Key Documents
Zhiguo Chen
Honors and Awards
- Tianjin Science and Technology Award, Tianjin (1996)
- Travel awards, Karolinska Institute (2003 and 2004)
- Award of Excellence in Route 28 Summits, Route 28 Summits (2005)
Professional Education
-
Doctor of Philosophy, Karolinska Institutet
(2004)
Publications
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Cellular repair of CNS disorders: an immunological perspective.
Chen Z,
Palmer TD.
Hum Mol Genet.
2008;
17
(R1):
R84-92
-
Decreased fractalkine and increased IP-10 expression in aged brain of APP(swe) transgenic mice.
Duan RS,
Yang X, Chen ZG, Lu MO, Morris C, Winblad B, Zhu J.
Neurochem Res.
2008;
33
(6):
1085-9
-
Aggravation of experimental autoimmune neuritis in TNF-alpha receptor 1 deficient mice.
Lu MO,
Duan RS, Quezada HC, Chen ZG, Mix E, Jin T, Yang X, Ljunggren HG, Zhu J.
J Neuroimmunol.
2007;
186
(1-2):
19-26
-
IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12.
Zhang XM,
Duan RS, Chen Z, Quezada HC, Mix E, Winblad B, Zhu J.
Exp Neurol.
2007;
205
(1):
64-73
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Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice.
Duan RS,
Chen Z, Dou YC, Concha Quezada H, Nennesmo I, Adem A, Winblad B, Zhu J.
Exp Neurol.
2006;
202
(2):
373-80
-
Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 mice.
Chen Z,
Duan RS, Quezada HC, Mix E, Nennesmo I, Adem A, Winblad B, Zhu J.
J Neurobiol.
2005;
62
(2):
207-18
-
SOD-1 inhibits FAS expression in cortex of APP transgenic mice.
Chen Z,
Duan RS, Lepécheur M, Paly E, London J, Zhu J.
Apoptosis.
2005;
10
(3):
499-502
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Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice.
Chen Z,
Duan RS, Zhu Y, Folkesson R, Albanese C, Winblad B, Zhu J.
J Neurochem.
2005;
92
(5):
1281-4
-
IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice.
Chen Z,
Duan RS, Q HC, Wu Q, Mix E, Winblad B, Ljunggren HG, Zhu J.
Neurobiol Dis.
2004;
17
(2):
171-8
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Reduced susceptibility to kainic acid-induced excitoxicity in T-cell deficient CD4/CD8(-/-) and middle-aged C57BL/6 mice.
Chen Z,
Ljunggren HG, Zhu SW, Winblad B, Zhu J.
J Neuroimmunol.
2004;
146
(1-2):
33-8
-
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis.
Chen Z,
Yu S, Concha HQ, Zhu Y, Mix E, Winblad B, Ljunggren HG, Zhu J.
Brain Behav Immun.
2004;
18
(2):
175-85
-
Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice.
Yu S,
Duan RS, Chen Z, Quezada HC, Bao L, Nennesmo I, Zhu SW, Winblad B, Ljunggren HG, Zhu J.
J Neuropathol Exp Neurol.
2004;
63
(2):
120-8
-
CCR5 deficiency does not prevent P0 peptide 180-199 immunized mice from experimental autoimmune neuritis.
Duan RS,
Chen Z, Bao L, Quezada HC, Nennesmo I, Winblad B, Zhu J.
Neurobiol Dis.
2004;
16
(3):
630-7
-
The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3.
Chen Z,
Yu S, Bakhiet M, Winblad B, Zhu J.
J Neurochem.
2003;
86
(1):
61-8
-
CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis.
Zhu Y,
Bao L, Zhu S, Chen Z, van der Meide P, Nennesmo I, Winblad B, Ljunggren HG, Zhu J.
Exp Neurol.
2002;
177
(1):
314-20
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Neutralizing antibodies to IL-18 ameliorate experimental autoimmune neuritis by counter-regulation of autoreactive Th1 responses to peripheral myelin antigen.
Yu S,
Chen Z, Mix E, Zhu SW, Winblad B, Ljunggren HG, Zhu J.
J Neuropathol Exp Neurol.
2002;
61
(7):
614-22
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Initiation and development of experimental autoimmune neuritis in Lewis rats is independent of the cytotoxic capacity of NKR-P1A+ cells.
Yu S,
Zhu Y, Chen Z, Alheim M, Ljungberg A, Zhu J.
J Neurosci Res.
2002;
67
(6):
823-8
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Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice.
Chen Z,
Ljunggren HG, Bogdanovic N, Nennesmo I, Winblad B, Zhu J.
Brain Res.
2002;
931
(2):
135-45
-
Telomerase activity in relation to pro- and anti-apoptotic protein expression in high grade non-Hodgkin's lymphomas.
MacNamara B,
Wang W, Chen Z, Hou M, Mazur J, Gruber A, Porwit-MacDonald A.
Haematologica.
2001;
86
(4):
386-93
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Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells.
Xu D,
Wang Q, Gruber A, Björkholm M, Chen Z, Zaid A, Selivanova G, Peterson C, Wiman KG, Pisa P.
Oncogene.
2000;
19
(45):
5123-33