Department: Stanford Cancer Institute
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Academic Appointments Member, Stanford Cancer Institute
Research InterestWe study the molecular and cellular mechanisms that control mitosis and cytokinesis in normal cells and their dysregulations that lead to aneuploidy and genomic instability in tumor cells. The current focus is on the cell cycle regulatory circuits consisting of kinases and ubiquitin ligases. In addition, we investigate the assembly, dynamics and function of mitotic structures. We use a combination of genomics, cell biology, biochemistry, and molecular genetics in mammalian cells.
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Academic Appointments Professor, Medicine - Immunology & Rheumatology
Member, Stanford Cancer Institute
Clinical Focus- Immunology
- Immunology and Rheumatology
Research InterestMy lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have identified and characterized a gene (GRAIL) that seems to control T cell anergy. We have recently characterized a gene (Deaf1) that seems to play a major role in peripheral tolerance in T1D.
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Academic Appointments Emeritus Faculty, Acad Council, Otolaryngology (Head and Neck Surgery)
Member, Stanford Cancer Institute
Clinical Focus- Cancer > Head and Neck Cancer
- Otolaryngology
- Head and Neck Tumor Surgery
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Academic Appointments Professor Emeritus, Medicine - Endocrinology, Gerontology, & Metabolism
Emeritus Faculty, Acad Council, Medicine - Endocrinology, Gerontology, & Metabolism
Member, Stanford Cancer Institute
Clinical Focus- Endocrinology
- Internal Medicine
Research InterestStudies of the role of the vitamin D receptor in the action of 1,25-dihydroxyvitamin D, the active vitamin D hormone. Current efforts are evaluating the vitamin D receptor in breast and prostate cancer, osteoporosis and rickets.
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Academic Appointments Assistant Professor, Pediatrics - Endocrinology and Diabetes
Member, Stanford Cancer Institute
Member, Bio-X
Member, Child Health Research Institute
Clinical Focus- Pediatric Endocrinology
Research InterestThe overall goal of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions and the role these pathways play in both physiology and disease. We use molecular biology and in vivo models to elucidate mechanisms of regulating cell fate determination by the endocrine system. Understanding these processes has profound and broad implications for both science and health.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Medicine - Oncology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Pathology
Clinical Focus- Cancer > Lymphoma
- Hodgkin's Disease
- Hodgkin's Disease - Hematology
Research InterestMy laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.
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Academic Appointments Professor, Chemical and Systems Biology
Member, Stanford Cancer Institute
Professor, Biochemistry
Research InterestMy lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits.
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Academic Appointments Associate Professor - Med Center Line, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Cancer > GI Oncology
- Medical Oncology
- Oncology
Research InterestClinical expertise in GI cancers with research which emphasizes Phase I and II clinical trials of novel therapies but also includes translational studies including biomarkers, molecular imaging, tumor immunology and development of immunotherapeutic trials.
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Academic Appointments Professor - Med Center Line, Neurology & Neurological Sciences
Member, Stanford Cancer Institute
Member, Child Health Research Institute
Professor - Med Center Line, Pediatrics
Professor - Med Center Line (By courtesy), Neurosurgery
Clinical Focus- Cancer > Neuro Oncology
- Neurology - Child Neurology
- Neuro-Oncology
Research InterestClinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies, and childhood headaches.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Associate Professor, Medicine - Oncology
Member, Bio-X
Member, Stanford Cancer Institute
Associate Professor, Genetics
Associate Professor (By courtesy), Pediatrics
Clinical Focus- Cancer > GI Oncology
- Cancer Genetics
- Gastrointestinal Cancers - Genetics
Research InterestMammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNA damage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Emeritus Faculty, Acad Council, Medicine
Member, Stanford Cancer Institute
Clinical Focus- Cardiology (Heart), Preventive
- Internal Medicine
- Primary Prevention
Research InterestPopulation-level (community) prevention of cardiovascular disease, epidemiology and prevention of chronic diseases, tobacco use cessation research, tobacco control policy, nutrition education, blood pressure control, and lipid disorders.
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Academic Appointments Assistant Professor, Biology (School of Humanities and Sciences)
Member, Child Health Research Institute
Member, Stanford Cancer Institute
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Academic Appointments Consulting Professor, Health Research & Policy - Epidemiology
Member, Stanford Cancer Institute
Research InterestChronic disease epidemiology, particularly cancer, cardiovascular disease, adverse effects of smoking, alcohol and pharmaceuticals, evaluation of screening tests. Most of my career has been in the Kaiser Permanente Division of Research where I was Director for 7 years and am still active. I especially enjoy mentoring students and trainees at Stanford.
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Academic Appointments Professor, Biology (School of Humanities and Sciences)
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestThe long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
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Academic Appointments Professor, Developmental Biology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Genetics
Research InterestRegulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.
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