Publications
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Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro.
Kuzmenkin A,
Liang H, Xu G, Pfannkuche K, Eichhorn H, Fatima A, Luo H, Saric T, Wernig M, Jaenisch R, Hescheler J.
FASEB J.
2009
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Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility.
Pfannkuche K,
Liang H, Hannes T, Xi J, Fatima A, Nguemo F, Matzkies M, Wernig M, Jaenisch R, Pillekamp F, Halbach M, Schunkert H, Sari? T, Hescheler J, Reppel M.
Cell Physiol Biochem.
2009;
24
(1-2):
73-86
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Dissecting direct reprogramming through integrative genomic analysis.
Mikkelsen TS,
Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A.
Nature.
2008;
454
(7200):
49-55
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Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
Hanna J,
Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, Lengner CJ, Dausman JA, Jaenisch R.
Cell.
2008;
133
(2):
250-64
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Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
Wernig M,
Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R.
Proc Natl Acad Sci U S A.
2008;
105
(15):
5856-61
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Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.
Brambrink T,
Foreman R, Welstead GG, Lengner CJ, Wernig M, Suh H, Jaenisch R.
Cell Stem Cell.
2008;
2
(2):
151-9
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c-Myc is dispensable for direct reprogramming of mouse fibroblasts.
Wernig M,
Meissner A, Cassady JP, Jaenisch R.
Cell Stem Cell.
2008;
2
(1):
10-2
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A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.
Wernig M,
Lengner CJ, Hanna J, Lodato MA, Steine E, Foreman R, Staerk J, Markoulaki S, Jaenisch R.
Nat Biotechnol.
2008;
26
(8):
916-24
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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.
Marson A,
Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA.
Cell.
2008;
134
(3):
521-33
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Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Meissner A,
Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES.
Nature.
2008;
454
(7205):
766-70
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Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
Hanna J,
Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R.
Science.
2007;
318
(5858):
1920-3
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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
Wernig M,
Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R.
Nature.
2007;
448
(7151):
318-24
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Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.
Meissner A,
Wernig M, Jaenisch R.
Nat Biotechnol.
2007;
25
(10):
1177-81
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
Mikkelsen TS,
Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander ES, Bernstein BE.
Nature.
2007;
448
(7153):
553-60
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Bernstein BE,
Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES.
Cell.
2006;
125
(2):
315-26
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Polycomb complexes repress developmental regulators in murine embryonic stem cells.
Boyer LA,
Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R.
Nature.
2006;
441
(7091):
349-53
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The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment.
Wernig G,
Janzen V, Schäfer R, Zweyer M, Knauf U, Hoegemeier O, Mundegar RR, Garbe S, Stier S, Franz T, Wernig M, Wernig A.
Proc Natl Acad Sci U S A.
2005;
102
(33):
11852-7
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Functional integration of embryonic stem cell-derived neurons in vivo.
Wernig M,
Benninger F, Schmandt T, Rade M, Tucker KL, Büssow H, Beck H, Brüstle O.
J Neurosci.
2004;
24
(22):
5258-68
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Migration and differentiation of myogenic precursors following transplantation into the developing rat brain.
Steffel J,
Wernig M, Knauf U, Kumar S, Wiestler OD, Wernig A, Brüstle O.
Stem Cells.
2003;
21
(2):
181-9
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Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.
Benninger F,
Beck H, Wernig M, Tucker KL, Brüstle O, Scheffler B.
J Neurosci.
2003;
23
(18):
7075-83
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Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation.
Wernig M,
Tucker KL, Gornik V, Schneiders A, Buschwald R, Wiestler OD, Barde YA, Brüstle O.
J Neurosci Res.
2002;
69
(6):
918-24
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Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair.
Wernig M,
Brüstle O.
J Neuropathol Exp Neurol.
2002;
61
(2):
101-10
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In vitro differentiation of transplantable neural precursors from human embryonic stem cells.
Zhang SC,
Wernig M, Duncan ID, Brüstle O, Thomson JA.
Nat Biotechnol.
2001;
19
(12):
1129-33
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A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Faiella A,
Wernig M, Consalez GG, Hostick U, Hofmann C, Hustert E, Boncinelli E, Balling R, Nadeau JH.
Hum Mol Genet.
2000;
9
(2):
227-36
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