Key Documents
Denise Chan
Professional Education
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Doctor of Philosophy, Stanford University
(2004)
Publications
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Regulation of the Histone Demethylase JMJD1A by HIF-1{alpha} Enhances Hypoxic Gene Expression and Tumor Growth.
Krieg AJ,
Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ.
Mol Cell Biol.
2009;
-
Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds.
Chang EI,
Bonillas RG, El-ftesi S, Chang EI, Ceradini DJ, Vial IN, Chan DA, Michaels J, Gurtner GC.
FASEB J.
2009;
23
(3):
906-15
-
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Chan DA,
Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ.
Cancer Cell.
2009;
15
(6):
527-38
-
Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.
Choi CY,
Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ.
Mol Imaging.
2008 May-Jun;
7
(3):
139-46
-
Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.
Pagé EL,
Chan DA, Giaccia AJ, Levine M, Richard DE.
Mol Biol Cell.
2008;
19
(1):
86-94
-
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.
Turcotte S,
Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ.
Cancer Cell.
2008;
14
(1):
90-102
-
Short hairpin RNA interference therapy for ischemic heart disease.
Huang M,
Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC.
Circulation.
2008;
118
(14 Suppl):
S226-33
-
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Lauzier MC,
Robitaille GA, Chan DA, Giaccia AJ, Richard DE.
Mol Pharmacol.
2008;
74
(1):
282-8
-
Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics.
Chan DA,
Giaccia AJ.
Cell Cycle.
2008;
7
(19):
2987-90
-
Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia.
Cecic I,
Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE.
Mol Imaging.
2007 Jul-Aug;
6
(4):
219-28
-
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
Glassford AJ,
Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS.
Am J Physiol Endocrinol Metab.
2007;
293
(6):
E1590-6
-
HIF gene expression in cancer therapy.
Chan DA,
Krieg AJ, Turcotte S, Giaccia AJ.
Methods Enzymol.
2007;
435
323-45
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Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
Pan Y,
Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC.
Mol Cell Biol.
2007;
27
(3):
912-25
-
Energy regulation: HIF MXIes it up with the C-MYC powerhouse.
Sutphin PD,
Giaccia AJ, Chan DA.
Dev Cell.
2007;
12
(6):
845-6
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Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia.
Chang EI,
Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC.
Circulation.
2007;
116
(24):
2818-29
-
Hypoxia, gene expression, and metastasis.
Chan DA,
Giaccia AJ.
Cancer Metastasis Rev.
2007;
26
(2):
333-9
-
Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.
Sutphin PD,
Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ.
Cancer Res.
2007;
67
(12):
5896-905
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The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels.
Spear W,
Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ.
Cell Microbiol.
2006;
8
(2):
339-52
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Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.
Chan DA,
Sutphin PD, Yen SE, Giaccia AJ.
Mol Cell Biol.
2005;
25
(15):
6415-26
-
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Baek JH,
Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.
Mol Cell.
2005;
17
(4):
503-12
-
Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.
Bemis L,
Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W.
Genes Dev.
2004;
18
(7):
739-44
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Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.
Pfander D,
Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E.
Development.
2004;
131
(10):
2497-508
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JunD reduces tumor angiogenesis by protecting cells from oxidative stress.
Gerald D,
Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouysségur J, Yaniv M, Mechta-Grigoriou F.
Cell.
2004;
118
(6):
781-94
-
Dead cells don't form tumors: HIF-dependent cytotoxins.
Sutphin PD,
Chan DA, Giaccia AJ.
Cell Cycle.
2004;
3
(2):
160-3
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
Chan DA,
Sutphin PD, Denko NC, Giaccia AJ.
J Biol Chem.
2002;
277
(42):
40112-7