Publications
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Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity.
Woodard LE,
Hillman RT, Keravala A, Lee S, Calos MP.
Gene Ther.
2009
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Mutational derivatives of PhiC31 integrase with increased efficiency and specificity.
Keravala A,
Lee S, Thyagarajan B, Olivares EC, Gabrovsky VE, Woodard LE, Calos MP.
Mol Ther.
2009;
17
(1):
112-20
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Factoring nonviral gene therapy into a cure for hemophilia A.
Gabrovsky V,
Calos MP.
Curr Opin Mol Ther.
2008;
10
(5):
464-70
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Long-term transgene expression in mouse neural progenitor cells modified with phiC31 integrase.
Keravala A,
Ormerod BK, Palmer TD, Calos MP.
J Neurosci Methods.
2008;
173
(2):
299-305
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Site-specific chromosomal integration mediated by phiC31 integrase.
Keravala A,
Calos MP.
Methods Mol Biol.
2008:
435
165-73
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Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid.
Fish MP,
Groth AC, Calos MP, Nusse R.
Nat Protoc.
2007;
2
(10):
2325-31
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Gene transfer to rabbit retina with electron avalanche transfection.
Chalberg TW,
Vankov A, Molnar FE, Butterwick AF, Huie P, Calos MP, Palanker DV.
Invest Ophthalmol Vis Sci.
2006;
47
(9):
4083-90
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Long-term increase in mVEGF164 in mouse hindlimb muscle mediated by phage phiC31 integrase after nonviral DNA delivery.
Portlock JL,
Keravala A, Bertoni C, Lee S, Rando TA, Calos MP.
Hum Gene Ther.
2006;
17
(8):
871-6
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Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.
Bertoni C,
Jarrahian S, Wheeler TM, Li Y, Olivares EC, Calos MP, Rando TA.
Proc Natl Acad Sci U S A.
2006;
103
(2):
419-24
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The phiC31 integrase system for gene therapy.
Calos MP,
Curr Gene Ther.
2006;
6
(6):
633-45
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PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints.
Keravala A,
Portlock JL, Nash JA, Vitrant DG, Robbins PD, Calos MP.
J Gene Med.
2006;
8
(8):
1008-17
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A diversity of serine phage integrases mediate site-specific recombination in mammalian cells.
Keravala A,
Groth AC, Jarrahian S, Thyagarajan B, Hoyt JJ, Kirby PJ, Calos MP.
Mol Genet Genomics.
2006;
276
(2):
135-46
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Integration specificity of phage phiC31 integrase in the human genome.
Chalberg TW,
Portlock JL, Olivares EC, Thyagarajan B, Kirby PJ, Hillman RT, Hoelters J, Calos MP.
J Mol Biol.
2006;
357
(1):
28-48
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phiC31 integrase confers genomic integration and long-term transgene expression in rat retina.
Chalberg TW,
Genise HL, Vollrath D, Calos MP.
Invest Ophthalmol Vis Sci.
2005;
46
(6):
2140-6
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Site-specific integration with phiC31 integrase for prolonged expression of therapeutic genes.
Ginsburg DS,
Calos MP.
Adv Genet.
2005:
54
179-87
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Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31.
Groth AC,
Fish M, Nusse R, Calos MP.
Genetics.
2004;
166
(4):
1775-82
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Phage integrases: biology and applications.
Groth AC,
Calos MP.
J Mol Biol.
2004;
335
(3):
667-78
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Epstein-Barr virus vectors provide prolonged robust factor IX expression in mice.
Sclimenti CR,
Neviaser AS, Baba EJ, Meuse L, Kay MA, Calos MP.
Biotechnol Prog.
2003 Jan-Feb;
19
(1):
144-51
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Phage integrases for the construction and manipulation of transgenic mammals.
Hollis RP,
Stoll SM, Sclimenti CR, Lin J, Chen-Tsai Y, Calos MP.
Reprod Biol Endocrinol.
2003:
1
79
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Site-specific genomic strategies for gene therapy.
Portlock JL,
Calos MP.
Curr Opin Mol Ther.
2003;
5
(4):
376-82
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PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa.
Ortiz-Urda S,
Thyagarajan B, Keene DR, Lin Q, Calos MP, Khavari PA.
Hum Gene Ther.
2003;
14
(9):
923-8
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Site-specific genomic integration produces therapeutic Factor IX levels in mice.
Olivares EC,
Hollis RP, Chalberg TW, Meuse L, Kay MA, Calos MP.
Nat Biotechnol.
2002;
20
(11):
1124-8
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Phage TP901-1 site-specific integrase functions in human cells.
Stoll SM,
Ginsburg DS, Calos MP.
J Bacteriol.
2002;
184
(13):
3657-63
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Extrachromosomal plasmid vectors for gene therapy.
Stoll SM,
Calos MP.
Curr Opin Mol Ther.
2002;
4
(4):
299-305
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Stable nonviral genetic correction of inherited human skin disease.
Ortiz-Urda S,
Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA.
Nat Med.
2002;
8
(10):
1166-70
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Directed evolution of a recombinase for improved genomic integration at a native human sequence.
Sclimenti CR,
Thyagarajan B, Calos MP.
Nucleic Acids Res.
2001;
29
(24):
5044-51
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Phage R4 integrase mediates site-specific integration in human cells.
Olivares EC,
Hollis RP, Calos MP.
Gene.
2001;
278
(1-2):
167-76
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Epstein-Barr virus/human vector provides high-level, long-term expression of alpha1-antitrypsin in mice.
Stoll SM,
Sclimenti CR, Baba EJ, Meuse L, Kay MA, Calos MP.
Mol Ther.
2001;
4
(2):
122-9
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Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase.
Thyagarajan B,
Olivares EC, Hollis RP, Ginsburg DS, Calos MP.
Mol Cell Biol.
2001;
21
(12):
3926-34
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A phage integrase directs efficient site-specific integration in human cells.
Groth AC,
Olivares EC, Thyagarajan B, Calos MP.
Proc Natl Acad Sci U S A.
2000;
97
(11):
5995-6000
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Mammalian genomes contain active recombinase recognition sites.
Thyagarajan B,
Guimarães MJ, Groth AC, Calos MP.
Gene.
2000;
244
(1-2):
47-54
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An extrachromosomal tetracycline-regulatable system for mammalian cells.
Sclimenti CR,
Baba EJ, Calos MP.
Nucleic Acids Res.
2000;
28
(17):
E80
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Epstein-Barr virus plasmid model system for analyzing recombination in human cells.
Phillips JE,
Thyagarajan B, Calos MP.
Plasmid.
1999;
41
(3):
198-206
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Effects of homology length and donor vector arrangement on the efficiency of double-strand break-mediated recombination in human cells.
Phillips JE,
Calos MP.
Somat Cell Mol Genet.
1999;
25
(2):
91-100
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EBV vectors for gene expression and delivery
Calos, M.P.,
Sclimenti, C.R..
Current Opinion Biotechnology.
1998
9
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Epstein-Barr virus vectors for gene expression and transfer.
Sclimenti CR,
Calos MP.
Curr Opin Biotechnol.
1998;
9
(5):
476-9
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Stability without a centromere.
Calos MP,
Proc Natl Acad Sci U S A.
1998;
95
(8):
4084-5
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Telomeric sequences from human herpesvirus 6 do not mediate nuclear retention of episomal DNA in human cells.
Bulboaca GH,
Deng H, Dewhurst S, Calos MP.
Arch Virol.
1998;
143
(3):
563-70
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Assaying extrachromosomal gene therapy vectors that carry replication/persistence elements.
Calos MP,
Sclimenti CR.
Adv Drug Deliv Rev.
1998;
30
(1-3):
13-21
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The potential of extrachromosomal replicating vectors for gene therapy.
Calos MP,
Trends Genet.
1996;
12
(11):
463-6
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Long-term gene expression from autonomously replicating vectors in mammalian cells.
Wohlgemuth JG,
Kang SH, Bulboaca GH, Nawotka KA, Calos MP.
Gene Ther.
1996;
3
(6):
503-12
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Replication of centromere II of Schizosaccharomyces pombe.
Smith JG,
Caddle MS, Bulboaca GH, Wohlgemuth JG, Baum M, Clarke L, Calos MP.
Mol Cell Biol.
1995;
15
(9):
5165-72
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Autonomous replication in Drosophila melanogaster tissue culture cells.
Smith JG,
Calos MP.
Chromosoma.
1995;
103
(9):
597-605
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Transcription inhibits the replication of autonomously replicating plasmids in human cells.
Haase SB,
Heinzel SS, Calos MP.
Mol Cell Biol.
1994;
14
(4):
2516-24
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Physical mapping of origins of replication in the fission yeast Schizosaccharomyces pombe.
Wohlgemuth JG,
Bulboaca GH, Moghadam M, Caddle MS, Calos MP.
Mol Biol Cell.
1994;
5
(8):
839-49
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Specific initiation at an origin of replication from Schizosaccharomyces pombe.
Caddle MS,
Calos MP.
Mol Cell Biol.
1994;
14
(3):
1796-805
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The replication behavior of Saccharomyces cerevisiae DNA in human cells.
Tran CT,
Caddle MS, Calos MP.
Chromosoma.
1993;
102
(2):
129-36
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Autonomous replication in human cells of multimers of specific human and bacterial DNA sequences.
Krysan PJ,
Smith JG, Calos MP.
Mol Cell Biol.
1993;
13
(5):
2688-96
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Epstein-Barr virus-based vectors that replicate in rodent cells.
Krysan PJ,
Calos MP.
Gene.
1993;
136
(1-2):
137-43
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Analysis of the autonomous replication behavior in human cells of the dihydrofolate reductase putative chromosomal origin of replication.
Caddle MS,
Calos MP.
Nucleic Acids Res.
1992;
20
(22):
5971-8
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Replication initiates at multiple locations on an autonomously replicating plasmid in human cells.
Krysan PJ,
Calos MP.
Mol Cell Biol.
1991;
11
(3):
1464-72
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Autonomous DNA replication in human cells is affected by the size and the source of the DNA.
Heinzel SS,
Krysan PJ, Tran CT, Calos MP.
Mol Cell Biol.
1991;
11
(4):
2263-72
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Replication control of autonomously replicating human sequences.
Haase SB,
Calos MP.
Nucleic Acids Res.
1991;
19
(18):
5053-8
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Improved EBV shuttle vectors.
Haase SB,
Heinzel SS, Krysan PJ, Calos MP.
Mutat Res.
1989 Mar-May;
220
(2-3):
125-32
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Isolation of human sequences that replicate autonomously in human cells.
Krysan PJ,
Haase SB, Calos MP.
Mol Cell Biol.
1989;
9
(3):
1026-33
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Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells.
Heinzel SS,
Krysan PJ, Calos MP, DuBridge RB.
J Virol.
1988;
62
(10):
3738-46
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Recombinant shuttle vectors for the study of mutation in mammalian cells.
DuBridge RB,
Calos MP.
Mutagenesis.
1988;
3
(1):
1-9
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