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Key Documents

Esther M. John

Member, Cancer Center

Contact Information

Academic Offices

Personal Information
Email ejohn@nccc.org Tel (510) 608-5007

Administrative Contact
Orawan Takaki Administrative Assistant Email orawan.takaki@nccc.org Tel Work 510-608-5012

Administrative Appointments

Co-Leader, Cancer Epidemiology, Stanford Cancer Center , (2005– present )
Consulting Associate Professor, Dept Health Research & Policy , (2004– present )
Senior Research Scientist, Northern California Cancer Center , (2009– present )

Professional Education

Ph.D., Univ North Carolina, Chapel Hill Epidemiology (1990)
M.S.P.H., Univ North Carolina, Chapel Hill Epidemiology (1987)
M.A., Univ North Carolina, Chapel Hill Geography (1986)
D.E.S., Univ Fribourg, Switzerland Secondary Education (1980)

Web Site Links

Northern California Cancer Center

Research Interests

Dr. John's research focus has been on the epidemiology of breast, prostate, and ovarian cancer, particularly in Hispanic and African-American populations. Since joining NCCC, Dr. John has established several large population-based resources to study the etiology of these cancers, with emphasis on the role of lifestyle factors that are potentially modifiable, genetic susceptibility, the combined effects of environmental and genetic factors, and racial/ethnic differences in risk factors that contribute to racial/ethnic disparities in the incidence of these cancers.

BREAST CANCER: Dr. John has conducted a series of population-based case-control studies of breast cancer, the San Francisco Bay Area Breast Cancer Study, in nearly 5,000 Hispanic, African-American and non-Hispanic white women. Extensive interview data were collected on a wide range of hormonal and lifestyle factors, as well as blood samples for studies of genetic susceptibility factors and gene-environment interactions. Major areas of interest concern the role of physical activity, body size and weight gain; vitamin D from sun exposure, diet and supplements, a topic that has gained major prominence in recent years; heterocyclic amines associated with cooking methods; and early-life exposures. Collaborative molecular studies have focused on the role of genetic admixture, polymorphisms in the vitamin D receptor (VDR) gene, obesity-related and fat-metabolizing genes, and gene-environment interactions. The Hispanic component of this resource is one of the largest case-control studies of breast cancer conducted in Hispanic women living in the U.S. Dr. John is interested in gaining a better understanding of changes in lifestyle factors that follow migration to the U.S. and subsequent acculturation and their impact on the occurrence of breast cancer in subsequent generations. Efforts are underway to study survival in relation to lifestyle and other factors among the over 2,200 breast cancer cases included in this study.

PROSTATE CANCER: A second major focus of Dr. John's work has been the etiology of prostate cancer which remains largely unknown. Most recently, she has conducted a population-based case-control study of advanced prostate cancer in conjunction with a similar study conducted in Southern California by Dr. Sue Ingles at the University of Southern California. This two-center study, the California Collaborative Study of Advanced Prostate Cancer, serves as a rich resource to elucidate the etiology of advanced prostate cancer in African-American, Hispanic and non-Hispanic white men. Current investigations focus on the role of vitamin D, physical activity, body size, diet, heterocyclic amines and genetic susceptibility factors. Dr. John is also participating in several large international consortia that seek to identify new susceptibility genes through admixture mapping and genome-wide association studies.

CANCER FAMILY REGISTRIES: In collaboration with researchers at Stanford University, Dr. John has been involved in the establishment of two family registries to study the genetic epidemiology of breast and ovarian cancer. She is Principal Investigator of the Northern California site of the Breast Cancer Family Registry, an international consortium established by the National Cancer Institute in 1995 for interdisciplinary and translational studies of the genetic epidemiology of breast cancer. The six collaborating family registries in the U.S., Canada and Australia have enrolled over 13,000 breast cancer families, with over 3,000 families from the San Francisco Bay area. Dr. John is involved in numerous international collaborations that use these resources, including studies of BRCA1 and BRCA2 mutations in minority populations, modifying effects of lifestyle factors in BRCA1 and BRCA2 mutation carriers, other susceptibility genes such as ATM and CHK2, and the genetics of mammographic density, a major risk factor for breast cancer.

Publications

Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family Registry. Chang ET, Milne RL, Phillips KA, Figueiredo JC, Sangaramoorthy M, Keegan TH, Andrulis IL, Hopper JL, Goodwin PJ, O'Malley FP, Weerasooriya N, Apicella C, Southey MC, Friedlander ML, Giles GG, Whittemore AS, West DW, John EM. Breast Cancer Res Treat. 2009; 117 (1): 167-76
An admixture scan in 1,484 African American women with breast cancer. Fejerman L, Haiman CA, Reich D, Tandon A, Deo RC, John EM, Ingles SA, Ambrosone CB, Bovbjerg DH, Jandorf LH, Davis W, Ciupak G, Whittemore AS, Press MF, Ursin G, Bernstein L, Huntsman S, Henderson BE, Ziv E, Freedman ML. Cancer Epidemiol Biomarkers Prev. 2009; 18 (11): 3110-7
Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Tavtigian SV, Oefner PJ, Babikyan D, Hartmann A, Healey S, Le Calvez-Kelm F, Lesueur F, Byrnes GB, Chuang SC, Forey N, Feuchtinger C, Gioia L, Hall J, Hashibe M, Herte B, McKay-Chopin S, Thomas A, Vallée MP, Voegele C, Webb PM, Whiteman DC, Sangrajrang S, Hopper JL, Southey MC, Andrulis IL, John EM, Chenevix-Trench G. Am J Hum Genet. 2009; 85 (4): 427-46
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, Easton DF. Nat Genet. 2009; 41 (10): 1116-21
Availability and Accuracy of Medical Record Information on Language Usage of Cancer Patients from a Multi-Ethnic Population. McClure LA, Glaser SL, Shema SJ, Allen L, Quesenberry C, John EM, Gomez SL. J Immigr Minor Health. 2009;
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Antoniou AC, Sinilnikova OM, McGuffog L, Healey S, Nevanlinna H, Heikkinen T, Simard J, Spurdle AB, Beesley J, Chen X, Neuhausen SL, Ding YC, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Peissel B, Bonanni B, Viel A, Bernard L, Radice P, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai PL, Rennert G, Lejbkowicz F, Andrulis IL, Ozcelik H, Glendon G, Gerdes AM, Thomassen M, Sunde L, Caligo MA, Laitman Y, Kontorovich T, Cohen S, Kaufman B, Dagan E, Baruch RG, Friedman E, Harbst K, Barbany-Bustinza G, Rantala J, Ehrencrona H, Karlsson P, Domchek SM, Nathanson KL, Osorio A, Blanco I, Lasa A, Benítez J, Hamann U, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, van der Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, van Roozendaal CE, Peock S, Cook M, Frost D, Oliver C, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Cole T, Hodgson S, Godwin AK, Stoppa-Lyonnet D, Buecher B, Léoné M, Bressac-de Paillerets B, Remenieras A, Caron O, Lenoir GM, Sevenet N, Longy M, Ferrer SF, Prieur F, Goldgar D, Miron A, John EM, Buys SS, Daly MB, Hopper JL, Terry MB, Yassin Y, Singer C, Gschwantler-Kaulich D, Staudigl C, Hansen TO, Barkardottir RB, Kirchhoff T, Pal P, Kosarin K, Offit K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deissler H, Fiebig B, Suttner C, Schönbuchner I, Gadzicki D, Caldes T, de la Hoya M, Pooley KA, Easton DF, Chenevix-Trench G. Hum Mol Genet. 2009; 18 (22): 4442-56
No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. Rebbeck TR, Antoniou AC, Llopis TC, Nevanlinna H, Aittomäki K, Simard J, Spurdle AB, Couch FJ, Pereira LH, Greene MH, Andrulis IL, Pasche B, Kaklamani V, Hamann U, Szabo C, Peock S, Cook M, Harrington PA, Donaldson A, Male AM, Gardiner CA, Gregory H, Side LE, Robinson AC, Emmerson L, Ellis I, Peyrat JP, Fournier J, Vennin P, Adenis C, Muller D, Fricker JP, Longy M, Sinilnikova OM, Stoppa-Lyonnet D, Schmutzler RK, Versmold B, Engel C, Meindl A, Kast K, Schaefer D, Froster UG, Chenevix-Trench G, Easton DF. Breast Cancer Res Treat. 2009; 115 (1): 185-92
Second primary breast cancer occurrence according to hormone receptor status. Kurian AW, McClure LA, John EM, Horn-Ross PL, Ford JM, Clarke CA. J Natl Cancer Inst. 2009; 101 (15): 1058-65
Prediagnosis reproductive factors and all-cause mortality for women with breast cancer in the breast cancer family registry. Phillips KA, Milne RL, West DW, Goodwin PJ, Giles GG, Chang ET, Figueiredo JC, Friedlander ML, Keegan TH, Glendon G, Apicella C, O'Malley FP, Southey MC, Andrulis IL, John EM, Hopper JL. Cancer Epidemiol Biomarkers Prev. 2009; 18 (6): 1792-7
Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California. Cheng I, Witte JS, McClure LA, Shema SJ, Cockburn MG, John EM, Clarke CA. Cancer Causes Control. 2009;
Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. Cheng CY, Kao WH, Patterson N, Tandon A, Haiman CA, Harris TB, Xing C, John EM, Ambrosone CB, Brancati FL, Coresh J, Press MF, Parekh RS, Klag MJ, Meoni LA, Hsueh WC, Fejerman L, Pawlikowska L, Freedman ML, Jandorf LH, Bandera EV, Ciupak GL, Nalls MA, Akylbekova EL, Orwoll ES, Leak TS, Miljkovic I, Li R, Ursin G, Bernstein L, Ardlie K, Taylor HA, Boerwinckle E, Zmuda JM, Henderson BE, Wilson JG, Reich D. PLoS Genet. 2009; 5 (5): e1000490
A qualitative study evaluating parental attitudes towards the creation of a female youth cohort (LEGACY) in the Breast Cancer Family Registry. Glendon G, Frost CJ, Andrulis IL, Hanna D, John EM, Phipps AI, Thompson A, Venne V, Ritvo P. Psychooncology. 2009;
Performance of prediction models for BRCA mutation carriage in three racial/ethnic groups: findings from the Northern California Breast Cancer Family Registry. Kurian AW, Gong GD, John EM, Miron A, Felberg A, Phipps AI, West DW, Whittemore AS. Cancer Epidemiol Biomarkers Prev. 2009; 18 (4): 1084-91
Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). Osorio A, Milne RL, Pita G, Peterlongo P, Heikkinen T, Simard J, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Healey S, Neuhausen SL, Ding YC, Couch FJ, Wang X, Lindor N, Manoukian S, Barile M, Viel A, Tizzoni L, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai P, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis IL, Ozcelik H, Weerasooriya N, Gerdes AM, Thomassen M, Cruger DG, Caligo MA, Friedman E, Kaufman B, Laitman Y, Cohen S, Kontorovich T, Gershoni-Baruch R, Dagan E, Jernström H, Askmalm MS, Arver B, Malmer B, Domchek SM, Nathanson KL, Brunet J, Ramón Y Cajal T, Yannoukakos D, Hamann U, Hogervorst FB, Verhoef S, García EG, Wijnen JT, van den Ouweland A, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Cook J, Hodgson S, Morrison PJ, Douglas F, Godwin AK, Sinilnikova OM, Barjhoux L, Stoppa-Lyonnet D, Moncoutier V, Giraud S, Cassini C, Olivier-Faivre L, Révillion F, Peyrat JP, Muller D, Fricker JP, Lynch HT, John EM, Buys S, Daly M, Hopper JL, Terry MB, Miron A, Yassin Y, Goldgar D, Singer CF, Gschwantler-Kaulich D, Pfeiler G, Spiess AC, Hansen TV, Johannsson OT, Kirchhoff T, Offit K, Kosarin K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deißler H, Fiebig B, Varon-Mateeva R, Schaefer D, Froster UG, Caldes T, de la Hoya M, McGuffog L, Antoniou AC, Nevanlinna H, Radice P, Benítez J. Br J Cancer. 2009;
BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative research. Neuhausen SL, Ozcelik H, Southey MC, John EM, Godwin AK, Chung W, Iriondo-Perez J, Miron A, Santella RM, Whittemore A, Andrulis IL, Buys SS, Daly MB, Hopper JL, Seminara D, Senie RT, Terry MB. Breast Cancer Res Treat. 2009; 116 (2): 379-86
A pilot genome-wide association study of early-onset breast cancer. Kibriya MG, Jasmine F, Argos M, Andrulis IL, John EM, Chang-Claude J, Ahsan H. Breast Cancer Res Treat. 2009; 114 (3): 463-77
Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years. Breast Cancer Res Treat. 2008; 109 (1): 67-75
Genetic ancestry and risk of breast cancer among U.S. Latinas. Fejerman L, John EM, Huntsman S, Beckman K, Choudhry S, Perez-Stable E, Burchard EG, Ziv E. Cancer Res. 2008; 68 (23): 9723-8
Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. Garner CP, Ding YC, John EM, Ingles SA, Olopade OI, Huo D, Adebamowo C, Ogundiran T, Neuhausen SL. Hum Genet. 2008; 123 (3): 247-55
Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women. Setiawan VW, Chu LH, John EM, Ding YC, Ingles SA, Bernstein L, Press MF, Ursin G, Haiman CA, Neuhausen SL. Cancer Genet Cytogenet. 2008; 181 (1): 16-9
Whole-genome amplification enables accurate genotyping for microarray-based high-density single nucleotide polymorphism array. Jasmine F, Ahsan H, Andrulis IL, John EM, Chang-Claude J, Kibriya MG. Cancer Epidemiol Biomarkers Prev. 2008; 17 (12): 3499-508
Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. Wang J, John EM, Horn-Ross PL, Ingles SA. Nutr Cancer. 2008; 60 (4): 492-504
Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Kote-Jarai Z, Easton DF, Stanford JL, Ostrander EA, Schleutker J, Ingles SA, Schaid D, Thibodeau S, Dörk T, Neal D, Donovan J, Hamdy F, Cox A, Maier C, Vogel W, Guy M, Muir K, Lophatananon A, Kedda MA, Spurdle A, Steginga S, John EM, Giles G, Hopper J, Chappuis PO, Hutter P, Foulkes WD, Hamel N, Salinas CA, Koopmeiners JS, Karyadi DM, Johanneson B, Wahlfors T, Tammela TL, Stern MC, Corral R, McDonnell SK, Schürmann P, Meyer A, Kuefer R, Leongamornlert DA, Tymrakiewicz M, Liu JF, O'Mara T, Gardiner RA, Aitken J, Joshi AD, Severi G, English DR, Southey M, Edwards SM, Al Olama AA, Eeles RA. Cancer Epidemiol Biomarkers Prev. 2008; 17 (8): 2052-61
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. Wang J, John EM, Ingles SA. Cancer Epidemiol Biomarkers Prev. 2008; 17 (10): 2748-54
Sun exposure and prostate cancer risk: evidence for a protective effect of early-life exposure. John EM, Koo J, Schwartz GG. Cancer Epidemiol Biomarkers Prev. 2007; 16 (6): 1283-6
Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. John EM, Miron A, Gong G, Phipps AI, Felberg A, Li FP, West DW, Whittemore AS. JAMA. 2007; 298 (24): 2869-76
Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population. John EM, Schwartz GG, Koo J, Wang W, Ingles SA. Am J Epidemiol. 2007; 166 (12): 1409-19
Validation study of the LAMBDA model for predicting the BRCA1 or BRCA2 mutation carrier status of North American Ashkenazi Jewish women. Apicella C, Dowty JG, Dite GS, Jenkins MA, Senie RT, Daly MB, Andrulis IL, John EM, Buys SS, Li FP, Glendon G, Chung W, Ozcelik H, Miron A, Kotar K, Southey MC, Foulkes WD, Hopper JL. Clin Genet. 2007; 72 (2): 87-97
A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans. Haiman CA, Setiawan VW, Xia LY, Le Marchand L, Ingles SA, Ursin G, Press MF, Bernstein L, John EM, Henderson BE. Cancer Res. 2007; 67 (8): 3565-8
Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry. Terry MB, Knight JA, Zablotska L, Wang Q, John EM, Andrulis IL, Senie RT, Daly M, Ozcelik H, Briollais L, Santella RM. Breast Cancer Res Treat. 2007; 106 (2): 281-8
Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family Registry. John EM, Phipps AI, Knight JA, Milne RL, Dite GS, Hopper JL, Andrulis IL, Southey M, Giles GG, West DW, Whittemore AS. Int J Cancer. 2007; 121 (2): 386-94
UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women. Hong AL, Huo D, Kim HJ, Niu Q, Fackenthal DL, Cummings SA, John EM, West DW, Whittemore AS, Das S, Olopade OI. Drug Metab Dispos. 2007; 35 (8): 1254-61
BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays. Bane AL, Beck JC, Bleiweiss I, Buys SS, Catalano E, Daly MB, Giles G, Godwin AK, Hibshoosh H, Hopper JL, John EM, Layfield L, Longacre T, Miron A, Senie R, Southey MC, West DW, Whittemore AS, Wu H, Andrulis IL, O'Malley FP. Am J Surg Pathol. 2007; 31 (1): 121-8
Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay area and California women: 1988 to 2004. Keegan TH, Chang ET, John EM, Horn-Ross PL, Wrensch MR, Glaser SL, Clarke CA. Breast Cancer Res. 2007; 9 (5): R62
No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years. McGuire V, John EM, Felberg A, Haile RW, Boyd NF, Thomas DC, Jenkins MA, Milne RL, Daly MB, Ward J, Terry MB, Andrulis IL, Knight JA, Godwin AK, Giles GG, Southey M, West DW, Hopper JL, Whittemore AS. Cancer Epidemiol Biomarkers Prev. 2006; 15 (8): 1565-7
Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay Area. Ziv E, John EM, Choudhry S, Kho J, Lorizio W, Perez-Stable EJ, Burchard EG. Cancer Epidemiol Biomarkers Prev. 2006; 15 (10): 1878-85
Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry. Bernstein JL, Teraoka S, Southey MC, Jenkins MA, Andrulis IL, Knight JA, John EM, Lapinski R, Wolitzer AL, Whittemore AS, West D, Seminara D, Olson ER, Spurdle AB, Chenevix-Trench G, Giles GG, Hopper JL, Concannon P. Hum Mutat. 2006; 27 (11): 1122-8
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Freedman ML, Haiman CA, Patterson N, McDonald GJ, Tandon A, Waliszewska A, Penney K, Steen RG, Ardlie K, John EM, Oakley-Girvan I, Whittemore AS, Cooney KA, Ingles SA, Altshuler D, Henderson BE, Reich D. Proc Natl Acad Sci U S A. 2006; 103 (38): 14068-73
The role of self-defined race/ethnicity in population structure control. Liu XQ, Paterson AD, John EM, Knight JA. Ann Hum Genet. 2006; 70 (Pt 4): 496-505
Breast and ovarian cancer in relatives of cancer patients, with and without BRCA mutations. Lee JS, John EM, McGuire V, Felberg A, Ostrow KL, DiCioccio RA, Li FP, Miron A, West DW, Whittemore AS. Cancer Epidemiol Biomarkers Prev. 2006; 15 (2): 359-63
The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry. Bernstein JL, Teraoka SN, John EM, Andrulis IL, Knight JA, Lapinski R, Olson ER, Wolitzer AL, Seminara D, Whittemore AS, Concannon P. Cancer Epidemiol Biomarkers Prev. 2006; 15 (2): 348-52
The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Spurdle AB, Antoniou AC, Kelemen L, Holland H, Peock S, Cook MR, Smith PL, Greene MH, Simard J, Plourde M, Southey MC, Godwin AK, Beck J, Miron A, Daly MB, Santella RM, Hopper JL, John EM, Andrulis IL, Durocher F, Struewing JP, Easton DF, Chenevix-Trench G. Cancer Epidemiol Biomarkers Prev. 2006; 15 (1): 76-9
An inverse association between ovarian cysts and breast cancer in the breast cancer family registry. Knight JA, John EM, Milne RL, Dite GS, Balbuena R, Shi EJ, Giles GG, Ziogas A, Andrulis IL, Whittemore AS, Hopper JL. Int J Cancer. 2006; 118 (1): 197-202
BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50. Haile RW, Thomas DC, McGuire V, Felberg A, John EM, Milne RL, Hopper JL, Jenkins MA, Levine AJ, Daly MM, Buys SS, Senie RT, Andrulis IL, Knight JA, Godwin AK, Southey M, McCredie MR, Giles GG, Andrews L, Tucker K, Miron A, Apicella C, Tesoriero A, Bane A, Pike MC, Whittemore AS. Cancer Epidemiol Biomarkers Prev. 2006; 15 (10): 1863-70
Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations. Milne RL, Knight JA, John EM, Dite GS, Balbuena R, Ziogas A, Andrulis IL, West DW, Li FP, Southey MC, Giles GG, McCredie MR, Hopper JL, Whittemore AS. Cancer Epidemiol Biomarkers Prev. 2005; 14 (2): 350-6
Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women. Wang W, John EM, Ingles SA. Cancer Epidemiol Biomarkers Prev. 2005; 14 (12): 2990-4
Obesity before age 30 years and risk of advanced prostate cancer. Robinson WR, Stevens J, Gammon MD, John EM. Am J Epidemiol. 2005; 161 (12): 1107-14
Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer. John EM, Schwartz GG, Koo J, Van Den Berg D, Ingles SA. Cancer Res. 2005; 65 (12): 5470-9
Migration history, acculturation, and breast cancer risk in Hispanic women. John EM, Phipps AI, Davis A, Koo J. Cancer Epidemiol Biomarkers Prev. 2005; 14 (12): 2905-13
The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. John EM, Hopper JL, Beck JC, Knight JA, Neuhausen SL, Senie RT, Ziogas A, Andrulis IL, Anton-Culver H, Boyd N, Buys SS, Daly MB, O'Malley FP, Santella RM, Southey MC, Venne VL, Venter DJ, West DW, Whittemore AS, Seminara D. Breast Cancer Res. 2004; 6 (4): R375-89
Residential sunlight exposure is associated with a decreased risk of prostate cancer. John EM, Dreon DM, Koo J, Schwartz GG. J Steroid Biochem Mol Biol. 2004; 89-90 (1-5): 549-52
Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations. McGuire V, Felberg A, Mills M, Ostrow KL, DiCioccio R, John EM, West DW, Whittemore AS. Am J Epidemiol. 2004; 160 (7): 613-8
Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites. Whittemore AS, Gong G, John EM, McGuire V, Li FP, Ostrow KL, Dicioccio R, Felberg A, West DW. Cancer Epidemiol Biomarkers Prev. 2004; 13 (12): 2078-83
Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations. Whittemore AS, Balise RR, Pharoah PD, Dicioccio RA, Oakley-Girvan I, Ramus SJ, Daly M, Usinowicz MB, Garlinghouse-Jones K, Ponder BA, Buys S, Senie R, Andrulis I, John E, Hopper JL, Piver MS. Br J Cancer. 2004; 91 (11): 1911-5
Lifetime physical activity and breast cancer risk in a multiethnic population: the San Francisco Bay area breast cancer study. John EM, Horn-Ross PL, Koo J. Cancer Epidemiol Biomarkers Prev. 2003; 12 (11 Pt 1): 1143-52
Phytoestrogen intake and endometrial cancer risk. Horn-Ross PL, John EM, Canchola AJ, Stewart SL, Lee MM. J Natl Cancer Inst. 2003; 95 (15): 1158-64
Segregation analysis of prostate cancer in 1,719 white, African-American and Asian-American families in the United States and Canada. Gong G, Oakley-Girvan I, Wu AH, Kolonel LN, John EM, West DW, Felberg A, Gallagher RP, Whittemore AS. Cancer Causes Control. 2002; 13 (5): 471-82
Successful transformation of cryopreserved lymphocytes: a resource for epidemiological studies. Beck JC, Beiswanger CM, John EM, Satariano E, West D. Cancer Epidemiol Biomarkers Prev. 2001; 10 (5): 551-4
Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. Wu AH, Whittemore AS, Kolonel LN, Stanczyk FZ, John EM, Gallagher RP, West DW. Cancer Epidemiol Biomarkers Prev. 2001; 10 (5): 533-8
Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Horn-Ross PL, John EM, Lee M, Stewart SL, Koo J, Sakoda LC, Shiau AC, Goldstein J, Davis P, Perez-Stable EJ. Am J Epidemiol. 2001; 154 (5): 434-41
Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States). Horn-Ross PL, Barnes S, Lee M, Coward L, Mandel JE, Koo J, John EM, Smith M. Cancer Causes Control. 2000; 11 (4): 289-98
Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Kolonel LN, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR, John EM, Howe GR, Dreon DM, West DW, Paffenbarger RS. Cancer Epidemiol Biomarkers Prev. 2000; 9 (8): 795-804
Sources of phytoestrogen exposure among non-Asian women in California, USA. Horn-Ross PL, Lee M, John EM, Koo J. Cancer Causes Control. 2000; 11 (4): 299-302
Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey. John EM, Schwartz GG, Dreon DM, Koo J. Cancer Epidemiol Biomarkers Prev. 1999; 8 (5): 399-406
Recreational and occupational physical activities and risk of breast cancer. Gammon MD, John EM, Britton JA. J Natl Cancer Inst. 1998; 90 (2): 100-17
Serum levels of prostate-specific antigen among Japanese-American and native Japanese men. Shibata A, Whittemore AS, Imai K, Kolonel LN, Wu AH, John EM, Stamey TA, Paffenbarger RS. J Natl Cancer Inst. 1997; 89 (22): 1716-20
Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada. Wu AH, Whittemore AS, Kolonel LN, John EM, Gallagher RP, West DW, Hankin J, Teh CZ, Dreon DM, Paffenbarger RS. Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov; 4 (7): 735-41
Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Whittemore AS, Wu AH, Kolonel LN, John EM, Gallagher RP, Howe GR, West DW, Teh CZ, Stamey T. Am J Epidemiol. 1995; 141 (8): 732-40
Vasectomy and prostate cancer: results from a multiethnic case-control study. John EM, Whittemore AS, Wu AH, Kolonel LN, Hislop TG, Howe GR, West DW, Hankin J, Dreon DM, Teh CZ. J Natl Cancer Inst. 1995; 87 (9): 662-9
Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. Whittemore AS, Kolonel LN, Wu AH, John EM, Gallagher RP, Howe GR, Burch JD, Hankin J, Dreon DM, West DW. J Natl Cancer Inst. 1995; 87 (9): 652-61
Effect of a monetary incentive on response to a mail survey. John EM, Savitz DA. Ann Epidemiol. 1994; 4 (3): 231-5
Spontaneous abortions among cosmetologists. John EM, Savitz DA, Shy CM. Epidemiology. 1994; 5 (2): 147-55
Lactation and the risk of breast cancer. Kelsey JL, John EM. N Engl J Med. 1994; 330 (2): 136-7
Use of NHANES data to assign nutrient densities to food groups in a multiethnic diet history questionnaire. Dreon DM, John EM, DiCiccio Y, Whittemore AS. Nutr Cancer. 1993; 20 (3): 223-30
Recent etiologic hypotheses concerning breast cancer. Gammon MD, John EM. Epidemiol Rev. 1993; 15 (1): 163-8
Reproductive factors and breast cancer. Kelsey JL, Gammon MD, John EM. Epidemiol Rev. 1993; 15 (1): 36-47
Characteristics relating to ovarian cancer risk: collaborative analysis of seven U.S. case-control studies. Epithelial ovarian cancer in black women. Collaborative Ovarian Cancer Group. John EM, Whittemore AS, Harris R, Itnyre J. J Natl Cancer Inst. 1993; 85 (2): 142-7
Radiation and other environmental exposures and breast cancer. John EM, Kelsey JL. Epidemiol Rev. 1993; 15 (1): 157-62
Use of a job-exposure matrix to evaluate parental occupation and childhood cancer. Feingold L, Savitz DA, John EM. Cancer Causes Control. 1992; 3 (2): 161-9
Association of paternal alcohol use with gestational age and birth weight. Savitz DA, Zhang J, Schwingl P, John EM. Teratology. 1992; 46 (5): 465-71
Prenatal exposure to parents' smoking and childhood cancer. John EM, Savitz DA, Sandler DP. Am J Epidemiol. 1991; 133 (2): 123-32
Magnetic field exposure from electric appliances and childhood cancer. Savitz DA, John EM, Kleckner RC. Am J Epidemiol. 1990; 131 (5): 763-73
Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. Savitz DA, Wachtel H, Barnes FA, John EM, Tvrdik JG. Am J Epidemiol. 1988; 128 (1): 21-38
Physicians' attitude to after-hours callers: A five year study in a university-based family practice center John EM, Curtis P. Int J Fam Pract. 1988; 5 168-73
Geographic variation in the onset of decline of ischemic heart disease mortality in the United States. Wing S, Hayes C, Heiss G, John E, Knowles M, Riggan W, Tyroler HA. Am J Public Health. 1986; 76 (12): 1404-8