Martin S. Angst
Effects of a peripheral nerve block on biomarkers of pain and inflammation
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.
Recruiting Status:
CompletedStanford Recruiting Status:
CompletedCondition(s):
Intervention(s):
- Procedure: femoral nerve block
Phase:
N/AEligibility
Ages Eligible for Study:
18 years to 50 yearsGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can participate as controls.Key Inclusion Criteria:
1. Between 18 and 50 years of age
2. Fluent in English language
3. Provide written informed consent
4. Skin pigmentation type II or III
Key Exclusion Criteria:
1. Current use of prescription drugs interfering with study objective
2. Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation
3. Current acute or chronic pain conditions
4. Significant medical conditions including psychiatric, neurological, and dermatological diseases
5. Pregnancy
6. Allergies to study drug(s)
7. Concomitant participation in other study protocol
Additional Study Details
Official Title:
Effect of peripheral nerve block on inflammatory and nociceptive biomarkers in a UV-B burn model in humansAnticipated start date:
10/9/2007Lead Sponsor:
Stanford UniversityInvestigator(s):
- Damian Horstman
- Brendan Carvalho
- Martin S Angst
Study Type:
InterventionalPurpose:
PreventionAllocation:
RandomizedMasking:
Double BlindControl:
noneAssignment:
Cross OverEndpoints:
EfficacyPrimary Outcomes:
- Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.
Secondary Outcomes:
- Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines.
Total Number to be Enrolled:
15Total Number to be Enrolled at Stanford:
15More Information
Secondary ID(s):
- eProtocol number 10740
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
11/21/2008PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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