Jerome Yesavage
PTSD, Sleep Disordered Breathing And Genetics: Effects On Cognition
Contact Information
VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto, CA 94304Brief
The current research program aims to study how sleep disordered breathing, age and genetics affect memory in older adult veterans with Posttraumatic Stress Disorder (PTSD). The study will help researchers and clinicians better understand the relationship among PTSD, sleep disordered breathing, genetics and memory function.
Recruiting Status:
RecruitingStanford Recruiting Status:
Condition(s):
Intervention(s):
- Behavior: observational testing
Phase:
N/AEligibility
Ages Eligible for Study:
55 years to 90 yearsGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can participate as controls.Key Inclusion Criteria:
1. Age 55 years or older, male or female veterans of any racial or ethnic group.
2. PTSD subjects will be positive for lifetime PTSD, related to any past lifetime traumatic experience and have a diagnosis of current, chronic PTSD by the Clinician Administered PTSD Scale (CAPS) criteria with current CAPS score > 40
3. Capable of giving informed consent for the study
4. Sufficient visual and auditory acuity for cognitive testing
Key Exclusion Criteria:
Psychiatric Exclusions
1. Current or lifetime history of any psychiatric disorder with psychotic features
2. Current or lifetime bipolar disorder or delusional disorder
3. Prominent suicidal or homicidal ideation
4. Current exposure to trauma or recent exposure to trauma in the past 3 months.
5. Currently or have within the past six months met DSM-IV criteria for drug or alcohol abuse or dependence (except nicotine).
6. Presence of alcohol intoxication (by breathalyzer) or alcohol withdrawal (by exam) during testing
7. Diagnosis of probable or possible dementia
8. MMSE < 23
9. History of seizure disorder.
Medical/Medication Exclusions
1. Acute illness or unstable chronic illness (e.g., history of severe liver disease (cirrhosis, esophageal varices, ascites, portal hypertension, hepatic encephalopathy). Clinical or laboratory evidence of active hepatic disease will be recorded.
2. History of neurologic (e.g., multiple sclerosis, seizure disorder, stroke, history of transient ischemic attacks) or systemic illness affecting CNS function (e.g. liver failure, kidney failure, congestive heart failure, systemic cancer)
3. Unstable or severe cardiovascular disease
4. Unstable gastrointestinal disorder
5. Uncontrolled hypertension
6. Head injury within one year
7. Loss of consciousness >24 hrs
8. Use of systemic steroid medication (with the exception of Estrogen replacement therapy which is permissible)
9. Illiterate or unable to read or write English or are judged by the investigator to be unable or unlikely to follow the study protocol
10. Toxicology evidence of illicit substance use.
Additional Study Details
Official Title:
PTSD, Sleep Disordered Breathing And Genetics: Effects On CognitionAnticipated start date:
9/22/2004Lead Sponsor:
Stanford UniversityInvestigator(s):
Study Type:
ObservationalPurpose:
NOTNEEDEDDuration:
LongitudinalSelection:
Defined PopulationTiming:
ProspectiveTotal Number to be Enrolled:
150Total Number to be Enrolled at Stanford:
150More Information
Secondary ID(s):
- 243
Locations & Contacts
Stanford Locations & Contacts:
VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto, CA 94304Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
6/30/2009PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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