Garry Gold
MRI Imaging of the Human Larynx
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
To determine if high resolution MRI can detect early invasion of cartilage by laryngeal carcinoma, and to determine if high resolution MRI may be superior to conventional MRI imaging or CT imaging to detect cartilage invasion.
Recruiting Status:
RecruitingStanford Recruiting Status:
RecruitingCondition(s):
Intervention(s):
- Procedure: High resolution MRI scan of the larynx using a custom-designed surface coil
Phase:
N/AEligibility
Ages Eligible for Study:
18 years to Any AgeGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can participate as controls.Key Inclusion Criteria:
- Patients with benign or malignant neoplasm of the larynx.
- Patients who have undergone prior surgery, radiation therapy, or chemotherapy for cancer of the laryngopharynx will be eligible to participate.
- Patients 18 years of age and older at time of evaluation, male and female, all ethnicities.
- Ability to understand and the willingness to sign a written informed consent document.
Key Exclusion Criteria:
- Pregnancy
- Claustrophobia.
- Anatomic parameters which preclude scanning, such as limited range of neck motion, or inability to remain flat for at least 15 minutes.
- Patients with implanted devices (eg, defibrillator, pacemaker) that are a known contraindication to magnetic resononance imaging.
- Allergy to gadolinium contrast.
Additional Study Details
Official Title:
High Resolution MRI in the Evaluation of Laryngeal NeoplasiaAnticipated start date:
7/1/2009Lead Sponsor:
Stanford UniversityInvestigator(s):
- Edward J. Damrose MD, FACS
- Garry Evan Gold
- Dwight G Nishimura
Study Type:
InterventionalPurpose:
TreatmentAllocation:
Non-randomizedMasking:
OpenControl:
noneAssignment:
Single GroupEndpoints:
Safety/EfficacyPrimary Outcomes:
- Tumor stage as determined by HRMRI.
- Tumor stage as determined by histopathology in excised larynges.
- Estimate the precision of HRMRI in terms of cartilage invasion.
- Estimate the precision of HRMRI in discriminating between edema and tumor in patients with prior radiotherapy or chemotherapy.
Total Number to be Enrolled:
20Total Number to be Enrolled at Stanford:
20More Information
Secondary ID(s):
- 96536
- ENT0019
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
8/18/2009PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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