Publications
-
New technologies and their impact on 'omics' research.
Bogyo M,
Rudd PM.
Curr Opin Chem Biol.
2013;
17
(1):
1-3
-
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.
Verdoes M,
Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, Bachmann MH, Ellman JA, Bogyo M.
Chem Biol.
2012;
19
(5):
619-28
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An optimized activity-based probe for the study of caspase-6 activation.
Edgington LE,
van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.
Chem Biol.
2012;
19
(3):
340-52
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Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.
Puri AW,
Broz P, Shen A, Monack DM, Bogyo M.
Nat Chem Biol.
2012;
8
(9):
745-7
-
New approaches for dissecting protease functions to improve probe development and drug discovery.
Deu E,
Verdoes M, Bogyo M.
Nat Struct Mol Biol.
2012;
19
(1):
9-16
-
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Lee J,
Bogyo M.
Bioorg Med Chem Lett.
2012;
22
(3):
1340-3
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Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity.
Li H,
Ponder EL, Verdoes M, Asbjornsdottir KH, Deu E, Edgington LE, Lee JT, Kirk CJ, Demo SD, Williamson KC, Bogyo M.
Chem Biol.
2012;
19
(12):
1535-45
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Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
Hall CI,
Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M.
Proc Natl Acad Sci U S A.
2011;
108
(26):
10568-73
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Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
Shen A,
Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M.
Nat Struct Mol Biol.
2011;
18
(3):
364-71
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Development of activity-based probes for cathepsin X.
Paulick MG,
Bogyo M.
ACS Chem Biol.
2011;
6
(6):
563-72
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Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
Albrow VE,
Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M.
Chem Biol.
2011;
18
(6):
722-32
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Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
Ponder EL,
Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M.
Chem Biol.
2011;
18
(6):
711-21
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Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes.
Edgington LE,
Verdoes M, Bogyo M.
Curr Opin Chem Biol.
2011;
15
(6):
798-805
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Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte.
Bowyer PW,
Simon GM, Cravatt BF, Bogyo M.
Mol Cell Proteomics.
2011;
10
(5):
M110.001636
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Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.
Ren G,
Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS, Bogyo M, Cheng Z.
PLoS One.
2011;
6
(11):
e28029
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Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
Lee J,
Bogyo M.
ACS Chem Biol.
2010;
5
(2):
233-43
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Finding enzymes that are actively involved in cancer.
Bogyo M,
Proc Natl Acad Sci U S A.
2010;
107
(6):
2379-80
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Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.
Deu E,
Leyva MJ, Albrow VE, Rice MJ, Ellman JA, Bogyo M.
Chem Biol.
2010;
17
(8):
808-19
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Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.
Puri AW,
Lupardus PJ, Deu E, Albrow VE, Garcia KC, Bogyo M, Shen A.
Chem Biol.
2010;
17
(11):
1201-11
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Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.
Deu E,
Yang Z, Wang F, Klemba M, Bogyo M.
PLoS One.
2010;
5
(8):
e11985
-
4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion.
Ravindran S,
Lodoen MB, Verhelst SH, Bogyo M, Boothroyd JC.
PLoS One.
2009;
4
(12):
e8143
-
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.
Barbero S,
Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG.
Cancer Res.
2009;
69
(9):
3755-63
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Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity.
Blum G,
Weimer RM, Edgington LE, Adams W, Bogyo M.
PLoS One.
2009;
4
(7):
e6374
-
Design, syntheses, and evaluation of Taspase1 inhibitors.
Lee JT,
Chen DY, Yang Z, Ramos AD, Hsieh JJ, Bogyo M.
Bioorg Med Chem Lett.
2009;
19
(17):
5086-90
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Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases.
Yang Z,
Fonović M, Verhelst SH, Blum G, Bogyo M.
Bioorg Med Chem.
2009;
17
(3):
1071-8
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Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Shen A,
Lupardus PJ, Albrow VE, Guzzetta A, Powers JC, Garcia KC, Bogyo M.
Nat Chem Biol.
2009;
5
(7):
469-78
-
Metabolomics cuts to the chase to chase the cuts.
Bogyo M,
Nat Chem Biol.
2009;
5
(1):
5-6
-
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes.
Edgington LE,
Berger AB, Blum G, Albrow VE, Paulick MG, Lineberry N, Bogyo M.
Nat Med.
2009;
15
(8):
967-73
-
Rab35 controls actin bundling by recruiting fascin as an effector protein.
Zhang J,
Fonovic M, Suyama K, Bogyo M, Scott MP.
Science.
2009;
325
(5945):
1250-4
-
Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag.
Shen A,
Lupardus PJ, Morell M, Ponder EL, Sadaghiani AM, Garcia KC, Bogyo M.
PLoS One.
2009;
4
(12):
e8119
-
Using small molecules to dissect mechanisms of microbial pathogenesis.
Puri AW,
Bogyo M.
ACS Chem Biol.
2009;
4
(8):
603-16
-
VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.
Chang SH,
Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF.
Cancer Res.
2009;
69
(10):
4537-44
-
Activity-based probes as a tool for functional proteomic analysis of proteases.
Fonović M,
Bogyo M.
Expert Rev Proteomics.
2008;
5
(5):
721-30
-
Application of activity-based probes to the study of enzymes involved in cancer progression.
Paulick MG,
Bogyo M.
Curr Opin Genet Dev.
2008;
18
(1):
97-106
-
Friend or foe? Turning a host defense protein into a pathogen's accomplice.
Shen A,
Bogyo M.
Chem Biol.
2008;
15
(9):
879-80
-
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.
Arastu-Kapur S,
Ponder EL, Fonović UP, Yeoh S, Yuan F, Fonović M, Grainger M, Phillips CI, Powers JC, Bogyo M.
Nat Chem Biol.
2008;
4
(3):
203-13
-
Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X.
Obermajer N,
Svajger U, Bogyo M, Jeras M, Kos J.
J Leukoc Biol.
2008;
84
(5):
1306-15
-
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.
Lupardus PJ,
Shen A, Bogyo M, Garcia KC.
Science.
2008;
322
(5899):
265-8
-
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.
Schurigt U,
Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, Reinheckel T.
Biol Chem.
2008;
389
(8):
1067-74
-
A mild chemically cleavable linker system for functional proteomic applications.
Verhelst SH,
Fonović M, Bogyo M.
Angew Chem Int Ed Engl.
2007;
46
(8):
1284-6
-
Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening.
Fonović M,
Bogyo M.
Curr Pharm Des.
2007;
13
(3):
253-61
-
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain.
Sexton KB,
Witte MD, Blum G, Bogyo M.
Bioorg Med Chem Lett.
2007;
17
(3):
649-53
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Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases.
Sadaghiani AM,
Verhelst SH, Gocheva V, Hill K, Majerova E, Stinson S, Joyce JA, Bogyo M.
Chem Biol.
2007;
14
(5):
499-511
-
Finding the needles in the haystack: mapping constitutive proteolytic events in vivo.
Bogyo M,
Biochem J.
2007;
407
(1):
e1-2
-
Influenza A virus elevates active cathepsin B in primary murine DC.
Burster T,
Giffon T, Dahl ME, Björck P, Bogyo M, Weber E, Mahmood K, Lewis DB, Mellins ED.
Int Immunol.
2007;
19
(5):
645-55
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Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus.
Rose PP,
Bogyo M, Moses AV, Früh K.
J Virol.
2007;
81
(15):
8050-62
-
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.
Blum G,
von Degenfeld G, Merchant MJ, Blau HM, Bogyo M.
Nat Chem Biol.
2007;
3
(10):
668-77
-
Proteomics evaluation of chemically cleavable activity-based probes.
Fonović M,
Verhelst SH, Sorum MT, Bogyo M.
Mol Cell Proteomics.
2007;
6
(10):
1761-70
-
Specificity of aza-peptide electrophile activity-based probes of caspases.
Sexton KB,
Kato D, Berger AB, Fonovic M, Verhelst SH, Bogyo M.
Cell Death Differ.
2007;
14
(4):
727-32
-
Tagging and detection strategies for activity-based proteomics.
Sadaghiani AM,
Verhelst SH, Bogyo M.
Curr Opin Chem Biol.
2007;
11
(1):
20-8
-
Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa.
Ponder EL,
Bogyo M.
Eukaryot Cell.
2007;
6
(11):
1943-52
-
Solid-phase methods for the preparation of epoxysuccinate-based inhibitors of cysteine proteases.
Sadaghiani AM,
Verhelst SH, Bogyo M.
J Comb Chem.
2006 Nov-Dec;
8
(6):
802-4
-
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.
Yuan F,
Verhelst SH, Blum G, Coussens LM, Bogyo M.
J Am Chem Soc.
2006;
128
(17):
5616-7
-
Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity.
Berger AB,
Sexton KB, Bogyo M.
Cell Res.
2006;
16
(12):
961-3
-
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
Berger AB,
Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M.
Mol Cell.
2006;
23
(4):
509-21
-
Metalloproteases see the light.
Bogyo M,
Nat Chem Biol.
2006;
2
(5):
229-30
-
Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases.
Verhelst SH,
Witte MD, Arastu-Kapur S, Fonovic M, Bogyo M.
Chembiochem.
2006;
7
(6):
943-50
-
A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases.
Kato D,
Verhelst SH, Sexton KB, Bogyo M.
Org Lett.
2005;
7
(25):
5649-52
-
Activity-based probes that target diverse cysteine protease families.
Kato D,
Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M.
Nat Chem Biol.
2005;
1
(1):
33-8
-
Chemical proteomics applied to target identification and drug discovery.
Verhelst SH,
Bogyo M.
Biotechniques.
2005;
38
(2):
175-7
-
Dynamic imaging of protease activity with fluorescently quenched activity-based probes.
Blum G,
Mullins SR, Keren K, Fonovic M, Jedeszko C, Rice MJ, Sloane BF, Bogyo M.
Nat Chem Biol.
2005;
1
(4):
203-9
-
Proteomics meets microbiology: technical advances in the global mapping of protein expression and function.
Phillips CI,
Bogyo M.
Cell Microbiol.
2005;
7
(8):
1061-76
-
Screening for selective small molecule inhibitors of the proteasome using activity-based probes.
Bogyo M,
Methods Enzymol.
2005:
399
609-22
-
Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases.
Verhelst SH,
Bogyo M.
Chembiochem.
2005;
6
(5):
824-7
-
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.
Goulet B,
Baruch A, Moon NS, Poirier M, Sansregret LL, Erickson A, Bogyo M, Nepveu A.
Mol Cell.
2004;
14
(2):
207-19
-
Activity profiling of papain-like cysteine proteases in plants.
van der Hoorn RA,
Leeuwenburgh MA, Bogyo M, Joosten MH, Peck SC.
Plant Physiol.
2004;
135
(3):
1170-8
-
Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery.
Berger AB,
Vitorino PM, Bogyo M.
Am J Pharmacogenomics.
2004;
4
(6):
371-81
-
Applications for chemical probes of proteolytic activity.
Bogyo M,
Baruch A, Jeffery DA, Greenbaum D, Borodovsky A, Ovaa H, Kessler B.
Curr Protoc Protein Sci.
2004:
Chapter 21
Unit 21.17
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Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones.
Hook V,
Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M.
Biol Chem.
2004;
385
(6):
473-80
-
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.
Yasuda Y,
Li Z, Greenbaum D, Bogyo M, Weber E, Brömme D.
J Biol Chem.
2004;
279
(35):
36761-70
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
Joyce JA,
Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M, Hanahan D.
Cancer Cell.
2004;
5
(5):
443-53
-
Enzyme activity--it's all about image.
Baruch A,
Jeffery DA, Bogyo M.
Trends Cell Biol.
2004;
14
(1):
29-35
-
Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis.
Oleksy A,
Golonka E, Bańbuła A, Szmyd G, Moon J, Kubica M, Greenbaum D, Bogyo M, Foster TJ, Travis J, Potempa J.
Biol Chem.
2004;
385
(6):
525-35
-
O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes.
Medzihradszky KF,
Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL.
Mol Cell Proteomics.
2004;
3
(5):
429-40
-
Regulation of collagenase activities of human cathepsins by glycosaminoglycans.
Li Z,
Yasuda Y, Li W, Bogyo M, Katz N, Gordon RE, Fields GB, Brömme D.
J Biol Chem.
2004;
279
(7):
5470-9
-
Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth.
Eksi S,
Czesny B, Greenbaum DC, Bogyo M, Williamson KC.
Mol Microbiol.
2004;
53
(1):
243-50
-
Biochemical analysis of the 20 S proteasome of Trypanosoma brucei.
Wang CC,
Bozdech Z, Liu CL, Shipway A, Backes BJ, Harris JL, Bogyo M.
J Biol Chem.
2003;
278
(18):
15800-8
-
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.
Yasothornsrikul S,
Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V.
Proc Natl Acad Sci U S A.
2003;
100
(16):
9590-5
-
Chemical proteomics and its application to drug discovery.
Jeffery DA,
Bogyo M.
Curr Opin Biotechnol.
2003;
14
(1):
87-95
-
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.
Sajid M,
McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR.
Mol Biochem Parasitol.
2003;
131
(1):
65-75
-
Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.
Rozman-Pungercar J,
Kopitar-Jerala N, Bogyo M, Turk D, Vasiljeva O, Stefe I, Vandenabeele P, Brömme D, Puizdar V, Fonović M, Trstenjak-Prebanda M, Dolenc I, Turk V, Turk B.
Cell Death Differ.
2003;
10
(8):
881-8
-
Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.
Kessler B,
Hong X, Petrovic J, Borodovsky A, Dantuma NP, Bogyo M, Overkleeft HS, Ploegh H, Glas R.
J Biol Chem.
2003;
278
(12):
10013-21
-
Sequential autolytic processing activates the zymogen of Arg-gingipain.
Mikolajczyk J,
Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS.
J Biol Chem.
2003;
278
(12):
10458-64
-
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite.
Greenbaum DC,
Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, Engel J, DeRisi J, Holder AA, Bogyo M.
Science.
2002;
298
(5600):
2002-6
-
Chemical approaches for functionally probing the proteome.
Greenbaum D,
Baruch A, Hayrapetian L, Darula Z, Burlingame A, Medzihradszky KF, Bogyo M.
Mol Cell Proteomics.
2002;
1
(1):
60-8
-
Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.
Groll M,
Nazif T, Huber R, Bogyo M.
Chem Biol.
2002;
9
(5):
655-62
-
Proteasome inhibitors: complex tools for a complex enzyme.
Bogyo M,
Wang EW.
Curr Top Microbiol Immunol.
2002:
268
185-208
-
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.
Greenbaum DC,
Arnold WD, Lu F, Hayrapetian L, Baruch A, Krumrine J, Toba S, Chehade K, Brömme D, Kuntz ID, Bogyo M.
Chem Biol.
2002;
9
(10):
1085-94
-
Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
Mathieu MA,
Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH.
Mol Biochem Parasitol.
2002;
121
(1):
99-105
-
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
Caffrey CR,
Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH.
Mol Biochem Parasitol.
2001;
118
(1):
61-73
-
Defining a link between gap junction communication, proteolysis, and cataract formation.
Baruch A,
Greenbaum D, Levy ET, Nielsen PA, Gilula NB, Kumar NM, Bogyo M.
J Biol Chem.
2001;
276
(31):
28999-9006
-
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.
Nazif T,
Bogyo M.
Proc Natl Acad Sci U S A.
2001;
98
(6):
2967-72
-
Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta.
Li J,
Gao X, Ortega J, Nazif T, Joss L, Bogyo M, Steven AC, Rechsteiner M.
EMBO J.
2001;
20
(13):
3359-69
-
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.
Greenbaum D,
Medzihradszky KF, Burlingame A, Bogyo M.
Chem Biol.
2000;
7
(8):
569-81
-
Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris.
Caffrey CR,
Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH.
FEBS Lett.
2000;
466
(2-3):
244-8
-
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Wang EW,
Kessler BM, Borodovsky A, Cravatt BF, Bogyo M, Ploegh HL, Glas R.
Proc Natl Acad Sci U S A.
2000;
97
(18):
9990-5
-
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.
Weihofen A,
Lemberg MK, Ploegh HL, Bogyo M, Martoglio B.
J Biol Chem.
2000;
275
(40):
30951-6
-
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs.
Bogyo M,
Verhelst S, Bellingard-Dubouchaud V, Toba S, Greenbaum D.
Chem Biol.
2000;
7
(1):
27-38
-
Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.
Selzer PM,
Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, McKerrow JH.
Proc Natl Acad Sci U S A.
1999;
96
(20):
11015-22
-
How an inhibitor of the HIV-I protease modulates proteasome activity.
Schmidtke G,
Holzhütter HG, Bogyo M, Kairies N, Groll M, de Giuli R, Emch S, Groettrup M.
J Biol Chem.
1999;
274
(50):
35734-40
-
A proteolytic system that compensates for loss of proteasome function.
Glas R,
Bogyo M, McMaster JS, Gaczynska M, Ploegh HL.
Nature.
1998;
392
(6676):
618-22
-
Antigen presentation. A protease draws first blood.
Bogyo M,
Ploegh HL.
Nature.
1998;
396
(6712):
625, 627
-
Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum.
Ruepp A,
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