (7): 1114-24
• The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. Hammond EM, Giaccia AJ. DNA Repair (Amst). 2004 Aug-Sep; 3 (8-9): 1117-22
• Hypoxic gene expression and metastasis. Le QT, Denko NC, Giaccia AJ. Cancer Metastasis Rev. 2004 Aug-Dec; 23 (3-4): 293-310
• Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Hammond EM, Dorie MJ, Giaccia AJ. Cancer Res. 2004; 64 (18): 6556-62
• The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Giaccia AJ, Simon MC, Johnson R. Genes Dev. 2004; 18 (18): 2183-94
• XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. Cancer Res. 2004; 64 (17): 5943-7
• Developmental response to hypoxia. Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, Tibshirani R, Giaccia AJ, Giudice LC. FASEB J. 2004; 18 (12): 1348-65
• The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers. Soltys SG, Le QT, Shi G, Tibshirani R, Giaccia AJ, Koong AC. Clin Cancer Res. 2004; 10 (14): 4806-12
• Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. Salim A, Nacamuli RP, Morgan EF, Giaccia AJ, Longaker MT. J Biol Chem. 2004; 279 (38): 40007-16
• Oxygen-dependent regulation of adipogenesis. Swiersz LM, Giaccia AJ, Yun Z. Methods Enzymol. 2004: 381 387-95
• Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Bedogni B, O'Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB. Cancer Res. 2004; 64 (7): 2552-60
• Dead cells don't form tumors: HIF-dependent cytotoxins. Sutphin PD, Chan DA, Giaccia AJ. Cell Cycle. 2004; 3 (2): 160-3
• Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Le QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ. Clin Cancer Res. 2003; 9 (1): 59-67
• Tumor deprivation of oxygen and tumor suppressor gene function. Yun Z, Giaccia AJ. Methods Mol Biol. 2003: 223 485-504
• Investigating hypoxic tumor physiology through gene expression patterns. Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ. Oncogene. 2003; 22 (37): 5907-14
• HIF-1 as a target for drug development. Giaccia A, Siim BG, Johnson RS. Nat Rev Drug Discov. 2003; 2 (10): 803-11
• Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer. Le QT, Giaccia AJ. Clin Cancer Res. 2003; 9 (12): 4287-95
• ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. Hammond EM, Dorie MJ, Giaccia AJ. J Biol Chem. 2003; 278 (14): 12207-13
• Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Hammond EM, Green SL, Giaccia AJ. Mutat Res. 2003; 532 (1-2): 205-13
• Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Shibata T, Giaccia AJ, Brown JM. Neoplasia. 2002 Jan-Feb; 4 (1): 40-8
• Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Dev Cell. 2002; 2 (3): 331-41
• Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Liu SC, Minton NP, Giaccia AJ, Brown JM. Gene Ther. 2002; 9 (4): 291-6
• Effects of perillyl alcohol on melanoma in the TPras mouse model. Lluria-Prevatt M, Morreale J, Gregus J, Alberts DS, Kaper F, Giaccia A, Powell MB. Cancer Epidemiol Biomarkers Prev. 2002; 11 (6): 573-9
• Antiangiogenic therapy and p53. Hammond EM, Giaccia AJ. Science. 2002; 297 (5581): 471; discussion 471
• Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. J Biol Chem. 2002; 277 (42): 40112-7
• Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Maecker HL, Yun Z, Maecker HT, Giaccia AJ. Cancer Cell. 2002; 2 (2): 139-48
• Hypoxia links ATR and p53 through replication arrest. Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Mol Cell Biol. 2002; 22 (6): 1834-43
• Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice LC. J Clin Endocrinol Metab. 2001; 86 (6): 2653-9
• Genetic determinants that influence hypoxia-induced apoptosis. Alarcon RM, Denko NC, Giaccia AJ. Novartis Found Symp. 2001: 240 115-28; discussion 128-32
• p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Green SL, Freiberg RA, Giaccia AJ. Mol Cell Biol. 2001; 21 (4): 1196-206
• Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Mol Cell Biol. 2001; 21 (4): 1297-310
• Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis. Denko NC, Giaccia AJ. Cancer Res. 2001; 61 (3): 795-8
• Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Chen EY, Mazure NM, Cooper JA, Giaccia AJ. Cancer Res. 2001; 61 (6): 2429-33
• Loss of PTEN facilitates HIF-1-mediated gene expression. Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. Genes Dev. 2000; 14 (4): 391-6
• Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Denko N, Schindler C, Koong A, Laderoute K, Green C, Giaccia A. Clin Cancer Res. 2000; 6 (2): 480-7
• Candidate genes for the hypoxic tumor phenotype. Koong AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT, Terris DJ, Giaccia AJ. Cancer Res. 2000; 60 (4): 883-7
• Development of a hypoxia-responsive vector for tumor-specific gene therapy. Shibata T, Giaccia AJ, Brown JM. Gene Ther. 2000; 7 (6): 493-8
• p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Denko NC, Green SL, Edwards D, Giaccia AJ. Exp Cell Res. 2000; 258 (1): 82-91
• Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. Sugawara J, Suh DS, Faessen GH, Suen LF, Shibata T, Kaper F, Giaccia AJ, Giudice LC. J Clin Endocrinol Metab. 2000; 85 (8): 2714-21
• Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Zundel W, Swiersz LM, Giaccia A. Mol Cell Biol. 2000; 20 (5): 1507-14
• Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. Sugawara J, Tazuke SI, Suen LF, Powell DR, Kaper F, Giaccia AJ, Giudice LC. J Clin Endocrinol Metab. 2000; 85 (10): 3821-7
• p53 promotes selection for Fas-mediated apoptotic resistance. Maecker HL, Koumenis C, Giaccia AJ. Cancer Res. 2000; 60 (16): 4638-44
• Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Alarcón R, Koumenis C, Geyer RK, Maki CG, Giaccia AJ. Cancer Res. 1999; 59 (24): 6046-51
• Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. Popovici RM, Irwin JC, Giaccia AJ, Giudice LC. J Clin Endocrinol Metab. 1999; 84 (6): 2245-8
• Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Chen EY, Fujinaga M, Giaccia AJ. Teratology. 1999; 60 (4): 215-25
• A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy. Wouters BG, Denko NC, Giaccia AJ, Brown JM. Oncogene. 1999; 18 (47): 6540-5
• Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy. Green SL, Giaccia AJ. Cancer J Sci Am. 1998 Jul-Aug; 4 (4): 218-23
• The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury. Lee JE, Kim CY, Giaccia AJ, Giffard RG. Brain Res. 1998; 795 (1-2): 10-6
• The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Brown JM, Giaccia AJ. Cancer Res. 1998; 58 (7): 1408-16
• Acidosis reduces neuronal apoptosis. Xu L, Glassford AJ, Giaccia AJ, Giffard RG. Neuroreport. 1998; 9 (5): 875-9
• Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Rupnow BA, Murtha AD, Alarcon RM, Giaccia AJ, Knox SJ. Cancer Res. 1998; 58 (9): 1779-84
• p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts. Rupnow BA, Alarcon RM, Giaccia AJ, Knox SJ. Cell Death Differ. 1998; 5 (2): 141-7
• Highly conserved RNA sequences that are sensors of environmental stress. Spicher A, Guicherit OM, Duret L, Aslanian A, Sanjines EM, Denko NC, Giaccia AJ, Blau HM. Mol Cell Biol. 1998; 18 (12): 7371-82
• The complexity of p53 modulation: emerging patterns from divergent signals. Giaccia AJ, Kastan MB. Genes Dev. 1998; 12 (19): 2973-83
• Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, Irwin JC, Powell DR, Giaccia AJ, Giudice LC. Proc Natl Acad Sci U S A. 1998; 95 (17): 10188-93
• Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Zundel W, Giaccia A. Genes Dev. 1998; 12 (13): 1941-6
• Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Lemmon MJ, van Zijl P, Fox ME, Mauchline ML, Giaccia AJ, Minton NP, Brown JM. Gene Ther. 1997; 4 (8): 791-6
• Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Koumenis C, Giaccia A. Mol Cell Biol. 1997; 17 (12): 7306-16
• Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Mazure NM, Chen EY, Laderoute KR, Giaccia AJ. Blood. 1997; 90 (9): 3322-31
• Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Wouters BG, Giaccia AJ, Denko NC, Brown JM. Cancer Res. 1997; 57 (21): 4703-6
• Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Kim CY, Tsai MH, Osmanian C, Graeber TG, Lee JE, Giffard RG, DiPaolo JA, Peehl DM, Giaccia AJ. Cancer Res. 1997; 57 (19): 4200-4
• Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation. Bergeron M, Mivechi NF, Giaccia AJ, Giffard RG. Neurol Res. 1996; 18 (1): 64-72
• Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia. Fox ME, Lemmon MJ, Mauchline ML, Davis TO, Giaccia AJ, Minton NP, Brown JM. Gene Ther. 1996; 3 (2): 173-8
• Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ. Cancer Res. 1996; 56 (15): 3436-40
• Modulation of c-Myc activity and apoptosis in vivo. Alarcon RM, Rupnow BA, Graeber TG, Knox SJ, Giaccia AJ. Cancer Res. 1996; 56 (19): 4315-9
• The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P, Allalunis-Turner J, Chen DJ, Fishel R, Giaccia AJ, Brown JM, Kirchgessner CU. Proc Natl Acad Sci U S A. 1996; 93 (24): 13825-30
• Hypoxic Stress Proteins: Survival of the Fittest. Giaccia AJ, Semin Radiat Oncol. 1996; 6 (1): 46-58
• Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Nature. 1996; 379 (6560): 88-91
• New directions for radiation biology research in cancer of the uterine cervix. Kapp DS, Giaccia AJ. J Natl Cancer Inst Monogr. 1996; (21): 131-9
• Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells. Mivechi NF, Giaccia AJ. Cancer Res. 1995; 55 (23): 5512-9
• Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. Mivechi NF, Koong AC, Giaccia AJ, Hahn GM. Int J Hyperthermia. 1994 May-Jun; 10 (3): 371-9
• Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Giaccia AJ. Mol Cell Biol. 1994; 14 (9): 6264-77
• Tumour hypoxia: the picture has changed in the 1990s. Brown JM, Giaccia AJ. Int J Radiat Biol. 1994; 65 (1): 95-102
• The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors. Koong AC, Auger EA, Chen EY, Giaccia AJ. Radiat Res. 1994; 138 (1 Suppl): S60-3
• Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Koong AC, Chen EY, Giaccia AJ. Cancer Res. 1994; 54 (6): 1425-30
• Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Koong AC, Chen EY, Lee AS, Brown JM, Giaccia AJ. Int J Radiat Oncol Biol Phys. 1994; 28 (3): 661-6
• Modulation of potassium channels by protein tyrosine kinase inhibitors. Saad AH, Kuo SS, Koong AC, Hahn GM, Giaccia AJ. J Cell Physiol. 1994; 161 (1): 142-8
• Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ. Cancer Res. 1994; 54 (20): 5273-9
• Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells. Koong AC, Chen EY, Kim CY, Giaccia AJ. Int J Radiat Oncol Biol Phys. 1994; 29 (2): 259-65
• Heat sensitivity of bleomycin-sensitive CHO derivatives is not due to improper initialization of heat shock response. Auger EA, Giaccia AJ, Hahn GM. Int J Hyperthermia. 1993 Mar-Apr; 9 (2): 275-84
• Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Kuo SS, Saad AH, Koong AC, Hahn GM, Giaccia AJ. Proc Natl Acad Sci U S A. 1993; 90 (3): 908-12
• Chromosomal radiosensitivity at intrachromosomal telomeric sites. Alvarez L, Evans JW, Wilks R, Lucas JN, Brown JM, Giaccia AJ. Genes Chromosomes Cancer. 1993; 8 (1): 8-14
• Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549. Koong AC, Giaccia AJ, Hahn GM, Saad AH. J Cell Physiol. 1993; 156 (2): 341-7
• Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. Giaccia AJ, Auger EA, Koong A, Terris DJ, Minchinton AI, Hahn GM, Brown JM. Int J Radiat Oncol Biol Phys. 1992; 23 (4): 891-7
• The use of asymmetric-field inversion gel electrophoresis to predict tumor cell radiosensitivity. Giaccia AJ, Schwartz J, Shieh J, Brown JM. Radiother Oncol. 1992; 24 (4): 231-8
• Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. Kim CY, Giaccia AJ, Strulovici B, Brown JM. Br J Cancer. 1992; 66 (5): 844-9
• What role do glutathione S-transferases play in the cellular response to ionizing radiation? Cholon A, Giaccia AJ, Lewis AD, Hickson I, Brown JM. Int J Radiat Oncol Biol Phys. 1992; 22 (4): 759-63
• Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233. Giaccia AJ, Biedermann KA, Tosto LM, Minchinton AI, Kovacs MS, Brown JM. Int J Radiat Oncol Biol Phys. 1992; 22 (4): 681-4
• The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity. Giaccia AJ, Lewis AD, Denko NC, Cholon A, Evans JW, Waldren CA, Stamato TD, Brown JM. Cancer Res. 1991; 51 (16): 4463-9
• Biochemical evidence for two different mechanisms for bleomycin-induced cell killing. Giaccia AJ, Shieh J, Cholon A, Brown JM. Mutat Res. 1991; 263 (2): 69-75
• Loss of the intrinsic heat resistance of human cells and changes in Mr 70,000 heat shock protein expression in human x hamster hybrids. Anderson RL, Fong KJ, Gabriele T, Lavagnini P, Hahn GM, Evans JW, Waldren CA, Stamato TD, Giaccia AJ. Cancer Res. 1991; 51 (10): 2636-41
• The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage. Evans JW, Chang JA, Giaccia AJ, Pinkel D, Brown JM. Br J Cancer. 1991; 63 (4): 517-21
• scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Biedermann KA, Sun JR, Giaccia AJ, Tosto LM, Brown JM. Proc Natl Acad Sci U S A. 1991; 88 (4): 1394-7
• Use of fluorescent in situ hybridization to detect chromosomal rearrangements in somatic cell hybrids. Giaccia AJ, Evans JW, Brown JM. Genes Chromosomes Cancer. 1990; 2 (3): 248-51