Publications
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Total synthesis and selective activity of a new class of conformationally restrained epothilones.
Alhamadsheh MM,
Gupta S, Hudson RA, Perera L, Tillekeratne LM.
Chemistry.
2008;
14
(2):
570-81
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cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme.
Palaniappan N,
Alhamadsheh MM, Reynolds KA.
J Am Chem Soc.
2008;
130
(37):
12236-7
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Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.
Alhamadsheh MM,
Palaniappan N, Daschouduri S, Reynolds KA.
J Am Chem Soc.
2007;
129
(7):
1910-1
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Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.
Alhamadsheh MM,
Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA.
Chem Biol.
2007;
14
(5):
513-24
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Design, total synthesis, and evaluation of novel open-chain epothilone analogues.
Alhamadsheh MM,
Hudson RA, Viranga Tillekeratne LM.
Org Lett.
2006;
8
(4):
685-8
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Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.
Mo S,
Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL.
Chem Biol.
2008;
15
(2):
137-48
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Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.
Sachdeva S,
Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA.
Chem Biol.
2008;
15
(4):
402-12
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Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis.
Turos E,
Revell KD, Ramaraju P, Gergeres DA, Greenhalgh K, Young A, Sathyanarayan N, Dickey S, Lim D, Alhamadsheh MM, Reynolds K.
Bioorg Med Chem.
2008;
16
(13):
6501-8
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Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.
Sachdeva S,
Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA.
Bioorg Chem.
2008;
36
(2):
85-90
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Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).
Alhamadsheh MM,
Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA.
Bioorg Med Chem Lett.
2007;
17
(4):
879-83
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