Jan van Riggelen

Honors and Awards

• Postdoc Fellowship, Lymphoma Research Foundation (2006-2008)

Professional Education

• Diploma, University of Heidelberg Molecular Biology (2000)
• Doctor of Philosophy, Ruprecht Karl Universitat Heidelberg (2005)

Faculty Advisor

• Dean Felsher

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Cell Biology
• Molecular and Genetic Medicine

Web Site Links

• Felsher Lab

Research Interests

The Impact of Epigenetics on MYC-induced Tumorigenesis

Publications

• Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Wu CH,  van Riggelen J, Yetil A, Fan AC, Bachireddy P, Felsher DW.  Proc Natl Acad Sci U S A.  2007; 104 (32): 13028-33
• Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Giuriato S,  Ryeom S, Fan AC, Bachireddy P, Lynch RC, Rioth MJ, van Riggelen J, Kopelman AM, Passegué E, Tang F, Folkman J, Felsher DW.  Proc Natl Acad Sci U S A.  2006; 103 (44): 16266-71
• Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells. van Riggelen J,  Buchwalter G, Soto U, De-Castro Arce J, Hausen HZ, Wasylyk B, Rösl F.  J Biol Chem.  2005; 280 (5): 3286-94
• Ectopic expression of nonliganded retinoic acid receptor beta abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells. De-Castro Arce J,  Soto U, van Riggelen J, Schwarz E, Hausen HZ, Rösl F.  J Biol Chem.  2004; 279 (44): 45408-16
• Disturbance of tumor necrosis factor alpha-mediated beta interferon signaling in cervical carcinoma cells. Bachmann A,  Hanke B, Zawatzky R, Soto U, van Riggelen J, zur Hausen H, Rösl F.  J Virol.  2002; 76 (1): 280-91