Euan A. Ashley

Clinical Focus

• Cardiology
• Cardiovascular genetics
• Hypertrophic Cardiomyopathy
• Heart Failure
• Sports Medicine
• Dilated Cardiomyopathy
• Long QT Syndrome
• Peripartum cardiomyopathy
• Arrhythmogenic Right Ventricular Dysplasia

Administrative Appointments

• Leadership committee, AHA Council on Functional Genomics and Translational Biology , (2009– present )
• Director, Stanford Cardiopulmonary Exercise Testing Laboratory , (2009– present )
• Director, Stanford Hypertrophic Cardiomyopathy Center , (2006– present )
• Executive Editor, Journal of Cardiovascular Translational Research , (2007– present )

Honors and Awards

• NIH Director's New Innovator Award, National Institutes of Health (2009)
• Innovative Research Award, American Heart Association (2009)
• Career Development Award (K08), National Institutes of Health (2006)
• Western Affiliates Young Investigator Award, American Heart Association (2004)
• Cardiovascular Medicine Basic Science Award, Stanford University (2004)
• Young Investigator Award (Basic), Astra-Zeneca (2003)
• Young Investigator Award, European Society of Cardiology (2002)
• Young Investigator Prize in Cardiovascular Medicine, UK Medical Research Society (2002)

Professional Education

• Stanford University Medical Center (2006) CA
• University of Oxford (2002) UK
• University of Oxford (1999) UK
• University of Glasgow (1997) Scotland, UK
• University of Glasgow (1996) Scotland, UK
• DPhil, University of Oxford Molecular Cardiology (2002)
• MRCP (UK), Royal College of Physicians (UK) Medicine (1999)
• MB ChB, University of Glasgow Medicine (1996)
• BSc (Hons), University of Glasgow Physiology (1993)

Postdoctoral Advisees

• Robert Turcott, Matthew Wheeler

Graduate & Fellowship Program Affiliations

• Medicine
• Molecular and Genetic Medicine

Community & International Work

• Arbor Free Cardiology Clinic More »

Web Site Links

• Ashley Lab website

Research Interests

My research interests are translational. We use high dimensional genomic analysis to identify myocardial gene expression networks then use molecular, cellular and classical physiology tools to assay the biological systems. Our interests range from fit to failing hearts.

Clinical Trials

• B-Receptor Signaling in Cardiomyopathy Recruiting

Publications

• Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Leeper NJ,  Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL, Quertermous T.  Am J Physiol Heart Circ Physiol.  2009; 296 (5): H1329-35
• Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy. Le VV,  Perez MV, Wheeler MT, Myers J, Schnittger I, Ashley EA.  Am Heart J.  2009; 158 (3): e27-34
• Re: A prospective randomized evaluation of VV delay optimization in CRT-D recipients: echocardiographic observations from the RHYTHM II ICD study. Turcott RG,  Das AK, Ashley EA.  Pacing Clin Electrophysiol.  2009; 32 (10): 1360-1; author reply 1361-2
• The ageing athlete: screening prior to vigorous exertion in asymptomatic adults without known cardiovascular disease. Freeman J,  Froelicher V, Ashley E.  Br J Sports Med.  2009; 43 (9): 696-701
• Electrocardiographic predictors of atrial fibrillation. Perez MV,  Dewey FE, Marcus R, Ashley EA, Al-Ahmad AA, Wang PJ, Froelicher VF.  Am Heart J.  2009; 158 (4): 622-8
• Endogenous regulation of cardiovascular function by apelin-APJ. Charo DN,  Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, Ho YD, Chun HJ, Bernstein D, Ashley EA, Quertermous T.  Am J Physiol Heart Circ Physiol.  2009; 297 (5): H1904-13
• Should the exercise ECG be used to screen for sudden cardiac death? Freeman J,  Ashley EA, Froelicher V.  Eur Heart J.  2009; 30 (5): 528-9
• Statin use and ventricular arrhythmias during clinical treadmill testing. Dewey FE,  Perez M, Hadley D, Freeman JV, Wang P, Ashley EA, Myers J, Froelicher VF.  J Cardiovasc Electrophysiol.  2009; 20 (2): 193-9
• Progressive Dyspnea After CABG: Complication of Retained Epicardial Pacing Wires. Horng GS,  Ashley E, Balsam L, Reitz B, Zamanian RT.  Ann Thorac Surg.  2008; 86 (4): 1352-4
• Low-dose growth hormone is cardioprotective in uremia. Rabkin R,  Awwad I, Chen Y, Ashley EA, Sun D, Sood S, Clusin W, Heidenreich P, Piecha G, Gross ML.  J Am Soc Nephrol.  2008; 19 (9): 1774-83
• Does size matter? Clinical applications of scaling cardiac size and function for body size. Dewey FE,  Rosenthal D, Murphy DJ, Froelicher VF, Ashley EA.  Circulation.  2008; 117 (17): 2279-87
• Ventricular arrhythmias during clinical treadmill testing and prognosis. Dewey FE,  Kapoor JR, Williams RS, Lipinski MJ, Ashley EA, Hadley D, Myers J, Froelicher VF.  Arch Intern Med.  2008; 168 (2): 225-34
• Age and double product (systolic blood pressure x heart rate) reserve-adjusted modification of the Duke Treadmill Score nomogram in men. Sadrzadeh Rafie AH,  Dewey FE, Sungar GW, Ashley EA, Hadley D, Myers J, Froelicher VF.  Am J Cardiol.  2008; 102 (10): 1407-12
• Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. Chun HJ,  Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T.  J Clin Invest.  2008; 118 (10): 3343-54
• Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. Hlatky MA,  Ashley E, Quertermous T, Boothroyd DB, Ridker P, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS.  Am Heart J.  2007; 154 (6): 1043-51
• Prognostic value of heart rate increase at onset of exercise testing. Leeper NJ,  Dewey FE, Ashley EA, Sandri M, Tan SY, Hadley D, Myers J, Froelicher V.  Circulation.  2007; 115 (4): 468-74
• Frontiers in nephrology: genomic approaches to understanding the molecular basis of atherosclerosis. Ashley EA,  Spin JM, Tabibiazar R, Quertermous T.  J Am Soc Nephrol.  2007; 18 (11): 2853-62
• Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse. Yue P,  Arai T, Terashima M, Sheikh AY, Cao F, Charo D, Hoyt G, Robbins RC, Ashley EA, Wu J, Yang PC, Tsao PS.  Am J Physiol Heart Circ Physiol.  2007; 292 (5): H2106-18
• Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise. Ashley EA,  Kardos A, Jack ES, Habenbacher W, Wheeler M, Kim YM, Froning J, Myers J, Whyte G, Froelicher V, Douglas P.  J Am Coll Cardiol.  2006; 48 (3): 523-31
• Emerging therapies for the management of decompensated heart failure: from bench to bedside. deGoma EM,  Vagelos RH, Fowler MB, Ashley EA.  J Am Coll Cardiol.  2006; 48 (12): 2397-409
• Perioperative cardiac risk: pathophysiology, assessment and management. Sista RR,  Ernst KV, Ashley EA.  Expert Rev Cardiovasc Ther.  2006; 4 (5): 731-43
• Network analysis of human in-stent restenosis. Ashley EA,  Ferrara R, King JY, Vailaya A, Kuchinsky A, He X, Byers B, Gerckens U, Oblin S, Tsalenko A, Soito A, Spin JM, Tabibiazar R, Connolly AJ, Simpson JB, Grube E, Quertermous T.  Circulation.  2006; 114 (24): 2644-54
• Opposing cardiovascular roles for the angiotensin and apelin signaling pathways. Ashley E,  Chun HJ, Quertermous T.  J Mol Cell Cardiol.  2006; 41 (5): 778-81
• Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Chong KS,  Gardner RS, Morton JJ, Ashley EA, McDonagh TA.  Eur J Heart Fail.  2006; 8 (4): 355-60
• Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. Tabibiazar R,  Wagner RA, Spin JM, Ashley EA, Narasimhan B, Rubin EM, Efron B, Tsao PS, Tibshirani R, Quertermous T.  Arterioscler Thromb Vasc Biol.  2005; 25 (2): 302-8
• The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Ashley EA,  Powers J, Chen M, Kundu R, Finsterbach T, Caffarelli A, Deng A, Eichhorn J, Mahajan R, Agrawal R, Greve J, Robbins R, Patterson AJ, Bernstein D, Quertermous T.  Cardiovasc Res.  2005; 65 (1): 73-82
• Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. Tabibiazar R,  Wagner RA, Ashley EA, King JY, Ferrara R, Spin JM, Sanan DA, Narasimhan B, Tibshirani R, Tsao PS, Efron B, Quertermous T.  Physiol Genomics.  2005; 22 (2): 213-26
• Preoperative cardiac evaluation: mechanisms, assessment, and reduction of risk. Ashley EA,  Vagelos RH.  Thorac Surg Clin.  2005; 15 (2): 263-75
• Pathway analysis of coronary atherosclerosis. King JY,  Ferrara R, Tabibiazar R, Spin JM, Chen MM, Kuchinsky A, Vailaya A, Kincaid R, Tsalenko A, Deng DX, Connolly A, Zhang P, Yang E, Watt C, Yakhini Z, Ben-Dor A, Adler A, Bruhn L, Tsao P, Quertermous T, Ashley EA.  Physiol Genomics.  2005; 23 (1): 103-18
• Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation. Spin JM,  Nallamshetty S, Tabibiazar R, Ashley EA, King JY, Chen M, Tsao PS, Quertermous T.  Physiol Genomics.  2004; 19 (3): 292-302
• Electrocardiographic arrhythmia risk testing. Engel G,  Beckerman JG, Froelicher VF, Yamazaki T, Chen HA, Richardson K, McAuley RJ, Ashley EA, Chun S, Wang PJ.  Curr Probl Cardiol.  2004; 29 (7): 365-432
• Ashley, Euan,  Niebauer, Josef.  Cardiology Explained.  2004; ISBN: 1901346226
• Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component? Sears CE,  Ashley EA, Casadei B.  Philos Trans R Soc Lond B Biol Sci.  2004; 359 (1446): 1021-44
• Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Chen MM,  Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R, Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS, Quertermous T.  Circulation.  2003; 108 (12): 1432-9
• Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling. Sears CE,  Bryant SM, Ashley EA, Lygate CA, Rakovic S, Wallis HL, Neubauer S, Terrar DA, Casadei B.  Circ Res.  2003; 92 (5): e52-9
• Diagnosing coronary artery disease in diabetic patients. Ashley EA,  Raxwal V, Finlay M, Froelicher V.  Diabetes Metab Res Rev.  2002 May-Jun; 18 (3): 201-8
• Better decisions through science: exercise testing scores. Froelicher V,  Shetler K, Ashley E.  Prog Cardiovasc Dis.  2002 Mar-Apr; 44 (5): 395-414
• Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes. Ashley EA,  Sears CE, Bryant SM, Watkins HC, Casadei B.  Circulation.  2002; 105 (25): 3011-6
• Exercise testing scores as an example of better decisions through science. Ashley E,  Myers J, Froelicher V.  Med Sci Sports Exerc.  2002; 34 (8): 1391-8
• An evidence-based review of the resting electrocardiogram as a screening technique for heart disease. Ashley EA,  Raxwal V, Froelicher V.  Prog Cardiovasc Dis.  2001 Jul-Aug; 44 (1): 55-67
• Sex, the heart, and sildenafil. Alloggiamento T,  Zipp C, Raxwal VK, Ashley E, Dey S, Levine S, Froelicher VF.  Curr Probl Cardiol.  2001; 26 (6): 388-415
• The post myocardial infarction exercise test: still worthy after all of these years. Ashley EA,  Froelicher V.  Eur Heart J.  2001; 22 (4): 273-6
• Medical education - beyond tomorrow? The new doctor - Asclepiad or Logiatros? Ashley EA,  Med Educ.  2000; 34 (6): 455-9
• Computer applications in the interpretation of the exercise electrocardiogram. Ashley EA,  Froelicher VF.  Sports Med.  2000; 30 (4): 231-48
• Exercise testing in clinical medicine. Ashley EA,  Myers J, Froelicher V.  Lancet.  2000; 356 (9241): 1592-7
• The prevalence and prognostic significance of electrocardiographic abnormalities. Ashley EA,  Raxwal VK, Froelicher VF.  Curr Probl Cardiol.  2000; 25 (1): 1-72
• Dangerous curves. A perspective on exercise, lactate, and the anaerobic threshold. Myers J,  Ashley E.  Chest.  1997; 111 (3): 787-95
• Hormonal responses to graded-resistance, FES-assisted strength training in spinal cord-injured. Wheeler GD,  Ashley EA, Harber V, Laskin JJ, Olenik LM, Sloley D, Burnham R, Steadward RD, Cumming DC.  Spinal Cord.  1996; 34 (5): 264-7
• Electrical stimulation-assisted rowing exercise in spinal cord injured people. A pilot study. Laskin JJ,  Ashley EA, Olenik LM, Burnham R, Cumming DC, Steadward RD, Wheeler GD.  Paraplegia.  1993; 31 (8): 534-41
• Evidence of autonomic dysreflexia during functional electrical stimulation in individuals with spinal cord injuries. Ashley EA,  Laskin JJ, Olenik LM, Burnham R, Steadward RD, Cumming DC, Wheeler GD.  Paraplegia.  1993; 31 (9): 593-605