Martin S. Angst
Heritability of Opioid Effects: A Twin Study
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
Proposed twin study will test to what degree inter-individual differences in pain sensitivity and amount of pain relief in response to opioid therapy are inherited or alternatively, are due to environmental factors. This knowledge is important to guide future studies trying to explain such inter-individual differences. For example, finding that differences are largely due to environmental factors would discourage genomic studies and emphasize epidemiological studies.
Recruiting Status:
RecruitingStanford Recruiting Status:
RecruitingCondition(s):
Intervention(s):
- Drug: Alfentanil
Phase:
N/AEligibility
Ages Eligible for Study:
18 years to 70 yearsGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can not participate as controls.Key Inclusion Criteria:
Monozygotic or dizygotic twins
Ages 18-70
Key Exclusion Criteria:
(1) Clinically relevant systemic diseases such as psychiatric, neurological, and dermatological conditions interfering with the collection and interpretation of study data
(2) History of addiction
(3) Allergy to study medication
(4) Chronic intake of medication potentially interfering with pain processing (except oral contraceptives)
(5) Intake of over-the-counter analgesics within the two days prior to study
(6)Reynaud's disease
(7)pregnancy
(8)Participation in other study within last 30 days
(9)Personnel with direct access to addicting drugs
Additional Study Details
Official Title:
Heritability of Opioid Effects: A Twin StudyAnticipated start date:
5/1/2008Lead Sponsor:
Stanford UniversityCollaborator(s):
- SRI
Investigator(s):
Study Type:
InterventionalPurpose:
OtherAllocation:
RandomizedMasking:
Double BlindControl:
noneAssignment:
Cross OverEndpoints:
Pharmacokinetics/dynamicsPrimary Outcomes:
- To what degree are inter-individual differences in pain sensitivity and pain relief in response to opioid therapy inherited.
Secondary Outcomes:
- To what degree are inter-individual differences in other effects of opioid medications inherited.
Total Number to be Enrolled:
250Total Number to be Enrolled at Stanford:
250More Information
Secondary ID(s):
- IRB # 13018
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
2/12/2009PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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