David J. Wong, M.D., Ph.D.

Clinical Focus

• Dermatology

Honors and Awards

• K08 Clinical Scientist Development Award, NIH (2009-2014)
• Young Investigator Award, American Academy of Dermatology (2008)
• Research Career Development Award, Dermatology Foundation (2006-2009)
• Research Fellowship, Dermatology Foundation (2005-2006)

Professional Education

• Doctor of Medicine, University of Washington (2002)
• Board Certification: Dermatology, American Board of Dermatology (2006)
• Stanford University Medical Center (2006) CA
• M.D., University of Washington (2002)
• Ph.D., Fred Hutchinson Cancer Center Molecular and Cellular Biology (2000)
• B.S., Brown University Biochemistry (1994)
• University of Washington School of Medicine (2002) WA
• Santa Clara Valley Medical Center (2003) CA USA
• University of Washington (2000) WA
• Residency, Stanford University Dermatology (2006)

Faculty Advisor

• Howard Chang

Graduate & Fellowship Program Affiliations

• Dermatology

Research Interests

My research interest is focused on investigating the molecular networks that underlie cancer stem cells and designing therapies that selectively target these cells, thereby eliminating a cancer's potential for regrowth.

Publications

• Stemness, cancer and cancer stem cells. Wong DJ,  Segal E, Chang HY.  Cell Cycle.  2008; 7 (23): 3622-4
• Deletional tolerance mediated by extrathymic Aire-expressing cells. Gardner JM,  Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS.  Science.  2008; 321 (5890): 843-7
• Module map of stem cell genes guides creation of epithelial cancer stem cells. Wong DJ,  Liu H, Ridky TW, Cassarino D, Segal E, Chang HY.  Cell Stem Cell.  2008; 2 (4): 333-44
• Revealing targeted therapy for human cancer by gene module maps. Wong DJ,  Nuyten DS, Regev A, Lin M, Adler AS, Segal E, van de Vijver MJ, Chang HY.  Cancer Res.  2008; 68 (2): 369-78
• Learning more from microarrays: insights from modules and networks. Wong DJ,  Chang HY.  J Invest Dermatol.  2005; 125 (2): 175-82
• p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium. Wong DJ,  Paulson TG, Prevo LJ, Galipeau PC, Longton G, Blount PL, Reid BJ.  Cancer Res.  2001; 61 (22): 8284-9
• Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Chan KS,  Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL.  Proc Natl Acad Sci U S A.  2009; 106 (33): 14016-21
• CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Adler AS,  Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY.  Cancer Res.  2008; 68 (2): 506-15
• Evolution of neoplastic cell lineages in Barrett oesophagus. Barrett MT,  Sanchez CA, Prevo LJ, Wong DJ, Galipeau PC, Paulson TG, Rabinovitch PS, Reid BJ.  Nat Genet.  1999; 22 (1): 106-9
• Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest. Wong DJ,  Foster SA, Galloway DA, Reid BJ.  Mol Cell Biol.  1999; 19 (8): 5642-51
• Inactivation of p16 in human mammary epithelial cells by CpG island methylation. Foster SA,  Wong DJ, Barrett MT, Galloway DA.  Mol Cell Biol.  1998; 18 (4): 1793-801
• Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. Trask BJ,  Friedman C, Martin-Gallardo A, Rowen L, Akinbami C, Blankenship J, Collins C, Giorgi D, Iadonato S, Johnson F, Kuo WL, Massa H, Morrish T, Naylor S, Nguyen OT, Rouquier S, Smith T, Wong DJ, Youngblom J, van den Engh G.  Hum Mol Genet.  1998; 7 (1): 13-26
• p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma. Funk JO,  Schiller PI, Barrett MT, Wong DJ, Kind P, Sander CA.  J Cutan Pathol.  1998; 25 (6): 291-6
• p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Wong DJ,  Barrett MT, Stöger R, Emond MJ, Reid BJ.  Cancer Res.  1997; 57 (13): 2619-22
• The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Ang SL,  Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS.  Development.  1993; 119 (4): 1301-15