Key Documents
NIH Biosketch available Online
Pankaj Jay Pasricha
- Professor, Medicine - Gastroenterology & Hepatology
- Professor (By courtesy), Surgery
- Member, Bio-X
Contact Information
- Clinical Offices
Gastroenterology Clinic 300 Pasteur Dr A175 MC 5309 Stanford, CA 94305 Telephone Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Personal Information Email pasricha@stanford.eduAdministrative Contact Marci Palacios Email mpalacios@stanford.edu Tel Work 650 725 6511Not for medical emergencies or patient use
Clinical Focus
- Neurogastroenterology and Gastrointestinal Motility
- Gastroparesis
- Abdominal Pain
- Chronic Pancreatitis
- Esophageal Achalasia
- non-cardiac chest pain
- Swallowing Disorders
- Gastroenterology
Administrative Appointments
- Chair, NIDDK Gastroparesis Clinical Research Consortium , (2006– present )
- Member, National Commission on Digestive Diseases , (2006– present )
- Chief, Division of Gastroenterology and Hepatology , (2007– present )
Honors and Awards
- Best Doctors in America, Best Doctors (2001-present)
- America's Top Doctors, Castle Connolly (2003-present)
Professional Education
- Board Certification: Gastroenterology, American Board of Internal Medicine (2006)
- Johns Hopkins University School of Medicine (1992) MD
- Tufts-New England Medical Center (1990) MA
- DC General Hospital - Verification Clerk (1988) DC
- All India Institute of Medical Science (1983) INDIA
- Board Certification: Internal Medicine, American Board of Internal Medicine (1988)
- MBBS, AIIMS Medicine and Surgery (1982)
Postdoctoral Advisees
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.
- Consulting: Eurand, GI Supply, Pentax
- Royalty Payments: GI Supply
- Equity: Apollo, Cavu, Endopace, GI Therapeutics, Jackson GI Medical
Research Interests
THE ENTERIC NEUROMUSCULAR DISORDERS AND PAIN (END PAIN) LABORATORY AT STANFORD
The defining theme in my research is the translation of fundamental knowledge to clinical solutions in neurogastroenterology. My laboratory focuses on exploring the molecular mechanisms of disorders of the enteric nervous system (the autonomous nervous system that controls gastrointestinal physiology) and visceral sensory nerves. Within this broad area, we are pursuing several themes, outlined as follows. Our techniques encompass behavioral, electrophysiological (single nerve fiber recordings, patch clamp) as well as molecular approaches.
VISCERAL PAIN. Work in this laboratory represents a systematic approach to uncover the neurobiology of visceral pain in chronic pancreatitis, irritable bowel syndrome and functional dyspepsia and has provided a framework for designing novel treatments for pancreatic, gastric and colonic pain including targeting PAR-2, TRPV1, 5-HT4 and trkA receptors, Kv ion channels and neurotransmitters such as BDNF.
GASTROINTESTINAL DYSMOTILITY. We study models of diabetic and idiopathic gastroparesis. We are focusing on two major questions- what is the biological basis of the gender bias seen in gastroparesis (80% of patients are women) and what are the mechanisms responsible for loss of nitric oxide/nNOS dysfunction including the role of advanced glycation end products (RAGE).
NEURAL STEM CELLS. Our laboratory has been exploring the use of neural stem cells into the gut for restoring function ine cure for this condition. We have shown proof of principle that neural stem cells isolated from the brain can indeed restore function when transplanted into the gut of a mouse with genetically determined dysmotility. We are now working on manipulating a specific signaling pathway (GDNF-RET) to produce an optimal long-term outcome after transplantation. In addition we are attempting to identify the nature of the neural stem cell in the post-natal gut.
CLINICAL AND TRANSLATIONAL RESEARCH. Stanford is part of the multicenter Gastroparesis Clinical Research Consortium (http://www.jhucct.com/gpcrc), a multicenter project funded by the NIH, which I chair. The goal of this consortium is to perform clinical, epidemiological, and therapeutic research in gastroparesis and provide an infrastructure that can rapidly and efficiently design and conduct clinical trials for effective medical, surgical, or other interventions to improve treatment of patients with gastroparesis.
BIOMARKER AND THERAPEUTIC TARGET DISCOVERY.
We have identified several novel therapeutic targets for the development of drugs for visceral pain, nausea and motility. These include PAR-2, TRPV1, D3 antagonists amongst others. In addition we are in the process of setting up high throughput assays for motility in order to facilitate the screening of ligand libraries.
NOVEL ENDOSCOPIC DEVICE AND PROCEDURE DEVELOPMENT.I have more than 30 patents (issued or pending) for devices and other inventions, and work has also been published in leading journals in gastrointestinal endoscopy. I have invented several devices in the laboratory that are now in clinical trials and have expanded the ability to provide effective therapy to patients in a relatively non-invasive (i.e. endoscopic) manner. These include endoscopic cryotherapy, a new design for pancreatic and biliary stents, a new device and method for treating gastroesophageal reflux disease and obesity. These early efforts led to the formation of the “Apollo Group” a think tank composed of several leading endoscopists around the country which amongst other advances, introduced the concept of natural orifice transluminal endoscopic surgery or NOTES. Additional innovations have occurred in gastrointestinal electrical stimulation. This technique has the potential for treatment of a variety of human diseases including visceral pain, nausea, gastroparesis and obesity, amongst others.
Publications
- Gastrointest Endosc. 2009;
- Neurogastroenterol Motil. 2009; (2): 103-12
- Dig Dis Sci. 2009; (5): 1003-10
- Gastrointest Endosc Clin N Am. 2008; (2): 279-89; viii
- Gastroenterology. 2008; (7): 2070-9
- Gut. 2008; (9): 1230-7
- Gastroenterology. 2007; (4): 1282-92
- Dig Dis Sci. 2009; (1): 57-62
- J Clin Gastroenterol. 2009; (2): 123-9
- Gut. 2009; (7): 897-8
- Am J Physiol Gastrointest Liver Physiol. 2009; (6): G1370-81
- Mol Pain. 2009; 44
- J Clin Gastroenterol. 2009; (8): 716-22
- Neurogastroenterol Motil. 2008; (3): 253-61
- Neurogastroenterol Motil. 2008; (4): 349-57
- Gastrointest Endosc. 2008; (3): 497-501
- Gastroenterology. 2008; (2): 597-616
- Am J Gastroenterol. 2008; (2): 424-6
- Curr Gastroenterol Rep. 2008; (2): 101-6
- Expert Rev Gastroenterol Hepatol. 2008; (3): 291-3
- Gastroenterology. 2008; (5): 1764-89.e2
- Gastrointest Endosc. 2008; (4): 754-9
- Gastrointest Endosc Clin N Am. 2008; (3): xv-xvi
- Gastrointest Endosc Clin N Am. 2008; (3): 607-17, xi
- J Clin Gastroenterol. 2008; (6): 692-8
- BMC Gastroenterol. 2008; 21
- Clin Gastroenterol Hepatol. 2008; (7): 726-33
- ACP J Club. 2007 Nov-Dec; (3): 69
- Endoscopy. 2007; (9): 761-4
- Gastrointest Endosc. 2007; (3): 497-500
- Curr Treat Options Gastroenterol. 2007; (1): 57-60
- Gastroenterology. 2007; (2): 615-27
- J Clin Gastroenterol. 2007; (2): 138-40
- Diagn Cytopathol. 2007; (1): 18-25
- Dev Dyn. 2007; (1): 33-43
- Endoscopy. 2007; (10): 849-53
- J Support Oncol. 2007; (8): 368-70
- Gastrointest Endosc. 2007; (5): 981-6
- Evid Based Med. 2007; (6): 177
- Endoscopy. 2007; (10): 876-80
- Am J Surg. 2007; (4): 530-7
- Gastroenterology. 2007; (4): 1388-400
- Gastrointest Endosc. 2007; (6): 884-5
- N Engl J Med. 2007; (20): e20
- Endoscopy. 2007; (5): 390-3
- Gastrointest Endosc. 2007; (7): 1028-34
- Nat Clin Pract Gastroenterol Hepatol. 2007; (6): 336-46
- Gastroenterology. 2007; (7): 2287-90
- Gastrointest Endosc Clin N Am. 2007; (3): 611-6, viii-ix
- Curr Gastroenterol Rep. 2007; (4): 280-5
- Am J Physiol Gastrointest Liver Physiol. 2007; (3): G725-33
- Gastrointest Endosc. 2007; (3): 510-3
- Gastrointest Endosc. 2006; (5): 808-12
- Neurogastroenterol Motil. 2006; (9): 799-804
- Dig Liver Dis. 2006; (8): 551-3
- Gastrointest Endosc. 2006; (1): 113-9
- Dig Liver Dis. 2006; (9): 665-6
- Appl Immunohistochem Mol Morphol. 2006; (2): 161-5
- Br J Pharmacol. 2006; (5): 565-78
- Gastrointest Endosc. 2006; (7): 1055-8
- Am J Physiol Gastrointest Liver Physiol. 2006; (3): G424-31
- Neurogastroenterol Motil. 2006; (5): 392-400
- Neurogastroenterol Motil. 2006; (4): 263-83
- Endoscopy. 2006; (3): 260-5
- Nat Clin Pract Gastroenterol Hepatol. 2006; (3): 138-48
- J Gastroenterol Hepatol. 2006; (2): 343-4
- Surg Endosc. 2006; (3): 522-5
- Gastrointest Endosc. 2006; (2): 317-20
- Curr Treat Options Gastroenterol. 2006; (1): 59-68
- Neurotox Res. 2006; (2-3): 149-59
- ACP J Club. 2005 Nov-Dec; (3): 78
- Gastroenterology. 2005; (6): 1817-24
- Endoscopy. 2005; (9): 847-51
- J Electrocardiol. 2005; (4): 337-9
- J Gastrointest Surg. 2005; (8): 1129-36; discussion 1136-7
- Endoscopy. 2005; (11): 1111-5
- Neurogastroenterol Motil. 2005; (4): 557-64
- Dig Dis Sci. 2005; (7): 1335-41
- Gastrointest Endosc. 2005; (2): 287-92
- Gastrointest Endosc. 2005; (2): 266-70
- Gastrointest Endosc. 2005; (2): 230-3
- Endoscopy. 2005; (6): 523-6
- Gastrointest Endosc. 2005; (6): 768-70
- Endoscopy. 2005; (5): 415-7
- Endoscopy. 2005; (5): 411-4
- Gastrointest Endosc. 2005; (3): 449-53
- BMC Gastroenterol. 2005; 8
- Regul Pept. 2005; (1-3): 66-73
- Pain. 2005; (1-2): 214-22
- Gastrointest Endosc. 2004; (4): 623-7
- Diabetes Care. 2004; (10): 2341-7
- Gastroenterology. 2004; (3): 883-91
- Am J Physiol Cell Physiol. 2004; (2): C558-63
- Clin Gastroenterol Hepatol. 2004; (4): 286-9
- Neurogastroenterol Motil. 2004; 3-7
- Gastrointest Endosc. 2004; (3): 416-9
- Digestion. 2004; (3): 159-66
- Gastrointest Endosc. 2003; (2): 219-35
- Gastrointest Endosc. 2003; (3): 403-6
- Dig Dis Sci. 2003; (3): 508-15
- Pancreas. 2003; (1): e13-7
- Am J Med. 2003; 114S-118S
- Curr Treat Options Gastroenterol. 2003; (5): 375-379
- J Pain. 2003; (6): 329-37
- Curr Gastroenterol Rep. 2003; (5): 419-24
- ACP J Club. 2002 May-Jun; (3): 95
- ACP J Club. 2002 May-Jun; (3): 92
- Endoscopy. 2002; (7): 580-1
- BMC Mol Biol. 2002; 2
- Gastroenterology. 2002; (2): 571-5
- Am J Physiol Gastrointest Liver Physiol. 2002; (2): G390-6
- Pancreas. 2002; (1): 31-8
- Gastrointest Endosc. 2002; (6 Suppl): S267-72
- Dig Liver Dis. 2002; (2): 97-8
- Gastrointest Endosc Clin N Am. 2001; (2): 311-24, vii
- Gastroenterology. 2001; (7): 1657-65
- Gastroenterology. 2001; (4): 757-66
- J Neurosci. 2001; (22): 9036-42
- Curr Treat Options Gastroenterol. 2001; (2): 123-131
- Pain. 2001; (2-3): 181-6
- Gastroenterology. 2000; (5): 1373-81
- Gastroenterology. 2000; (5): 1276-85
- Gastrointest Endosc. 2000; (1): 15-9
- Can J Gastroenterol. 2000; (5): 406-9
- Gastrointest Endosc Clin N Am. 2000; (1): 81-8, vi
- Dig Dis. 2000; (3): 138-46
- Gastroenterology. 1999; (6): 1502-1504
- Gastrointest Endosc. 1999; (3 Pt 2): S94-5
- Gastrointest Endosc. 1999; (5): 627-31
- Am J Physiol. 1999; (6 Pt 1): G1173-9
- Baillieres Best Pract Res Clin Gastroenterol. 1999; (1): 131-43
- Gastrointest Endosc. 1999; (4 Pt 1): 518-21
- Gastroenterology. 1999; (4): 1005-6
- Am J Gastroenterol. 1999; (4): 1029-33
- Gastrointest Endosc Clin N Am. 1998; (1): 79-85
- Gastrointest Endosc. 1998; (2): 195-7
- Dig Dis Sci. 1998; (4): 694-701
- Gastroenterology. 1998; (4): 846-7
- Gut. 1998; (4): 507-10
- Gastroenterology. 1998; (4): 1024-5
- Gastroenterology. 1997; (1): 309-10
- Am J Gastroenterol. 1997; (1): 147-9
- Dysphagia. 1997; (2): 84-5
- Gastrointest Endosc Clin N Am. 1997; (2): 191-206
- Gut. 1997; (3): 375-80
- Gastroenterology. 1997; (4): 1415-7
- Gastrointest Endosc. 1997; (3): 342-8
- Gastroenterology. 1997; (1): 360-1
- Gastroenterology. 1997; (3): 1040-2
- Gastroenterology. 1996; (3): 829-30
- Endoscopy. 1996; (7): 574-5
- Am J Gastroenterol. 1996; (10): 2228-32
- Gastrointest Endosc. 1996; (6): 696-9
- Gastroenterology. 1996; (5): 1410-5
- Gastroenterology. 1996; (4): 1314-6
- Gastroenterology. 1996; (1): 311-2; discussion 312-3
- Gastroenterology. 1996; (2): 531-3
- Gastrointest Endosc Clin N Am. 1996; (1): 117-25
- Endoscopy. 1995; (1): 70-2
- J Pediatr Gastroenterol Nutr. 1995; S29-30
- N Engl J Med. 1995; (12): 774-8
- Dig Dis Sci. 1995; (4): 745-8
- Cancer Res. 1995; (9): 1811-6
- Gastroenterology. 1995; (3): 994-8
- Gastroenterology. 1995; (4): 1398-400
- Gastrointest Endosc. 1994 Sep-Oct; (5): 608-10
- Clin Nucl Med. 1994; (8): 713-9
- Ann Intern Med. 1994; (8): 590-1
- Gastrointest Endosc Clin N Am. 1994; (4): 851-62
- Gut. 1994; (9): 1319-21
- Gastroenterology. 1994; (3): 787-802
- N Engl J Med. 1993; (1): 58; author reply 59
- Lancet. 1993; (8839): 244-5
- Gastroenterology. 1993; (4): 1045-9
- Prostaglandins. 1992; (1): 5-19
- Am J Respir Cell Mol Biol. 1989; (5): 377-84