Key Exclusion Criteria:

- Disease-Specific Exclusions
1. Prior oxaliplatin for any reason.
2. Prior full field radiotherapy <= 4 weeks or limited field radiotherapy <= 2 weeks prior to enrollment. Patients must have recovered from all therapy-related toxicities. The site of previous radiotherapy should have evidence of progressive disease if this is the only site of disease.
3. Prior biologic or immunotherapy <= 2 weeks prior to registration. Patients must have recovered from all therapy-related toxicities
4. Prior therapy with anti-VEGF agents
5. If history of other primary cancer, subject will be eligible only if she or he has:
o Curatively resected non-melanomatous skin cancer
o Curatively treated cervical carcinoma in situ
o Other primary solid tumor curatively treated with no known active disease present and no treatment administered for the last 3 years
6. Concurrent use of other investigational agents and patients who have received investigational drugs <= 4 weeks prior to enrollment.

- General Medical Exclusions
1. Subjects known to have chronic or active hepatitis B or C infection
2. History of any medical or psychiatric condition or laboratory abnormality that in the opinion of the investigator may increase the risks associated with study participation or study drug administration or may interfere with the conduct of the study or interpretation of study results
3. Male subject who is not willing to use adequate contraception upon enrollment into this study and for 6 months following the last dose of second-line treatment
4. Female subject (of childbearing potential, post-menopausal for less than 6 months, not surgically sterilized, or not abstinent) who is not willing to use an oral, patch or implanted contraceptive, double-barrier birth control, or an IUD during the course of the study and for 6 months following the last dose of second-line treatment
5. Female subject who is breast-feeding or who has positive serum pregnancy test 72 hours prior to randomization
6. Pleural effusion or ascites that causes respiratory compromise (>= CTCAE grade 2 dyspnea)
7. Any of the following concurrent severe and/or uncontrolled medical conditions within 24 weeks of enrollment which could compromise participation in the study:
o Unstable angina pectoris
o Symptomatic congestive heart failure
o Myocardial infarction <= 6 months prior to registration and/or randomization
o Serious uncontrolled cardiac arrhythmia
o Uncontrolled diabetes
o Active or uncontrolled infection
o Interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung
o Chronic renal disease
o Acute or chronic liver disease (e.g., hepatitis, cirrhosis)
8. Patients unwilling to or unable to comply with the protocol
9. Life expectancy of less than 12 weeks
10. Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than a Genentech-sponsored bevacizumab cancer study

- Bevacizumab-Specific Exclusions
1. Inadequately controlled hypertension (defined as systolic blood pressure > 150 and/or diastolic blood pressure > 100 mmHg on antihypertensive medications)
2. Any prior history of hypertensive crisis or hypertensive encephalopathy
3. New York Heart Association (NYHA) Grade II or greater congestive heart failure (see Appendix E)
4. History of myocardial infarction or unstable angina within 6 months prior to study enrollment
5. History of stroke or transient ischemic attack within 6 months prior to study enrollment
6. Known CNS disease
7. Significant vascular disease (e.g., aortic aneurysm, aortic dissection)
8. Symptomatic peripheral vascular disease
9. Evidence of bleeding diathesis or coagulopathy
10. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment or anticipation of need for major surgical procedure during the course of the study
11. Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to study enrollment
12. History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to study enrollment
13. Serious, non-healing wound, ulcer, or bone fracture
14. Urine protein >= 2+ on urinalysis dipstick and >= 1.0 gram on 24-hour urine collection
15. Known hypersensitivity to any component of bevacizumab