Department: Radiology

Keywords: Tumor Imaging, Contrast Agents, Cancer imaging, MR imaging, Radiology I am interested in and involved with novel approaches for Tumor MR Imaging, with an emphasis on the development and evaluation of cell-specific contrast agents. For example, I have utilized superparamagnetic iron oxide nanoparticles (USPIO's) to visualize tumor associated macrophages (TAMs). TAMs are of importance because they correlate strongly with poor outcome in patients with breast cancer and other cancers b..

Cardiac differentiation of human induced pluripotent stem cells using developmental biology paradigms, chemically defined reprogramming, culture, and differentiation, disease modeling, cardiotoxicity, electrophysiology

(1) development of new chemical probes for studying biological problems in human health and disease, (2) method for fast and specific post-synthesis modification of DNA and its further applications for, e.g. aptamer selection and array analysis (3) borononic acid-based lectin mimics (5) drug design, synthesis and biological evaluation

Noninvasive oxygenation measurement with MRI MRI relaxometry Numerical simulation 19F MRI

Dr. Ertosun graduated from Bilkent Üniversitesi (Bilkent University) with a B.S. degree in Electrical & Electronics Engineering in 2004. During his undergraduate studies at Bilkent, he conducted research with Prof. Haldun Ozaktas in the fields of optics and signal processing. He received an M.S. degree in Electrical Engineering from Stanford University in 2006, where his research focused on optoelectronic & semiconductor devices, and carbon nanotubes. He received a second M.S. degree in Financ..

MRI brain Image Processing, Atlas Creation, Atlas-based segmentation, Deformation-based Morphometry, registration, statistical analysis.

Evaluation of novel PET detectors based on semiconductor photodetectors, Design and development of hardware for MR compatible PET system, Image correction methods for PET images.

My research is focused on developing and evaluating molecular imaging agents for visualizing neurological diseases in living subjects.

Developing novel medical devices (based on optical, ultrasound and photoacoustic technologies) and integrating them with clinically relevant molecular imaging strategies to improve the current standards in cancer/disease screening and management.

My research focuses on understanding how voltage-gated Na+ channels function at the molecular level. Specifically, I use natural products such as aconitine and batrachotoxin as molecular probes to identify key protein interactions that are responsible for the healthy behaviour of the channels. In addition, synthetic modification of the natural products allow us to design molecular tools for applications that range from real-time protein imaging to next generation pain treatments.

The Wu lab studies the biological mechanisms of adult stem cells, embryonic stem cells, and induced pluripotent stem cells.

Stem Cell Imaging: The ultimate goal of my research is to develop clinically applicable, non-invasive and repeatable imaging tools, which can be used for long-term tracking of transplanted stem cells in bone defects and osteochondral defects. I evaluate novel contrast agents for non-invasive in vivo detection of stem cells with MR imaging in mouse models of bone and cartilage repair, I test smart, activatable MR contrast agents, which can provide non-invasive information about the viability and..

Development of novel gene expression systems for potent, tumor-specific gene therapy of cancer, and to link therapeutic gene expression with imaging reporter gene expression in order to longitudinally track treatment efficacy in living subjects using bioluminescence imaging and positron emission tomography. Emphasis has also been on labeling therapeutic cells with imaging probes or reporter genes to track the fate of these cells in both small animal models and human subjects.

Novel acquisition techniques for quantitative perfusion MRI in stroke and tumor patients

My research interests are concerned with signal processing for molecular imaging. Current applications I am working on include Raman spectroscopy and photoacoustic tomography.

High-Field MRI

High performance PET Instrumentations - Ultra high temporal resolution Time-of-Flight (ToF) PET based on silicon photomultipliers (SiPM) - PET detectors with depth-of-interaction (DOI) infomation Characterization and application of novel detectors for PET and photon counting CT Emerging molecular imaging techniques. E.g. Magnetic Particle Imaging (MPI)