Department: Biochemistry
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Academic Appointments Emeritus Faculty, Acad Council, Biochemistry
Research InterestI closed my laboratory when I retired in 1998. I continue to do research, chiefly in collaboration with Franc Avbelj, on problems of protein folding energetics, especially peptide backbone solvation, and to write reviews.
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Academic Appointments Professor, Biochemistry
Member, Bio-X
Professor, Developmental Biology
Research InterestFunction of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
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Academic Appointments Life Sci Tech I, Biochemistry
Current Role at StanfordLife Sciences Technician in the Das Lab
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Academic Appointments Emeritus Faculty, Acad Council, Biochemistry
Professor Emeritus, Biochemistry
Professor Emeritus, SoM Dean's Office Administrative Units - Dean's Office Operations
Research InterestFor about 10 years until 2000, my lab's research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems: one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence. We also explored the ro..
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Academic Appointments Postdoctoral Research fellow, Biochemistry
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Academic Appointments Professor, Biochemistry
Member, Stanford Cancer Institute
Research InterestDr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program. The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.
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Academic Appointments Postdoctoral Research fellow, Biochemistry
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Academic Appointments Professor Emeritus, Biochemistry
Member, Bio-X
Research InterestMy primary interest is to understand the flow of information from the genome to the phenotype of an organism. This interest includes predicting the structure and function of genes and proteins from their primary sequence, predicting function from structure and finally simulating protein folding and ligand docking. These goals are the same as the goals of molecular biology, however, we use primarily computational approaches.
