Martin S. Angst
A human in-vivo model for the detection of inflammatory and nociceptive biomarkers
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
This study aims to establish a novel approach assisting the rational development of analgesic and anti-inflammatory drugs. In a first step we will test in healthy human volunteers whether proteins mediating inflammation and pain can be detected in an experimentally induced inflammatory skin lesion. Fluids that will be used to detect such proteins will be collected from the inflamed skin site via small porous catheters. We wish to establish the expression pattern of different proteins and correlate it with various tests assessing pain.
Recruiting Status:
CompletedStanford Recruiting Status:
CompletedCondition(s):
Intervention(s):
- Procedure: Micro-plasmapheresis
Phase:
N/AEligibility
Ages Eligible for Study:
21 years to 60 yearsGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can not participate as controls.Key Inclusion Criteria:
1. Age between 21-60.
2. Skin type II or III according to the classification of Fitzpatrick (II: fair skin, always burns, sometimes tans, III: medium skin, sometimes burns, always tans).
Key Exclusion Criteria:
1. History of a significant systemic disease, a dermatological disease, bleeding disorder, or chronic pain.
2. Consumption of analgesic drugs.
3. Hypersensitivity to sunlight.
Additional Study Details
Official Title:
Proof-of-concept study for bio-marker assay validation in humansAnticipated start date:
Lead Sponsor:
Stanford UniversityInvestigator(s):
Study Type:
InterventionalPurpose:
DiagnosticAllocation:
RandomizedMasking:
Double BlindControl:
noneAssignment:
Cross OverEndpoints:
UnspecifiedPrimary Outcomes:
- Cytokine-release profile in response to inflammation, noxious heat, and asministration of a COX-inhibitor
Total Number to be Enrolled:
13Total Number to be Enrolled at Stanford:
13More Information
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
11/21/2008PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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