Maxence Nachury

Honors and Awards

• Fellowship Award in the Neurosciences, The Esther A. & Joseph Klingenstein Fund (2009-2012)
• Research Fellowship, Alfred P. Sloan Foundation (2009-2011)
• Basil O'Connor Award, March of Dimes (2009-2011)
• Scientist Development Award, American Heart Association (2009-2012)
• Career Development Award, AACR-Pancreatic Cancer Action Network (2009-2011)
• Frederick E. Terman Fellow, Stanford University (2008-2011)
• Postdoctoral Fellowship, Damon Runyon Cancer Research Foundation (2003-2005)
• Ph.D. Fellowship, Boehringer Ingelheim Foundation (1998-2001)

Professional Education

• Postdoc, Genentech Cell Biology and Biochemistry (2007)
• Ph.D., UC Berkeley and Université Paris-Orsay Molecular and Cellular Biology (2001)
• B.Sc., Ecole Normale Supérieure (Paris) Biology and Biochemistry (1997)

Postdoctoral Advisees

• Hua Jin, Susan White

Graduate & Fellowship Program Affiliations

• Molecular and Cellular Physiology

Web Site Links

• Nachury Lab

Current Research Interests

We study the primary cilium, a once-obscure cellular organelle recently "re-discovered" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.

Publications

• A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Loktev AV,  Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV.  Dev Cell.  2008; 15 (6): 854-65
• A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Nachury MV,  Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.  Cell.  2007; 129 (6): 1201-13
• A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly Blower MD*,  Nachury MV*, Heald R, Weis K.  Cell.  2005; 121 (2): 223-234
• Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Nachury MV,  Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K.  Cell.  2001; 104 (1): 95-106
• The BBSome. Jin H,  Nachury MV.  Curr Biol.  2009; 19 (12): R472-3
• The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Berdougo E,  Nachury MV, Jackson PK, Jallepalli PV.  Cell Cycle.  2008; 7 (9): 1184-90
• Tandem affinity purification of the BBSome, a critical regulator of Rab8 in ciliogenesis. Nachury MV,  Methods Enzymol.  2008; 439 501-13
• The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Ban KH,  Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK.  Dev Cell.  2007; 13 (1): 29-42
• Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Miller JJ,  Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK.  Genes Dev.  2006; 20 (17): 2410-20
• Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. Kaiser BK,  Nachury MV, Gardner BE, Jackson PK.  BMC Cell Biol.  2004; 5 27
• The direction of transport through the nuclear pore can be inverted. Nachury MV,  Weis K.  Proc Natl Acad Sci U S A.  1999; 96 (17): 9622-7
• Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. Nachury MV,  Ryder UW, Lamond AI, Weis K.  Proc Natl Acad Sci U S A.  1998; 95 (2): 582-7