Hua Tang

Professional Education

• AB, Harvard and Radcliffe College Biology (1997)
• PhD, Stanford University Statistics (minor Genetics) (2002)

Postdoctoral Advisees

• Sandra De Sousa Beleza

Graduate & Fellowship Program Affiliations

• Genetics

Research Interests

I am interested in various aspects of human genetics and genomics, including statistical and population genetics, mapping of disease susceptibility loci, and inference of the evolutionary histories of human populations. By integrating evolutionary theory into statistical modeling, my methodology research aims at developing analytic and computational approaches for identifying disease susceptibility loci in stratified or admixed populations. My applied research includes a large population-based study of the genetics of hypertension in humans. I have also collaborated on genetic studies of asthma in the Hispanic population, neurological disorder in the Romani population, and lysosomal storage diseases in the Jewish population.

Publications

• Worldwide human relationships inferred from genome-wide patterns of variation. Li JZ,  Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM.  Science.  2008; 319 (5866): 1100-4
• Reconstructing genetic ancestry blocks in admixed individuals. Tang H,  Coram M, Wang P, Zhu X, Risch N.  Am J Hum Genet.  2006; 79 (1): 1-12
• Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Tang H,  Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, Pankow JS, Province MA, Hunt SC, Boerwinkle E, Schork NJ, Risch NJ.  Am J Hum Genet.  2005; 76 (2): 268-75
• A newly discovered founder population: the Roma/Gypsies. Kalaydjieva L,  Morar B, Chaix R, Tang H.  Bioessays.  2005; 27 (10): 1084-94
• Ethnicity and human genetic linkage maps. Jorgenson E,  Tang H, Gadde M, Province M, Leppert M, Kardia S, Schork N, Cooper R, Rao DC, Boerwinkle E, Risch N.  Am J Hum Genet.  2005; 76 (2): 276-90
• Recent genetic selection in the ancestral admixture of Puerto Ricans. Tang H,  Choudhry S, Mei R, Morgan M, Rodriguez-Cintron W, Burchard EG, Risch NJ.  Am J Hum Genet.  2007; 81 (3): 626-33
• A statistical method for chromatographic alignment of LC-MS data. Wang P,  Tang H, Fitzgibbon MP, McIntosh M, Coram M, Zhang H, Yi E, Aebersold R.  Biostatistics.  2007; 8 (2): 357-67
• Genomewide evolutionary rates in laboratory and wild yeast. Ronald J,  Tang H, Brem RB.  Genetics.  2006; 174 (1): 541-4
• Estimation of individual admixture: analytical and study design considerations. Tang H,  Peng J, Wang P, Risch NJ.  Genet Epidemiol.  2005; 28 (4): 289-301
• Locally weighted transmission/disequilibrium test for genetic association analysis. Hsu L,  Yu X, Houwing-Duistermaat JJ, Uh HW, El Galta R, Lebrec JJ, Tang H.  BMC Genet.  2005; 6 Suppl 1 S60