Department: Molecular & Cellular Physiology
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Academic Appointments Assistant Professor, Anesthesia
Assistant Professor (By courtesy), Molecular & Cellular Physiology
Research InterestOur laboratory investigates the cellular and molecular mechanisms of pain and its control by opioids. When chronic, pain is no longer an essential warning system critical to our survival, but a disease that severely affects the quality of life of many patients. We search to identity the neurons that participate in generating the sensation of pain and the molecular mechanisms that regulate neural activity in pain circuits to develop novel analgesic strategies against pathological pain.
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Academic Appointments Professor, Molecular & Cellular Physiology
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestResearch in the Smith Laboratory addresses basic mechanisms and and disorders of brain function. Present efforts are focused on the development and application of new proteomic imaging methods to explore the circuit and molecular architectures of memory storage and retrieval in cerebral cortex.
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Academic Appointments Emeritus Faculty, Acad Council, Molecular & Cellular Physiology
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Academic Appointments Professor, Molecular & Cellular Physiology
Professor (By courtesy), Neurology & Neurological Sciences
Professor (By courtesy), Psychiatry & Behavioral Science
Research InterestInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
