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Key Documents

Curriculum Vitae available Online

Leonore A. Herzenberg

Professor (Research), Genetics
Member, Cancer Center

Contact Information

Academic Offices

Personal Information
Email LEEHERZ@DARWIN.stanford.edu

Administrative Contact
John Mantovani Administrator to the Herzenbergs Email johnjm@stanford.edu Tel Work 650 723-5054

Honors and Awards

Heroic Achievement in Information Technology, The ComputerWorld Smithsonian Award (June 4, 1996)
Symposium Chair & Speaker, International Congress of Immunology (1986)
Member, Genetics Society of America (0)
Member, American Association of Immunologists (0)
Eleanor Roosevelt Cancer Fellowship,, American Cancer Society (1986)

Professional Education

D.Sc-equiv., Universioty Paris V Sorbonne Immunolgy (1981)

Postdoctoral Advisees

Eliver Ghosn, Tetyana Obukhanych

Graduate & Fellowship Program Affiliations

Web Site Links

Herzenberg Laboratory Home Page

Research Interests

We maintain jointly functioning laboratory groups. Our focus is on gene regulation in the immune system, development and function of B cell subpopulations, and applications of Fluorescence-Activated Cell Sorting(FACS).

We have been interested for many years in the genetics and development of the immune system in mice. A major tool we have developed to aid us in this work is the Fluorescence-Activated Cell Sorter(FACS), which permits analysis and sorting of viable cells very rapidly on the basis of fluorescence marking. Recently we have devised a method to study gene regulation at the individual cell level using the FACS and a fluorogenic substrate for E. coli lac Z-encoded ß-galactosidase (ß-gal).

Current Studies include:

1) A new population of B cells, Ly-1B, which follow different rules of differentiation than conventional B-cells, have different V gene repertoires and provide a model for autoimmune diseases and chronic lymphocytic leukemia (CLL).

2) Regulation of lymphocyte development, especially B and T cell development.

3) Cis and trans-acting elements regulating the variation of ß-gal expresstion in populations of lymphoid cells infected with lacZ recombinant retroviruses in which various viral and cellular promoters "drive" lacZ.

4) Cell lineage studies using introduced lacZ rDNA retroviruses as cellular markers with the FACS / b-gal assay.

5) The cell biology of AIDS in model systems including activation of b-gal expression in cells carrying the lacZ gene under control of HIV promoters and regulatory elements.

6) What transgenic mice can and can't tell us about cellular and molecular development of the immune system.

In addition to improving FACS operations with a dedicated group of engineers, computer scientists, programmers, and a physicist, opportunities always exist for technologically oriented students interested in molecular biology and immunology.

Publications

Epitope-specific regulation: the elephant in the bathtub. Herzenberg LA, Nat Immunol. 2007; 8 (8): 783-6
Interpreting flow cytometry data: a guide for the perplexed. Herzenberg LA, Tung J, Moore WA, Herzenberg LA, Parks DR. Nat Immunol. 2006; 7 (7): 681-5
B cell lineages: documented at last! Herzenberg LA, Tung JW. Nat Immunol. 2006; 7 (3): 225-6
Genetics, FACS, immunology, and redox: a tale of two lives intertwined. Herzenberg LA, Herzenberg LA. Annu Rev Immunol. 2004; 22 1-31
FR255734, a humanized, Fc-Silent, Anti-CD28 antibody, improves psoriasis in the SCID mouse-psoriasis xenograft model. Raychaudhuri SP, Kundu-Raychaudhuri S, Tamura K, Masunaga T, Kubo K, Hanaoka K, Jiang WY, Herzenberg LA, Herzenberg LA. J Invest Dermatol. 2008; 128 (8): 1969-76
CD11b expression distinguishes sequential stages of peritoneal B-1 development. Ghosn EE, Yang Y, Tung J, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2008; 105 (13): 5195-200
[Phospho-FACS: a powerful tool for exploring intracellular transduction cascades] Gernez Y, Herzenberg LA, Herzenberg LA, Tirouvanziam R. Rev Mal Respir. 2007; 24 (8): 955-64
Knowledge acquisition and visualization for biomedical research. Zimmerman N, Meehan S, Herzenberg LA, Das AK. AMIA Annu Symp Proc. 2007; 1177
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. Curr Opin Pharmacol. 2007; 7 (4): 355-9
Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium. Wang D, Carroll GT, Turro NJ, Koberstein JT, Kovác P, Saksena R, Adamo R, Herzenberg LA, Herzenberg LA, Steinman L. Proteomics. 2007; 7 (2): 180-4
B-cell development fails in the absence of the Pbx1 proto-oncogene. Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML. Blood. 2007; 109 (10): 4191-9
Unraveling B-1 progenitors. Tung JW, Herzenberg LA. Curr Opin Immunol. 2007; 19 (2): 150-5
Importance of culturing primary lymphocytes at physiological oxygen levels. Atkuri KR, Herzenberg LA, Niemi AK, Cowan T, Herzenberg LA. Proc Natl Acad Sci U S A. 2007; 104 (11): 4547-52
Division and differentiation of natural antibody-producing cells in mouse spleen. Yang Y, Tung JW, Ghosn EE, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2007; 104 (11): 4542-6
Modern flow cytometry: a practical approach. Tung JW, Heydari K, Tirouvanziam R, Sahaf B, Parks DR, Herzenberg LA, Herzenberg LA. Clin Lab Med. 2007; 27 (3): 453-68, v
High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Tirouvanziam R, Conrad CK, Bottiglieri T, Herzenberg LA, Moss RB, Herzenberg LA. Proc Natl Acad Sci U S A. 2006; 103 (12): 4628-33
Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse. Tung JW, Mrazek MD, Yang Y, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2006; 103 (16): 6293-8
MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. Ray S, Atkuri KR, Deb-Basu D, Adler AS, Chang HY, Herzenberg LA, Felsher DW. Cancer Res. 2006; 66 (13): 6598-605
The extracellular microenvironment plays a key role in regulating the redox status of cell surface proteins in HIV-infected subjects. Sahaf B, Heydari K, Herzenberg LA, Herzenberg LA. Arch Biochem Biophys. 2005; 434 (1): 26-32
Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Cao YA, Bachmann MH, Beilhack A, Yang Y, Tanaka M, Swijnenburg RJ, Reeves R, Taylor-Edwards C, Schulz S, Doyle TC, Fathman CG, Robbins RC, Herzenberg LA, Negrin RS, Contag CH. Transplantation. 2005; 80 (1): 134-9
Culturing at atmospheric oxygen levels impacts lymphocyte function. Atkuri KR, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2005; 102 (10): 3756-9
Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Davidson CJ, Tirouvanziam R, Herzenberg LA, Lipsick JS. Genetics. 2005; 169 (1): 215-29
Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes. Tirouvanziam R, Davidson CJ, Lipsick JS, Herzenberg LA. Proc Natl Acad Sci U S A. 2004; 101 (9): 2912-7
The E47 transcription factor negatively regulates CD5 expression during thymocyte development. Yang Y, Contag CH, Felsher D, Shachaf CM, Cao Y, Herzenberg LA, Herzenberg LA, Tung JW. Proc Natl Acad Sci U S A. 2004; 101 (11): 3898-902
Identification of B-cell subsets: an exposition of 11-color (Hi-D) FACS methods. Tung JW, Parks DR, Moore WA, Herzenberg LA, Herzenberg LA. Methods Mol Biol. 2004; 271 37-58
New approaches to fluorescence compensation and visualization of FACS data. Tung JW, Parks DR, Moore WA, Herzenberg LA, Herzenberg LA. Clin Immunol. 2004; 110 (3): 277-83
Ontogeny of gamma delta T cells in humans. De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg LA, Herzenberg LA, Roederer M. J Immunol. 2004; 172 (3): 1637-45
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Perez OD, Mitchell D, Jager GC, South S, Murriel C, McBride J, Herzenberg LA, Kinoshita S, Nolan GP. Nat Immunol. 2003; 4 (11): 1083-92
Lymphocyte surface thiol levels. Sahaf B, Heydari K, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2003; 100 (7): 4001-5
The history and future of the fluorescence activated cell sorter and flow cytometry: a view from Stanford. Herzenberg LA, Parks D, Sahaf B, Perez O, Roederer M, Herzenberg LA. Clin Chem. 2002; 48 (10): 1819-27
Motexafin gadolinium (Gd-Tex) selectively induces apoptosis in HIV-1 infected CD4+ T helper cells. Perez OD, Nolan GP, Magda D, Miller RA, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2002; 99 (4): 2270-4
Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Ghezzi P, Romines B, Fratelli M, Eberini I, Gianazza E, Casagrande S, Laragione T, Mengozzi M, Herzenberg LA, Herzenberg LA. Mol Immunol. 2002; 38 (10): 773-80
Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway. Lu LS, Tung J, Baumgarth N, Herman O, Gleimer M, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2002; 99 (5): 3007-12
Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells. Mengozzi M, Malipatlolla M, De Rosa SC, Herzenberg LA, Herzenberg LA, Roederer M. Proc Natl Acad Sci U S A. 2001; 98 (20): 11644-9
Phycoerythrin-allophycocyanin: a resonance energy transfer fluorochrome for immunofluorescence. Tjioe I, Legerton T, Wegstein J, Herzenberg LA, Roederer M. Cytometry. 2001; 44 (1): 24-9
The regulation of CD5 expression in murine T cells. Tung JW, Kunnavatana SS, Herzenberg LA, Herzenberg LA. BMC Mol Biol. 2001; 2 5
Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS. Nakamura H, De Rosa SC, Yodoi J, Holmgren A, Ghezzi P, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 2001; 98 (5): 2688-93
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Chem Biol. 2001; 8 (1): 71-80
B-1 cells: the lineage question revisited. Herzenberg LA, Immunol Rev. 2000; 175 9-22
N-acetylcysteine replenishes glutathione in HIV infection. De Rosa SC, Zaretsky MD, Dubs JG, Roederer M, Anderson M, Green A, Mitra D, Watanabe N, Nakamura H, Tjioe I, Deresinski SC, Moore WA, Ela SW, Parks D, Herzenberg LA, Herzenberg LA. Eur J Clin Invest. 2000; 30 (10): 915-29
An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. Torres-Roca JF, Tung JW, Greenwald DR, Brown JM, Herzenberg LA, Herzenberg LA, Katsikis PD. J Immunol. 2000; 165 (9): 4822-30
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Proc Natl Acad Sci U S A. 2000; 97 (26): 14766-71
Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA. Proc Natl Acad Sci U S A. 2000; 97 (6): 2680-5
B-1 cell origins and VH repertoire determination. Herzenberg LA, Baumgarth N, Wilshire JA. Curr Top Microbiol Immunol. 2000; 252 3-13
Monoclonal antibodies and the FACS: complementary tools for immunobiology and medicine. Herzenberg LA, De Rosa SC. Immunol Today. 2000; 21 (8): 383-90
B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. Baumgarth N, Herman OC, Jager GC, Brown LE, Herzenberg LA, Chen J. J Exp Med. 2000; 192 (2): 271-80
CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Baumgarth N, Jager GC, Herman OC, Herzenberg LA. Proc Natl Acad Sci U S A. 2000; 97 (9): 4766-71
The role of B-1 and B-2 cells in immune protection from influenza virus infection. Baumgarth N, Chen J, Herman OC, Jager GC, Herzenberg LA. Curr Top Microbiol Immunol. 2000; 252 163-9
Single cell analysis and selection of living retrovirus vector-corrected mucopolysaccharidosis VII cells using a fluorescence-activated cell sorting-based assay for mammalian beta-glucuronidase enzymatic activity. Lorincz MC, Parente MK, Roederer M, Nolan GP, Diwu Z, Martin DI, Herzenberg LA, Wolfe JH. J Biol Chem. 1999; 274 (2): 657-65
Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. Baumgarth N, Herman OC, Jager GC, Brown L, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1999; 96 (5): 2250-5
Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Seidl KJ, Wilshire JA, MacKenzie JD, Kantor AB, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1999; 96 (5): 2262-7
An improved monobromobimane assay for glutathione utilizing tris- (2-carboxyethyl)phosphine as the reductant. Anderson MT, Trudell JR, Voehringer DW, Tjioe IM, Herzenberg LA, Herzenberg LA. Anal Biochem. 1999; 272 (1): 107-9
Nine color eleven parameter immunophenotyping using three laser flow cytometry. Bigos M, Baumgarth N, Jager GC, Herman OC, Nozaki T, Stovel RT, Parks DR, Herzenberg LA. Cytometry. 1999; 36 (1): 36-45
Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases. Mitra DK, De Rosa SC, Luke A, Balamurugan A, Khaitan BK, Tung J, Mehra NK, Terr AI, O'Garra A, Herzenberg LA, Roederer M. Int Immunol. 1999; 11 (11): 1801-10
Pairs of violet-light-excited fluorochromes for flow cytometric analysis. Anderson MT, Baumgarth N, Haugland RP, Gerstein RM, Tjioe T, Herzenberg LA, Herzenberg LA. Cytometry. 1998; 33 (4): 435-44
CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms. Amano M, Baumgarth N, Dick MD, Brossay L, Kronenberg M, Herzenberg LA, Strober S. J Immunol. 1998; 161 (4): 1710-7
Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation. Roederer M, De Rosa SC, Watanabe N, Herzenberg LA. Semin Immunol. 1997; 9 (6): 389-96
Long-term depletion of naive T cells in patients treated for Hodgkin's disease. Watanabe N, De Rosa SC, Cmelak A, Hoppe R, Herzenberg LA, Roederer M. Blood. 1997; 90 (9): 3662-72
Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection. Katsikis PD, Garcia-Ojeda ME, Torres-Roca JF, Tijoe IM, Smith CA, Herzenberg LA, Herzenberg LA. J Exp Med. 1997; 186 (8): 1365-72
HIV type 1 Tat protein enhances activation-but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals. Katsikis PD, García-Ojeda ME, Torres-Roca JF, Greenwald DR, Herzenberg LA, Herzenberg LA. Int Immunol. 1997; 9 (6): 835-41
Frequent occurrence of identical heavy and light chain Ig rearrangements. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Int Immunol. 1997; 9 (5): 689-702
Detection and isolation of gene-corrected cells in Gaucher disease via a fluorescence-activated cell sorter assay for lysosomal glucocerebrosidase activity. Lorincz M, Herzenberg LA, Diwu Z, Barranger JA, Kerr WG. Blood. 1997; 89 (9): 3412-20
Recurrent identical rearrangement and repeated expression of identical heavy and light chains in single anti-phosphatidylcholine B cells. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Ann N Y Acad Sci. 1997; 815 484-8
HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. Roederer M, Raju PA, Mitra DK, Herzenberg LA, Herzenberg LA. J Clin Invest. 1997; 99 (7): 1555-64
Glutathione deficiency is associated with impaired survival in HIV disease. Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, Deresinski SC, Herzenberg LA. Proc Natl Acad Sci U S A. 1997; 94 (5): 1967-72
An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells. Kantor AB, Merrill CE, Herzenberg LA, Hillson JL. J Immunol. 1997; 158 (3): 1175-86
Cy7PE and Cy7APC: bright new probes for immunofluorescence. Roederer M, Kantor AB, Parks DR, Herzenberg LA. Cytometry. 1996; 24 (3): 191-7
Enzyme-generated intracellular fluorescence for single-cell reporter gene analysis utilizing Escherichia coli beta-glucuronidase. Lorincz M, Roederer M, Diwu Z, Herzenberg LA, Nolan GP. Cytometry. 1996; 24 (4): 321-9
Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals. Katsikis PD, García-Ojeda ME, Wunderlich ES, Smith CA, Yagita H, Okumura K, Kayagaki N, Alderson M, Herzenberg LA, Herzenberg LA. Int Immunol. 1996; 8 (8): 1311-7
Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins. Anderson MT, Tjioe IM, Lorincz MC, Parks DR, Herzenberg LA, Nolan GP, Herzenberg LA. Proc Natl Acad Sci U S A. 1996; 93 (16): 8508-11
NF-kappa B homodimer binding within the HIV-1 initiator region and interactions with TFII-I. Montano MA, Kripke K, Norina CD, Achacoso P, Herzenberg LA, Roy AL, Nolan GP. Proc Natl Acad Sci U S A. 1996; 93 (22): 12376-81
Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains. Kerr WG, Heller M, Herzenberg LA. Proc Natl Acad Sci U S A. 1996; 93 (9): 3947-52
Elevation of plasma thioredoxin levels in HIV-infected individuals. Nakamura H, De Rosa S, Roederer M, Anderson MT, Dubs JG, Yodoi J, Holmgren A, Herzenberg LA, Herzenberg LA. Int Immunol. 1996; 8 (4): 603-11
Changes in antigen densities on leukocyte subsets correlate with progression of HIV disease. Roederer M, Herzenberg LA, Herzenberg LA. Int Immunol. 1996; 8 (1): 1-11
Heterogeneous calcium flux in peripheral T cell subsets revealed by five-color flow cytometry using log-ratio circuitry. Roederer M, Bigos M, Nozaki T, Stovel RT, Parks DR, Herzenberg LA. Cytometry. 1995; 21 (2): 187-96
Development of the antibody repertoire as revealed by single-cell PCR of FACS-sorted B-cell subsets. Kantor AB, Merrill CE, MacKenzie JD, Herzenberg LA, Hillson JL. Ann N Y Acad Sci. 1995; 764 224-7
De novo development and self-replenishment of B cells. Kantor AB, Stall AM, Adams S, Watanabe K, Herzenberg LA. Int Immunol. 1995; 7 (1): 55-68
Human CD5+ B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy. Bhat NM, Mithal A, Bieber MM, Herzenberg LA, Teng NN. J Reprod Immunol. 1995; 28 (1): 53-60
Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. Rabin RL, Roederer M, Maldonado Y, Petru A, Herzenberg LA, Herzenberg LA. J Clin Invest. 1995; 95 (5): 2054-60
Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Serafini AT, Lewis RS, Clipstone NA, Bram RJ, Fanger C, Fiering S, Herzenberg LA, Crabtree GR. Immunity. 1995; 3 (2): 239-50
Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA. J Exp Med. 1995; 181 (6): 2029-36
CD8 naive T cell counts decrease progressively in HIV-infected adults. Roederer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA, Herzenberg LA. J Clin Invest. 1995; 95 (5): 2061-6
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication. Raju PA, Herzenberg LA, Herzenberg LA, Roederer M. AIDS Res Hum Retroviruses. 1994; 10 (8): 961-7
Pattern sorting: a computer-controlled multidimensional sorting method using k-d trees. Bigos M, Parks DR, Moore WA, Herzenberg LA, Herzenberg LA. Cytometry. 1994; 16 (4): 357-63
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway. Anderson MT, Staal FJ, Gitler C, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1994; 91 (24): 11527-31
Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. Staal FJ, Anderson MT, Staal GE, Herzenberg LA, Gitler C, Herzenberg LA. Proc Natl Acad Sci U S A. 1994; 91 (9): 3619-22
Origin of murine B cell lineages. Kantor AB, Herzenberg LA. Annu Rev Immunol. 1993; 11 501-38
B-cell lineages exist in the mouse. Herzenberg LA, Kantor AB. Immunol Today. 1993; 14 (2): 79-83; discussion 88-90
Disregulation of leukocyte glutathione in AIDS. Roederer M, Staal FJ, Anderson M, Rabin R, Raju PA, Herzenberg LA, Herzenberg LA. Ann N Y Acad Sci. 1993; 677 113-25
Antioxidants inhibit stimulation of HIV transcription. Staal FJ, Roederer M, Raju PA, Anderson MT, Ela SW, Herzenberg LA, Herzenberg LA. AIDS Res Hum Retroviruses. 1993; 9 (4): 299-306
Beta-galactosidase activity in single differentiating bacterial cells. Russo-Marie F, Roederer M, Sager B, Herzenberg LA, Kaiser D. Proc Natl Acad Sci U S A. 1993; 90 (17): 8194-8
N-acetylcysteine: potential for AIDS therapy. Roederer M, Staal FJ, Ela SW, Herzenberg LA, Herzenberg LA. Pharmacology. 1993; 46 (3): 121-9
Characteristics and development of the murine B-1b (Ly-1 B sister) cell population. Stall AM, Adams S, Herzenberg LA, Kantor AB. Ann N Y Acad Sci. 1992; 651 33-43
Glutathione and immunophenotypes of T and B lymphocytes in HIV-infected individuals. Staal FJ, Roederer M, Herzenberg LA, Herzenberg LA. Ann N Y Acad Sci. 1992; 651 453-63
Adoptive transfer of murine B-cell lineages. Kantor AB, Stall AM, Adams S, Herzenberg LA, Herzenberg LA. Ann N Y Acad Sci. 1992; 651 168-9
Layered evolution in the immune system. A model for the ontogeny and development of multiple lymphocyte lineages. Herzenberg LA, Kantor AB, Herzenberg LA. Ann N Y Acad Sci. 1992; 651 1-9
CD20 expression is increased on B lymphocytes from HIV-infected individuals. Staal FJ, Roederer M, Bubp J, Mole LA, Anderson MT, Raju PA, Israelski DM, Deresinski SC, Moore WA, Herzenberg LA. J Acquir Immune Defic Syndr. 1992; 5 (6): 627-32
Differential development of progenitor activity for three B-cell lineages. Kantor AB, Stall AM, Adams S, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1992; 89 (8): 3320-4
Glutathione deficiency and human immunodeficiency virus infection. Staal FJ, Ela SW, Roederer M, Anderson MT, Herzenberg LA, Herzenberg LA. Lancet. 1992; 339 (8798): 909-12
N-acetylcysteine: a new approach to anti-HIV therapy. Roederer M, Ela SW, Staal FJ, Herzenberg LA, Herzenberg LA. AIDS Res Hum Retroviruses. 1992; 8 (2): 209-17
The ontogeny and functional characteristics of human B-1 (CD5+ B) cells. Bhat NM, Kantor AB, Bieber MM, Stall AM, Herzenberg LA, Teng NN. Int Immunol. 1992; 4 (2): 243-52
Molecular cloning, reconstruction and expression of the gene encoding the alpha-chain of the bovine CD8--definition of three peptide regions conserved across species. Lalor P, Bucci C, Fornaro M, Rattazzi MC, Nakauchi H, Herzenberg LA, Alberti S. Immunology. 1992; 76 (1): 95-102
CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses. Roederer M, Staal FJ, Osada H, Herzenberg LA, Herzenberg LA. Int Immunol. 1991; 3 (9): 933-7
Heparin alters the expression of different forms of immunoglobulin mu heavy chains and their associated proteins by pre-B cell lines and normal Ly-1 (CD5+) B cells. Chen J, Herzenberg LA, Herzenberg LA. Int Immunol. 1991; 3 (11): 1117-27
N-acetylcysteine inhibits latent HIV expression in chronically infected cells. Roederer M, Raju PA, Staal FJ, Herzenberg LA, Herzenberg LA. AIDS Res Hum Retroviruses. 1991; 7 (6): 563-7
Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Fiering SN, Roederer M, Nolan GP, Micklem DR, Parks DR, Herzenberg LA. Cytometry. 1991; 12 (4): 291-301
In situ detection of stage-specific genes and enhancers in B cell differentiation via gene-search retroviruses. Kerr WG, Nolan GP, Johnsen JB, Herzenberg LA. Adv Exp Med Biol. 1991; 292 187-200
Whole animal cell sorting of Drosophila embryos. Krasnow MA, Cumberledge S, Manning G, Herzenberg LA, Nolan GP. Science. 1991; 251 (4989): 81-5
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Staal FJ, Roederer M, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1990; 87 (24): 9943-7
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. Mattila PS, Ullman KS, Fiering S, Emmel EA, McCutcheon M, Crabtree GR, Herzenberg LA. EMBO J. 1990; 9 (13): 4425-33
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Fiering S, Northrop JP, Nolan GP, Mattila PS, Crabtree GR, Herzenberg LA. Genes Dev. 1990; 4 (10): 1823-34
Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals. Chen JZ, Stall AM, Herzenberg LA, Herzenberg LA. EMBO J. 1990; 9 (7): 2117-24
Zidovudine (azido dideoxythymidine) inhibits characteristic early alterations of lymphoid cell populations in retrovirus-induced murine AIDS. Portnoi D, Stall AM, Schwartz D, Merigan TC, Herzenberg LA, Basham T. J Immunol. 1990; 144 (5): 1705-10
Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation. Fariñas MC, Stall AM, Solovera JJ, Tarlinton DM, Herzenberg LA, Strober S. Arthritis Rheum. 1990; 33 (4): 553-62
Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Roederer M, Staal FJ, Raju PA, Ela SW, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1990; 87 (12): 4884-8
Heparin inhibits EcoRI endonuclease cleavage of DNA at certain EcoRI sites. Chen JZ, Herzenberg LA, Herzenberg LA. Nucleic Acids Res. 1990; 18 (11): 3255-60
The rat B cell system: the anatomical localization of flow cytometry-defined B cell subpopulations. Kroese FG, Butcher EC, Lalor PA, Stall AM, Herzenberg LA. Eur J Immunol. 1990; 20 (7): 1527-34
Murine suppressor T cells: mirage or cloudy reality? Herzenberg LA, Res Immunol. 1989 Mar-Apr; 140 (3): 337-8; discussion 339-45
A major peritoneal reservoir of precursors for intestinal IgA plasma cells. Kroese FG, Butcher EC, Stall AM, Herzenberg LA. Immunol Invest. 1989 Jan-May; 18 (1-4): 47-58
In situ detection of transcriptionally active chromatin and genetic regulatory elements in individual viable mammalian cells. Kerr WG, Nolan GP, Herzenberg LA. Immunol Suppl. 1989; 2 74-8; discussion 79
Permanent alteration of the murine Ly-1 B repertoire due to selective depletion of Ly-1 B cells in neonatal animals. Lalor PA, Stall AM, Adams S, Herzenberg LA. Eur J Immunol. 1989; 19 (3): 501-6
Toward a layered immune system. Herzenberg LA, Herzenberg LA. Cell. 1989; 59 (6): 953-4
Are Ly-1 B cells important in autoimmune disease? Herzenberg LA, Lalor PA, Stall AM. J Autoimmun. 1989; 2 Suppl 225-31
Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Kroese FG, Butcher EC, Stall AM, Lalor PA, Adams S, Herzenberg LA. Int Immunol. 1989; 1 (1): 75-84
Conventional and Ly-1 B-cell lineages in normal and mu transgenic mice. Herzenberg LA, Stall AM. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1 219-25
Transcriptionally defective retroviruses containing lacZ for the in situ detection of endogenous genes and developmentally regulated chromatin. Kerr WG, Nolan GP, Serafini AT, Herzenberg LA. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2 767-76
Repetitive usage of immunoglobulin VH and D gene segments in CD5+ Ly-1 B clones of (NZB x NZW)F1 mice. Tarlinton D, Stall AM, Herzenberg LA. EMBO J. 1988; 7 (12): 3705-10
DNA methylation prevents transfection of genes for specific surface antigens. Alberti S, Herzenberg LA. Proc Natl Acad Sci U S A. 1988; 85 (22): 8391-4
Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. Jutila MA, Kroese FG, Jutila KL, Stall AM, Fiering S, Herzenberg LA, Berg EL, Butcher EC. Eur J Immunol. 1988; 18 (11): 1819-26
Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Stall AM, Fariñas MC, Tarlinton DM, Lalor PA, Herzenberg LA, Strober S, Herzenberg LA. Proc Natl Acad Sci U S A. 1988; 85 (19): 7312-6
Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies. Dangl JL, Wensel TG, Morrison SL, Stryer L, Herzenberg LA, Oi VT. EMBO J. 1988; 7 (7): 1989-94
Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM. Stall AM, Kroese FG, Gadus FT, Sieckmann DG, Herzenberg LA, Herzenberg LA. Proc Natl Acad Sci U S A. 1988; 85 (10): 3546-50
Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ. Nolan GP, Fiering S, Nicolas JF, Herzenberg LA. Proc Natl Acad Sci U S A. 1988; 85 (8): 2603-7
Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody. Waldor MK, Mitchell D, Kipps TJ, Herzenberg LA, Steinman L. J Immunol. 1987; 139 (11): 3660-4
Transfection of genes encoding lymphocyte differentiation antigens: applications in veterinary immunology. Lalor PA, Herzenberg LA. Vet Immunol Immunopathol. 1987; 17 (1-4): 291-302
GENETICS OF A GAMMA GLOBULIN ISOANTIGEN (ALLOTYPE) IN THE MOUSE. Wunderlich J, Herzenberg LA. Proc Natl Acad Sci U S A. 1963; 49 (5): 592-8