Andrew J. Connolly

Clinical Focus

• Anatomic Pathology

Administrative Appointments

• Associate Director, Autopsy Service, Stanford University , (2004– present )

Professional Education

• Board Certification: Anatomic Pathology, American Board of Pathology (1992)
• UCSF Medical Center (1992) CA
• UCSF Medical Center (1991) CA
• UCSF Medical Center (1989) CA
• Harvard Medical School (1989) MA
• AB, Princeton University Chemistry (1984)
• MD, Harvard University Medicine (1989)
• PhD, UCSF Biomedical Sciences (1997)

Research Interests

My research interests are vascular biology and cardiovascular pathology. We are currently working on gene expression in endothelial cells at sites of pathology.

Clinical Trials

• Abdominal Aortic Aneurysms: Simple Treatment or Prevention (AAA: STOP) Recruiting

Publications

• Effects of cell number on teratoma formation by human embryonic stem cells. Lee AS,  Tang C, Cao F, Xie X, van der Bogt K, Hwang A, Connolly AJ, Robbins RC, Wu JC.  Cell Cycle.  2009; 8 (16): 2608-12
• Imaging gene expression in human mesenchymal stem cells: from small to large animals. Willmann JK,  Paulmurugan R, Rodriguez-Porcel M, Stein W, Brinton TJ, Connolly AJ, Nielsen CH, Lutz AM, Lyons J, Ikeno F, Suzuki Y, Rosenberg J, Chen IY, Wu JC, Yeung AC, Yock P, Robbins RC, Gambhir SS.  Radiology.  2009; 252 (1): 117-27
• Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women. McLaughlin T,  Deng A, Gonzales O, Aillaud M, Yee G, Lamendola C, Abbasi F, Connolly AJ, Sherman A, Cushman SW, Reaven G, Tsao PS.  Diabetologia.  2008; 51 (12): 2303-8
• In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Sheikh AY,  Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D, Hendry SL, Wagner RA, Chen MM, Ali ZA, Yue P, Huynh DT, Connolly AJ, Pelletier MP, Tsao PS, Robbins RC, Quertermous T.  Am J Physiol Heart Circ Physiol.  2008; 294 (1): H88-98
• Introducing the first polymer-free leflunomide eluting stent. Deuse T,  Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S.  Atherosclerosis.  2008; 200 (1): 126-34
• Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. Li Z,  Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC.  Stem Cells.  2008; 26 (4): 864-73
• Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. Hendry SL,  van der Bogt KE, Sheikh AY, Arai T, Dylla SJ, Drukker M, McConnell MV, Kutschka I, Hoyt G, Cao F, Weissman IL, Connolly AJ, Pelletier MP, Wu JC, Robbins RC, Yang PC.  J Thorac Cardiovasc Surg.  2008; 136 (4): 1028-1037.e1
• Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme. Veeravagu A,  Liu Z, Niu G, Chen K, Jia B, Cai W, Jin C, Hsu AR, Connolly AJ, Tse V, Wang F, Chen X.  Clin Cancer Res.  2008; 14 (22): 7330-9
• In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation. Swijnenburg RJ,  Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC.  Stem Cells Dev.  2008; 17 (6): 1023-9
• Spatial and temporal kinetics of teratoma formation from murine embryonic stem cell transplantation. Cao F,  van der Bogt KE, Sadrzadeh A, Xie X, Sheikh AY, Wang H, Connolly AJ, Robbins RC, Wu JC.  Stem Cells Dev.  2007; 16 (6): 883-91
• Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function. Xie X,  Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC.  Cloning Stem Cells.  2007; 9 (4): 549-63
• Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. Cao F,  Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC.  Cloning Stem Cells.  2007; 9 (1): 107-17
• Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells. Wu JC,  Cao F, Dutta S, Xie X, Kim E, Chungfat N, Gambhir S, Mathewson S, Connolly AJ, Brown M, Wang EW.  Proteomics.  2006; 6 (23): 6234-49
• Network analysis of human in-stent restenosis. Ashley EA,  Ferrara R, King JY, Vailaya A, Kuchinsky A, He X, Byers B, Gerckens U, Oblin S, Tsalenko A, Soito A, Spin JM, Tabibiazar R, Connolly AJ, Simpson JB, Grube E, Quertermous T.  Circulation.  2006; 114 (24): 2644-54
• In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Cao F,  Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC.  Circulation.  2006; 113 (7): 1005-14
• Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts. Kutschka I,  Kofidis T, Chen IY, von Degenfeld G, Zwierzchoniewska M, Hoyt G, Arai T, Lebl DR, Hendry SL, Sheikh AY, Cooke DT, Connolly A, Blau HM, Gambhir SS, Robbins RC.  Circulation.  2006; 114 (1 Suppl): I174-80
• Pathway analysis of coronary atherosclerosis. King JY,  Ferrara R, Tabibiazar R, Spin JM, Chen MM, Kuchinsky A, Vailaya A, Kincaid R, Tsalenko A, Deng DX, Connolly A, Zhang P, Yang E, Watt C, Yakhini Z, Ben-Dor A, Adler A, Bruhn L, Tsao P, Quertermous T, Ashley EA.  Physiol Genomics.  2005; 23 (1): 103-18
• Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Lim YC,  Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW.  Am J Pathol.  2003; 162 (5): 1591-601
• Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Ishihara H,  Zeng D, Connolly AJ, Tam C, Coughlin SR.  Blood.  1998; 91 (11): 4152-7
• Protease-activated receptor 3 is a second thrombin receptor in humans. Ishihara H,  Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR.  Nature.  1997; 386 (6624): 502-6
• Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. Connolly AJ,  Suh DY, Hunt TK, Coughlin SR.  Am J Pathol.  1997; 151 (5): 1199-204
• Role of the thrombin receptor in development and evidence for a second receptor. Connolly AJ,  Ishihara H, Kahn ML, Farese RV, Coughlin SR.  Nature.  1996; 381 (6582): 516-9
• The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. Trejo J,  Connolly AJ, Coughlin SR.  J Biol Chem.  1996; 271 (35): 21536-41
• Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene. McCormick SP,  Ng JK, Véniant M, Borén J, Pierotti V, Flynn LM, Grass DS, ConnollyA, Young SG.  J Biol Chem.  1996; 271 (20): 11963-70
• Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. Kahn M,  Ishii K, Kuo WL, Piper M, Connolly A, Shi YP, Wu R, Lin CC, Coughlin SR.  Mol Med.  1996; 2 (3): 349-57
• A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. Young SG,  Cham CM, Pitas RE, Burri BJ, Connolly A, Flynn L, Pappu AS, Wong JS, Hamilton RL, Farese RV.  J Clin Invest.  1995; 96 (6): 2932-46
• Design and initial testing of an ultrasound-guided directional atherectomy device. Fitzgerald PJ,  Belef M, Connolly AJ, Sudhir K, Yock PG.  Am Heart J.  1995; 129 (3): 593-8
• Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Charo IF,  Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR.  Proc Natl Acad Sci U S A.  1994; 91 (7): 2752-6
• Potassium preserves endothelial function and enhances aortic compliance in Dahl rats. Sudhir K,  Kurtz TW, Yock PG, Connolly AJ, Morris RC.  Hypertension.  1993; 22 (3): 315-22
• Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Shen J,  Luscinskas FW, Connolly A, Dewey CF, Gimbrone MA.  Am J Physiol.  1992; 262 (2 Pt 1): C384-90
• Intravascular ultrasound imaging of coronary arteries. Is three layers the norm? Fitzgerald PJ,  St Goar FG, Connolly AJ, Pinto FJ, Billingham ME, Popp RL, Yock PG.  Circulation.  1992; 86 (1): 154-8
• Myocardial infarction: assessment with an intravascular MR contrast medium. Work in progress. Saeed M,  Wendland MF, Masui T, Connolly AJ, Derugin N, Brasch RC, Higgins CB.  Radiology.  1991; 180 (1): 153-60
• The effects of dimethyl sulfoxide on the osmotic properties of a rat megakaryocytopoietic cell line. Connolly A,  Hempling HG.  Cryobiology.  1985; 22 (4): 351-8