Publications
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Association of age and packed red blood cell transfusion to 1-year survival - an observational study of ICU patients.
Mudumbai SC,
Cronkite R, Hu KU, Heidenreich PA, Gonzalez C, Bertaccini E, Stafford RS, Cason BA, Mariano ER, Wagner T.
Transfus Med.
2013
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Induced changes in protein receptors conferring resistance to anesthetics.
Bertaccini EJ,
Trudell JR.
Curr Opin Anaesthesiol.
2012;
25
(4):
405-10
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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.
Murail S,
Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E.
PLoS Comput Biol.
2012;
8
(10):
e1002710
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Teaching an old GABA receptor new tricks.
Trudell JR,
Bertaccini E, Maciver MB.
Anesth Analg.
2012;
115
(2):
270-3
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Association of admission hematocrit with 6-month and 1-year mortality in intensive care unit patients.
Mudumbai SC,
Cronkite R, Hu KU, Wagner T, Hayashi K, Ozanne GM, Davies MF, Heidenreich P, Bertaccini E.
Transfusion.
2011;
51
(10):
2148-59
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Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.
Murail S,
Wallner B, Trudell JR, Bertaccini E, Lindahl E.
Biophys J.
2011;
100
(7):
1642-50
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Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.
Todorovic J,
Welsh BT, Bertaccini EJ, Trudell JR, Mihic SJ.
Proc Natl Acad Sci U S A.
2010;
107
(17):
7987-92
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ICU Management after Cardiac Surgery
Bertaccini E,
Wall M, Roberts P, Farmer JC.
Pocket ICU Management, 2nd edition (electronic).
2010
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ICU Management after Thoracic Aorta Surgery
Bertaccini E,
Wall M, Roberts P, Farmer JC.
Pocket ICU Management, 2nd edition (electronic).
2010
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Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4.
Bertaccini EJ,
Wallner B, Trudell JR, Lindahl E.
J Chem Inf Model.
2010;
50
(12):
2248-55
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Normal mode gating motions of a ligand-gated ion channel persist in a fully hydrated lipid bilayer model.
Bertaccini EJ,
Trudell JR, Lindahl E.
ACS Chem Neurosci.
2010;
1
(8):
552-8
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The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling
Bertaccini E,
Pharmaceuticals.
2010;
3
(7):
2178-2196
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Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein.
Bertaccini EJ,
Lindahl E, Sixma T, Trudell JR.
J Chem Inf Model.
2008;
48
(4):
855-60
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Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit.
Trudell JR,
Yue ME, Bertaccini EJ, Jenkins A, Harrison NL.
J Chem Inf Model.
2008;
48
(2):
344-9
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Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.
Crawford DK,
Perkins DI, Trudell JR, Bertaccini EJ, Davies DL, Alkana RL.
J Biol Chem.
2008;
283
(41):
27698-706
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Normal-mode analysis of the glycine alpha1 receptor by three separate methods.
Bertaccini EJ,
Trudell JR, Lindahl E.
J Chem Inf Model.
2007 Jul-Aug;
47
(4):
1572-9
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Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.
Crawford DK,
Trudell JR, Bertaccini EJ, Li K, Davies DL, Alkana RL.
J Neurochem.
2007;
102
(6):
2097-109
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The common chemical motifs within anesthetic binding sites.
Bertaccini EJ,
Trudell JR, Franks NP.
Anesth Analg.
2007;
104
(2):
318-24
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Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site.
Bertaccini EJ,
Shapiro J, Brutlag DL, Trudell JR.
J Chem Inf Model.
2005 Jan-Feb;
45
(1):
128-35
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Normal Mode Analysis Reveals the Channel Gating Motion within a Ligand Gated Ion Channel Model
Bertaccini E,
Trudell JR, Lindahl E.
Proceedings of the 7th International Conference on Basic and Systematic Mechanisms of Anesthesia Nara, Japan 25-27 February 2005, International Congress Series.
2005:
1283
160-163
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Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates.
Trudell JR,
Bertaccini E.
J Mol Graph Model.
2004;
23
(1):
39-49
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Correlation of approximate entropy, bispectral index, and spectral edge frequency 95 (SEF95) with clinical signs of "anesthetic depth" during coadministration of propofol and remifentanil.
Bruhn J,
Bouillon TW, Radulescu L, Hoeft A, Bertaccini E, Shafer SL.
Anesthesiology.
2003;
98
(3):
621-7
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Use of a fully simulated intensive care unit environment for critical event management training for internal medicine residents.
Lighthall GK,
Barr J, Howard SK, Gellar E, Sowb Y, Bertacini E, Gaba D.
Crit Care Med.
2003;
31
(10):
2437-43
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Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype.
Takada K,
Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M.
Anesthesiology.
2002;
96
(6):
1420-6
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Molecular modelling of anesthetic binding sites in ligand-gated ion channels
Trudell JR,
Bertaccini, E.
Molecular and Basic Mechanisms of Anesthesia, Pabst Science Publishers.
2002:
18-22
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Molecular modelling of specific and non-specific anaesthetic interactions.
Trudell JR,
Bertaccini E.
Br J Anaesth.
2002;
89
(1):
32-40
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Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil.
Bouillon T,
Bruhn J, Radu-Radulescu L, Bertaccini E, Park S, Shafer S.
Anesthesiology.
2002;
97
(6):
1350-62
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Predicting the transmembrane secondary structure of ligand-gated ion channels.
Bertaccini E,
Trudell JR.
Protein Eng.
2002;
15
(6):
443-54
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A double-blind, randomized comparison of i.v. lorazepam versus midazolam for sedation of ICU patients via a pharmacologic model.
Barr J,
Zomorodi K, Bertaccini EJ, Shafer SL, Geller E.
Anesthesiology.
2001;
95
(2):
286-98
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Anesthetics and ion channels: molecular models and sites of action.
Yamakura T,
Bertaccini E, Trudell JR, Harris RA.
Annu Rev Pharmacol Toxicol.
2001:
41
23-51
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Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.
Jenkins A,
Greenblatt EP, Faulkner HJ, Bertaccini E, Light A, Lin A, Andreasen A, Viner A, Trudell JR, Harrison NL.
J Neurosci.
2001;
21
(6):
RC136
-
Molecular modeling of ligand-gated ion channels: progress and challenges.
Bertaccini E,
Trudell JR.
Int Rev Neurobiol.
2001:
48
141-66
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The Interface Of Molecular Modeling and Molecular Genetics: A Search for Sites of Anesthetic Action
Trudell J,
Bertaccini E, Eger EI, Harrison NL, Mihic SJ, Harris RA.
Progress in Anesthesia Mechanisms.
2000:
6
172-178
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Evaluation of forcefields for molecular mechanics/dynamics calculations involving halogenated anesthetics.
Trudell JR,
Bertaccini E.
Toxicol Lett.
1998:
100-101
413-9
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The Pharmacology of ICU Sedation: A Review
Hill L,
Bertaccini E, Barr J, Geller E.
Journal of Intensive Care Medicine.
1998;
13
(4):
174-183
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Benzodiazepine Antagonists And Their Role In Anesthesia And Critical Care
Bertaccini E,
Geller E.
Anaesthetic Pharmacology Review.
1995;
3
(1):
74-81
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Molecular dynamics simulation of anesthetic-phospholipid bilayer interactions.
Huang P,
Bertaccini E, Loew GH.
J Biomol Struct Dyn.
1995;
12
(4):
725-54
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Use of whole bowel irrigation in an infant following iron overdose.
Everson GW,
Bertaccini EJ, O'Leary J.
Am J Emerg Med.
1991;
9
(4):
366-9
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