Katrin Andreasson

Clinical Focus

• Neurology

Honors and Awards

• Pfizer/AFAR Innovations in Aging Research Award, American Federation for Aging Research (07/05)
• Paul Beeson Physician Faculty Scholars in Aging Award, American Federation for Aging Research (07/2001)

Professional Education

• Board Certification: Neurology, American Board of Psychiatry and Neurology (1995)
• Johns Hopkins School of Medicine (1992) MD
• University of Maryland Hospital for Children (1989) MD
• Columbia University College of Physicians & Surgeons (1988) NY
• M.D., Columbia University Medicine (1988)

Postdoctoral Advisees

• Jenny Johansson, Lu Lin, Ju Shi, Hidetoshi Taniguchi

Graduate & Fellowship Program Affiliations

• Neurology and Neurol Sciences
• Neurosciences

Web Site Links

• Neurology

Research Interests

We are interested in understanding the basic mechanisms by which neurons die in stroke and in neurodegenerative disease, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Our focus is on the cyclooxygenase-2 (COX-2) pathway, which has been found to play a critical role in promoting neuronal death in a number of models of neurological disease, including stroke, Parkinson’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. We are examining the function of downstream prostaglandin receptor signaling pathways, focusing on the functions of prostaglandin receptors in glutamate toxicity, ischemia, and neuroinflammation. Using a combination of in vitro and in vivo genetic and pharmacological strategies, we are finding that specific prostaglandin receptor signaling pathways impact dramatically on disease progression in models of both acute and chronic neurodegeneration. The long-term goal of our research is to understand the contribution of prostaglandin signaling to neuronal injury in a wide array of neurological diseases and to develop therapeutic strategies targeting these pathways in human disease.

Publications

• The hypoxic-ischemic encephalopathy model of perinatal ischemia. Taniguchi H,  Andreasson K.  J Vis Exp.  2008; (21)
• COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity. Yang H,  Zhang J, Andreasson K, Chen C.  Mol Cell Neurosci.  2008; 37 (4): 682-95
• Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia. Li J,  Liang X, Wang Q, Breyer RM, McCullough L, Andreasson K.  Neurosci Lett.  2008; 438 (2): 210-5
• The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Liang X,  Wang Q, Shi J, Lokteva L, Breyer RM, Montine TJ, Andreasson K.  Ann Neurol.  2008; 64 (3): 304-14
• Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. Yang T,  Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.  PLoS One.  2008; 3 (11): e3604
• Divergent effects of prostaglandin receptor signaling on neuronal survival. Wu L,  Wang Q, Liang X, Andreasson K.  Neurosci Lett.  2007; 421 (3): 253-8
• Function of COX-2 and prostaglandins in neurological disease. Liang X,  Wu L, Wang Q, Hand T, Bilak M, McCullough L, Andreasson K.  J Mol Neurosci.  2007; 33 (1): 94-9
• Trial of celecoxib in amyotrophic lateral sclerosis. Cudkowicz ME,  Shefner JM, Schoenfeld DA, Zhang H, Andreasson KI, Rothstein JD, Drachman DB.  Ann Neurol.  2006; 60 (1): 22-31
• Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Melnikova T,  Savonenko A, Wang Q, Liang X, Hand T, Wu L, Kaufmann WE, Vehmas A, Andreasson KI.  Neuroscience.  2006; 141 (3): 1149-62
• Prostaglandin D2 mediates neuronal protection via the DP1 receptor. Liang X,  Wu L, Hand T, Andreasson K.  J Neurochem.  2005; 92 (3): 477-86
• Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. Liang X,  Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K.  J Neurosci.  2005; 25 (44): 10180-7
• Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity. Zagol-Ikapitte I,  Masterson TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA.  J Neurochem.  2005; 94 (4): 1140-5
• Sex differences in cell death. Li H,  Pin S, Zeng Z, Wang MM, Andreasson KA, McCullough LD.  Ann Neurol.  2005; 58 (2): 317-21
• Cyclooxygenase-dependent lipid-modification of brain proteins. Boutaud O,  Andreasson KI, Zagol-Ikapitte I, Oates JA.  Brain Pathol.  2005; 15 (2): 139-42
• Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Liu D,  Wu L, Breyer R, Mattson MP, Andreasson K.  Ann Neurol.  2005; 57 (5): 758-61
• PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. Bilak M,  Wu L, Wang Q, Haughey N, Conant K, St Hillaire C, Andreasson K.  Ann Neurol.  2004; 56 (2): 240-8
• Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. McCullough L,  Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K.  J Neurosci.  2004; 24 (1): 257-68
• Neuronal overexpression of COX-2 results in dominant production of PGE2 and altered fever response. Vidensky S,  Zhang Y, hand T, Goellner J, Shaffer A, Isakson P, Andreasson K.  Neuromolecular Med.  2003; 3 (1): 15-28
• Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Doré S,  Otsuka T, Mito T, Sugo N, Hand T, Wu L, Hurn PD, Traystman RJ, Andreasson K.  Ann Neurol.  2003; 54 (2): 155-62
• Role of immediate early gene expression in cortical morphogenesis and plasticity. Andreasson KI,  Kaufmann WE.  Results Probl Cell Differ.  2002; 39 113-37
• Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. Andreasson KI,  Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley PF, Isakson P, Markowska AL.  J Neurosci.  2001; 21 (20): 8198-209
• Arcadlin is a neural activity-regulated cadherin involved in long term potentiation. Yamagata K,  Andreasson KI, Sugiura H, Maru E, Dominique M, Irie Y, Miki N, Hayashi Y, Yoshioka M, Kaneko K, Kato H, Worley PF.  J Biol Chem.  1999; 274 (27): 19473-1979
• Cyclooxygenases and the central nervous system. Kaufmann WE,  Andreasson KI, Isakson PC, Worley PF.  Prostaglandins.  1997; 54 (3): 601-24
• A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. Wang Y,  Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J.  J Biol Chem.  1996; 271 (8): 4468-76
• Induction of beta-A activin expression by synaptic activity and during neocortical development. Andreasson K,  Worley PF.  Neuroscience.  1995; 69 (3): 781-96
• Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268. Yamagata K,  Kaufmann WE, Lanahan A, Papapavlou M, Barnes CA, Andreasson KI, Worley PF.  Learn Mem.  1994 Jul-Aug; 1 (2): 140-52
• Rapid response genes as markers of cellular signaling during cortical histogenesis: their potential in understanding mental retardation. Kaufmann WE,  Yamagata K, Andreasson KI, Worley PF.  Int J Dev Neurosci.  1994; 12 (4): 263-71
• LTP saturation and spatial learning disruption: effects of task variables and saturation levels. Barnes CA,  Jung MW, McNaughton BL, Korol DL, Andreasson K, Worley PF.  J Neurosci.  1994; 14 (10): 5793-806
• Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Yamagata K,  Andreasson KI, Kaufmann WE, Barnes CA, Worley PF.  Neuron.  1993; 11 (2): 371-86