Sean Mackey, M.D., Ph.D.
Effect of IV Lidocaine Infusions on Pain
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
Our goals for this study involve using intravenous lidocaine as it is normally used in the Stanford Pain Management Center to assess the effect of intravenous lidocaine on chronic pain. Studies have been done determining the efficacy of intravenous lidocaine for treating pain but little research has been done to determine the effects of an intravenous lidocaine infusion on the different components of the pain experience. Our study will incorporate psychophysical and behavioral testing both before and during the infusions of lidocaine to determine changes in mood. In addition, we will use functional magnetic resonance imaging to observe what changes occur in the brain during a lidocaine infusion.
Recruiting Status:
RecruitingStanford Recruiting Status:
RecruitingCondition(s):
Intervention(s):
- Drug: Intravenous lidocaine
Phase:
N/AEligibility
Ages Eligible for Study:
18 years to 100 yearsGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can participate as controls.Key Inclusion Criteria:
- subjects between the ages of 18 and 100 years for clinical component; subjects between the ages of 18 and 70 for the MRI component
- meets the study criteria of chronic pain of either peripheral or central origin
- male or a non-pregnant, non-lactating female. If females are of reproductive potential (i.e., not surgically sterilized and/or not post menopausal), they must be practicing an accepted method of birth control, agree to a urine pregnancy test at the start of each study session (for patient scheduled through the clinic, this has already been addressed by the recommending physician)
-is not currently on a sodium channel blocking agent, anticonvulsant, or tricyclic antidepressant,
- must be able to comply with any other study requirements and complete experimental tasks
- have no reported substance abuse within the past six months;
Key Exclusion Criteria:
- subject is lactating or pregnant;
- subject suffers from clinically significant cardiac, pulmonary, renal or liver disease;
- subject allergic to lidocaine.
- MRI Component: any metal objects (especially surgical clips), devices, or implants or any other MRI contraindication
Additional Study Details
Official Title:
Effect of IV Lidocaine Infusions on PainAnticipated start date:
9/3/2008Lead Sponsor:
Stanford UniversityInvestigator(s):
Study Type:
InterventionalPurpose:
TreatmentAllocation:
Non-randomizedMasking:
Single BlindControl:
noneAssignment:
Single GroupEndpoints:
EfficacyPrimary Outcomes:
- Blood Oxygenation Level Dependent (BOLD) signal in insular cortex, Prefrontal cortex, Rostroventral Medulla, Ventral Tegmental Area, and Caudate Nucleus.
Total Number to be Enrolled:
100Total Number to be Enrolled at Stanford:
100More Information
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
2/6/2009PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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