Publications
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Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
Sekar TV,
Foygel K, Willmann JK, Paulmurugan R.
Gene Ther.
2013;
20
(5):
529-37
-
The impact of oxidative stress on islet transplantation and monitoring the graft survival by non-invasive imaging.
Ramkumar KM,
Sekar TV, Bhakkiyalakshmi E, Foygel K, Rajaguru P, Berger F, Paulmurugan R.
Curr Med Chem.
2013;
20
(9):
1127-46
-
Biodegradable polymer nanocarriers for therapeutic antisense microRNA delivery in living animals.
Paulmurugan R,
Sekar NM, and Sekar TV.
Proceedings of SPIE.
2012;
8232 (1)
(Jan 21)
-
Cationic versus neutral microbubbles for ultrasound-mediated gene delivery in cancer.
Wang DS,
Panje C, Pysz MA, Paulmurugan R, Rosenberg J, Gambhir SS, Schneider M, Willmann JK.
Radiology.
2012;
264
(3):
721-32
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Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
Chan CT,
Reeves RE, Geller R, Yaghoubi SS, Hoehne A, Solow-Cordero DE, Chiosis G, Massoud TF, Paulmurugan R, Gambhir SS.
Proc Natl Acad Sci U S A.
2012;
109
(37):
E2476-85
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Intratumoral versus intravenous gene therapy using a transcriptionally targeted viral vector in an orthotopic hepatocellular carcinoma rat model.
Kim YI,
Ahn BC, Ronald JA, Katzenberg R, Singh A, Paulmurugan R, Ray S, Gambhir SS, Hofmann LV.
J Vasc Interv Radiol.
2012;
23
(5):
704-11
-
Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals.
Bhaumik S,
Sekar TV, Depuy J, Klimash J, Paulmurugan R.
Gene Ther.
2012;
19
(3):
295-302
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Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO2 nanofibers in HeLa cells.
Ramkumar KM,
Manjula C, Gnanakumar G, Kanjwal MA, Sekar TV, Paulmurugan R, Rajaguru P.
Eur J Pharm Biopharm.
2012;
81
(2):
324-33
-
Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase (HDAC) Inhibitors by Multimodality Molecular Imaging of Heat Shock Protein 90 (Hsp90) Chaperone Interactions in Living Subjects.
Chan CT,
Qi J, West N, Bradner J, Mazitschek R, Reeves R, Chiosis G, Schreiber SL, Paulmurugan R, Gambhir SS.
JNCI.
2012:
(Under Review)
-
Therapeutic Evaluation of microRNAs by Molecular Imaging.
Sekar TV,
Ramkumar KM, Foygel K, Paulmurugan R.
Theranostics.
2012:
(in press)
-
Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency.
Panje CM,
Wang DS, Pysz MA, Paulmurugan R, Ren Y, Tranquart F, Tian L, Willmann JK.
Theranostics.
2012;
2
(11):
1078-91
-
Imaging cellular receptors in breast cancers: an overview.
Sekar TV,
Dhanabalan A, Paulmurugan R.
Curr Pharm Biotechnol.
2011;
12
(4):
508-27
-
In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.
Paulmurugan R,
Tamrazi A, Massoud TF, Katzenellenbogen JA, Gambhir SS.
Mol Endocrinol.
2011;
25
(12):
2029-40
-
Molecular imaging in current pharmaceutical.
Paulmurugan R,
Curr Pharm Biotechnol.
2011;
12
(4):
458
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Non-invasive bioluminescence imaging of myoblast-mediated hypoxia-inducible factor-1 alpha gene transfer.
Gheysens O,
Chen IY, Rodriguez-Porcel M, Chan C, Rasooly J, Vaerenberg C, Paulmurugan R, Willmann JK, Deroose C, Wu J, Gambhir SS.
Mol Imaging Biol.
2011;
13
(6):
1124-32
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Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats.
Auer VJ,
Bucher J, Schremmer-Danninger E, Paulmurugan R, Maechler P, Reiser MF, Stangl MJ, Berger F.
Curr Pharm Biotechnol.
2011;
12
(4):
488-96
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Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells.
Thakor AS,
Paulmurugan R, Kempen P, Zavaleta C, Sinclair R, Massoud TF, Gambhir SS.
Small.
2011;
7
(1):
126-36
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Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector.
Ahn BC,
Ronald JA, Kim YI, Katzenberg R, Singh A, Paulmurugan R, Ray S, Hofmann LV, Gambhir SS.
Gene Ther.
2011;
18
(6):
606-12
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The fate and toxicity of Raman-active silica-gold nanoparticles in mice.
Thakor AS,
Luong R, Paulmurugan R, Lin FI, Kempen P, Zavaleta C, Chu P, Massoud TF, Sinclair R, Gambhir SS.
Sci Transl Med.
2011;
3
(79):
79ra33
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A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.
Massoud TF,
Paulmurugan R, Gambhir SS.
Nat Med.
2010;
16
(8):
921-6
-
Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium.
Rodriguez-Porcel M,
Gheysens O, Paulmurugan R, Chen IY, Peterson KM, Willmann JK, Wu JC, Zhu X, Lerman LO, Gambhir SS.
Mol Imaging Biol.
2010;
12
(3):
325-34
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Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy.
Chen IY,
Gheysens O, Ray S, Wang Q, Padmanabhan P, Paulmurugan R, Loening AM, Rodriguez-Porcel M, Willmann JK, Sheikh AY, Nielsen CH, Hoyt G, Contag CH, Robbins RC, Biswal S, Wu JC, Gambhir SS.
Gene Ther.
2010;
17
(7):
827-38
-
Noninvasive molecular imaging of c-Myc activation in living mice.
Fan-Minogue H,
Cao Z, Paulmurugan R, Chan CT, Massoud TF, Felsher DW, Gambhir SS.
Proc Natl Acad Sci U S A.
2010;
107
(36):
15892-7
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Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation.
Chen IY,
Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ, Paulmurugan R, Yang PC, Wu JC, Gambhir SS.
Mol Imaging Biol.
2009 May-Jun;
11
(3):
178-87
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Molecular imaging of phosphorylation events for drug development.
Chan CT,
Paulmurugan R, Reeves RE, Solow-Cordero D, Gambhir SS.
Mol Imaging Biol.
2009 May-Jun;
11
(3):
144-58
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A novel estrogen receptor intramolecular folding-based titratable transgene expression system.
Paulmurugan R,
Padmanabhan P, Ahn BC, Ray S, Willmann JK, Massoud TF, Biswal S, Gambhir SS.
Mol Ther.
2009;
17
(10):
1703-11
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Imaging gene expression in human mesenchymal stem cells: from small to large animals.
Willmann JK,
Paulmurugan R, Rodriguez-Porcel M, Stein W, Brinton TJ, Connolly AJ, Nielsen CH, Lutz AM, Lyons J, Ikeno F, Suzuki Y, Rosenberg J, Chen IY, Wu JC, Yeung AC, Yock P, Robbins RC, Gambhir SS.
Radiology.
2009;
252
(1):
117-27
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Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.
Choi CY,
Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ.
Mol Imaging.
2008 May-Jun;
7
(3):
139-46
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A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.
Paulmurugan R,
Tamrazi A, Katzenellenbogen JA, Katzenellenbogen BS, Gambhir SS.
Mol Endocrinol.
2008;
22
(7):
1552-64
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Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo.
Willmann JK,
Lutz AM, Paulmurugan R, Patel MR, Chu P, Rosenberg J, Gambhir SS.
Radiology.
2008;
248
(3):
936-44
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Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Chan CT,
Paulmurugan R, Gheysens OS, Kim J, Chiosis G, Gambhir SS.
Cancer Res.
2008;
68
(1):
216-26
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Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography.
Willmann JK,
Chen K, Wang H, Paulmurugan R, Rollins M, Cai W, Wang DS, Chen IY, Gheysens O, Rodriguez-Porcel M, Chen X, Gambhir SS.
Circulation.
2008;
117
(7):
915-22
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Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy.
Ray S,
Paulmurugan R, Patel MR, Ahn BC, Wu L, Carey M, Gambhir SS.
Mol Ther.
2008;
16
(11):
1848-56
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RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.
Ramnarain DB,
Paulmurugan R, Park S, Mickey BE, Asaithamby A, Saha D, Kelliher MA, Mukhopadhyay P, Banani F, Madden CJ, Wright PS, Chakravarty S, Habib AA.
Cell Death Differ.
2008;
15
(2):
344-53
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The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway.
Park S,
Ramnarain DB, Hatanpaa KJ, Mickey BE, Saha D, Paulmurugan R, Madden CJ, Wright PS, Bhai S, Ali MA, Puttaparthi K, Hu W, Elliott JL, Stuve O, Habib AA.
EMBO Rep.
2008;
9
(8):
766-73
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US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice.
Willmann JK,
Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM, Chen IY, Chen X, Gambhir SS.
Radiology.
2008;
246
(2):
508-18
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Uptake kinetics and biodistribution of 14C-D-luciferin--a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging.
Berger F,
Paulmurugan R, Bhaumik S, Gambhir SS.
Eur J Nucl Med Mol Imaging.
2008;
35
(12):
2275-85
-
Antibacterial activity of subterranean termites used in South Indian folk medicine.
Solavan A,
Paulmurugan R, Wilsanand V.
Indian Journal of Traditional Knowledge.
2007;
6(4)
(Oct):
559-562
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Combinatorial library screening for developing an improved split-firefly luciferase fragment-assisted complementation system for studying protein-protein interactions.
Paulmurugan R,
Gambhir SS.
Anal Chem.
2007;
79
(6):
2346-53
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Reporter gene imaging of protein-protein interactions in living subjects.
Massoud TF,
Paulmurugan R, De A, Ray P, Gambhir SS.
Curr Opin Biotechnol.
2007;
18
(1):
31-7
-
An intramolecular folding sensor for imaging estrogen receptor-ligand interactions.
Paulmurugan R,
Gambhir SS.
Proc Natl Acad Sci U S A.
2006;
103
(43):
15883-8
-
Effect of the subterranean termite used in the South Indian folk medicine.
Solavan A,
Paulmurugan R, Wilsanand V.
Indian Journal of Traditional Knowledge.
2006;
5(3)
(Jul):
376-9
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Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging.
Krishnan M,
Park JM, Cao F, Wang D, Paulmurugan R, Tseng JR, Gonzalgo ML, Gambhir SS, Wu JC.
FASEB J.
2006;
20
(1):
106-8
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Split luciferase complementation assay for studying interaction of proteins x and y in cells.
Paulmurugan R,
Ray P, De A, Chan CT, Gambhir SS.
CSH Protoc.
2006;
Nov1;(6)
(10.1101/):
pdb.prot4596
-
Split luciferase complementation assay for studying interaction of proteins x and y in living mice.
Paulmurugan R,
Ray P, De A, Chan CT, Gambhir SS.
CSH Protoc.
2006;
Nov1(6)
(10.1101/):
pdb.prot4596
-
Visualization of telomerase reverse transcriptase (hTERT) promoter activity using a trimodality fusion reporter construct.
Padmanabhan P,
Otero J, Ray P, Paulmurugan R, Hoffman AR, Gambhir SS, Biswal S, Ulaner GA.
J Nucl Med.
2006;
47
(2):
270-7
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Firefly luciferase enzyme fragment complementation for imaging in cells and living animals.
Paulmurugan R,
Gambhir SS.
Anal Chem.
2005;
77
(5):
1295-302
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Imaging protein-protein interactions in living subjects.
Paulmurugan R,
Ray P, De A, Chan C, Gambhir SS.
TRAC: Trends in Analytical Chemistry.
2005:
24(5)
446-458
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Novel fusion protein approach for efficient high-throughput screening of small molecule-mediating protein-protein interactions in cells and living animals.
Paulmurugan R,
Gambhir SS.
Cancer Res.
2005;
65
(16):
7413-20
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Impact of physico- chemical parameters on the microbial population and its nature in a major retting zone of Kerala, S. India.
Paulmurugan R,
Thomas S, Nair SC, Das MR.
International Journal of Environmental Studies, UK.
2004:
61(5)
595-597
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MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene.
Sundaresan G,
Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS.
Gene Ther.
2004;
11
(7):
609-18
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Molecular imaging of drug-modulated protein-protein interactions in living subjects.
Paulmurugan R,
Massoud TF, Huang J, Gambhir SS.
Cancer Res.
2004;
64
(6):
2113-9
-
Molecular imaging of homodimeric protein-protein interactions in living subjects.
Massoud TF,
Paulmurugan R, Gambhir SS.
FASEB J.
2004;
18
(10):
1105-7
-
Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression.
Ray S,
Paulmurugan R, Hildebrandt I, Iyer M, Wu L, Carey M, Gambhir SS.
Hum Gene Ther.
2004;
15
(7):
681-90
-
Traditional therapeutic uses of animals among tribal population of Tamil Nadu.
Solavan A,
Paulmurugan R, Wilsanand V, Ranjith Sing AJA.
Indian Journal of Traditional Knowledge.
2004;
3(2)
(Apr):
198-205
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Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer.
Maliekal TT,
Antony ML, Nair A, Paulmurugan R, Karunagaran D.
Oncogene.
2003;
22
(31):
4889-97
-
Monitoring protein-protein interactions using split synthetic renilla luciferase protein-fragment-assisted complementation.
Paulmurugan R,
Gambhir SS.
Anal Chem.
2003;
75
(7):
1584-9
-
Simple radioactive assay for the estimation of DNA breaks.
Sreekumaran Nair R,
Paulmurugan R, Singh AJ.
J Appl Toxicol.
2002 Jan-Feb;
22
(1):
19-23
-
Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies.
Paulmurugan R,
Umezawa Y, Gambhir SS.
Proc Natl Acad Sci U S A.
2002;
99
(24):
15608-13
-
Noninvasive quantitative imaging of protein-protein interactions in living subjects.
Ray P,
Pimenta H, Paulmurugan R, Berger F, Phelps ME, Iyer M, Gambhir SS.
Proc Natl Acad Sci U S A.
2002;
99
(5):
3105-10
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Distribution of HCH residues in the Kuttanad wetland ecosystem of Kerala.
Harikrishnan K,
George S, Thomas S, Paulmurugan R, Das MR.
Inter. J. Ecology and Environmental Science.
2001:
7(1)
105-109
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Studies on the water quality of Kuttanad wetland ecosystem of Kerala.
Thomas S,
Harikrishnan K, George S, Paulmurugan R, Das MR.
Pollution Research.
2001;
20(1)
(62):
138-148
-
Drinking water quality status of Kottarakara area, Kollam District, Kerala.
Thomas S,
Nair SC, Paulmurugan R.
Indian J. Environ. & Ecoplanning.
2000:
3(1)
143-145
-
Duplex RT-PCR for simultaneous detection of hepatitis A and hepatitis E virus isolated from drinking water samples.
Jothikumar N,
Paulmurugan R, Padmanabhan P, Sundari RB, Kamatchiammal S, Rao KS.
J Environ Monit.
2000;
2
(6):
587-90
-
Pollution and infectious diseases.
Thomas S,
Paulmurugan R.
Science, India.
2000:
3
39-42
-
A study on the distribution and ecology of phytoplankton in the Kuttanad wetland ecosystem, Kerala.
Harikrishnan K,
Thomas S, George S, Paulmurugan R, Mundayoor S, Das MR.
Pollution Research.
1999:
18(3)
261-269
-
Distribution of heavy metals in Kuttanad wetland ecosystem of Kerala, India.
George S,
Harikrishnan K, Thomas S, Paulmurugan R, Mundayoor S, Das MR.
Inter. J. Ecology and Environmental Science.
1999:
25
91-95
-
Spatio temporal distribution and ecology of benthos in the Kuttanad wetland ecosystem.
Thomas S,
George S, Harikrishnan K, Paulmurugan R, Mundayoor S, Das MR.
Pollution Research.
1999:
18(3)
235-243
-
Analysis of human immune response to potential hepatitis C viral epitopes.
Khanna A,
Poduri CD, Paulmurugan R, Kumar S, Sugunan VS, Shenoy KT, Das MR.
Acta Virologica.
1998:
42
141-145
-
Membrane impregnated probe for simultaneous PCR amplification and detection.
Jothikumar N,
Khanna P, Paulmurugan R, Padmanabhan P.
World Journal of Microbiology and Biotechnology.
1998:
14
933-934
-
A simple device for the concentration and detection of enterovirus, hepatitis E virus and rotavirus from water samples by reverse transcription-polymerase chain reaction.
Jothikumar N,
Khanna P, Paulmurugan R, Kamatchiammal S, Padmanabhan P.
J Virol Methods.
1995;
55
(3):
401-15
-
Concentration and detection of rota virus in water samples using polymerase chain reaction during a gasteroenteries epidemic outbreak in Madras city.
Jothikumar N,
Khanna P, Kamatchiammal S, Paulmurugan R, Saravanadevi S, Padmanabhan P, Kuganandham P.
International Journal of Environmental Studies.
1994:
46
323-327
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Detection of hepatitis E virus in raw and treated wastewater with the polymerase chain reaction.
Jothikumar N,
Aparna K, Kamatchiammal S, Paulmurugan R, Saravanadevi S, Khanna P.
Appl Environ Microbiol.
1993;
59
(8):
2558-62
-
Rapid detection of waterborne viruses using the polymerase chain reaction and a gene probe.
Jothikumar N,
Khanna P, Kamatchiammal S, Paulmurugan R.
Intervirology.
1991:
34
184-191
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