Publications
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Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands.
Chang CL,
Park JI, Hsu SY.
J Biol Chem.
2009
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Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability.
Pfeil U,
Aslam M, Paddenberg R, Quanz K, Chang CL, Park JI, Gries B, Rafiq A, Faulhammer P, Goldenberg A, Papadakis T, Noll T, Hsu SY, Weissmann N, Kummer W.
Am J Physiol Lung Cell Mol Physiol.
2009;
297
(5):
L837-45
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GPCR genes are preferentially retained after whole genome duplication.
Semyonov J,
Park JI, Chang CL, Hsu SY.
PLoS One.
2008;
3
(4):
e1903
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Origin of INSL3-mediated testicular descent in therian mammals.
Park JI,
Semyonov J, Chang CL, Yi W, Warren W, Hsu SY.
Genome Res.
2008;
18
(6):
974-85
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Regulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogs.
Park JI,
Semyonov J, Yi W, Chang CL, Hsu SY.
J Biol Chem.
2008;
283
(46):
32099-109
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Intermedin: a skin peptide that is downregulated in atopic dermatitis.
Kindt F,
Wiegand S, Löser C, Nilles M, Niemeier V, Hsu SY, Steinhoff M, Kummer W, Gieler U, Haberberger RV.
J Invest Dermatol.
2007;
127
(3):
605-13
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Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary.
Dissen GA,
Garcia-Rudaz C, Tapia V, Parada LF, Hsu SY, Ojeda SR.
Endocrinology.
2006;
147
(1):
155-65
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New Insights into biological roles of relaxin and relaxin-related peptides.
Park JI,
Chang CL, Hsu SY.
Rev Endocr Metab Disord.
2005;
6
(4):
291-6
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Intermedin functions as a pituitary paracrine factor regulating prolactin release.
Lin Chang C,
Roh J, Park JI, Klein C, Cushman N, Haberberger RV, Hsu SY.
Mol Endocrinol.
2005;
19
(11):
2824-38
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Relaxin research in the postgenomic era.
Kawamura K,
Sudo S, Kumagai J, Pisarska M, Hsu SY, Bathgate R, Wade J, Hsueh AJ.
Ann N Y Acad Sci.
2005:
1041
1-7
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Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.
Sudo S,
Kuwabara Y, Park JI, Hsu SY, Hsueh AJ.
Endocrinology.
2005;
146
(8):
3596-604
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Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
Luo CW,
Dewey EM, Sudo S, Ewer J, Hsu SY, Honegger HW, Hsueh AJ.
Proc Natl Acad Sci U S A.
2005;
102
(8):
2820-5
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Evolution of the signaling system in relaxin-family peptides.
Hsu SY,
Semyonov J, Park JI, Chang CL.
Ann N Y Acad Sci.
2005:
1041
520-9
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Conservation of the heterodimeric glycoprotein hormone subunit family proteins and the LGR signaling system from nematodes to humans.
Park JI,
Semyonov J, Chang CL, Hsu SY.
Endocrine.
2005;
26
(3):
267-76
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Bioinformatics in reproductive biology--functional annotation based on comparative sequence analysis.
Hsu SY,
J Reprod Immunol.
2004;
63
(1):
75-83
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Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes.
Roh J,
Chang CL, Bhalla A, Klein C, Hsu SY.
J Biol Chem.
2004;
279
(8):
7264-74
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Relaxin signaling in reproductive tissues.
Hsu SY,
Nakabayashi K, Nishi S, Kumagai J, Kudo M, Bathgate RA, Sherwood OD, Hsueh AJ.
Mol Cell Endocrinol.
2003;
202
(1-2):
165-70
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New insights into the evolution of the relaxin-LGR signaling system.
Hsu SY,
Trends Endocrinol Metab.
2003;
14
(7):
303-9
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Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.
Nakabayashi K,
Matsumi H, Bhalla A, Bae J, Mosselman S, Hsu SY, Hsueh AJ.
J Clin Invest.
2002;
109
(11):
1445-52
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Activation of orphan receptors by the hormone relaxin.
Hsu SY,
Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ.
Science.
2002;
295
(5555):
671-4
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INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.
Kumagai J,
Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RA, Hsueh AJ.
J Biol Chem.
2002;
277
(35):
31283-6
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Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.
Hsu SY,
Nakabayashi K, Bhalla A.
Mol Endocrinol.
2002;
16
(7):
1538-51
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Hormonal genomics.
Leo CP,
Hsu SY, Hsueh AJ.
Endocr Rev.
2002;
23
(3):
369-81
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Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.
Bae J,
Hsu SY, Leo CP, Zell K, Hsueh AJ.
Apoptosis.
2001;
6
(5):
319-30
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Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.
Hsu SY,
Hsueh AJ.
Nat Med.
2001;
7
(5):
605-11
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Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules.
Vitt UA,
Hsu SY, Hsueh AJ.
Mol Endocrinol.
2001;
15
(5):
681-94
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The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells.
Kudo M,
Chen T, Nakabayashi K, Hsu SY, Hsueh AJ.
Mol Endocrinol.
2000;
14
(2):
272-84
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MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.
Bae J,
Leo CP, Hsu SY, Hsueh AJ.
J Biol Chem.
2000;
275
(33):
25255-61
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Discovering new hormones, receptors, and signaling mediators in the genomic era.
Hsu SY,
Hsueh AJ.
Mol Endocrinol.
2000;
14
(5):
594-604
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Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigm.
Hsu SY,
Hsueh AJ.
Physiol Rev.
2000;
80
(2):
593-614
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Characterization of two fly LGR (leucine-rich repeat-containing, G protein-coupled receptor) proteins homologous to vertebrate glycoprotein hormone receptors: constitutive activation of wild-type fly LGR1 but not LGR2 in transfected mammalian cells.
Nishi S,
Hsu SY, Zell K, Hsueh AJ.
Endocrinology.
2000;
141
(11):
4081-90
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Hormonal regulation of early follicle development in the rat ovary.
Hsueh AJ,
McGee EA, Hayashi M, Hsu SY.
Mol Cell Endocrinol.
2000;
163
(1-2):
95-100
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The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7.
Hsu SY,
Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ.
Mol Endocrinol.
2000;
14
(8):
1257-71
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Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary.
Leo CP,
Hsu SY, Chun SY, Bae HW, Hsueh AJ.
Endocrinology.
1999;
140
(12):
5469-77
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Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence.
Chun SY,
McGee EA, Hsu SY, Minami S, LaPolt PS, Yao HH, Bahr JM, Gougeon A, Schomberg DW, Hsueh AJ.
Biol Reprod.
1999;
60
(2):
365-73
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Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney.
Hsu SY,
Mol Endocrinol.
1999;
13
(12):
2163-74
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Intracellular mechanisms of ovarian cell apoptosis.
Hsu SY,
Hsueh AJ.
Mol Cell Endocrinol.
1998;
145
(1-2):
21-5
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BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members.
Hsu SY,
Lin P, Hsueh AJ.
Mol Endocrinol.
1998;
12
(9):
1432-40
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Cell death and survival during ovarian follicle development.
McGee EA,
Hsu SY, Kaipia A, Hsueh AJ.
Mol Cell Endocrinol.
1998;
140
(1-2):
15-8
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DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells.
Leo CP,
Hsu SY, McGee EA, Salanova M, Hsueh AJ.
Endocrinology.
1998;
139
(12):
4839-48
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Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region.
Hsu SY,
Liang SG, Hsueh AJ.
Mol Endocrinol.
1998;
12
(12):
1830-45
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A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro.
Hsu SY,
Hsueh AJ.
J Biol Chem.
1998;
273
(46):
30139-46
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Expression and function of a proapoptotic Bcl-2 family member Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary.
Kaipia A,
Hsu SY, Hsueh AJ.
Endocrinology.
1997;
138
(12):
5497-504
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Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.
Hsu SY,
Kaipia A, McGee E, Lomeli M, Hsueh AJ.
Proc Natl Acad Sci U S A.
1997;
94
(23):
12401-6
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Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.
Hsu SY,
Kaipia A, Zhu L, Hsueh AJ.
Mol Endocrinol.
1997;
11
(12):
1858-67
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Preantral ovarian follicles in serum-free culture: suppression of apoptosis after activation of the cyclic guanosine 3',5'-monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone.
McGee E,
Spears N, Minami S, Hsu SY, Chun SY, Billig H, Hsueh AJ.
Endocrinology.
1997;
138
(6):
2417-24
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Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis.
Hsu SY,
Lai RJ, Finegold M, Hsueh AJ.
Endocrinology.
1996;
137
(11):
4837-43
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Gonadal cell apoptosis.
Hsueh AJ,
Eisenhauer K, Chun SY, Hsu SY, Billig H.
Recent Prog Horm Res.
1996:
51
433-55; discussion 455-6
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Different 5'-flanking regions of the inhibin-alpha gene target transgenes to the gonad and adrenal in an age-dependent manner in transgenic mice.
Hsu SY,
Lai RJ, Nanuel D, Hsueh AJ.
Endocrinology.
1995;
136
(12):
5577-86
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Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter.
Hsu SY,
Kubo M, Chun SY, Haluska FG, Housman DE, Hsueh AJ.
Mol Endocrinol.
1995;
9
(10):
1356-66
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