Sam P. Most, M.D., F.A.C.S.

Clinical Focus

• Facial Plastics
• Otolaryngology
• Otolaryngology - Head & Neck Surgery (Ear, Nose and Throat)

Professional Education

• Board Certification: Otolaryngology, American Board of Otolaryngology (2002)
• University of Washington Medical Center (2002) WA USA
• University of Washington Medical Center (2001) WA USA
• Yale - New Haven Hospital (1996) CT
• Stanford University School of Medicine (1995) CA
• Board Certification: Diplomate, American Board of Facial Plas Recon Surgery
• M.D., Stanford University Medicine (1995)
• B.S., University of Michigan-Ann Arbor Honors College Biology (Neuroscience) (1990)

Graduate & Fellowship Program Affiliations

• Surgery

Research Interests

Division of Facial Plastic and Reconstructive Surgery-Research Program Summary

Evidence-based medicine in Facial Plastic Surgery
The primary goal of this research program is to develop a higher standard of care for facial plastic surgery patients. The approach to this goal is two-fold. The first involves development of prospective studies that examine the efficacy of new or existing surgical techniques in facial plastic surgery1. One clinical problem we have already begun to examine is nasal obstruction. Functional rhinoplasty techniques have been a mainstay of otolaryngology, and facial plastic surgery in particular, for decades. While many have attempted, with mixed success, to examine nasal function using quantitative measures, few prospective studies of quality of life have been performed. To this end, we have begun to examine prospectively various functional rhinoplasty techniques2, 3.

The second approach to development of a higher standard of care for our patients is the testing of various over-the-counter ‘cosmeceutical’ products. Generally, products that are touted as effective by industry have little or no clinical evidence to back up said claims. Two of these studies have been completed and have resulted in remarkable response from industry as well as the media4, 5. More importantly, these types of studies provide valuable information about product efficacy to physicians and patients alike.

Facial Nerve Recovery after Injury
Facial nerve injury after trauma or extirpative surgery can be devastating to patients. The Division seeks to develop a clinical and basic research program studying facial nerve recovery after such injuries. The basic research program within the Division will use a previously developed animal (mouse) model for facial nerve injury to examine the age-dependence of motor neuron survival in the facial nucleus and its correlation to facial nerve recovery6. Furthermore, the role of apoptotic cell death in the facial nerve nucleus will be studied, with the hope that anti-apoptotic processes may aid in facial nerve recovery. The clinical research program will study quality of life issues in facial nerve injury patients.

Bibliography:
1.

Publications

• Trends in functional rhinoplasty. Most SP,  Arch Facial Plast Surg.  2008 Nov-Dec; 10 (6): 410-3
• Volumetric imaging of the malar fat pad and implications for facial plastic surgery. Barrera JE,  Most SP.  Arch Facial Plast Surg.  2008 Mar-Apr; 10 (2): 140-2
• Management of the lower lid in male blepharoplasty. Barrera JE,  Most SP.  Facial Plast Surg Clin North Am.  2008; 16 (3): 313-6, vi
• Prospective examination of the efficacy of 2 topical over-the-counter cosmeceutical creams for rapid treatment of facial rhytids. Most SP,  Arch Facial Plast Surg.  2007 Sep-Oct; 9 (5): 340-3
• Analysis of outcomes after functional rhinoplasty using a disease-specific quality-of-life instrument. Most SP,  Arch Facial Plast Surg.  2006 Sep-Oct; 8 (5): 306-9