Publications
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A fully humanized transgenic mouse model of Huntington disease.
Southwell AL,
Warby SC, Carroll JB, Doty CN, Skotte NH, Zhang W, Villanueva EB, Kovalik V, Xie Y, Pouladi MA, Collins JA, Yang XW, Franciosi S, Hayden MR.
Hum Mol Genet.
2013;
22
(1):
18-34
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CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
Lee JM,
Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS, Landwehrmeyer GB, Myers RH, MacDonald ME, Gusella JF.
Neurology.
2012;
78
(10):
690-5
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Determinants of cortical synchrony.
Mongrain V,
Warby SC.
Sleep.
2012;
35
(3):
309-10
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Common variants in P2RY11 are associated with narcolepsy.
Kornum BR,
Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E.
Nat Genet.
2011;
43
(1):
66-71
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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.
Warby SC,
Visscher H, Collins JA, Doty CN, Carter C, Butland SL, Hayden AR, Kanazawa I, Ross CJ, Hayden MR.
Eur J Hum Genet.
2011;
19
(5):
561-6
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Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China.
Han F,
Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, Yan H, Gao ZC, Yuan Y, Strohl KP, Mignot E.
Ann Neurol.
2011;
70
(3):
410-7
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Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.
Carroll JB,
Warby SC, Southwell AL, Doty CN, Greenlee S, Skotte N, Hung G, Bennett CF, Freier SM, Hayden MR.
Mol Ther.
2011;
19
(12):
2178-85
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Huntington Disease
Warby SC,
Graham RK, Hayden MR.
GeneReviews.
2010
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A prickly cause of progressive myoclonic epilepsy.
Warby S,
Clin Genet.
2009;
75
(3):
225-6
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CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.
Warby SC,
Montpetit A, Hayden AR, Carroll JB, Butland SL, Visscher H, Collins JA, Semaka A, Hudson TJ, Hayden MR.
Am J Hum Genet.
2009;
84
(3):
351-66
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Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
Warby SC,
Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR.
Mol Cell Neurosci.
2009;
40
(2):
121-7
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Response to Falush: a role for cis-element polymorphisms in HD.
Warby SC,
Visscher H, Butland S, Pearson CE, Hayden MR.
Am J Hum Genet.
2009;
85
(6):
942-5
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Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Warby SC,
Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR.
Hum Mol Genet.
2008;
17
(15):
2390-404
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Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats.
Semaka A,
Warby S, Leavitt BR, Hayden MR.
Mov Disord.
2008;
23
(12):
1794-5; author reply 1793
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Selective degeneration in YAC mouse models of Huntington disease.
Van Raamsdonk JM,
Warby SC, Hayden MR.
Brain Res Bull.
2007;
72
(2-3):
124-31
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Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.
Kishikawa S,
Li JL, Gillis T, Hakky MM, Warby S, Hayden M, MacDonald ME, Myers RH, Gusella JF.
Neurobiol Dis.
2006;
24
(2):
280-5
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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Graham RK,
Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.
Cell.
2006;
125
(6):
1179-91
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FASA-57 cDNA shares no homology with coding sequence of HD gene.
Warby S,
MacDonald M, Hayden M, Butland S, Ouellette F.
J Reprod Immunol.
2006;
69
(1):
9-10; author reply 11
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Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.
Li JL,
Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gómez-Tortosa E, García CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djoussé L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH.
BMC Med Genet.
2006:
7
71
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Predictive testing for Huntington disease: interpretation and significance of intermediate alleles.
Semaka A,
Creighton S, Warby S, Hayden MR.
Clin Genet.
2006;
70
(4):
283-94
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Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Warby SC,
Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR.
Hum Mol Genet.
2005;
14
(11):
1569-77
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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL,
Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR.
J Neurosci.
2002;
22
(18):
7862-72
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HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Singaraja RR,
Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR.
Hum Mol Genet.
2002;
11
(23):
2815-28
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Modeling classic female Rett Syndrome in male mice.
Warby S,
Clin Genet.
2002;
62
(5):
368-70
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Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
Hackam AS,
Yassa AS, Singaraja R, Metzler M, Gutekunst CA, Gan L, Warby S, Wellington CL, Vaillancourt J, Chen N, Gervais FG, Raymond L, Nicholson DW, Hayden MR.
J Biol Chem.
2000;
275
(52):
41299-308
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