Department: Bio-X

M

• 
  Macario, Alex 
  Academic Appointments Professor - Med Center Line,  Anesthesia
  Member,  Bio-X
  Professor - Med Center Line (By courtesy),  Health Research & Policy
  
  Clinical Focus

  • Anesthesia
  Research Interest

  Dr. Macario is interested in the economics of health care, in particular the tradeoffs between costs and outcomes for patients having surgery and anesthesia. Dr. Macario has completed internationally recognized studies on the management of the operating room suite, as well as pioneering work on the cost-effectiveness of drugs and devices. He is Founder and Director of a Postgraduate Fellowship for physicians interested in developing their research, management, and leadership skills.
• 
  MacIver, M 
  Academic Appointments Professor (Research),  Anesthesia
  Member,  Bio-X
  
  Research Interest

  We study drug effects on the nervous system. Cellular, synaptic and molecular drug actions are investigated using electrophysiological and pharmacological tools in cortical/hippocampal brain slice preparations. We are also interested in mechanisms of neuronal integration and synchronization, especially related to patterns of EEG activity seen in vivo and in brain slices.
• 
  Mackey, Sean 
  Academic Appointments Professor - Med Center Line,  Anesthesia
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  Professor - Med Center Line (By courtesy),  Neurology & Neurological Sciences
  
  Clinical Focus

  • Pain Medicine
  • Chronic Pain
  • Acute Pain
  Research Interest

  Functional neuroimaging of pain. Imaging of cognitive and affective dimensions of pain, neural plasticity contributing to chronic pain and effects of treatment. Effects of membrane stabilizing medications on neuropathic pain. Chronic pain outcomes tools development and measurement.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Madison, Vernon 
  Academic Appointments Associate Professor,  Molecular & Cellular Physiology
  Member,  Bio-X
  
  Research Interest

  Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system.
• 
  Maduke, Merritt 
  Academic Appointments Associate Professor,  Molecular & Cellular Physiology
  Member,  Bio-X
  
  Research Interest

  Molecular mechanisms of chloride channels & transporters studied by integration of structural and electrophysiological methods.
• 
  Maecker, Holden Terry
  Academic Appointments Associate Professor (Research),  Microbiology & Immunology
  Member,  Bio-X
  
  Research Interest

  I'm interested in immune monitoring of T cell responses to chronic pathogens such as CMV, and the correlation of T cell response signatures with disease protection.
• 
  Majeti, Ravindra 
  Academic Appointments Assistant Professor,  Medicine - Hematology
  Member,  Bio-X
  
  Clinical Focus

  • Hematology
  Research Interest

  Ravindra Majeti focuses on the molecular characterization and therapeutic targeting of leukemia stem cells in human hematologic disorders, particularly acute myeloid leukemia (AML LSC). A major focus is the identification of cell surface molecules preferentially expressed on LSC and the development of therapeutic monoclonal antibodies targeting these proteins. Toward this goal, together with Irv Weissman, the lab is actively developing an anti-CD47 antibody for clinical trials in human AML.
• 
  Malenka, Robert 
  Academic Appointments Professor,  Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS
  Member,  Bio-X
  
  Research Interest

  Long-lasting changes in synaptic strength are important for the modification of neural circuits by experience. A major goal of my laboratory is to elucidate the molecular events that trigger various forms of synaptic plasticity and the modifications in synaptic proteins that are responsible for the changes in synaptic efficacy.
• 
  Manche, Edward 
  Academic Appointments Professor - Med Center Line,  Ophthalmology
  Member,  Bio-X
  
  Clinical Focus

  • Ophthalmology
• 
  Manning, Chris 
  Academic Appointments Member,  Bio-X
  
• 
  Marmor, Michael 
  Academic Appointments Professor,  Ophthalmology
  Member,  Bio-X
  
  Clinical Focus

  • Ophthalmology
  • Medical retinal disease: in particular, retinal dystrophies, macular dystrophies, toxic retinopathy, disorders of retinal function such as night or color blindness, unexplained visual loss
  • Supervision of physiologic testing including electroretinogram ERG), multifocal electroretinogram (mfERG) and visually evoked potentials (VEP)
  Research Interest

  Research concerns diseases of retinal function, techniques of clinical electrophysiology, and experimental studies on retinal pigment epithelial (RPE) function including fluid transport and retinal adhesiveness. Other studies consider aspects of vision and art, and ophthalmic history. Published over 300 journal articles, chapters, books (only selected articles listed).

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Martinez, Olivia 
  Academic Appointments Professor (Research),  Surgery - Multi-Organ Transplantation
  Member,  Child Health Research Institute
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  
  Research Interest

  EBV B cell lymphomas; pathways of immune evasion in the growth and survival of EBV B cell lymphomas; mechanisms of graft rejection and tolerance induction; stem cell and solid organ transplantation.
• 
  Massoud, Tarik F
  Academic Appointments Professor - Med Center Line,  Radiology - Diagnostic Radiology
  Member,  Bio-X
  
  Research Interest

  My current interests are in molecular and translational imaging of the brain especially in neuro-oncology and cerebrovascular diseases, experimental aspects of neuroimaging, clinical neuroradiology, neuroradiological anatomy, and research education and academic training of radiologists.
• 
  Matin, AC 
  Academic Appointments Professor,  Microbiology & Immunology
  Member,  Bio-X
  
  Research Interest

  1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite and newly developed single-cell tracking by MRI. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity -- development of new countermeasures; 4. Bioremediation.
• 
  Maxim, Peter Gregor
  Academic Appointments Assistant Professor - Med Center Line,  Radiation Oncology - Radiation Physics
  Member,  Bio-X
  
  Research Interest

  My research is focused on developing optical imaging technologies for the early detection and characterization of malignant tissue. Furthermore, I am interested in the design and implementation of novel radiation delivery approaches.
• 
  McAdams, Harley 
  Academic Appointments Professor (Research),  Developmental Biology
  Member,  Bio-X
  
  Research Interest

  Experimental and theoretical analysis and modeling of genetic regulatory circuits, particularly bacterial regulation and with emphasis on global regulation of Caulobacter crescentus. Bioinformatic analysis of bacterial genomes, of microarray expression patterns, and cross-species genomic analysis. Techniques: gene expression microarrays, fluorescent microscopy, electron microscopy, genetics, molecular biology
• 
  Mcclelland, Jay 
  Academic Appointments Member,  Bio-X
  
  Research Interest

  My research addresses a broad range of cognitive neuroscience issues in learning, memory, language and cognitive development. I view cognitive functions as emerging from the parallel, distributed processing activity of neural populations, with learning occurring through the adaptation of connections among participating neurons. A new focus is the neural basis of decision making. We seek to understand how brain regions work together as we weigh the factors affecting our decisions.
• 
  McClure, Samuel M
  Academic Appointments Assistant Professor,  Social Sciences Cluster - Psychology
  Member,  Bio-X
  
• 
  McConnell, Michael 
  Academic Appointments Professor - Med Center Line,  Medicine - Cardiovascular Medicine
  Member,  Bio-X
  Professor - Med Center Line (By courtesy),  Molecular & Cellular Physiology
  Professor - Med Center Line (By courtesy),  Electrical Engineering
  
  Clinical Focus

  • Coronary Artery Disease
  • Preventive Cardiology
  • Cardiovascular Imaging
  Research Interest

  Clinical and molecular Imaging of cardiovascular disease, with a focus on coronary and vascular diseases, including atherosclerosis, aortic aneurysms, and vascular inflammation.
• 
  McConnell, Susan K
  Academic Appointments Professor,  Biology (School of Humanities and Sciences)
  Member,  Bio-X
  
  Research Interest

  The McConnell Lab studies the cellular and molecular mechanisms that underlie the development of the mammalian cerebral cortex. Our work focuses on the earliest events that pattern the developing forebrain, enable neural progenitors to divide asymmetrically to generate young neurons, propel the migration of postmitotic neurons outward into their final positions, and sculpt the fates and phenotypes of the neurons as they differentiate.
• 
  McKay, David 
  Academic Appointments Emeritus Faculty, Acad Council,  Structural Biology
  Member,  Bio-X
  
  Research Interest

  Three-dimensional structure determination and biophysical studies of macromolecules.
• 
  McMahan, Uel 
  Academic Appointments Emeritus Faculty, Acad Council,  Neurobiology
  Member,  Bio-X
  
  Research Interest

  We are currently investigating mechanisms involved in synaptic transmission and synaptogenesis using electron microscope tomography in ways that provide in situ 3D structural information at macromolecular resolution.
• 
  McNab, Jennifer A
  Academic Appointments Assistant Professor (Research),  Radiology - Diagnostic Radiology
  Member,  Bio-X
  
  Research Interest

  I am interested in developing magnetic resonance imaging (MRI) methods that provide more detailed information about the structural and functional micro-architecture of the brain compared to current methods. This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation. Applications of these methods include neurodevelopment, plasticity, aging, traumatic brain injury, multiple sclerosis and epilepsy.
• 
  Mellins, Elizabeth D.
  Academic Appointments Professor - Med Center Line,  Pediatrics - Human Gene Therapy
  Member,  Child Health Research Institute
  Member,  Bio-X
  
  Clinical Focus

  • Pediatric Rheumatology
  • Rheumatology, Pediatric
  Research Interest

  Molecular mechanisms and intracellular pathways of antigen processing and presentation; structure/function of HLA-DR,-DM, -DO; HLA allele association with disease; disease mechanisms in systemic idiopathic juveile arthritis
• 
  Melosh, Nicholas 
  Academic Appointments Member,  Child Health Research Institute
  Member,  Bio-X
  
• 
  Menon, Vinod 
  Academic Appointments Professor (Research),  Psychiatry & Behavioral Science - Child and Adolescent Psychiatry
  Member,  Bio-X
  Member,  Child Health Research Institute
  Professor (Research) (By courtesy),  Neurology & Neurological Sciences
  
  Research Interest

  EXPERIMENTAL AND THEORETICAL SYSTEMS NEUROSCIENCE: Cognitive neuroscience; Cognitive development; Psychiatric neuroscience; Functional brain imaging; Dynamical basis of brain function; Nonlinear dynamics of neural systems
• 
  Meyer, Tobias 
  Academic Appointments Professor,  Chemical and Systems Biology
  Member,  Bio-X
  
  Research Interest

  CELLULAR INFORMATION PROCESSING The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks. This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information.
• 
  Michie, Sara 
  Academic Appointments Professor,  Pathology
  Member,  Bio-X
  
  Clinical Focus

  • Anatomic Pathology
  • Pathology and Laboratory Medicine
  Research Interest

  Lymphocyte/endothelial cell adhesion mechanisms involved in lymphocyte migration to sites of inflammation; regulation of expression of endothelial cell adhesion molecules.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Mignot, Emmanuel 
  Academic Appointments Professor,  Psychiatry & Behavioral Science - Sleep Center
  Member,  Bio-X
  
  Clinical Focus

  • Narcolepsy Cataplexy Syndrome
  • Kleine-Levin Syndrome
  • Sleep Medicine
  Research Interest

  The research focus of the laboratory is the study of sleep and sleep disorders such as narcolepsy and Kleine Levin syndrome. We also study the neurobiological and genetic basis of the EEG and develop new tools to study sleep using nocturnal polysomnography. Approaches mostly involve human genetic studies (GWAS, sequencing), EEG signal analysis, and immunology (as narcolepsy is an autoimmune disease of the brain).
• 
  Mochly-Rosen, Daria 
  Academic Appointments Professor,  Chemical and Systems Biology
  Member,  Bio-X
  
  Research Interest

  Two areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. We focus on protein kinase C (PKC)-mediated signal transduction and on mitochondrial dynamics in several disease models. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, we study their involvement in normal cells and in models of human diseases.
• 
  Moerner, W 
  Academic Appointments Member,  Bio-X
  
  Research Interest

  Physical chemistry/chemical physics: single-molecule imaging and spectroscopy in condensed phases; superresolution imaging of biomolecules in cells; fluorophores for cellular imaging; single-molecule biophysics; nanophotonics to produce enhanced optical fields; trapping single molecules in solution
• 
  Moler, Kathryn 
  Academic Appointments Professor,  Natural Sciences Cluster - Applied Physics
  Member,  Bio-X
  Professor,  Natural Sciences Cluster - Physics
  
• 
  Monje-Deisseroth, Michelle 
  Academic Appointments Assistant Professor,  Neurology & Neurological Sciences
  Member,  Child Health Research Institute
  Member,  Bio-X
  Assistant Professor (By courtesy),  Neurosurgery
  Assistant Professor (By courtesy),  Pediatrics
  
  Clinical Focus

  • Neurology
  Research Interest

  The Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Montgomery, Stephen B.
  Academic Appointments Assistant Professor,  Pathology
  Member,  Child Health Research Institute
  Member,  Bio-X
  Assistant Professor,  Genetics
  Assistant Professor (By courtesy),  Computer Science
  
  Research Interest

  We focus on understanding the effects of genome variation on cellular phenotypes and cellular modeling of disease through genomic approaches such as next generation RNA sequencing in combination with developing and utilizing state-of-the-art bioinformatics and statistical genetics approaches. See our website at http://montgomerylab.stanford.edu/
• 
  Moore, Tirin 
  Academic Appointments Associate Professor,  Neurobiology
  Member,  Bio-X
  
  Research Interest

  We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and
• 
  Moseley, Michael 
  Academic Appointments Professor,  Radiology - Diagnostic Radiology
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  
  Research Interest

  MR physics into tissue contrast mechanisms such as diffusion, perfusion, and functional imaging describes the research direction. Applications of cerebral stroke (brain attacks) and neurocognitive disorders are also being developed from these methods
• 
  Moshfeghi, Darius 
  Academic Appointments Associate Professor - Med Center Line,  Ophthalmology
  Member,  Bio-X
  
  Clinical Focus

  • Vitreoretinal Surgery, Pediatric vitreretinal surgery, Age-Related Macular Degeneration, Retinal Detachment, Retinopathy of Prematurity, Diabetic Retinopathy, Cystoid Macular Edema, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
  • Ophthalmology
  • Coats disease, familial exudative vitreoretinopathy, x-linked retinoschisis
  Research Interest

  Dr. Moshfeghi leads the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP network). The SUNDROP network utilizes RetCam II cameras to provide remote screening of retinopathy of prematurity at outlying neonatal intensive care units. Active sites include Dominican Hospital, Washington Hospital, Santa Clara Valley Medical Center, and O'Connor Hospital.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Musen, Mark 
  Academic Appointments Professor,  Medicine - Biomedical Informatics Research
  Member,  Bio-X
  
  Clinical Focus

  • Internal Medicine
  • Unknown
  Research Interest

  My laboratory investigates the use of distributed, component-based software architectures to build intelligent computer systems. Emphasis is on knowledge modeling and knowledge reuse. Our goals are to enhance methodologies that faculitate building and maintaining electronic knowledge bases that can drive useful biomedical computer systems. Current work concentrates on automation of clinical practice guidelines and clinical-trial protocols, and surveillance for potential episodes of bioterrorism.
• 
  Mustapha, Mirna 
  Academic Appointments Assistant Professor,  Otolaryngology (Head and Neck Surgery)
  Member,  Bio-X
  
  Research Interest

  Hearing is one of the most sensitive functions controlled by thyroid hormone (TH). TH is required for the timely coordination of a complex set of differentiation events in the maturing cochlea. Hypothyroidism retards the differentiation of the cochlea, including synaptogenesis, neurogenesis and myelinogenesis. The mechanisms that prompt the progression of these developmental events are poorly understood. Our preliminary data shows that many genes are differentially regulated by thyroid hormone ..