Department: Chemical and Systems Biology
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Academic Appointments Emeritus Faculty, Acad Council, Chemical and Systems Biology
Research InterestStructure, dynamics and function of proteins involved in transport and regulatory processes; high resolution nuclear magnetic resonance studies of conformational transitions and protein folding; study of the mechanism of action of the trp-repressor, ankyrin-domain proteins and the development of programs to calculate protein solution structure
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Academic Appointments Assistant Professor, Chemical and Systems Biology
Assistant Professor, Developmental Biology
Research InterestSurvival in changing environments requires the acquisition of new heritable traits. However, mechanisms that safeguard the fidelity of DNA replication often limit the source of such novelty to relatively modest changes in the genetic code. Thus, the acquisition of new forms and functions is thought to be driven by rare variants that occur at random, and are enriched during times of stress. We have begun to study an intriguing alternative hypothesis: that intrinsic links between protein folding ..
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